FR2934161B1 - Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules. - Google Patents

Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules.

Info

Publication number
FR2934161B1
FR2934161B1 FR0855179A FR0855179A FR2934161B1 FR 2934161 B1 FR2934161 B1 FR 2934161B1 FR 0855179 A FR0855179 A FR 0855179A FR 0855179 A FR0855179 A FR 0855179A FR 2934161 B1 FR2934161 B1 FR 2934161B1
Authority
FR
France
Prior art keywords
microparticular
nanoparticles
modified release
oral form
form useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0855179A
Other languages
English (en)
Other versions
FR2934161A1 (fr
Inventor
Remi Meyrueix
Rafael Jorda
Anne Sophie Daviaud
Alain Constancis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Technologies SA
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0855179A priority Critical patent/FR2934161B1/fr
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Priority to US12/509,109 priority patent/US20100021549A1/en
Priority to CA2731449A priority patent/CA2731449A1/fr
Priority to EP09740381A priority patent/EP2317990A2/fr
Priority to CN2009801330449A priority patent/CN102131500A/zh
Priority to JP2011520564A priority patent/JP2011529100A/ja
Priority to PCT/FR2009/051495 priority patent/WO2010012940A2/fr
Publication of FR2934161A1 publication Critical patent/FR2934161A1/fr
Application granted granted Critical
Publication of FR2934161B1 publication Critical patent/FR2934161B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0855179A 2008-07-28 2008-07-28 Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules. Expired - Fee Related FR2934161B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0855179A FR2934161B1 (fr) 2008-07-28 2008-07-28 Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules.
CA2731449A CA2731449A1 (fr) 2008-07-28 2009-07-24 Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules
EP09740381A EP2317990A2 (fr) 2008-07-28 2009-07-24 Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules
CN2009801330449A CN102131500A (zh) 2008-07-28 2009-07-24 可用于纳米颗粒的修饰释放的微颗粒口服剂型
US12/509,109 US20100021549A1 (en) 2008-07-28 2009-07-24 Microparticle oral form useful for the modified release of nanoparticles
JP2011520564A JP2011529100A (ja) 2008-07-28 2009-07-24 ナノ粒子の調節放出に有用な微粒子状経口剤形
PCT/FR2009/051495 WO2010012940A2 (fr) 2008-07-28 2009-07-24 Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0855179A FR2934161B1 (fr) 2008-07-28 2008-07-28 Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules.

Publications (2)

Publication Number Publication Date
FR2934161A1 FR2934161A1 (fr) 2010-01-29
FR2934161B1 true FR2934161B1 (fr) 2010-09-17

Family

ID=40210723

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0855179A Expired - Fee Related FR2934161B1 (fr) 2008-07-28 2008-07-28 Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules.

Country Status (6)

Country Link
EP (1) EP2317990A2 (fr)
JP (1) JP2011529100A (fr)
CN (1) CN102131500A (fr)
CA (1) CA2731449A1 (fr)
FR (1) FR2934161B1 (fr)
WO (1) WO2010012940A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2940619B1 (fr) * 2008-12-31 2012-02-10 Flamel Technologies Sa Composition comprenant un actif de solubilite aqueuse faible ou moyenne
US10441549B2 (en) * 2015-08-13 2019-10-15 The Johns Hopkins University Methods of preparing polyelectrolyte complex nanoparticles
CN107648182B (zh) * 2016-07-26 2020-03-17 天津大学 超稳定纳米药物载体mPEG-PGlu(D)-VE(D)及制备方法及用途
US11491114B2 (en) 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
JP2021512176A (ja) * 2018-02-06 2021-05-13 スリーエム イノベイティブ プロパティズ カンパニー 多孔質又は中空コアとｐＨ感受性シェルとを有するマイクロカプセル及びその使用
CN109875978A (zh) * 2019-04-12 2019-06-14 常州大学 一种可用于药物缓释的聚丙烯酸-生育酚琥珀酸酯自组装载药体系的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
FR2904219B1 (fr) * 2006-07-28 2010-08-13 Flamel Tech Sa Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant

Also Published As

Publication number Publication date
WO2010012940A3 (fr) 2010-03-25
CA2731449A1 (fr) 2010-02-04
EP2317990A2 (fr) 2011-05-11
CN102131500A (zh) 2011-07-20
WO2010012940A2 (fr) 2010-02-04
FR2934161A1 (fr) 2010-01-29
JP2011529100A (ja) 2011-12-01

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20140331