EA030137B1 - Кристаллическая форма (s)-(2-(6-хлор-7-метил-1н-бензо[d]имидазол-2-ил)-2-метилпирролидин-1-ил)(5-метокси-2-(2h-1,2,3-триазол-2-ил)фенил)метанона и ее применение в качестве антагонистов орексинового рецептора - Google Patents
Кристаллическая форма (s)-(2-(6-хлор-7-метил-1н-бензо[d]имидазол-2-ил)-2-метилпирролидин-1-ил)(5-метокси-2-(2h-1,2,3-триазол-2-ил)фенил)метанона и ее применение в качестве антагонистов орексинового рецептора Download PDFInfo
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- EA030137B1 EA030137B1 EA201600435A EA201600435A EA030137B1 EA 030137 B1 EA030137 B1 EA 030137B1 EA 201600435 A EA201600435 A EA 201600435A EA 201600435 A EA201600435 A EA 201600435A EA 030137 B1 EA030137 B1 EA 030137B1
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- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
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| PCT/IB2014/066508 WO2015083070A1 (en) | 2013-12-03 | 2014-12-02 | Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists |
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| EA201600435A1 EA201600435A1 (ru) | 2016-11-30 |
| EA030137B1 true EA030137B1 (ru) | 2018-06-29 |
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| KR101995683B1 (ko) | 2012-06-04 | 2019-07-02 | 이도르시아 파마슈티컬스 리미티드 | 벤즈이미다졸-프롤린 유도체 |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| HK1225734B (en) | 2013-12-04 | 2017-09-15 | Idorsia Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives |
| KR102582197B1 (ko) | 2017-05-03 | 2023-09-22 | 이도르시아 파마슈티컬스 리미티드 | 2-([1,2,3]트리아졸-2-일)-벤조산 유도체의 제조 |
| JP2023521492A (ja) * | 2020-04-19 | 2023-05-24 | イドーシア ファーマシューティカルズ リミテッド | ダリドレキサントの医学的用途 |
| CN116783182B (zh) * | 2021-02-02 | 2025-08-29 | 南京明德新药研发有限公司 | 四氢吡咯并环化合物及其应用 |
| WO2023160004A1 (zh) * | 2022-02-25 | 2023-08-31 | 南京知和医药科技有限公司 | 具有镇痛活性的稠环化合物及其制备方法与用途 |
| ES3038762A1 (es) | 2024-04-12 | 2025-10-14 | Moehs Iberica Sl | Procedimiento de síntesis de ácido 5-metoxi-2-(2H-1,2,3-triazol-2yl)benzoico, sal sódica de dicho ácido como intermedio de síntesis y uso del ácido o de su sal en la preparación de daridorexant y ciertos intermedios en la síntesis del mismo |
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| WO2003002561A1 (en) * | 2001-06-28 | 2003-01-09 | Smithkline Beecham P.L.C. | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
| WO2010072722A1 (en) * | 2008-12-23 | 2010-07-01 | Glaxo Group Limited | Piperidine derivatives useful as orexin antagonists |
| WO2013182972A1 (en) * | 2012-06-04 | 2013-12-12 | Actelion Pharmaceuticals Ltd | Benzimidazole-proline derivatives |
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