FR2915684B1 - Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules - Google Patents

Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules

Info

Publication number
FR2915684B1
FR2915684B1 FR0703187A FR0703187A FR2915684B1 FR 2915684 B1 FR2915684 B1 FR 2915684B1 FR 0703187 A FR0703187 A FR 0703187A FR 0703187 A FR0703187 A FR 0703187A FR 2915684 B1 FR2915684 B1 FR 2915684B1
Authority
FR
France
Prior art keywords
particles
polyelectrolytes
active ingredients
pharmaceutical formulations
formulations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0703187A
Other languages
English (en)
Other versions
FR2915684A1 (fr
Inventor
Gonnet Cecile Bonnet
Frederic Checot
You Ping Chan
Olivier Breyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Technologies SA
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0703187A priority Critical patent/FR2915684B1/fr
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Priority to MX2009011815A priority patent/MX2009011815A/es
Priority to CA002685855A priority patent/CA2685855A1/fr
Priority to CN200880014547XA priority patent/CN101674814B/zh
Priority to JP2010504755A priority patent/JP2010526040A/ja
Priority to US12/149,552 priority patent/US8481019B2/en
Priority to EP08750062A priority patent/EP2155173A1/fr
Priority to BRPI0810878-1A2A priority patent/BRPI0810878A2/pt
Priority to KR1020097025178A priority patent/KR20100017574A/ko
Priority to AU2008248602A priority patent/AU2008248602B2/en
Priority to PCT/EP2008/055505 priority patent/WO2008135561A1/fr
Publication of FR2915684A1 publication Critical patent/FR2915684A1/fr
Priority to IL201689A priority patent/IL201689A/en
Application granted granted Critical
Publication of FR2915684B1 publication Critical patent/FR2915684B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0703187A 2007-05-03 2007-05-03 Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules Expired - Fee Related FR2915684B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR0703187A FR2915684B1 (fr) 2007-05-03 2007-05-03 Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
KR1020097025178A KR20100017574A (ko) 2007-05-03 2008-05-05 고분자 전해질 및 활성 성분을 베이스로 하는 조절 방출 입자 및 이들 입자를 함유하는 약학 제제
CN200880014547XA CN101674814B (zh) 2007-05-03 2008-05-05 基于聚电解质和活性成分的改性释放颗粒以及含有这些颗粒的药物制剂
JP2010504755A JP2010526040A (ja) 2007-05-03 2008-05-05 高分子電解質および活性成分を基にした放出制御粒子および該粒子を含む製剤
US12/149,552 US8481019B2 (en) 2007-05-03 2008-05-05 Modified-release particles of polyelectrolytes and pharmaceutical formulations thereof
EP08750062A EP2155173A1 (fr) 2007-05-03 2008-05-05 Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
MX2009011815A MX2009011815A (es) 2007-05-03 2008-05-05 Particulas de liberacion modificadas basadas en polielectrolitos y en un principio activo y formulaciones farmaceuticas que contienen estas particulas.
CA002685855A CA2685855A1 (fr) 2007-05-03 2008-05-05 Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
AU2008248602A AU2008248602B2 (en) 2007-05-03 2008-05-05 Modified-release particles based on polyelectrolytes and on an active principle and pharmaceutical formulations containing these particles
PCT/EP2008/055505 WO2008135561A1 (fr) 2007-05-03 2008-05-05 Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
BRPI0810878-1A2A BRPI0810878A2 (pt) 2007-05-03 2008-05-05 Partículas à base de polieletrólitos e de princípio ativo de liberação modificada e formulações farmacêuticas contendo estas partículas.
IL201689A IL201689A (en) 2007-05-03 2009-10-22 Delayed-release particles based on polyelectrolytic polymers and active substance and medicinal preparations containing these particles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0703187A FR2915684B1 (fr) 2007-05-03 2007-05-03 Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules

Publications (2)

Publication Number Publication Date
FR2915684A1 FR2915684A1 (fr) 2008-11-07
FR2915684B1 true FR2915684B1 (fr) 2011-01-14

Family

ID=38787100

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0703187A Expired - Fee Related FR2915684B1 (fr) 2007-05-03 2007-05-03 Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules

Country Status (12)

Country Link
US (1) US8481019B2 (fr)
EP (1) EP2155173A1 (fr)
JP (1) JP2010526040A (fr)
KR (1) KR20100017574A (fr)
CN (1) CN101674814B (fr)
AU (1) AU2008248602B2 (fr)
BR (1) BRPI0810878A2 (fr)
CA (1) CA2685855A1 (fr)
FR (1) FR2915684B1 (fr)
IL (1) IL201689A (fr)
MX (1) MX2009011815A (fr)
WO (1) WO2008135561A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110150837A1 (en) * 2009-12-23 2011-06-23 Flamel Technologies Amphiphilic polymer functionalized by methionine
FR2954325B1 (fr) 2009-12-23 2012-02-03 Flamel Tech Sa Polymere amphiphile fonctionnalise par la methionine
FR2968994B1 (fr) * 2010-12-17 2012-12-28 Flamel Tech Sa Procede de preparation de nanoparticules
FR2968993B1 (fr) 2010-12-17 2012-12-28 Flamel Tech Sa Nanoparticules comportant au moins un actif et au moins deux polyelectrolytes
BR112014016889A8 (pt) * 2012-01-09 2017-07-04 Adocia composição sob a forma de uma solução aquosa injetável, sujo ph está compreendido entre 6,0 e 8,0 e, formulação de dose unitária com ph compreendido entre 7 e 7,8

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786098B1 (fr) * 1998-11-20 2003-05-30 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
FR2801226B1 (fr) 1999-11-23 2002-01-25 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation
FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2855521B1 (fr) 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques
FR2862541B1 (fr) * 2003-11-21 2007-04-20 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
IL162390A0 (en) * 2004-06-07 2005-11-20 Medigus Ltd Multipurpose endoscopy suite
FR2873704B1 (fr) * 2004-07-30 2006-12-08 Flamel Technologies Sa Polyaminoacides fonctionnalises par des greffons hydrophobes portant une charge anionique et leurs applications notamment therapeutiques
FR2881140B1 (fr) * 2005-01-27 2007-04-06 Flamel Technologies Sa Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2892725B1 (fr) * 2005-10-31 2011-03-04 Flamel Tech Sa Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques
FR2902007B1 (fr) * 2006-06-09 2012-01-13 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s) ainsi que leurs applications notamment therapeutiques
FR2915748B1 (fr) * 2007-05-03 2012-10-19 Flamel Tech Sa Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques

Also Published As

Publication number Publication date
CA2685855A1 (fr) 2008-11-13
FR2915684A1 (fr) 2008-11-07
IL201689A (en) 2013-08-29
AU2008248602A1 (en) 2008-11-13
US8481019B2 (en) 2013-07-09
MX2009011815A (es) 2009-11-13
AU2008248602B2 (en) 2012-07-26
EP2155173A1 (fr) 2010-02-24
JP2010526040A (ja) 2010-07-29
IL201689A0 (en) 2010-05-31
US20090011039A1 (en) 2009-01-08
WO2008135561A1 (fr) 2008-11-13
KR20100017574A (ko) 2010-02-16
CN101674814B (zh) 2013-10-16
BRPI0810878A2 (pt) 2014-10-29
CN101674814A (zh) 2010-03-17

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20160129