WO2008071407A3 - Pilules enrobées - Google Patents

Pilules enrobées Download PDF

Info

Publication number
WO2008071407A3
WO2008071407A3 PCT/EP2007/010862 EP2007010862W WO2008071407A3 WO 2008071407 A3 WO2008071407 A3 WO 2008071407A3 EP 2007010862 W EP2007010862 W EP 2007010862W WO 2008071407 A3 WO2008071407 A3 WO 2008071407A3
Authority
WO
WIPO (PCT)
Prior art keywords
coated pellets
lipophilic component
active ingredient
coated
ingredient under
Prior art date
Application number
PCT/EP2007/010862
Other languages
German (de)
English (en)
Other versions
WO2008071407A2 (fr
Inventor
Iris Ziegler
Irwin Jacobs
Original Assignee
Gruenenthal Gmbh
Iris Ziegler
Irwin Jacobs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh, Iris Ziegler, Irwin Jacobs filed Critical Gruenenthal Gmbh
Priority to PL07856610T priority Critical patent/PL2120890T3/pl
Priority to EP07856610A priority patent/EP2120890B1/fr
Priority to AT07856610T priority patent/ATE522204T1/de
Publication of WO2008071407A2 publication Critical patent/WO2008071407A2/fr
Publication of WO2008071407A3 publication Critical patent/WO2008071407A3/fr
Priority to US12/483,646 priority patent/US8147874B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

L'invention concerne des pilules enrobées qui contiennent un principe actif pharmaceutique peu soluble dans l'eau, qui libèrent au moins 80 % du principe actif au bout de 30 minutes en conditions in vitro dans du tampon phosphate à pH 5,0 et qui, dans les conditions du test in vivo non à jeun, sont bioéquivalentes à une formulation du principe actif dans les sucs gastriques et/ou sont enrobées d'une composition qui contient un composant lipophile (A) et un agent de formation d'hydrogel (B). Le composant lipophile (A) pur présente (i) une valeur EHL ≤ 5 et/ou (ii) une plage de fusion ≥ 60°C et/ou (iii) une plage de solidification Δ inférieure à 35°C et/ou (iv) une densité ≥ 0,80 g cm-3.
PCT/EP2007/010862 2006-12-14 2007-12-12 Pilules enrobées WO2008071407A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL07856610T PL2120890T3 (pl) 2006-12-14 2007-12-12 Peletki powlekane
EP07856610A EP2120890B1 (fr) 2006-12-14 2007-12-12 Pilules enrobées
AT07856610T ATE522204T1 (de) 2006-12-14 2007-12-12 Beschichtete pellets
US12/483,646 US8147874B2 (en) 2006-12-14 2009-06-12 Coated pellets

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006059510.6 2006-12-14
DE102006059510A DE102006059510A1 (de) 2006-12-14 2006-12-14 Beschichtete Pellets

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/483,646 Continuation US8147874B2 (en) 2006-12-14 2009-06-12 Coated pellets

Publications (2)

Publication Number Publication Date
WO2008071407A2 WO2008071407A2 (fr) 2008-06-19
WO2008071407A3 true WO2008071407A3 (fr) 2009-02-26

Family

ID=39272252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/010862 WO2008071407A2 (fr) 2006-12-14 2007-12-12 Pilules enrobées

Country Status (7)

Country Link
US (1) US8147874B2 (fr)
EP (1) EP2120890B1 (fr)
AT (1) ATE522204T1 (fr)
DE (1) DE102006059510A1 (fr)
ES (1) ES2369589T3 (fr)
PL (1) PL2120890T3 (fr)
WO (1) WO2008071407A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2268142B1 (fr) 2007-11-27 2017-02-22 Algipharma As Utilisation d'oligomeres d'alginate pour lutter contre les biofilms
CN102458474B (zh) 2009-06-03 2014-06-11 阿尔吉法玛公司 使用藻酸盐低聚物和抗生素治疗不动杆菌
US20110217426A1 (en) * 2010-03-04 2011-09-08 Perry Stephen C Enteric coating composition
ES2674332T3 (es) * 2011-11-28 2018-06-28 Tate & Lyle Ingredients Americas Llc Edulcorante de mesa natural con sabor mejorado
EP2983650B1 (fr) 2013-04-12 2017-06-28 Hermes Arzneimittel GmbH Compositions pharmaceutiques orales contenant de la n-acétylcystéine à goût masqué
EA030984B1 (ru) * 2013-04-19 2018-10-31 Дегама Смарт Лтд. Жидкий пищевой продукт, содержащий гранулы с устойчивыми к нагреву и влажности пробиотическими бактериями
CN104116713B (zh) * 2013-04-24 2016-10-19 南京亿华药业有限公司 一种头孢地尼颗粒及其制备方法
WO2015193485A1 (fr) 2014-06-20 2015-12-23 Hermes Arzneimittel Gmbh Composition pharmaceutique par voie orale à goût masqué
HUP1500164A2 (en) * 2015-04-14 2016-10-28 Ferenc Ecseri Filled straw with edible homogeneous structured granules and process for producing thereof
US11090702B2 (en) 2016-06-28 2021-08-17 Trustees Of Tufts College Compositions and methods for delivery of active agents
WO2018115130A1 (fr) 2016-12-23 2018-06-28 Hermes Arzneimittel Gmbh Composition pharmaceutique orale présentant des propriétés de masquage du goût améliorées
CN108904451A (zh) * 2018-07-27 2018-11-30 广州柏赛罗药业有限公司 缓释制剂
US20210169820A1 (en) * 2019-09-12 2021-06-10 Nulixir Inc. Controlled release concentrate and suspensions including the same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1594102A (en) * 1977-09-26 1981-07-30 Sankyo Co Ingestible coating compositions
US4675236A (en) * 1985-01-29 1987-06-23 Ohkawara Kokohki Co., Ltd. Mono-core type microcapsules and process for producing them
WO2001080831A2 (fr) * 2000-04-27 2001-11-01 Verion Inc. Microcapsules a liberation d'ordre nul et commande par la temperature, et procede pour leur elaboration
WO2005023216A2 (fr) * 2003-09-04 2005-03-17 Grünenthal GmbH Forme galenique multiparticulaire orale formulee par fusion
WO2006069920A1 (fr) * 2004-12-23 2006-07-06 Grünenthal GmbH Formes galeniques a liberation rapide pour antibiotiques
DE102005019458A1 (de) * 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341563A (en) * 1978-11-17 1982-07-27 Sankyo Company Limited Protective coating compositions
US4676236A (en) * 1983-09-09 1987-06-30 Gentex Corporation Helmet airflow system
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
DE10228175A1 (de) 2002-03-27 2003-10-09 Gruenenthal Gmbh Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
DE10228171A1 (de) 2002-06-24 2004-01-22 Grünenthal GmbH Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
DE10228179A1 (de) 2002-06-24 2004-01-22 Grünenthal GmbH Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen
DE10342513A1 (de) * 2003-09-12 2005-05-12 Gruenenthal Gmbh Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen, Kit und Verwendung

