EA200000548A1 - Сфероиды, способ получения и фармацевтические композиции - Google Patents
Сфероиды, способ получения и фармацевтические композицииInfo
- Publication number
- EA200000548A1 EA200000548A1 EA200000548A EA200000548A EA200000548A1 EA 200000548 A1 EA200000548 A1 EA 200000548A1 EA 200000548 A EA200000548 A EA 200000548A EA 200000548 A EA200000548 A EA 200000548A EA 200000548 A1 EA200000548 A1 EA 200000548A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- spheroids
- producing
- pharmaceutical compositions
- pharmaceutical preparations
- present
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 238000003825 pressing Methods 0.000 abstract 1
- PBJUNZJWGZTSKL-MRXNPFEDSA-N tiagabine Chemical compound C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C PBJUNZJWGZTSKL-MRXNPFEDSA-N 0.000 abstract 1
- 229960001918 tiagabine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
(57) Настоящее изобретение относится к новой галеновой форме в виде сфероидов, содержащей одно или несколько действующих начал, за исключением тиагабина. Настоящее изобретение относится, кроме того, к способу получения таких сфероидов и к многокомпонентным фармацевтическим препаратам, таким как таблетки, содержащим эти сфероиды. Эти фармацевтические препараты предназначены для высвобождения содержащихся в них сфероидов и характеризуются отсутствием изменения профиля высвобождения действующего начала или действующих начал вследствие возможной стадии прессования.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9714631A FR2771291B1 (fr) | 1997-11-21 | 1997-11-21 | Spheroides, procede de preparation et compositions pharmaceutiques |
PCT/IB1998/001911 WO1999026608A1 (fr) | 1997-11-21 | 1998-11-19 | Spheroides, procede de preparation et compositions pharmaceutiques |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200000548A1 true EA200000548A1 (ru) | 2000-12-25 |
EA003324B1 EA003324B1 (ru) | 2003-04-24 |
Family
ID=9513635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000548A EA003324B1 (ru) | 1997-11-21 | 1998-11-19 | Сфероиды, способ получения и фармацевтические композиции |
Country Status (29)
Country | Link |
---|---|
US (1) | US6077544A (ru) |
EP (1) | EP1032374B1 (ru) |
JP (1) | JP2001523706A (ru) |
KR (1) | KR100502938B1 (ru) |
CN (1) | CN1223341C (ru) |
AT (1) | ATE246496T1 (ru) |
AU (1) | AU744580B2 (ru) |
BG (1) | BG65117B1 (ru) |
BR (1) | BR9814672A (ru) |
CA (1) | CA2310147C (ru) |
CZ (1) | CZ299110B6 (ru) |
DE (1) | DE69817010T2 (ru) |
DK (1) | DK1032374T3 (ru) |
EA (1) | EA003324B1 (ru) |
ES (1) | ES2203989T3 (ru) |
FR (1) | FR2771291B1 (ru) |
HR (1) | HRP20000323B1 (ru) |
HU (1) | HU230053B1 (ru) |
IL (2) | IL136215A0 (ru) |
MX (1) | MXPA00004959A (ru) |
NO (1) | NO329728B1 (ru) |
NZ (1) | NZ504662A (ru) |
PL (1) | PL193878B1 (ru) |
PT (1) | PT1032374E (ru) |
SK (1) | SK284493B6 (ru) |
TR (1) | TR200002130T2 (ru) |
WO (1) | WO1999026608A1 (ru) |
YU (1) | YU31000A (ru) |
ZA (1) | ZA9810631B (ru) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2790668B1 (fr) * | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
EP1165042B1 (fr) | 1999-04-06 | 2005-02-02 | Ethypharm | Suspension pharmaceutique buvable d'ibuprofene |
FR2794646B1 (fr) * | 1999-06-09 | 2001-09-21 | Ethypharm Lab Prod Ethiques | Microgranules de sulfate de morphine, procede de preparation et composition les contenant |
