DE60000014T2 - Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung - Google Patents

Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung

Info

Publication number
DE60000014T2
DE60000014T2 DE60000014T DE60000014T DE60000014T2 DE 60000014 T2 DE60000014 T2 DE 60000014T2 DE 60000014 T DE60000014 T DE 60000014T DE 60000014 T DE60000014 T DE 60000014T DE 60000014 T2 DE60000014 T2 DE 60000014T2
Authority
DE
Germany
Prior art keywords
linker system
bioconjugation
activating surfaces
linker
activating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60000014T
Other languages
English (en)
Other versions
DE60000014D1 (de
Inventor
Holger Klapproth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biochip Technologies GmbH
Original Assignee
Biochip Technologies GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochip Technologies GmbH filed Critical Biochip Technologies GmbH
Application granted granted Critical
Publication of DE60000014D1 publication Critical patent/DE60000014D1/de
Publication of DE60000014T2 publication Critical patent/DE60000014T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE60000014T 2000-05-16 2000-05-16 Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung Expired - Lifetime DE60000014T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00110428A EP1132739B1 (de) 2000-05-16 2000-05-16 Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung

Publications (2)

Publication Number Publication Date
DE60000014D1 DE60000014D1 (de) 2001-11-22
DE60000014T2 true DE60000014T2 (de) 2002-05-02

Family

ID=8168735

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60000014T Expired - Lifetime DE60000014T2 (de) 2000-05-16 2000-05-16 Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung

Country Status (11)

Country Link
US (1) US6921669B2 (de)
EP (1) EP1132739B1 (de)
JP (1) JP2003533697A (de)
AT (1) ATE206211T1 (de)
AU (1) AU7404201A (de)
CA (1) CA2375160A1 (de)
DE (1) DE60000014T2 (de)
DK (1) DK1132739T3 (de)
ES (1) ES2164632T3 (de)
PT (1) PT1132739E (de)
WO (1) WO2001088535A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
CA2463725A1 (en) * 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations of nucleic acids and arrays and methods of using them
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
FR2840324B1 (fr) * 2002-05-28 2005-07-15 Europ Synchrotron Radiation Fa Fabrication de monocouches moleculaires organisees et substrat adapte
AU2003254782A1 (en) * 2002-07-30 2004-04-30 Fujisawa Pharmaceutical Co., Ltd. Method of inhibiting nonspecific interaction between molecules on solid phase support
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7070922B2 (en) 2002-12-04 2006-07-04 International Business Machines Corporation Surface treatment
US20050059105A1 (en) * 2003-07-25 2005-03-17 Board Of Trustees Of Michigan State University Impedimetric biosensor and its use for rapid detection of bacterial pathogens in solution
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
JP2006194796A (ja) * 2005-01-14 2006-07-27 Kyushu Inoac Co Ltd 診断用容器
US20070055013A1 (en) * 2005-02-21 2007-03-08 Noriho Kamiya Substrate and method of immobilizing protein
AU2007248473B2 (en) 2006-05-05 2011-01-27 The Regents Of The University Of Michigan Bivalent Smac mimetics and the uses thereof
KR100819064B1 (ko) 2006-12-19 2008-04-04 (재)대구경북과학기술연구원 생분자 고정화 링커
US9090542B2 (en) 2009-11-11 2015-07-28 University Of Georgia Research Foundation, Inc. Methods for labeling a substrate using a hetero-diels-alder reaction
US20110108411A1 (en) * 2009-11-11 2011-05-12 Popik Vladimir V Methods for labeling a substrate using a hetero-diels-alder reaction
US20150076049A1 (en) * 2012-04-20 2015-03-19 Agency For Science, Technology And Research Microfilter and apparatus for separating a biological entity from a sample volume
WO2013158044A1 (en) * 2012-04-20 2013-10-24 Agency For Science, Technology And Research Apparatus and method for separating a biological entity from a sample volume
EP3733209A1 (de) 2014-10-03 2020-11-04 Synaffix B.V. Sulfamid-linker, konjugate davon und herstellungsverfahren
WO2017137457A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
CN109152844B (zh) 2016-02-08 2022-11-22 西纳福克斯股份有限公司 用于治疗的含有磺酰胺接头的生物缀合物
EP3413922A1 (de) 2016-02-08 2018-12-19 SynAffix B.V. Verbesserte sulfamid-linker zur verwendung in biokonjugaten
EP3413915A1 (de) 2016-02-08 2018-12-19 Synaffix B.V. Antikörperkonjugate mit verbessertem therapeutischem index zur abzielung auf her2-tumoren und verfahren zur verbesserung des therapeutischen index von antikörperkonjugaten
EP3413916A1 (de) 2016-02-08 2018-12-19 Synaffix B.V. Antikörperkonjugate mit verbessertem therapeutischem index zur abzielung auf cd30-tumoren und verfahren zur verbesserung des therapeutischen index von antikörperkonjugaten
WO2019185586A1 (en) 2018-03-26 2019-10-03 Universidad Complutense De Madrid Ligands for enhanced imaging and drug delivery to neuroblastoma cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707296B1 (fr) * 1993-07-09 1995-09-29 Genset Sa Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.
JPH08220673A (ja) * 1995-02-17 1996-08-30 Konica Corp ハロゲン化銀写真乳剤及びハロゲン化銀写真要素及びその処理方法
ES2279544T3 (es) * 1997-08-08 2007-08-16 Dade Behring Marburg Gmbh Conjugados de polisacaridos y biomoleculas.
WO1999017120A1 (en) * 1997-09-26 1999-04-08 Becton, Dickinson And Company Preparing conjugates using polyethylene glycol linkers
WO1999036571A2 (en) * 1998-01-13 1999-07-22 Biochip Technologies Gmbh Method for the detection or nucleic acid of nucleic acid sequences