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1594102A (en) * 1977-09-26 1981-07-30 Sankyo Co Ingestible coating compositions
US4675236A (en) * 1985-01-29 1987-06-23 Ohkawara Kokohki Co., Ltd. Mono-core type microcapsules and process for producing them
WO2001080831A2 (fr) * 2000-04-27 2001-11-01 Verion Inc. Microcapsules a liberation d'ordre nul et commande par la temperature, et procede pour leur elaboration
WO2005023216A2 (fr) * 2003-09-04 2005-03-17 Grünenthal GmbH Forme galenique multiparticulaire orale formulee par fusion
WO2006069920A1 (fr) * 2004-12-23 2006-07-06 Grünenthal GmbH Formes galeniques a liberation rapide pour antibiotiques
DE102005019458A1 (de) * 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil

Also Published As

Publication number Publication date
EP2120890B1 (fr) 2011-08-31
WO2008071407A2 (fr) 2008-06-19
DE102006059510A1 (de) 2008-06-19
ATE522204T1 (de) 2011-09-15
US8147874B2 (en) 2012-04-03
EP2120890A2 (fr) 2009-11-25
ES2369589T3 (es) 2011-12-02
US20100068290A1 (en) 2010-03-18
PL2120890T3 (pl) 2012-01-31

Similar Documents

Publication Publication Date Title
WO2008071407A3 (fr) Pilules enrobées
SI1663216T1 (sl) Sestavek z modificiranim sproščanjem ki vsebuje takrolimus
WO2006113631A3 (fr) Compositions ameliorees biologiquement
NZ610701A (en) Once daily formulation of lacosamide
WO2007084460A3 (fr) Compositions pharmaceutiques a stabilite amelioree
WO2009034541A3 (fr) Formes galéniques à libération contrôlée à base de trimétazidine
WO2010125323A8 (fr) Composition biocide
WO2008036147A3 (fr) Administration de médicament avec biopolymères sensibles aux stimuli
WO2010081824A3 (fr) Enrobage actif de formes pharmaceutiques
WO2007000778A3 (fr) Compositions pharmaceutiques a liberation modifiee et leurs procedes
HRP20110745T1 (hr) Formulacija rasagilina s odgođenim oslobađanjem
WO2008140507A3 (fr) Formulations de nanoparticules et de polymères pour les analogues, les antagonistes et les formulations de l'hormone thyroïde et leurs utilisations
WO2009052171A3 (fr) Système et composition de remédiation à libération contrôlée
WO2006127685A3 (fr) Systemes de distribution permettant de gerer la liberation d'edulcorants dans une composition comestible
WO2009113703A3 (fr) Préparation solide orodispersible
WO2006116565A3 (fr) Compositions a liberation prolongee comprenant des peptides et leurs utilisations
BRPI0707465B8 (pt) composições farmacêuticas compreendendo misturas de polímeros e ingredientes ativos dificilmente solúveis em água, seu uso e seus processos de preparação, forma farmacêutica e seu processo de produção
TN2009000197A1 (en) Sustained - release composition and method for producing the same
WO2008084698A1 (fr) Composition pharmaceutique à libération entretenue de tacrolimus
WO2008113901A3 (fr) Composition à libération prolongée de lévétiracetam et procédé de préparation.
WO2007010584A3 (fr) Systeme d'administration commandee de substances actives sur le plan pharmaceutique, procede de preparation et utilisation medicale de celui-ci
UA93530C2 (ru) Композиция c пролонгированным высвобождением активного вещества, способ ee получения и применения
WO2010019611A3 (fr) Compositions à base de composés polycycliques pontés pour des applications topiques et orales
TN2009000476A1 (en) Slow release pharmaceutical composition made of microparticles
MX2010004556A (es) Formulacion farmaceutica de acido clavulanico.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07856610

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2007856610

Country of ref document: EP