FR2904219B1 - Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant - Google Patents

Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant

Info

Publication number
FR2904219B1
FR2904219B1 FR0653191A FR0653191A FR2904219B1 FR 2904219 B1 FR2904219 B1 FR 2904219B1 FR 0653191 A FR0653191 A FR 0653191A FR 0653191 A FR0653191 A FR 0653191A FR 2904219 B1 FR2904219 B1 FR 2904219B1
Authority
FR
France
Prior art keywords
active ingredient
pharmaceutical formulations
formulations containing
modified release
containing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0653191A
Other languages
English (en)
Other versions
FR2904219A1 (fr
Inventor
Alain Constancis
You Ping Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Ireland Ltd
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0653191A priority Critical patent/FR2904219B1/fr
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Priority to ZA200900929A priority patent/ZA200900929B/xx
Priority to AU2007291577A priority patent/AU2007291577B2/en
Priority to PCT/EP2007/006722 priority patent/WO2008025425A1/fr
Priority to CA2661567A priority patent/CA2661567C/fr
Priority to JP2009525938A priority patent/JP5302197B2/ja
Priority to MX2009000951A priority patent/MX2009000951A/es
Priority to CN2007800318934A priority patent/CN101568328B/zh
Priority to KR1020097004345A priority patent/KR101407033B1/ko
Priority to BRPI0714943-3A priority patent/BRPI0714943A2/pt
Priority to EP07801468A priority patent/EP2049085A1/fr
Publication of FR2904219A1 publication Critical patent/FR2904219A1/fr
Priority to IL196426A priority patent/IL196426A/en
Application granted granted Critical
Publication of FR2904219B1 publication Critical patent/FR2904219B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0653191A 2006-07-28 2006-07-28 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant Expired - Fee Related FR2904219B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR0653191A FR2904219B1 (fr) 2006-07-28 2006-07-28 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
KR1020097004345A KR101407033B1 (ko) 2006-07-28 2007-07-30 변형 방출형의 활성 성분 및 양친매성 공중합체에 기초한 미립자 및 이를 함유하는 약학 제형
PCT/EP2007/006722 WO2008025425A1 (fr) 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
CA2661567A CA2661567C (fr) 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
JP2009525938A JP5302197B2 (ja) 2006-07-28 2007-07-30 両親媒性コポリマーおよび調節放出の有効成分を基にした微小粒子、ならびにこれらを含む医薬製剤
MX2009000951A MX2009000951A (es) 2006-07-28 2007-07-30 Microparticulas de liberacion modificada en base a copolimero anfifilico y a principio(s) activo(s) y formulaciones farmaceuticas que las comprenden.
ZA200900929A ZA200900929B (en) 2006-07-28 2007-07-30 Microparticles based on an amphiphilic copolymer and on active ingredient(s) with modified release and pharmaceutical formulations containing same
AU2007291577A AU2007291577B2 (en) 2006-08-28 2007-07-30 Microparticles based on an amphiphilic copolymer and on active ingredient(s) with modified release and pharmaceutical formulations containing same
BRPI0714943-3A BRPI0714943A2 (pt) 2006-07-28 2007-07-30 micropartÍculas de liberaÇço modificada baseada em copolÍmero anfifÍlico e em princÍpio(s) ativo(s) e formulaÇÕes farmacÊuticas compreendendo as mesmas
EP07801468A EP2049085A1 (fr) 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
CN2007800318934A CN101568328B (zh) 2006-07-28 2007-07-30 基于两性分子共聚物和活性成分的改性释放的微颗粒以及含有它们的药物制剂
IL196426A IL196426A (en) 2006-07-28 2009-01-11 Micro-particles based on amphiphilic copolymer, their preparation processes and their pharmaceutical preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0653191A FR2904219B1 (fr) 2006-07-28 2006-07-28 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
FR2904219A1 FR2904219A1 (fr) 2008-02-01
FR2904219B1 true FR2904219B1 (fr) 2010-08-13

Family

ID=37814390

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0653191A Expired - Fee Related FR2904219B1 (fr) 2006-07-28 2006-07-28 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant

Country Status (11)

