WO2007051923A3 - Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques - Google Patents

Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques Download PDF

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Publication number
WO2007051923A3
WO2007051923A3 PCT/FR2006/002443 FR2006002443W WO2007051923A3 WO 2007051923 A3 WO2007051923 A3 WO 2007051923A3 FR 2006002443 W FR2006002443 W FR 2006002443W WO 2007051923 A3 WO2007051923 A3 WO 2007051923A3
Authority
WO
WIPO (PCT)
Prior art keywords
modified
novel
relates
histidine derivatives
hydrophobic groups
Prior art date
Application number
PCT/FR2006/002443
Other languages
English (en)
Other versions
WO2007051923A2 (fr
Inventor
Olivier Soula
Remi Soula
Olivier Breyne
Original Assignee
Flamel Tech Sa
Olivier Soula
Remi Soula
Olivier Breyne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa, Olivier Soula, Remi Soula, Olivier Breyne filed Critical Flamel Tech Sa
Priority to JP2008537144A priority Critical patent/JP5292099B2/ja
Priority to CN2006800409623A priority patent/CN101300267B/zh
Priority to US12/084,368 priority patent/US8293255B2/en
Priority to EP06831050A priority patent/EP1945655A2/fr
Priority to CA002627746A priority patent/CA2627746A1/fr
Publication of WO2007051923A2 publication Critical patent/WO2007051923A2/fr
Publication of WO2007051923A3 publication Critical patent/WO2007051923A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des nouveaux matériaux à base de polyaminoacides modifiés, biodégradables, utiles notamment pour la vectorisation de principe(s) actif(s) (PA). L'invention vise aussi de nouvelles compositions pharmaceutiques, cosmétiques, diététiques ou phytosanitaires à base de ces polyaminoacides. Le but de l'invention est de fournir une nouvelle matière première polymère, susceptible d'être utilisée pour la vectorisation de PA et permettant de satisfaire de manière optimale à toutes les spécifications requises en l'espèce : biocompatibilité, biodégradabilité, aptitude à s'associer facilement avec de nombreux principes actifs ou à les solubiliser, et à libérer ces principes actifs in vivo. Ce but est atteint par la présente invention qui concerne des nouveaux polyglutamates modifiés par des dérivés de l'histidine, et par des groupements hydrophobes comportant de 8 à 30 atomes de carbone. Ces polyglutamates modifiés par des dérivés de l'histidine sont solubles à pH inférieur à 5 et sont aptes à se transformer aisément et économiquement en particules de vectorisation de principes actifs, ces particules étant elles même propres à former des suspensions colloïdales aqueuses stables. Ces polyglutamates modifiés sont en revanche insolubles dans l'eau à pH physiologique (7,4) et devraient donc, lors d'une injection sous-cutanée, précipiter sur le site d'injection.
PCT/FR2006/002443 2005-10-31 2006-10-31 Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques WO2007051923A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2008537144A JP5292099B2 (ja) 2005-10-31 2006-10-31 ヒスチジン誘導体および疎水基で官能化されたポリグルタミン酸類、ならびに特に治療目的のためのそれらの使用
CN2006800409623A CN101300267B (zh) 2005-10-31 2006-10-31 被组氨酸衍生物和疏水基官能化的聚谷氨酸及其应用
US12/084,368 US8293255B2 (en) 2005-10-31 2006-10-31 Polyglutamic acids functionalised by histidine derivatives and hydrophobic groups and the uses thereof, in particular for therapeutic purposes
EP06831050A EP1945655A2 (fr) 2005-10-31 2006-10-31 Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques
CA002627746A CA2627746A1 (fr) 2005-10-31 2006-10-31 Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0553302A FR2892725B1 (fr) 2005-10-31 2005-10-31 Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques
FR0553302 2005-10-31

Publications (2)

Publication Number Publication Date
WO2007051923A2 WO2007051923A2 (fr) 2007-05-10
WO2007051923A3 true WO2007051923A3 (fr) 2007-06-28

Family

ID=36677271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/002443 WO2007051923A2 (fr) 2005-10-31 2006-10-31 Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques

Country Status (7)

Country Link
US (1) US8293255B2 (fr)
EP (1) EP1945655A2 (fr)
JP (1) JP5292099B2 (fr)
CN (1) CN101300267B (fr)
CA (1) CA2627746A1 (fr)
FR (1) FR2892725B1 (fr)
WO (1) WO2007051923A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103751789B (zh) * 2008-12-31 2016-08-17 弗拉梅爱尔兰有限公司 包含具有低水溶解度的活性物质的组合物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2915684B1 (fr) * 2007-05-03 2011-01-14 Flamel Tech Sa Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
FR2915683B1 (fr) 2007-05-03 2009-08-07 Flamel Technologies Sa Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif
FR2915748B1 (fr) * 2007-05-03 2012-10-19 Flamel Tech Sa Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
JP4655298B1 (ja) 2010-02-23 2011-03-23 ナノキャリア株式会社 短鎖のカチオン性ポリアミノ酸およびその使用
CN103893813B (zh) * 2012-12-28 2018-04-17 财团法人工业技术研究院 高分子组合物与高分子材料
CN106749522B (zh) * 2016-11-23 2023-11-14 华东理工大学 一种含有聚组氨酸的抗癌多肽及其制备与应用
CN108623802B (zh) * 2018-05-08 2021-01-08 四川大学 一种功能性聚氨基酸衍生物及其制备方法和应用
EP4308288A1 (fr) * 2021-03-18 2024-01-24 Agfa-Gevaert Nv Capsules à base de poly(acide aminé)

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1991015589A1 (fr) * 1990-04-09 1991-10-17 The Upjohn Company Procede ameliore de purification de proteines de recombinaison et procedes utiles dans ledit procede
WO2003104303A1 (fr) * 2002-06-07 2003-12-18 Flamel Technologies Polyaminoacides fonctionnalisés par de l'alpha-tocopherol et leurs applications notamment thérapeutiques
WO2004013206A2 (fr) * 2002-07-30 2004-02-12 Flamel Technologies Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques

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WO2003104303A1 (fr) * 2002-06-07 2003-12-18 Flamel Technologies Polyaminoacides fonctionnalisés par de l'alpha-tocopherol et leurs applications notamment thérapeutiques
WO2004013206A2 (fr) * 2002-07-30 2004-02-12 Flamel Technologies Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103751789B (zh) * 2008-12-31 2016-08-17 弗拉梅爱尔兰有限公司 包含具有低水溶解度的活性物质的组合物

Also Published As

Publication number Publication date
US20100034886A1 (en) 2010-02-11
EP1945655A2 (fr) 2008-07-23
US8293255B2 (en) 2012-10-23
JP5292099B2 (ja) 2013-09-18
WO2007051923A2 (fr) 2007-05-10
CN101300267B (zh) 2013-10-16
JP2009519211A (ja) 2009-05-14
FR2892725B1 (fr) 2011-03-04
CN101300267A (zh) 2008-11-05
FR2892725A1 (fr) 2007-05-04
CA2627746A1 (fr) 2007-05-10

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