MXPA03007430A - Mesilato de 8-{4-[3 -(5-fluoro -1h-indol-3-il) -propyl] -piperazin-1-il} -2-metil-4h-benzo [1, 4]oxazin-3 -ona con alta afinidad para el receptor de dopamina d2 y el sitio de recaptacion de serotonina. - Google Patents

Mesilato de 8-{4-[3 -(5-fluoro -1h-indol-3-il) -propyl] -piperazin-1-il} -2-metil-4h-benzo [1, 4]oxazin-3 -ona con alta afinidad para el receptor de dopamina d2 y el sitio de recaptacion de serotonina.

Info

Publication number
MXPA03007430A
MXPA03007430A MXPA03007430A MXPA03007430A MXPA03007430A MX PA03007430 A MXPA03007430 A MX PA03007430A MX PA03007430 A MXPA03007430 A MX PA03007430A MX PA03007430 A MXPA03007430 A MX PA03007430A MX PA03007430 A MXPA03007430 A MX PA03007430A
Authority
MX
Mexico
Prior art keywords
seotonin
benzoxazin
indol
dopamine
methanesulfonate
Prior art date
Application number
MXPA03007430A
Other languages
English (en)
Inventor
Cornelis Bakker
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of MXPA03007430A publication Critical patent/MXPA03007430A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
MXPA03007430A 2001-02-21 2002-02-19 Mesilato de 8-{4-[3 -(5-fluoro -1h-indol-3-il) -propyl] -piperazin-1-il} -2-metil-4h-benzo [1, 4]oxazin-3 -ona con alta afinidad para el receptor de dopamina d2 y el sitio de recaptacion de serotonina. MXPA03007430A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200610 2001-02-21
PCT/EP2002/001795 WO2002066473A1 (en) 2001-02-21 2002-02-19 8’4-’3-(5-fluoro-1h-indol-3yl) propyl!-1-piperazynyl!-2-methyl-2h-1,4-benzoxazin -3 (4h)- one methanesulfonate with high affinity for the dopamine d 2 receptor and the serotonin reuptake site

Publications (1)

Publication Number Publication Date
MXPA03007430A true MXPA03007430A (es) 2003-11-18

Family

ID=8179909

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007430A MXPA03007430A (es) 2001-02-21 2002-02-19 Mesilato de 8-{4-[3 -(5-fluoro -1h-indol-3-il) -propyl] -piperazin-1-il} -2-metil-4h-benzo [1, 4]oxazin-3 -ona con alta afinidad para el receptor de dopamina d2 y el sitio de recaptacion de serotonina.

Country Status (25)

Country Link
US (2) US6958396B2 (es)
EP (1) EP1366044B1 (es)
JP (1) JP4216072B2 (es)
KR (1) KR100859107B1 (es)
CN (1) CN1284780C (es)
AR (1) AR032712A1 (es)
AT (1) ATE472545T1 (es)
AU (1) AU2002250983B2 (es)
BR (1) BR0206162A (es)
CA (1) CA2430707C (es)
CZ (1) CZ20032171A3 (es)
DE (1) DE60236848D1 (es)
DZ (1) DZ3490A1 (es)
ES (1) ES2347321T3 (es)
HK (1) HK1078569A1 (es)
HU (1) HUP0303330A3 (es)
IL (1) IL155720A0 (es)
MX (1) MXPA03007430A (es)
NO (1) NO325298B1 (es)
NZ (1) NZ526018A (es)
PL (1) PL201176B1 (es)
RU (1) RU2281945C2 (es)
SK (1) SK10412003A3 (es)
WO (1) WO2002066473A1 (es)
ZA (1) ZA200304267B (es)

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AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
RU2007125636A (ru) * 2004-12-07 2009-01-20 Солвей Фармасьютикалс Б.В. (Nl) Фенилпиперазины с комбинацией свойств сродства к d2 допаминовым рецепторам и центрам обратного захвата серотонина
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US20070072870A2 (en) 2004-12-08 2007-03-29 Solvay Pharmeceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
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US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease

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Also Published As

Publication number Publication date
PL362288A1 (en) 2004-10-18
HK1078569A1 (en) 2006-03-17
CA2430707C (en) 2011-04-26
NO325298B1 (no) 2008-03-17
NO20032914L (no) 2003-06-24
CA2430707A1 (en) 2002-08-29
US8106044B2 (en) 2012-01-31
ES2347321T3 (es) 2010-10-28
WO2002066473A8 (en) 2004-01-29
WO2002066473A1 (en) 2002-08-29
US6958396B2 (en) 2005-10-25
JP2004518747A (ja) 2004-06-24
US20040024207A1 (en) 2004-02-05
RU2281945C2 (ru) 2006-08-20
SK10412003A3 (sk) 2004-03-02
KR100859107B1 (ko) 2008-09-18
CN1639156A (zh) 2005-07-13
EP1366044A1 (en) 2003-12-03
ZA200304267B (en) 2004-08-30
DE60236848D1 (de) 2010-08-12
HUP0303330A3 (en) 2009-10-28
AR032712A1 (es) 2003-11-19
IL155720A0 (en) 2003-11-23
JP4216072B2 (ja) 2009-01-28
ATE472545T1 (de) 2010-07-15
AU2002250983B2 (en) 2006-02-02
CZ20032171A3 (cs) 2003-11-12
PL201176B1 (pl) 2009-03-31
EP1366044B1 (en) 2010-06-30
NO20032914D0 (no) 2003-06-24
KR20030072633A (ko) 2003-09-15
DZ3490A1 (fr) 2002-08-29
CN1284780C (zh) 2006-11-15
HUP0303330A2 (en) 2006-02-28
NZ526018A (en) 2005-03-24
US20050209228A1 (en) 2005-09-22
BR0206162A (pt) 2003-10-28

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