DK1414956T3 (da) | 2001-06-22 | 2008-03-03 | Genencor Int | Höjt påvirkningsresistente granula |
AR034813A1 (es) † | 2001-07-20 | 2004-03-17 | Novartis Ag | Composiciones farmaceuticas y uso de las mismas |
FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
FR2837100B1 (fr) * | 2002-03-18 | 2004-07-23 | Flamel Tech Sa | Comprimes a bases de microcapsules a liberation modifiee |
PT1492511E (pt) | 2002-04-09 | 2009-04-09 | Flamel Tech Sa | Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s) |
CA2480824A1 (fr) * | 2002-04-09 | 2003-10-16 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee d'amoxicilline |
FR2838647B1 (fr) * | 2002-04-23 | 2006-02-17 | Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant | |
US20040013737A1 (en) * | 2002-07-19 | 2004-01-22 | Philippe Becourt | Taste masked oral composition of telithromycin |
FR2845289B1 (fr) * | 2002-10-04 | 2004-12-03 | Ethypharm Sa | Spheroides, procede de preparation et compositions pharmaceutiques. |
US9107804B2 (en) * | 2002-12-10 | 2015-08-18 | Nortec Development Associates, Inc. | Method of preparing biologically active formulations |
NZ523946A (en) | 2003-01-31 | 2004-06-25 | Carl Ernest Alexander | Portable hygiene compositions comprising a semi-solid gel and active ingredients in bead form for use in personal oral, dental or skin care |
ES2221804B1 (es) * | 2003-06-18 | 2006-04-01 | Lipofoods, S.L. | Microcapsulas para la administracion de ingredientes activos. |
JP5171038B2 (ja) * | 2003-10-10 | 2013-03-27 | エティファルム | イチョウ・エキスを含む放出持続性の微小顆粒およびそのような顆粒の製造方法 |
FR2861990B1 (fr) | 2003-11-10 | 2006-02-10 | Nouveaux Produits Pharma | Comprimes faiblement doses a reseau de polymeres |
EP1737433B1 (en) * | 2004-04-12 | 2007-11-14 | Pfizer Products Incorporated | Taste-masked drugs in rupturing multiparticulates |
CA2569961A1 (en) * | 2004-06-10 | 2005-12-29 | Glatt Air Techniques, Inc | Controlled release pharmaceutical formulation |
FR2883179B1 (fr) | 2005-03-18 | 2009-04-17 | Ethypharm Sa | Comprime enrobe |
US20100233257A1 (en) * | 2006-06-09 | 2010-09-16 | Ethypharm | Low dose sublingual tablets of opioid analgesics and preparation process |
US20070286900A1 (en) * | 2006-06-09 | 2007-12-13 | Catherine Herry | Low dose tablets of opioid analgesics and preparation process |
US11116728B2 (en) | 2006-11-30 | 2021-09-14 | Bend Research, Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
WO2008065504A1 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
EP2468263A1 (en) | 2010-12-23 | 2012-06-27 | Laboratorios Del. Dr. Esteve, S.A. | Compressed solid dosage forms |
EP3790822A4 (en) | 2018-05-11 | 2022-01-26 | Stolle Machinery Company, LLC | PROCESS SHANK TOOLING ARRANGEMENT |
CN112135785B (zh) | 2018-05-11 | 2022-04-19 | 斯多里机械有限责任公司 | 快速更换式转移组件 |
WO2019217607A2 (en) | 2018-05-11 | 2019-11-14 | Stolle Machinery Company, Llc | Infeed assembly quick change features |
CN115958118A (zh) | 2018-05-11 | 2023-04-14 | 斯多里机械有限责任公司 | 快速更换工具组件 |
CN112105916B (zh) | 2018-05-11 | 2024-01-02 | 斯多里机械有限责任公司 | 馈入组件全面检查组件 |
WO2019217711A1 (en) | 2018-05-11 | 2019-11-14 | Stolle Machinery Company, Llc | Drive assembly |
JP7312196B2 (ja) | 2018-05-11 | 2023-07-20 | ストール マシーナリ カンパニー,エルエルシー | 回転マニホールド |
