DE60236848D1 - 8-ä4-Ä3-(5-FLUORO-1H-INDOL-3-YL)PROPYLÜ -1-PIPERAZINYLü -2-METHYL-2H-1, 4-BENZOXAZIN-3(4H)-ON METHANESULFONAT MIT HOHER AFFINITÄT FÜR DEN DOPAMIN D2 REZEPTOR UND DEN SEROTONIN REUPTAKE SITE - Google Patents

8-ä4-Ä3-(5-FLUORO-1H-INDOL-3-YL)PROPYLÜ -1-PIPERAZINYLü -2-METHYL-2H-1, 4-BENZOXAZIN-3(4H)-ON METHANESULFONAT MIT HOHER AFFINITÄT FÜR DEN DOPAMIN D2 REZEPTOR UND DEN SEROTONIN REUPTAKE SITE

Info

Publication number
DE60236848D1
DE60236848D1 DE60236848T DE60236848T DE60236848D1 DE 60236848 D1 DE60236848 D1 DE 60236848D1 DE 60236848 T DE60236848 T DE 60236848T DE 60236848 T DE60236848 T DE 60236848T DE 60236848 D1 DE60236848 D1 DE 60236848D1
Authority
DE
Germany
Prior art keywords
propylü
oneh
methanesulphonate
benzoxazine
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60236848T
Other languages
English (en)
Inventor
Cornelis Bakker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Healthcare Products BV
Original Assignee
Abbott Healthcare Products BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Healthcare Products BV filed Critical Abbott Healthcare Products BV
Application granted granted Critical
Publication of DE60236848D1 publication Critical patent/DE60236848D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60236848T 2001-02-21 2002-02-19 8-ä4-Ä3-(5-FLUORO-1H-INDOL-3-YL)PROPYLÜ -1-PIPERAZINYLü -2-METHYL-2H-1, 4-BENZOXAZIN-3(4H)-ON METHANESULFONAT MIT HOHER AFFINITÄT FÜR DEN DOPAMIN D2 REZEPTOR UND DEN SEROTONIN REUPTAKE SITE Expired - Lifetime DE60236848D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200610 2001-02-21
PCT/EP2002/001795 WO2002066473A1 (en) 2001-02-21 2002-02-19 8’4-’3-(5-fluoro-1h-indol-3yl) propyl!-1-piperazynyl!-2-methyl-2h-1,4-benzoxazin -3 (4h)- one methanesulfonate with high affinity for the dopamine d 2 receptor and the serotonin reuptake site

Publications (1)

Publication Number Publication Date
DE60236848D1 true DE60236848D1 (de) 2010-08-12

Family

ID=8179909

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60236848T Expired - Lifetime DE60236848D1 (de) 2001-02-21 2002-02-19 8-ä4-Ä3-(5-FLUORO-1H-INDOL-3-YL)PROPYLÜ -1-PIPERAZINYLü -2-METHYL-2H-1, 4-BENZOXAZIN-3(4H)-ON METHANESULFONAT MIT HOHER AFFINITÄT FÜR DEN DOPAMIN D2 REZEPTOR UND DEN SEROTONIN REUPTAKE SITE

Country Status (25)

Country Link
US (2) US6958396B2 (de)
EP (1) EP1366044B1 (de)
JP (1) JP4216072B2 (de)
KR (1) KR100859107B1 (de)
CN (1) CN1284780C (de)
AR (1) AR032712A1 (de)
AT (1) ATE472545T1 (de)
AU (1) AU2002250983B2 (de)
BR (1) BR0206162A (de)
CA (1) CA2430707C (de)
CZ (1) CZ20032171A3 (de)
DE (1) DE60236848D1 (de)
DZ (1) DZ3490A1 (de)
ES (1) ES2347321T3 (de)
HK (1) HK1078569A1 (de)
HU (1) HUP0303330A3 (de)
IL (1) IL155720A0 (de)
MX (1) MXPA03007430A (de)
NO (1) NO325298B1 (de)
NZ (1) NZ526018A (de)
PL (1) PL201176B1 (de)
RU (1) RU2281945C2 (de)
SK (1) SK10412003A3 (de)
WO (1) WO2002066473A1 (de)
ZA (1) ZA200304267B (de)

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US20070072870A2 (en) 2004-12-08 2007-03-29 Solvay Pharmeceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
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Also Published As

Publication number Publication date
CA2430707C (en) 2011-04-26
SK10412003A3 (sk) 2004-03-02
NO20032914D0 (no) 2003-06-24
JP4216072B2 (ja) 2009-01-28
KR20030072633A (ko) 2003-09-15
JP2004518747A (ja) 2004-06-24
NO20032914L (no) 2003-06-24
EP1366044A1 (de) 2003-12-03
IL155720A0 (en) 2003-11-23
US20040024207A1 (en) 2004-02-05
HUP0303330A3 (en) 2009-10-28
HK1078569A1 (en) 2006-03-17
US20050209228A1 (en) 2005-09-22
CZ20032171A3 (cs) 2003-11-12
EP1366044B1 (de) 2010-06-30
AU2002250983B2 (en) 2006-02-02
HUP0303330A2 (en) 2006-02-28
RU2281945C2 (ru) 2006-08-20
NO325298B1 (no) 2008-03-17
CA2430707A1 (en) 2002-08-29
MXPA03007430A (es) 2003-11-18
ES2347321T3 (es) 2010-10-28
CN1284780C (zh) 2006-11-15
WO2002066473A1 (en) 2002-08-29
PL362288A1 (en) 2004-10-18
US6958396B2 (en) 2005-10-25
ZA200304267B (en) 2004-08-30
CN1639156A (zh) 2005-07-13
BR0206162A (pt) 2003-10-28
NZ526018A (en) 2005-03-24
AR032712A1 (es) 2003-11-19
KR100859107B1 (ko) 2008-09-18
WO2002066473A8 (en) 2004-01-29
DZ3490A1 (fr) 2002-08-29
US8106044B2 (en) 2012-01-31
PL201176B1 (pl) 2009-03-31
ATE472545T1 (de) 2010-07-15

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