EA200600459A1 - Способ получения цитотоксических лимфоцитов - Google Patents
Способ получения цитотоксических лимфоцитовInfo
- Publication number
- EA200600459A1 EA200600459A1 EA200600459A EA200600459A EA200600459A1 EA 200600459 A1 EA200600459 A1 EA 200600459A1 EA 200600459 A EA200600459 A EA 200600459A EA 200600459 A EA200600459 A EA 200600459A EA 200600459 A1 EA200600459 A1 EA 200600459A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cytotoxic lymphocytes
- vol
- obtaining cytotoxic
- stage
- obtaining
- Prior art date
Links
- 231100000433 cytotoxic Toxicity 0.000 title abstract 3
- 230000001472 cytotoxic effect Effects 0.000 title abstract 3
- 210000004698 lymphocyte Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Настоящее изобретение относится к способу получения цитотоксических лимфоцитов, отличающемуся тем, что способ включает в себя стадию осуществления по меньшей мере одной стадии, выбранной из индукции, поддержания и экспансии цитотоксических лимфоцитов с использованием среды, содержащей сыворотку и плазму в суммарной концентрации, большей или равной 0 об.%, но меньшей 5 об.%, в присутствии фибронектина, его фрагмента или их смеси.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003298208 | 2003-08-22 | ||
JP2004000699 | 2004-01-05 | ||
JP2004115648 | 2004-04-09 | ||
JP2004222441 | 2004-07-29 | ||
PCT/JP2004/012238 WO2005019450A1 (ja) | 2003-08-22 | 2004-08-19 | 細胞傷害性リンパ球の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600459A1 true EA200600459A1 (ru) | 2006-08-25 |
EA012520B1 EA012520B1 (ru) | 2009-10-30 |
Family
ID=34222501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600459A EA012520B1 (ru) | 2003-08-22 | 2004-08-19 | Способ получения цитотоксических лимфоцитов |
Country Status (14)
Country | Link |
---|---|
US (1) | US8927273B2 (ru) |
EP (1) | EP1666589B1 (ru) |
JP (1) | JP4870432B2 (ru) |
KR (2) | KR101331746B1 (ru) |
CN (1) | CN1839202B (ru) |
AT (1) | ATE458046T1 (ru) |
AU (1) | AU2004267313B2 (ru) |
CA (1) | CA2536492C (ru) |
DE (1) | DE602004025591D1 (ru) |
EA (1) | EA012520B1 (ru) |
HK (1) | HK1095606A1 (ru) |
MX (1) | MXPA06002039A (ru) |
TW (1) | TW200517501A (ru) |
WO (1) | WO2005019450A1 (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8728811B2 (en) | 2002-03-25 | 2014-05-20 | Takara Bio Inc. | Process for producing cytotoxic lymphocyte |
EP1666589B1 (en) | 2003-08-22 | 2010-02-17 | Takara Bio Inc. | Process for producing cytotoxic lymphocytes |
EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
JP4929174B2 (ja) * | 2005-08-17 | 2012-05-09 | タカラバイオ株式会社 | リンパ球の製造方法 |
JP4741906B2 (ja) * | 2005-08-31 | 2011-08-10 | タカラバイオ株式会社 | リンパ球の製造方法 |
EA016168B1 (ru) * | 2005-09-30 | 2012-02-28 | Такара Био Инк. | Способ получения т-клеточной популяции и ее применение |
EP2028266A4 (en) * | 2006-06-09 | 2010-08-11 | Takara Bio Inc | PROCESS FOR PRODUCING LYMPHOCYTES |
US20110158954A1 (en) * | 2007-03-09 | 2011-06-30 | Mitsuko Ideno | Method for producing gamma delta t cell population |
US20100247579A1 (en) * | 2007-05-11 | 2010-09-30 | Hiroshi Shiku | Therapeutic agent for cancer |
JP5485139B2 (ja) * | 2008-03-27 | 2014-05-07 | タカラバイオ株式会社 | 遺伝子導入細胞の製造方法 |
CN102656263A (zh) | 2009-08-25 | 2012-09-05 | 宝生物工程株式会社 | 用于在视黄酸存在下制备t细胞群的方法 |
CA2951746C (en) | 2014-06-10 | 2023-08-22 | Polybiocept Ab | Culture medium for cellular immunotherapy |