US11420242B2 (en) | 2019-08-16 | 2022-08-23 | Stolle Machinery Company, Llc | Reformer assembly |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4684516A (en) * | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
CA1338596C (en) * | 1988-09-27 | 1996-09-17 | Hiroyoshi Koyama | Granules having core and their production |
EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
JP2572673B2 (ja) * | 1990-07-25 | 1997-01-16 | エスエス製薬株式会社 | 徐放性錠剤 |
FR2679451B1 (fr) * | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | Comprime multiparticulaire a delitement rapide. |
GB9117361D0 (en) * | 1991-08-12 | 1991-09-25 | Euro Celtique Sa | Oral dosage form |
FR2692146B1 (fr) * | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
SK279684B6 (sk) * | 1993-06-14 | 1999-02-11 | Janssen Pharmaceutica N.V. | Tableta a spôsob jej výroby |
SE9402422D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New beads for controlled release and a pharmaceutical preparation containing the same |
SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
FR2771292B1 (fr) * | 1997-11-21 | 2000-02-18 | Ethypharm Lab Prod Ethiques | Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques |
-
1997
- 1997-11-21 FR FR9714631A patent/FR2771291B1/fr not_active Expired - Lifetime
-
1998
- 1998-10-19 TR TR2000/02130T patent/TR200002130T2/xx unknown
- 1998-11-19 PT PT98954683T patent/PT1032374E/pt unknown
- 1998-11-19 CZ CZ20001849A patent/CZ299110B6/cs not_active IP Right Cessation
- 1998-11-19 MX MXPA00004959A patent/MXPA00004959A/es unknown
- 1998-11-19 DE DE69817010T patent/DE69817010T2/de not_active Expired - Lifetime
- 1998-11-19 AT AT98954683T patent/ATE246496T1/de active
- 1998-11-19 PL PL98340659A patent/PL193878B1/pl unknown
- 1998-11-19 KR KR10-2000-7005544A patent/KR100502938B1/ko not_active IP Right Cessation
- 1998-11-19 IL IL13621598A patent/IL136215A0/xx active IP Right Grant
- 1998-11-19 AU AU11704/99A patent/AU744580B2/en not_active Expired
- 1998-11-19 DK DK98954683T patent/DK1032374T3/da active
- 1998-11-19 ES ES98954683T patent/ES2203989T3/es not_active Expired - Lifetime
- 1998-11-19 HU HU0100562A patent/HU230053B1/hu unknown
- 1998-11-19 BR BR9814672-6A patent/BR9814672A/pt not_active Application Discontinuation
- 1998-11-19 SK SK756-2000A patent/SK284493B6/sk unknown
- 1998-11-19 EP EP98954683A patent/EP1032374B1/fr not_active Expired - Lifetime
- 1998-11-19 WO PCT/IB1998/001911 patent/WO1999026608A1/fr active IP Right Grant
- 1998-11-19 NZ NZ504662A patent/NZ504662A/xx not_active IP Right Cessation
- 1998-11-19 CN CNB988124270A patent/CN1223341C/zh not_active Expired - Lifetime
- 1998-11-19 CA CA2310147A patent/CA2310147C/fr not_active Expired - Lifetime
- 1998-11-19 EA EA200000548A patent/EA003324B1/ru not_active IP Right Cessation
- 1998-11-19 YU YU31000A patent/YU31000A/sh unknown
- 1998-11-19 JP JP2000521810A patent/JP2001523706A/ja active Pending
- 1998-11-20 ZA ZA9810631A patent/ZA9810631B/xx unknown
- 1998-11-23 US US09/197,466 patent/US6077544A/en not_active Expired - Lifetime
-
2000
- 2000-05-18 IL IL136215A patent/IL136215A/en not_active IP Right Cessation
- 2000-05-19 NO NO20002605A patent/NO329728B1/no not_active IP Right Cessation
- 2000-05-19 HR HR20000323A patent/HRP20000323B1/xx not_active IP Right Cessation
- 2000-06-06 BG BG104511A patent/BG65117B1/bg unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |