WO2008025425A8 - Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant - Google Patents

Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant Download PDF

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Publication number
WO2008025425A8
WO2008025425A8 PCT/EP2007/006722 EP2007006722W WO2008025425A8 WO 2008025425 A8 WO2008025425 A8 WO 2008025425A8 EP 2007006722 W EP2007006722 W EP 2007006722W WO 2008025425 A8 WO2008025425 A8 WO 2008025425A8
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
active ingredient
pharmaceutical formulations
suspension
formulations containing
Prior art date
Application number
PCT/EP2007/006722
Other languages
English (en)
Other versions
WO2008025425A1 (fr
WO2008025425B1 (fr
WO2008025425A9 (fr
Inventor
Alain Constancis
You-Ping Chan
Original Assignee
Flamel Tech Sa
Alain Constancis
You-Ping Chan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2009000951A priority Critical patent/MX2009000951A/es
Application filed by Flamel Tech Sa, Alain Constancis, You-Ping Chan filed Critical Flamel Tech Sa
Priority to EP07801468A priority patent/EP2049085A1/fr
Priority to JP2009525938A priority patent/JP5302197B2/ja
Priority to CA2661567A priority patent/CA2661567C/fr
Priority to KR1020097004345A priority patent/KR101407033B1/ko
Priority to BRPI0714943-3A priority patent/BRPI0714943A2/pt
Priority to AU2007291577A priority patent/AU2007291577B2/en
Priority to CN2007800318934A priority patent/CN101568328B/zh
Publication of WO2008025425A1 publication Critical patent/WO2008025425A1/fr
Publication of WO2008025425B1 publication Critical patent/WO2008025425B1/fr
Publication of WO2008025425A9 publication Critical patent/WO2008025425A9/fr
Priority to IL196426A priority patent/IL196426A/en
Publication of WO2008025425A8 publication Critical patent/WO2008025425A8/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Abstract

La présente invention concerne de nouvelles microparticules de polyaminoacides amphiphiles transporteurs de principe(s) actif(s) -PA-, en particulier protéinique(s) et peptidique(s), ainsi que de nouvelles formulations pharmaceutiques à libération modifiée contenant lesdites microparticules de PA. Le but de l'invention est de mettre au point de nouvelles microparticules chargées en PA obtenues par agrégation de nanoparticules de polyaminoacides amphiphiles, et ayant des propriétés améliorées, notamment sous forme solide sèche, au regard de leur aptitude à la dispersion, et, s'agissant de la suspension reconstituée, de sa stabilité et de son aptitude à être facilement manipulée et injectée. L'invention concerne dans un premier aspect, des microparticules de polyaminoacide amphiphile (PO) contenant au moins un PA (associé de façon non covalente), formant spontanément une suspension colloïdale de nanoparticules dans l'eau, à pH 7,0, en condition isotonique; lesdites microparticules étant caractérisées a. en ce qu'elles sont obtenues par atomisation d'une solution ou d'une suspension colloïdale de PO comprenant au moins un PA, b. par une taillecomprise entre 0,5 et 100 μm, c. et en ce qu'elles sont dispersables en suspension colloïdale. L'invention concerne également le procédé de préparation de ces microparticules, une formulation liquide comprenant une suspension de ces microparticules PO/PA, un procédé et un nécessaire de reconstitution de cette formulation, et une forme sèche de cette formulation.
PCT/EP2007/006722 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant WO2008025425A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BRPI0714943-3A BRPI0714943A2 (pt) 2006-07-28 2007-07-30 micropartÍculas de liberaÇço modificada baseada em copolÍmero anfifÍlico e em princÍpio(s) ativo(s) e formulaÇÕes farmacÊuticas compreendendo as mesmas
EP07801468A EP2049085A1 (fr) 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
JP2009525938A JP5302197B2 (ja) 2006-07-28 2007-07-30 両親媒性コポリマーおよび調節放出の有効成分を基にした微小粒子、ならびにこれらを含む医薬製剤
CA2661567A CA2661567C (fr) 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
KR1020097004345A KR101407033B1 (ko) 2006-07-28 2007-07-30 변형 방출형의 활성 성분 및 양친매성 공중합체에 기초한 미립자 및 이를 함유하는 약학 제형
MX2009000951A MX2009000951A (es) 2006-07-28 2007-07-30 Microparticulas de liberacion modificada en base a copolimero anfifilico y a principio(s) activo(s) y formulaciones farmaceuticas que las comprenden.
AU2007291577A AU2007291577B2 (en) 2006-08-28 2007-07-30 Microparticles based on an amphiphilic copolymer and on active ingredient(s) with modified release and pharmaceutical formulations containing same
CN2007800318934A CN101568328B (zh) 2006-07-28 2007-07-30 基于两性分子共聚物和活性成分的改性释放的微颗粒以及含有它们的药物制剂
IL196426A IL196426A (en) 2006-07-28 2009-01-11 Micro-particles based on amphiphilic copolymer, their preparation processes and their pharmaceutical preparations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0653191A FR2904219B1 (fr) 2006-07-28 2006-07-28 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
FR0653191 2006-07-28

Publications (4)

