HK1083840A1 - Tetracyclic 3-substituted indoles having serotoninreceptor affinity - Google Patents

Tetracyclic 3-substituted indoles having serotoninreceptor affinity

Info

Publication number
HK1083840A1
HK1083840A1 HK06103973A HK06103973A HK1083840A1 HK 1083840 A1 HK1083840 A1 HK 1083840A1 HK 06103973 A HK06103973 A HK 06103973A HK 06103973 A HK06103973 A HK 06103973A HK 1083840 A1 HK1083840 A1 HK 1083840A1
Authority
HK
Hong Kong
Prior art keywords
tetracyclic
affinity
serotoninreceptor
substituted indoles
indoles
Prior art date
Application number
HK06103973A
Other languages
English (en)
Inventor
Ramakrishna Venkata Satya Nirogi
Shirsath Vikas Shreekrishna
Kambhampati Rama Sastri
Rao Venkata Satya V Vadlamudi
Jasti Venkateswarlu
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of HK1083840A1 publication Critical patent/HK1083840A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
HK06103973A 2002-12-18 2006-03-30 Tetracyclic 3-substituted indoles having serotoninreceptor affinity HK1083840A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN951MA2002 2002-12-18
PCT/IN2003/000393 WO2004055026A1 (en) 2002-12-18 2003-12-16 Tetracyclic 3-substituted indoles having serotonin receptor affinity

Publications (1)

Publication Number Publication Date
HK1083840A1 true HK1083840A1 (en) 2006-07-14

Family

ID=40848934

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06103973A HK1083840A1 (en) 2002-12-18 2006-03-30 Tetracyclic 3-substituted indoles having serotoninreceptor affinity

Country Status (20)

Country Link
US (1) US7781476B2 (xx)
EP (1) EP1581538B1 (xx)
JP (1) JP4571507B2 (xx)
KR (1) KR100739987B1 (xx)
CN (1) CN100378109C (xx)
AT (1) ATE355292T1 (xx)
AU (1) AU2003292510B2 (xx)
BR (1) BRPI0316895C1 (xx)
CA (1) CA2507923C (xx)
DE (1) DE60312226T2 (xx)
DK (1) DK1581538T3 (xx)
EA (1) EA009367B1 (xx)
HK (1) HK1083840A1 (xx)
MX (1) MXPA05005808A (xx)
NO (1) NO334030B1 (xx)
NZ (1) NZ540841A (xx)
PT (1) PT1581538E (xx)
SI (1) SI1581538T1 (xx)
WO (1) WO2004055026A1 (xx)
ZA (1) ZA200504042B (xx)

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KR101049868B1 (ko) 2004-01-02 2011-07-19 수벤 라이프 사이언시스 리미티드 신규한 인데노[2,1ａ]인덴 및 이소인돌[2,1-ａ]인돌
EP1856132B1 (en) * 2005-03-08 2009-04-01 Suven Life Sciences Limited Process for preparing substituted benzothiazinoindoles
DE602005018554D1 (de) 2005-08-12 2010-02-04 Suven Life Sciences Ltd Aminoarylsulfonamidderivate als funktionelle 5-ht6-liganden
WO2007020654A1 (en) 2005-08-16 2007-02-22 Suven Life Sciences An improved process for the preparation of losartan
KR101103023B1 (ko) 2007-01-08 2012-01-05 수벤 라이프 사이언시스 리미티드 ５­（헤테로시클릴）알킬­ｎ­（아릴술포닐）인돌 화합물 및 ５­ｈｔ６ 리간드로서 이들의 용도
WO2008136017A1 (en) 2007-05-03 2008-11-13 Suven Life Sciences Limited Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands
US7807705B2 (en) 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
ES2370680T3 (es) * 2007-10-26 2011-12-21 Suven Life Sciences Limited Compuestos de aminoarilsulfonamida y su empleo como ligandos de 5-ht6.
AU2009294181B2 (en) 2008-09-17 2011-11-17 Suven Life Sciences Limited Aryl sulfonamide amine compounds and their use as 5-HT6 ligands
US8318725B2 (en) 2008-09-17 2012-11-27 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
JP6151453B2 (ja) * 2013-12-02 2017-06-21 スヴェン・ライフ・サイエンシズ・リミテッド １−［（２−ブロモフェニル）スルホニル］−５−メトキシ−３−［（４−メチル−１−ピペラジニル）メチル］−１ｈ−インドールジメシラート一水和物の大規模合成法
AU2014404000B2 (en) * 2014-08-16 2017-11-16 Suven Life Sciences Limited Active metabolite of 1-[(2-bromophenyl) sulfonyl]-5-methoxy-3- [(4-methyl-1-piperazinyl) methyl]-1H-indole dimesylate monohydrate and dimesylate dihydrate salt of active metabolite
EP3648765A1 (en) * 2017-07-03 2020-05-13 Suven Life Sciences Limited New uses of a pure 5-ht 6 receptor antagonist

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Also Published As

Publication number Publication date
NO20052909L (no) 2005-09-12
BRPI0316895B1 (pt) 2018-07-24
DK1581538T3 (da) 2007-06-25
AU2003292510A1 (en) 2004-07-09
CA2507923C (en) 2010-02-02
DE60312226D1 (de) 2007-04-12
WO2004055026A1 (en) 2004-07-01
KR100739987B1 (ko) 2007-07-16
MXPA05005808A (es) 2005-09-08
ZA200504042B (en) 2006-01-26
ATE355292T1 (de) 2006-03-15
JP2006515843A (ja) 2006-06-08
EA009367B1 (ru) 2007-12-28
EA200500994A1 (ru) 2006-02-24
EP1581538B1 (en) 2007-02-28
AU2003292510B2 (en) 2009-04-23
EP1581538A1 (en) 2005-10-05
BR0316895A (pt) 2005-10-25
JP4571507B2 (ja) 2010-10-27
US7781476B2 (en) 2010-08-24
KR20050084185A (ko) 2005-08-26
CN1729197A (zh) 2006-02-01
SI1581538T1 (sl) 2007-08-31
DE60312226T2 (de) 2007-11-15
BRPI0316895C1 (pt) 2021-05-25
NO334030B1 (no) 2013-11-18
NO20052909D0 (no) 2005-06-15
US20070142398A1 (en) 2007-06-21
PT1581538E (pt) 2007-05-31
WO2004055026A8 (en) 2005-06-23
CN100378109C (zh) 2008-04-02
BRPI0316895B8 (pt) 2019-09-03
NZ540841A (en) 2008-08-29
CA2507923A1 (en) 2004-07-01

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20201216