EA200500994A1 - Тетрациклические 3-замещенные индолы, обладающие аффинностью к рецептору серотонина - Google Patents

Тетрациклические 3-замещенные индолы, обладающие аффинностью к рецептору серотонина

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Publication number
EA200500994A1
EA200500994A1 EA200500994A EA200500994A EA200500994A1 EA 200500994 A1 EA200500994 A1 EA 200500994A1 EA 200500994 A EA200500994 A EA 200500994A EA 200500994 A EA200500994 A EA 200500994A EA 200500994 A1 EA200500994 A1 EA 200500994A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tetracyclic
affinity
serotonin receptor
substituted
indols
Prior art date
Application number
EA200500994A
Other languages
English (en)
Other versions
EA009367B1 (ru
Inventor
Венката Сатья Нироги Рамакришна
Викас Шрикришна Ширсатх
Рама Састри Камбхампати
Венката Сатья Веерабхадра Вадламуди Рао
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA200500994A1 publication Critical patent/EA200500994A1/ru
Publication of EA009367B1 publication Critical patent/EA009367B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Настоящее изобретение относится к тетрациклическим 3-замещенным индолам общей формулы (I), их стереоизомерам, их радиоактивным изотопам, их N-оксидам, их полиморфам, их фармацевтически приемлемым солям, их фармацевтически приемлемым сольватам, их полезным биологически активным метаболитам и любому приемлемому сочетанию указанных выше веществ, а также к способам получения таких соединений общей формулы (I), их стереоизомеров, их радиоактивных изотопов, их N-оксидов, их полиморфов, их фармацевтически приемлемых солей, их фармацевтически приемлемых сольватов, их полезных биологически активных метаболитов, а также включает любую приемлемую комбинацию указанных выше веществ.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500994A 2002-12-18 2003-12-16 ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА EA009367B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN951MA2002 2002-12-18
PCT/IN2003/000393 WO2004055026A1 (en) 2002-12-18 2003-12-16 Tetracyclic 3-substituted indoles having serotonin receptor affinity

Publications (2)

Publication Number Publication Date
EA200500994A1 true EA200500994A1 (ru) 2006-02-24
EA009367B1 EA009367B1 (ru) 2007-12-28

Family

ID=40848934

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500994A EA009367B1 (ru) 2002-12-18 2003-12-16 ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА

Country Status (20)

Country Link
US (1) US7781476B2 (ru)
EP (1) EP1581538B1 (ru)
JP (1) JP4571507B2 (ru)
KR (1) KR100739987B1 (ru)
CN (1) CN100378109C (ru)
AT (1) ATE355292T1 (ru)
AU (1) AU2003292510B2 (ru)
BR (1) BRPI0316895C1 (ru)
CA (1) CA2507923C (ru)
DE (1) DE60312226T2 (ru)
DK (1) DK1581538T3 (ru)
EA (1) EA009367B1 (ru)
HK (1) HK1083840A1 (ru)
MX (1) MXPA05005808A (ru)
NO (1) NO334030B1 (ru)
NZ (1) NZ540841A (ru)
PT (1) PT1581538E (ru)
SI (1) SI1581538T1 (ru)
WO (1) WO2004055026A1 (ru)
ZA (1) ZA200504042B (ru)

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EP1856132B1 (en) * 2005-03-08 2009-04-01 Suven Life Sciences Limited Process for preparing substituted benzothiazinoindoles
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WO2007020654A1 (en) 2005-08-16 2007-02-22 Suven Life Sciences An improved process for the preparation of losartan
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WO2008136017A1 (en) 2007-05-03 2008-11-13 Suven Life Sciences Limited Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands
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ES2370680T3 (es) * 2007-10-26 2011-12-21 Suven Life Sciences Limited Compuestos de aminoarilsulfonamida y su empleo como ligandos de 5-ht6.
AU2009294181B2 (en) 2008-09-17 2011-11-17 Suven Life Sciences Limited Aryl sulfonamide amine compounds and their use as 5-HT6 ligands
US8318725B2 (en) 2008-09-17 2012-11-27 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
JP6151453B2 (ja) * 2013-12-02 2017-06-21 スヴェン・ライフ・サイエンシズ・リミテッド １−［（２−ブロモフェニル）スルホニル］−５−メトキシ−３−［（４−メチル−１−ピペラジニル）メチル］−１ｈ−インドールジメシラート一水和物の大規模合成法
AU2014404000B2 (en) * 2014-08-16 2017-11-16 Suven Life Sciences Limited Active metabolite of 1-[(2-bromophenyl) sulfonyl]-5-methoxy-3- [(4-methyl-1-piperazinyl) methyl]-1H-indole dimesylate monohydrate and dimesylate dihydrate salt of active metabolite
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Also Published As

Publication number Publication date
NO20052909L (no) 2005-09-12
BRPI0316895B1 (pt) 2018-07-24
DK1581538T3 (da) 2007-06-25
AU2003292510A1 (en) 2004-07-09
CA2507923C (en) 2010-02-02
DE60312226D1 (de) 2007-04-12
WO2004055026A1 (en) 2004-07-01
KR100739987B1 (ko) 2007-07-16
MXPA05005808A (es) 2005-09-08
ZA200504042B (en) 2006-01-26
ATE355292T1 (de) 2006-03-15
JP2006515843A (ja) 2006-06-08
EA009367B1 (ru) 2007-12-28
EP1581538B1 (en) 2007-02-28
AU2003292510B2 (en) 2009-04-23
EP1581538A1 (en) 2005-10-05
BR0316895A (pt) 2005-10-25
JP4571507B2 (ja) 2010-10-27
HK1083840A1 (en) 2006-07-14
US7781476B2 (en) 2010-08-24
KR20050084185A (ko) 2005-08-26
CN1729197A (zh) 2006-02-01
SI1581538T1 (sl) 2007-08-31
DE60312226T2 (de) 2007-11-15
BRPI0316895C1 (pt) 2021-05-25
NO334030B1 (no) 2013-11-18
NO20052909D0 (no) 2005-06-15
US20070142398A1 (en) 2007-06-21
PT1581538E (pt) 2007-05-31
WO2004055026A8 (en) 2005-06-23
CN100378109C (zh) 2008-04-02
BRPI0316895B8 (pt) 2019-09-03
NZ540841A (en) 2008-08-29
CA2507923A1 (en) 2004-07-01

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