Publication Number Publication Date
WO2008025425A1 WO2008025425A1 (fr) 2008-03-06
WO2008025425B1 WO2008025425B1 (fr) 2008-05-02
WO2008025425A9 WO2008025425A9 (fr) 2008-06-12
WO2008025425A8 true WO2008025425A8 (fr) 2009-04-16

Family

ID=37814390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/006722 WO2008025425A1 (fr) 2006-07-28 2007-07-30 Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant

Country Status (11)

Country Link
EP (1) EP2049085A1 (fr)
JP (1) JP5302197B2 (fr)
KR (1) KR101407033B1 (fr)
CN (1) CN101568328B (fr)
BR (1) BRPI0714943A2 (fr)
CA (1) CA2661567C (fr)
FR (1) FR2904219B1 (fr)
IL (1) IL196426A (fr)
MX (1) MX2009000951A (fr)
WO (1) WO2008025425A1 (fr)
ZA (1) ZA200900929B (fr)

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* Cited by examiner, † Cited by third party
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FR2934161B1 (fr) * 2008-07-28 2010-09-17 Flamel Tech Sa Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules.
FR2940619B1 (fr) * 2008-12-31 2012-02-10 Flamel Technologies Sa Composition comprenant un actif de solubilite aqueuse faible ou moyenne
FR2954325B1 (fr) 2009-12-23 2012-02-03 Flamel Tech Sa Polymere amphiphile fonctionnalise par la methionine
JP4829351B2 (ja) * 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物
CN102232932B (zh) * 2010-04-27 2013-06-05 重庆莱美药业股份有限公司 果胶-阿霉素轭合物的冻干制剂及制备方法
CN102657843A (zh) * 2012-06-05 2012-09-12 云南民族大学 抗菌肽组合物及其制备方法
CN103483583B (zh) * 2013-09-24 2015-11-18 昆明理工大学 一种ε-聚赖氨酸的制备方法
WO2015151103A1 (fr) * 2014-04-03 2015-10-08 Biondvax Pharmaceuticals Ltd. Compositions de polypeptides multimères-multi-épitopes de grippe et leur production
AU2015338717B2 (en) 2014-10-31 2018-12-20 Glaxosmithkline Intellectual Property Development Limited Powder formulation
KR101891715B1 (ko) * 2016-01-15 2018-08-27 연세대학교 산학협력단 바이러스 감염의 치료용 폴리아미노산 기반의 생체환경 감응형 나노입자
WO2018025699A1 (fr) * 2016-08-02 2018-02-08 日本化薬株式会社 Dérivé de polymère du type à ciblage actif, composition contenant ledit dérivé de polymère, et utilisations dudit dérivé de polymère et de ladite composition
CN110483785B (zh) * 2019-07-01 2020-05-19 中山大学 一种三嵌段聚合物、载药纳米胶束、纳米药物及其制备方法和应用
CN110343245B (zh) * 2019-07-16 2021-09-28 天津大学 一种ε-聚赖氨酸-接枝-疏水氨基酸-接枝-海藻糖的糖肽及制备方法
CN112553759A (zh) * 2020-11-30 2021-03-26 福建凤竹纺织科技股份有限公司 一种多功能海藻纤维针织面料

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DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US5250293A (en) * 1991-04-22 1993-10-05 Gleich Gerald J Method for the treatment of hypersensitivity diseases by administration of anionic polymers
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
DE4407898A1 (de) * 1994-03-09 1995-09-14 Hoechst Ag Nanopartikel, enthaltend einen Wirkstoff und ein Polyketalweinsäureamid, Verfahren zu ihrer Herstellung und Verwendung derselben
DK1071407T3 (da) * 1999-01-18 2014-10-20 Lg Life Sciences Ltd Lipofile mikropartikler indeholdende et proteinlægemiddel eller et antigen og formulering omhandlende samme
FR2814951B1 (fr) * 2000-10-06 2003-01-17 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation
WO2003035051A2 (fr) * 2001-10-19 2003-05-01 Inhale Therapeutic Systems, Inc. Utilisation d'agents sequestrants des protons dans des formulations medicamenteuses
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
FR2862541B1 (fr) * 2003-11-21 2007-04-20 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques

Also Published As

Publication number Publication date
IL196426A (en) 2014-07-31
KR101407033B1 (ko) 2014-06-20
CA2661567A1 (fr) 2008-03-06
CN101568328A (zh) 2009-10-28
CA2661567C (fr) 2016-09-20
WO2008025425A1 (fr) 2008-03-06
AU2007291577A1 (en) 2008-03-06
WO2008025425B1 (fr) 2008-05-02
MX2009000951A (es) 2009-02-04
FR2904219A1 (fr) 2008-02-01
WO2008025425A9 (fr) 2008-06-12
ZA200900929B (en) 2010-06-30
EP2049085A1 (fr) 2009-04-22
CN101568328B (zh) 2012-09-05
KR20090054976A (ko) 2009-06-01
BRPI0714943A2 (pt) 2013-05-21
FR2904219B1 (fr) 2010-08-13
JP5302197B2 (ja) 2013-10-02
JP2009544759A (ja) 2009-12-17
IL196426A0 (en) 2009-09-22

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