FR3026744B1 (fr) * | 2014-10-06 | 2024-04-19 | Hopitaux Paris Assist Publique | Methode de generation de progeniteurs de cellules t |
RU2596505C1 (ru) * | 2015-07-02 | 2016-09-10 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России) | Способ лечения онкологических больных цитотоксическими лимфоцитами |
EP3572502B1 (en) * | 2017-01-20 | 2023-01-11 | Kyoto University | Method for producing cd8alpha +beta + cytotoxic t cells |
CN107099503A (zh) * | 2017-06-01 | 2017-08-29 | 溯源生命科技股份有限公司 | 具有高杀伤力的自然杀伤性细胞高效体外扩增培养方法 |
RU2652752C1 (ru) * | 2017-06-15 | 2018-04-28 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" | Способ лечения бронхиальной астмы |
CN111655842B (zh) * | 2018-01-25 | 2023-10-20 | 宝生物工程株式会社 | 淋巴细胞生产方法 |
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US5019646A (en) | 1987-08-25 | 1991-05-28 | Regents Of The University Of Minnesota | Polypeptides with fibronectin activity |
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US8728811B2 (en) | 2002-03-25 | 2014-05-20 | Takara Bio Inc. | Process for producing cytotoxic lymphocyte |
JP4406607B2 (ja) | 2002-08-26 | 2010-02-03 | オンコセラピー・サイエンス株式会社 | ペプチド及びこれを含む医薬 |
EP1666589B1 (en) | 2003-08-22 | 2010-02-17 | Takara Bio Inc. | Process for producing cytotoxic lymphocytes |
JP4297494B2 (ja) | 2003-11-06 | 2009-07-15 | タイヨーエレック株式会社 | 組合せ式遊技機 |
-
2004
- 2004-08-19 EP EP04772194A patent/EP1666589B1/en active Active
- 2004-08-19 US US10/568,745 patent/US8927273B2/en active Active
- 2004-08-19 KR KR1020127008838A patent/KR101331746B1/ko active IP Right Grant
- 2004-08-19 MX MXPA06002039A patent/MXPA06002039A/es active IP Right Grant
- 2004-08-19 DE DE602004025591T patent/DE602004025591D1/de active Active
- 2004-08-19 CN CN2004800241727A patent/CN1839202B/zh active Active
- 2004-08-19 JP JP2005513357A patent/JP4870432B2/ja active Active
- 2004-08-19 KR KR1020067003419A patent/KR20060039940A/ko not_active Application Discontinuation
- 2004-08-19 WO PCT/JP2004/012238 patent/WO2005019450A1/ja active Application Filing
- 2004-08-19 EA EA200600459A patent/EA012520B1/ru not_active IP Right Cessation
- 2004-08-19 AU AU2004267313A patent/AU2004267313B2/en not_active Ceased
- 2004-08-19 CA CA2536492A patent/CA2536492C/en active Active
- 2004-08-19 AT AT04772194T patent/ATE458046T1/de not_active IP Right Cessation
- 2004-08-20 TW TW093125347A patent/TW200517501A/zh unknown
-
2007
- 2007-03-16 HK HK07102871.3A patent/HK1095606A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2536492A1 (en) | 2005-03-03 |
WO2005019450A1 (ja) | 2005-03-03 |
JPWO2005019450A1 (ja) | 2006-10-19 |
EP1666589B1 (en) | 2010-02-17 |
US8927273B2 (en) | 2015-01-06 |
CA2536492C (en) | 2013-10-08 |
EA012520B1 (ru) | 2009-10-30 |
EP1666589A1 (en) | 2006-06-07 |
HK1095606A1 (en) | 2007-05-11 |
EP1666589A4 (en) | 2006-10-04 |
AU2004267313A1 (en) | 2005-03-03 |
DE602004025591D1 (de) | 2010-04-01 |
JP4870432B2 (ja) | 2012-02-08 |
CN1839202A (zh) | 2006-09-27 |
MXPA06002039A (es) | 2006-05-25 |
KR20120051089A (ko) | 2012-05-21 |
KR20060039940A (ko) | 2006-05-09 |
AU2004267313B2 (en) | 2009-09-24 |
KR101331746B1 (ko) | 2013-11-20 |
TW200517501A (en) | 2005-06-01 |
US20090221077A1 (en) | 2009-09-03 |
ATE458046T1 (de) | 2010-03-15 |
CN1839202B (zh) | 2012-07-18 |
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