MX2009011813A - Acidos poliglutamicos funcionalizados con grupos cationicos y grupos hidrofobicos y aplicaciones de los mismos, en particular aplicaciones terapeuticas de los mismos. - Google Patents

Acidos poliglutamicos funcionalizados con grupos cationicos y grupos hidrofobicos y aplicaciones de los mismos, en particular aplicaciones terapeuticas de los mismos.

Info

Publication number
MX2009011813A
MX2009011813A MX2009011813A MX2009011813A MX2009011813A MX 2009011813 A MX2009011813 A MX 2009011813A MX 2009011813 A MX2009011813 A MX 2009011813A MX 2009011813 A MX2009011813 A MX 2009011813A MX 2009011813 A MX2009011813 A MX 2009011813A
Authority
MX
Mexico
Prior art keywords
modified
novel
vectorization
polyglutamates
groups
Prior art date
Application number
MX2009011813A
Other languages
English (en)
Inventor
You-Ping Chan
Olivier Breyne
Gonnet Cecile Bonnet
Original Assignee
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Publication of MX2009011813A publication Critical patent/MX2009011813A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a materiales biodegradables novedosos basados en poliaminoácidos modificados, que son útiles en particular en la vectorización de principios activos (PA's); la invención también está dirigida a composiciones farmacéuticas, cosméticas, nutracéuticas o de protección de las plantas, basadas en estos poliaminoácidos; la finalidad de la invención es proveer un material inicial polimérico novedoso que se puede usar para la vectorización de PA's y que satisface todos los requerimientos: biocompatibilidad, biodegradabilidad, capacidad para asociarse fácilmente con muchos principios activos o disolverlos, y liberar estos principios activos in vivo; este objetivo es alcanzado por la presente invención, que se refiere a poliglutamatos novedosos modificados con grupos catiónicos, que si se pueden desprotonar exhiben un pKa igual o mayor que 7, y con grupos hidrofóbicos que comprenden de 8 a 30 átomos de carbono; estos poliglutamatos modificados con grupos catiónicos son convertidos fácil y económicamente en partículas para la vectorización de principios activos; estas partículas son, por si solas, capaces de formar suspensiones acuosas coloidales estables; estos poliglutamatos modificados tienen la ventaja de ser menos viscosos que otros polímeros análogos, reteniendo al mismo tiempo la capacidad para asociarse a proteínas como la insulina; algunos son solubles en agua a pH ácido y se hacen insolubles al pH fisiológico (7.4) y por lo tanto durante una inyección subcutánea precipitarían en el sitio de la inyección.
MX2009011813A 2007-05-03 2008-05-05 Acidos poliglutamicos funcionalizados con grupos cationicos y grupos hidrofobicos y aplicaciones de los mismos, en particular aplicaciones terapeuticas de los mismos. MX2009011813A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0703185A FR2915748B1 (fr) 2007-05-03 2007-05-03 Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
PCT/EP2008/055507 WO2008135563A1 (fr) 2007-05-03 2008-05-05 Acides polyglutamiques fonctionnalises par des groupements cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques

Publications (1)

Publication Number Publication Date
MX2009011813A true MX2009011813A (es) 2009-11-13

Family

ID=38792517

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011813A MX2009011813A (es) 2007-05-03 2008-05-05 Acidos poliglutamicos funcionalizados con grupos cationicos y grupos hidrofobicos y aplicaciones de los mismos, en particular aplicaciones terapeuticas de los mismos.

Country Status (15)