Country Link
EP (1) EP2049085A1 (fr)
JP (1) JP5302197B2 (fr)
KR (1) KR101407033B1 (fr)
CN (1) CN101568328B (fr)
BR (1) BRPI0714943A2 (fr)
CA (1) CA2661567C (fr)
FR (1) FR2904219B1 (fr)
IL (1) IL196426A (fr)
MX (1) MX2009000951A (fr)
WO (1) WO2008025425A1 (fr)
ZA (1) ZA200900929B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934161B1 (fr) * 2008-07-28 2010-09-17 Flamel Tech Sa Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules.
FR2940619B1 (fr) * 2008-12-31 2012-02-10 Flamel Technologies Sa Composition comprenant un actif de solubilite aqueuse faible ou moyenne
FR2954325B1 (fr) 2009-12-23 2012-02-03 Flamel Tech Sa Polymere amphiphile fonctionnalise par la methionine
JP4829351B2 (ja) * 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物
CN102232932B (zh) * 2010-04-27 2013-06-05 重庆莱美药业股份有限公司 果胶-阿霉素轭合物的冻干制剂及制备方法
CN102657843A (zh) * 2012-06-05 2012-09-12 云南民族大学 抗菌肽组合物及其制备方法
CN103483583B (zh) * 2013-09-24 2015-11-18 昆明理工大学 一种ε-聚赖氨酸的制备方法
WO2015151103A1 (fr) 2014-04-03 2015-10-08 Biondvax Pharmaceuticals Ltd. Compositions de polypeptides multimères-multi-épitopes de grippe et leur production
CN107106641B (zh) 2014-10-31 2021-12-21 葛兰素史密斯克莱知识产权发展有限公司 粉末制剂
KR101891715B1 (ko) * 2016-01-15 2018-08-27 연세대학교 산학협력단 바이러스 감염의 치료용 폴리아미노산 기반의 생체환경 감응형 나노입자
CN109642024A (zh) * 2016-08-02 2019-04-16 日本化药株式会社 主动靶向型高分子衍生物、包含该高分子衍生物的组合物以及它们的用途
CN110483785B (zh) * 2019-07-01 2020-05-19 中山大学 一种三嵌段聚合物、载药纳米胶束、纳米药物及其制备方法和应用
CN110343245B (zh) * 2019-07-16 2021-09-28 天津大学 一种ε-聚赖氨酸-接枝-疏水氨基酸-接枝-海藻糖的糖肽及制备方法
CN112553759A (zh) * 2020-11-30 2021-03-26 福建凤竹纺织科技股份有限公司 一种多功能海藻纤维针织面料

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US5250293A (en) * 1991-04-22 1993-10-05 Gleich Gerald J Method for the treatment of hypersensitivity diseases by administration of anionic polymers
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
DE4407898A1 (de) * 1994-03-09 1995-09-14 Hoechst Ag Nanopartikel, enthaltend einen Wirkstoff und ein Polyketalweinsäureamid, Verfahren zu ihrer Herstellung und Verwendung derselben
NZ506975A (en) * 1999-01-18 2004-01-30 Lg Chemical Ltd Lipophilic microparticles containing a protein drug or antigen and formulation comprising same
FR2814951B1 (fr) * 2000-10-06 2003-01-17 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation
AU2002335046A1 (en) * 2001-10-19 2003-05-06 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques
FR2862541B1 (fr) * 2003-11-21 2007-04-20 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques

Also Published As

Publication number Publication date
FR2904219A1 (fr) 2008-02-01
WO2008025425B1 (fr) 2008-05-02
KR20090054976A (ko) 2009-06-01
WO2008025425A9 (fr) 2008-06-12
KR101407033B1 (ko) 2014-06-20
JP5302197B2 (ja) 2013-10-02
WO2008025425A1 (fr) 2008-03-06
MX2009000951A (es) 2009-02-04
ZA200900929B (en) 2010-06-30
CN101568328A (zh) 2009-10-28
CA2661567C (fr) 2016-09-20
AU2007291577A1 (en) 2008-03-06
CN101568328B (zh) 2012-09-05
CA2661567A1 (fr) 2008-03-06
WO2008025425A8 (fr) 2009-04-16
EP2049085A1 (fr) 2009-04-22
IL196426A (en) 2014-07-31
JP2009544759A (ja) 2009-12-17
BRPI0714943A2 (pt) 2013-05-21
IL196426A0 (en) 2009-09-22

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Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 10

TP Transmission of property

Owner name: FLAMEL IRELAND LIMITED, IE

Effective date: 20151119

PLFP Fee payment

Year of fee payment: 11

ST Notification of lapse

Effective date: 20180330