EA200802285A1 - Бивалентные миметики smac и их применения - Google Patents

Бивалентные миметики smac и их применения

Info

Publication number
EA200802285A1
EA200802285A1 EA200802285A EA200802285A EA200802285A1 EA 200802285 A1 EA200802285 A1 EA 200802285A1 EA 200802285 A EA200802285 A EA 200802285A EA 200802285 A EA200802285 A EA 200802285A EA 200802285 A1 EA200802285 A1 EA 200802285A1
Authority
EA
Eurasian Patent Office
Prior art keywords
memetics
applications
bivalent smac
bivalent
relates
Prior art date
Application number
EA200802285A
Other languages
English (en)
Other versions
EA017279B1 (ru
Inventor
Шаомэн Ван
Хайин Сунь
Дунгуан Цинь
Занета Николовска-Цолеска
Цзяньфэн Лу
Су Цю
Юэфэн Пэн
Цянь Цай
Original Assignee
Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган filed Critical Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
Publication of EA200802285A1 publication Critical patent/EA200802285A1/ru
Publication of EA017279B1 publication Critical patent/EA017279B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к бивалентным миметикам Smac, которые функционируют в качестве ингибиторов ингибитора белков апоптоза. Изобретение также относится к применению этих миметиков для индукции апоптической гибели клеток и для сенсибилизации клеток к индукторам апоптоза.
EA200802285A 2006-05-05 2007-05-04 БИВАЛЕНТНЫЕ МИМЕТИКИ Smac И ИХ ПРИМЕНЕНИЯ EA017279B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79801806P 2006-05-05 2006-05-05
US92341507P 2007-04-13 2007-04-13
PCT/US2007/010924 WO2007130626A2 (en) 2006-05-05 2007-05-04 Bivalent smac mimetics and the uses thereof

Publications (2)

Publication Number Publication Date
EA200802285A1 true EA200802285A1 (ru) 2009-08-28
EA017279B1 EA017279B1 (ru) 2012-11-30

Family

ID=38668354

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802285A EA017279B1 (ru) 2006-05-05 2007-05-04 БИВАЛЕНТНЫЕ МИМЕТИКИ Smac И ИХ ПРИМЕНЕНИЯ

Country Status (23)

Country Link
US (1) US7960372B2 (ru)
EP (1) EP2019671B1 (ru)
JP (1) JP5230610B2 (ru)
KR (1) KR101071516B1 (ru)
CN (1) CN101484151B (ru)
AU (1) AU2007248473B2 (ru)
BR (1) BRPI0711326B8 (ru)
CA (1) CA2651206C (ru)
CY (1) CY1115808T1 (ru)
DK (1) DK2019671T3 (ru)
EA (1) EA017279B1 (ru)
ES (1) ES2525585T3 (ru)
HK (1) HK1124536A1 (ru)
HR (1) HRP20141253T1 (ru)
IL (1) IL195075A (ru)
MX (1) MX2008014140A (ru)
NO (1) NO341896B1 (ru)
NZ (1) NZ572531A (ru)
PL (1) PL2019671T3 (ru)
PT (1) PT2019671E (ru)
SI (1) SI2019671T1 (ru)
WO (1) WO2007130626A2 (ru)
ZA (1) ZA200809496B (ru)

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Publication number Publication date
NZ572531A (en) 2011-09-30
CN101484151A (zh) 2009-07-15
SI2019671T1 (sl) 2015-03-31
AU2007248473A1 (en) 2007-11-15
EA017279B1 (ru) 2012-11-30
KR20090009307A (ko) 2009-01-22
WO2007130626A2 (en) 2007-11-15
ZA200809496B (en) 2010-02-24
US7960372B2 (en) 2011-06-14
JP2009536204A (ja) 2009-10-08
US20080089896A1 (en) 2008-04-17
EP2019671B1 (en) 2014-09-24
JP5230610B2 (ja) 2013-07-10
CN101484151B (zh) 2012-11-21
CA2651206C (en) 2013-11-12
DK2019671T3 (en) 2014-12-08
BRPI0711326B1 (pt) 2020-12-01
PT2019671E (pt) 2014-12-18
MX2008014140A (es) 2009-01-19
CY1115808T1 (el) 2017-01-25
AU2007248473B2 (en) 2011-01-27
EP2019671A2 (en) 2009-02-04
WO2007130626A3 (en) 2008-01-17
PL2019671T3 (pl) 2015-02-27
BRPI0711326B8 (pt) 2021-05-25
HRP20141253T1 (en) 2015-03-13
EP2019671A4 (en) 2010-06-02
BRPI0711326A2 (pt) 2011-08-30
NO341896B1 (no) 2018-02-12
IL195075A0 (en) 2009-08-03
IL195075A (en) 2015-03-31
NO20085074L (no) 2009-02-04
HK1124536A1 (en) 2009-07-17
ES2525585T3 (es) 2014-12-26
KR101071516B1 (ko) 2011-10-10
CA2651206A1 (en) 2007-11-15

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