Country Link
US (1) US8716217B2 (es)
EP (1) EP2152782A1 (es)
JP (1) JP2010529214A (es)
KR (1) KR20100016280A (es)
CN (1) CN101663346B (es)
AU (1) AU2008248604B2 (es)
BR (1) BRPI0809208A2 (es)
CA (1) CA2683741A1 (es)
EA (1) EA016911B1 (es)
FR (1) FR2915748B1 (es)
IL (1) IL201017A (es)
MX (1) MX2009011813A (es)
NZ (1) NZ580906A (es)
WO (1) WO2008135563A1 (es)
ZA (1) ZA200906941B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2822834B1 (fr) 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
FR2915684B1 (fr) 2007-05-03 2011-01-14 Flamel Tech Sa Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
FR2915683B1 (fr) 2007-05-03 2009-08-07 Flamel Technologies Sa Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif
GB0814519D0 (en) * 2008-08-08 2008-09-17 Imp Innovations Ltd Process
GB0820865D0 (en) * 2008-11-14 2008-12-24 Membrane Extraction Tech Ltd Degradable supports for tide synthesis
FR2940619B1 (fr) * 2008-12-31 2012-02-10 Flamel Technologies Sa Composition comprenant un actif de solubilite aqueuse faible ou moyenne
US20110256227A1 (en) * 2010-04-14 2011-10-20 Intezyne Technologies, Inc. Controlled polyplex assembly
JP2013234207A (ja) * 2010-08-31 2013-11-21 Jsr Corp 新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法
WO2012051458A1 (en) * 2010-10-14 2012-04-19 Nitto Denko Corporation Nucleic acid delivery compounds
FR2968994B1 (fr) 2010-12-17 2012-12-28 Flamel Tech Sa Procede de preparation de nanoparticules
FR2968993B1 (fr) 2010-12-17 2012-12-28 Flamel Tech Sa Nanoparticules comportant au moins un actif et au moins deux polyelectrolytes
US9272020B2 (en) 2011-05-20 2016-03-01 Ares Trading S.A. IFN-beta compositions, preparation methods and uses thereof
FR2975912B1 (fr) 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
EP2554161A1 (en) * 2011-08-02 2013-02-06 LFB Biotechnologies Pharmaceutical composition comprising factor VII encapsulated in micelles
CN102698279B (zh) * 2012-07-03 2013-12-04 南京医科大学 一种两亲性γ-聚谷氨酸纳米药物载体的制备方法
US9357772B2 (en) 2013-04-09 2016-06-07 International Business Machines Corporation Antimicrobial cationic polycarbonates
US9999633B2 (en) 2013-04-09 2018-06-19 International Business Machines Corporation Antimicrobial cationic polycarbonates
WO2014169153A1 (en) * 2013-04-10 2014-10-16 Echogen, Inc. Peptide complexes and therapeutic uses
KR101507119B1 (ko) * 2013-05-31 2015-03-30 주식회사 바이오리더스 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체
CN103590133B (zh) * 2013-10-11 2015-09-16 华东理工大学 一种利用静电纺丝制备聚肽共聚物多孔纳米纤维的方法
JP6564361B2 (ja) * 2014-03-07 2019-08-21 日本化薬株式会社 核酸送達のための組成物
WO2015146731A1 (ja) * 2014-03-26 2015-10-01 日本化薬株式会社 核酸送達用組成物及び核酸含有医薬組成物
CN111698999A (zh) * 2017-12-06 2020-09-22 阿道恰公司 包含至少一种pi在5.8与8.5之间的基础胰岛素和带有羧酸根电荷及疏水基的共聚氨基酸的ph为7的可注射溶液
EP3740227A1 (fr) * 2017-12-07 2020-11-25 Adocia Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide
CN108465104A (zh) * 2018-03-07 2018-08-31 佛山实瑞先导材料研究院（普通合伙） 一种生长激素控释包衣及其制备方法
CN110903410B (zh) * 2019-12-05 2021-07-23 南京大学 聚阳离子型多糖及其应用
CN111804151B (zh) * 2020-07-27 2021-08-27 上海恩捷新材料科技有限公司 一种用于生活污水处理的mbr平板滤膜及其制备方法
CN115975185A (zh) * 2022-12-15 2023-04-18 广州微冠生物科技有限公司 一种含多肽的可溶性微针贴及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351337A (en) 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE60340T1 (de) 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
US6153193A (en) 1993-04-28 2000-11-28 Supratek Pharma Inc. Compositions for targeting biological agents
FR2732218B1 (fr) 1995-03-28 1997-08-01 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation
US6686446B2 (en) * 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
EP0963758A3 (en) 1998-05-07 2000-03-22 Universiteit Gent Synthetic polyaminoacid complexes for delivery of nucleic acids to target cells
GB9811059D0 (en) 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
FR2786098B1 (fr) 1998-11-20 2003-05-30 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
FR2801226B1 (fr) 1999-11-23 2002-01-25 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation
JP2002069177A (ja) * 2000-06-12 2002-03-08 Mitsui Chemicals Inc 重合体及びその製造方法
JP4585114B2 (ja) * 2000-12-27 2010-11-24 三井化学株式会社 重合体及びその製造方法
FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
WO2004060968A1 (fr) 2002-12-04 2004-07-22 Flamel Technologies Polyaminoacides fonctionnalises par au moins un groupement (oligo)aminoacide et leurs applications notamment therapeutiques
FR2855521B1 (fr) 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
FR2873703B1 (fr) * 2004-07-30 2006-12-08 Flamel Technologies Sa Polyaminoacides branches, fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
JP4735933B2 (ja) * 2004-09-03 2011-07-27 独立行政法人産業技術総合研究所 ｐＨ応答性両性イオン微粒子状ポリマー及びその用途
FR2892725B1 (fr) * 2005-10-31 2011-03-04 Flamel Tech Sa Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques
CA2631704A1 (en) * 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
JP2009007547A (ja) * 2007-05-25 2009-01-15 Tokyo Metropolitan Univ 核酸キャリア及び核酸デリバリー方法

Also Published As

Publication number Publication date
WO2008135563A1 (fr) 2008-11-13
EA200901481A1 (ru) 2010-04-30
BRPI0809208A2 (pt) 2016-11-16
FR2915748B1 (fr) 2012-10-19
US8716217B2 (en) 2014-05-06
IL201017A0 (en) 2010-05-17
ZA200906941B (en) 2010-12-29
US20090012028A1 (en) 2009-01-08
FR2915748A1 (fr) 2008-11-07
CA2683741A1 (fr) 2008-11-13
EP2152782A1 (fr) 2010-02-17
JP2010529214A (ja) 2010-08-26
CN101663346B (zh) 2012-03-21
IL201017A (en) 2013-03-24
AU2008248604B2 (en) 2012-11-08
CN101663346A (zh) 2010-03-03
KR20100016280A (ko) 2010-02-12
EA016911B1 (ru) 2012-08-30
AU2008248604A1 (en) 2008-11-13
NZ580906A (en) 2011-07-29

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