Also Published As

Publication number Publication date
WO2001088535A1 (en) 2001-11-22
US20030022189A1 (en) 2003-01-30
JP2003533697A (ja) 2003-11-11
PT1132739E (pt) 2002-03-28
ATE206211T1 (de) 2001-10-15
EP1132739B1 (de) 2001-09-26
ES2164632T3 (es) 2002-03-01
AU7404201A (en) 2001-11-26
DK1132739T3 (da) 2002-01-28
US6921669B2 (en) 2005-07-26
DE60000014D1 (de) 2001-11-22
CA2375160A1 (en) 2001-11-22
EP1132739A1 (de) 2001-09-12

Similar Documents

Publication Publication Date Title
DE60000014T2 (de) Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung
ATE351921T1 (de) Verfahren für fluoreszenzerkennungstest
DE60223635D1 (de) Reagenzien, Verfahren und Vorrichtungen zum Nachweis von Analyten
DK0943097T3 (da) Fremgangsmåde til at påvise IgE
ATE373236T1 (de) Puffer-arrays zum nachweis von biomolekülen anhand ihres isoelektrischen punktes
ATE438737T1 (de) Verfahren für den nachweis von erkrankungen
DE69710077T2 (de) Verfahren zur erkennung von verbindungen, die die interaktion von rna und rna-bindeproteinen beeinflussen
DE60041355D1 (de) Verfahren zur detektion von erkrankungen
DE60115653D1 (de) Verfahren zur Detektion von Emotionen, unter Verwendung von Untergruppenspezialisten
DE60233142D1 (de) Verfahren und reagentien zum nachweis von endotoxin
ATE205884T1 (de) Assays und vorrichtungen zum nachweis von extrahepatischer biliäreratresie
FI953990A (fi) Menetelmä nukleiinihappomonistusreaktiotuotteen tekemiseksi kykenemät-tömäksi olemaan lisämonistuksen kohteena, diagnostinen määritysmenetelmä, jossa tätä menetelmää käytetään, ja menetelmän tai määrityksen toteutukseen sopiva testipakkaus ja säiliö
DE60332382D1 (de) Zentrifugalvorrichtung und verfahren zur durchführung von bindungsversuchen
ATE283481T1 (de) Verfahren zum auffinden von reagenzien und festphasenkomponenten in spezifischen bindungsassays, frei von fortgeschrittenen glykosylierungsendprodukten
DE69839632D1 (de) Verfahren zur Einführung von Selektivität bei nicht-selektiven Gassensoren
ATE471989T1 (de) Verfahren zur identifizierung einer auf einen körper aufgebrachten markierung
ATE223491T1 (de) Verfahren zur reinigung von biomolekül- oder proteinkomplexen
DE50204680D1 (de) Verfahren zur detektion von nukleinsäuremolekülen
DE60043618D1 (de) Verfahren zum nachweis einer reaktion zur molekularen erkennung
DE60130970D1 (de) Reagenziensatz zur detektion von mikroorganismen, vorrichtung zur quantifizierungvon mikroorganismen und verfahren zur quantifizierung von mikroorganismen
ATE408832T1 (de) Verfahren zum nachweis von blutzell-antigenen und gegen diese gerichtete antikörper
DE1218076T1 (de) Verfahren zur reinigung von sequentiellen reaktionsprodukten durch ultrafiltration bei konstantem differentialdruck
ATE340998T1 (de) Verfahren zur bestimmung von flüchtigen substanzen in lösung
ATE297472T1 (de) Verfahren zur messung der aktivität der no- synthase
DE69921715D1 (de) Chip für die Nukleinsäuretrennung, strukturelles Element und Verfahren zu dessenBildung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition