NO20052909L - Tetracyclic 3-substituted indoles having serotonin receptor affinity. - Google Patents

Tetracyclic 3-substituted indoles having serotonin receptor affinity.

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Publication number
NO20052909L
NO20052909L NO20052909A NO20052909A NO20052909L NO 20052909 L NO20052909 L NO 20052909L NO 20052909 A NO20052909 A NO 20052909A NO 20052909 A NO20052909 A NO 20052909A NO 20052909 L NO20052909 L NO 20052909L
Authority
NO
Norway
Prior art keywords
tetracyclic
serotonin receptor
receptor affinity
substituted indoles
indoles
Prior art date
Application number
NO20052909A
Other languages
English (en)
Other versions
NO20052909D0 (no
NO334030B1 (no
Inventor
Venkata Satya Niro Ramakrishna
Vikas Shreekrishna Shirsath
Rama Sastri Kambhampati
Venkata Satya Veerabhadra Rao
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of NO20052909D0 publication Critical patent/NO20052909D0/no
Publication of NO20052909L publication Critical patent/NO20052909L/no
Publication of NO334030B1 publication Critical patent/NO334030B1/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)

Abstract

Det beskrives nye, substituerte, tetrasykliske, 3-substituerte indoler, representert ved den generelle formel (I) samt deres stereoisomerer, radioisotoper, N-oksider, poly-morfer, farmasøytisk akseptable salter eller solvater, brukbare, bioaktive metabolitter og en hvilken som helst egnet kombinasjon av det ovenfor angitte. Det beskrives videre fremgangsmåter for fremstilling av slike forbindelser med formel (I) og deres stereoisomerer, radioisotoper, N-oksider, polymorfer, farmasøytisk akseptable salter eller solvater, brukbare, bioaktive metabolitter og egnede kombinasjoner derav.
NO20052909A 2002-12-18 2005-06-15 Tetrasykliske, 3-substituerte indoler samt deres fremstilling og anvendelse NO334030B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN951MA2002 2002-12-18
PCT/IN2003/000393 WO2004055026A1 (en) 2002-12-18 2003-12-16 Tetracyclic 3-substituted indoles having serotonin receptor affinity

Publications (3)

Publication Number Publication Date
NO20052909D0 NO20052909D0 (no) 2005-06-15
NO20052909L true NO20052909L (no) 2005-09-12
NO334030B1 NO334030B1 (no) 2013-11-18

Family

ID=40848934

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052909A NO334030B1 (no) 2002-12-18 2005-06-15 Tetrasykliske, 3-substituerte indoler samt deres fremstilling og anvendelse

Country Status (19)

Country Link
US (1) US7781476B2 (no)
EP (1) EP1581538B1 (no)
JP (1) JP4571507B2 (no)
KR (1) KR100739987B1 (no)
CN (1) CN100378109C (no)
AT (1) ATE355292T1 (no)
AU (1) AU2003292510B2 (no)
BR (1) BRPI0316895C1 (no)
CA (1) CA2507923C (no)
DE (1) DE60312226T2 (no)
DK (1) DK1581538T3 (no)
EA (1) EA009367B1 (no)
MX (1) MXPA05005808A (no)
NO (1) NO334030B1 (no)
NZ (1) NZ540841A (no)
PT (1) PT1581538E (no)
SI (1) SI1581538T1 (no)
WO (1) WO2004055026A1 (no)
ZA (1) ZA200504042B (no)

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* Cited by examiner, † Cited by third party
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WO2005005439A1 (en) * 2003-07-09 2005-01-20 Suven Life Sciences Limited Benzothiazino indoles
HRP20090419T1 (hr) 2004-01-02 2009-09-30 Suven Life Sciences Limited Novi indeno[2,1a]indeni i izoindol[2,1-a]indoli
PL1856132T3 (pl) 2005-03-08 2009-10-30 Suven Life Sciences Ltd Sposób wytwarzania podstawionych benzotiazynoindoli
BRPI0520579B8 (pt) 2005-08-12 2021-05-25 Suven Life Sciences Ltd composto, processo para a preparação de um composto e composição farmacêutica
WO2007020654A1 (en) 2005-08-16 2007-02-22 Suven Life Sciences An improved process for the preparation of losartan
DK2114878T3 (da) 2007-01-08 2011-03-14 Suven Life Sciences Ltd 5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indolforbindelser og deres anvendelse som 5-HT6-ligander
WO2008136017A1 (en) 2007-05-03 2008-11-13 Suven Life Sciences Limited Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands
US7807705B2 (en) 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
EP2200980B9 (en) 2007-10-26 2011-12-28 Suven Life Sciences Limited Amino arylsulfonamide compounds and their use as 5-ht6 ligands field of invention
WO2010032257A1 (en) 2008-09-17 2010-03-25 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands
EA019496B1 (ru) 2008-09-17 2014-04-30 Сувен Лайф Сайенсиз Лимитед Арилсульфонамидные аминосоединения и их применение в качестве лигандов 5-ht
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
CN105814020B (zh) * 2013-12-02 2018-04-17 苏文生命科学有限公司 用于大规模生产1‑[(2‑溴苯基)磺酰基]‑5‑甲氧基‑3‑[(4‑甲基‑1‑哌嗪基)甲基]‑1h‑吲哚二甲磺酸盐一水合物的方法
HRP20190446T1 (hr) 2014-08-16 2019-05-03 Suven Life Sciences Limited Aktivni metabolit 1-[(2-bromofenil) sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilat monohidrata i dimezilat dihidrat sol aktivnog metabolita
CN114642667A (zh) * 2016-05-18 2022-06-21 苏文生命科学有限公司 纯5-ht6受体拮抗剂与乙酰胆碱酯酶抑制剂的组合
DK3458040T3 (da) * 2016-05-18 2021-05-03 Suven Life Sciences Ltd Kombination af rene 5-ht6-receptorantagonister med nmda-receptorantagonist
HUE055452T2 (hu) * 2016-10-03 2021-11-29 Suven Life Sciences Ltd 5-HT6 antagonista gyógyszerkészítmények
JP6959371B2 (ja) * 2017-07-03 2021-11-02 スヴェン・ライフ・サイエンシーズ・リミテッドＳｕｖｅｎ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｉｍｉｔｅｄ 純粋な５−ｈｔ６受容体アンタゴニストの新たな使用

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Also Published As

Publication number Publication date
CN100378109C (zh) 2008-04-02
AU2003292510A1 (en) 2004-07-09
BRPI0316895B1 (pt) 2018-07-24
NO20052909D0 (no) 2005-06-15
US7781476B2 (en) 2010-08-24
NO334030B1 (no) 2013-11-18
BRPI0316895C1 (pt) 2021-05-25
EA200500994A1 (ru) 2006-02-24
EP1581538B1 (en) 2007-02-28
CA2507923A1 (en) 2004-07-01
MXPA05005808A (es) 2005-09-08
KR20050084185A (ko) 2005-08-26
NZ540841A (en) 2008-08-29
BRPI0316895B8 (pt) 2019-09-03
WO2004055026A1 (en) 2004-07-01
PT1581538E (pt) 2007-05-31
DE60312226T2 (de) 2007-11-15
HK1083840A1 (en) 2006-07-14
WO2004055026A8 (en) 2005-06-23
SI1581538T1 (sl) 2007-08-31
DK1581538T3 (da) 2007-06-25
DE60312226D1 (de) 2007-04-12
ZA200504042B (en) 2006-01-26
CA2507923C (en) 2010-02-02
BR0316895A (pt) 2005-10-25
EP1581538A1 (en) 2005-10-05
ATE355292T1 (de) 2006-03-15
CN1729197A (zh) 2006-02-01
AU2003292510B2 (en) 2009-04-23
JP4571507B2 (ja) 2010-10-27
KR100739987B1 (ko) 2007-07-16
JP2006515843A (ja) 2006-06-08
EA009367B1 (ru) 2007-12-28
US20070142398A1 (en) 2007-06-21

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