EA026668B1 - Новые бициклические пиридиноны - Google Patents

Новые бициклические пиридиноны Download PDF

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Publication number
EA026668B1
EA026668B1 EA201590319A EA201590319A EA026668B1 EA 026668 B1 EA026668 B1 EA 026668B1 EA 201590319 A EA201590319 A EA 201590319A EA 201590319 A EA201590319 A EA 201590319A EA 026668 B1 EA026668 B1 EA 026668B1
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EA
Eurasian Patent Office
Prior art keywords
mmol
methyl
phenyl
compound
tetrahydrofuran
Prior art date
Application number
EA201590319A
Other languages
English (en)
Russian (ru)
Other versions
EA201590319A1 (ru
Inventor
Кристофер Уилльям Эм Энде
Майкл Эрик Грин
Дуглас Скотт Джонсон
Грегори Уэйн Кауффман
Кристофер Джон О'Доннелл
Нандини Чатурбхаи Пател
Мартин Янгчжин Петтерссон
Антониа Фредерике Стипэн
Кори Майкл Стифф
Чакрапани Субраманиам
Туан Пхон Трэн
Патрик Роберт Верхоуэст
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA201590319A1 publication Critical patent/EA201590319A1/ru
Publication of EA026668B1 publication Critical patent/EA026668B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epidemiology (AREA)
EA201590319A 2012-09-21 2013-09-06 Новые бициклические пиридиноны EA026668B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261703969P 2012-09-21 2012-09-21
PCT/IB2013/058347 WO2014045156A1 (en) 2012-09-21 2013-09-06 Novel bicyclic pyridinones

Publications (2)

Publication Number Publication Date
EA201590319A1 EA201590319A1 (ru) 2015-09-30
EA026668B1 true EA026668B1 (ru) 2017-05-31

Family

ID=49585452

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590319A EA026668B1 (ru) 2012-09-21 2013-09-06 Новые бициклические пиридиноны

Country Status (46)

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US (3) US8916564B2 (Direct)
EP (1) EP2897956B1 (Direct)
JP (1) JP5844018B2 (Direct)
KR (1) KR101725696B1 (Direct)
CN (1) CN104662021B (Direct)
AP (1) AP2015008277A0 (Direct)
AR (1) AR092628A1 (Direct)
AU (1) AU2013319845B2 (Direct)
BR (1) BR112015006436A2 (Direct)
CA (1) CA2882386C (Direct)
CL (1) CL2015000717A1 (Direct)
CR (1) CR20150053A (Direct)
CU (1) CU20150021A7 (Direct)
CY (1) CY1118662T1 (Direct)
DK (1) DK2897956T3 (Direct)
DO (1) DOP2015000069A (Direct)
EA (1) EA026668B1 (Direct)
EC (1) ECSP15015594A (Direct)
ES (1) ES2609987T3 (Direct)
GE (1) GEP201706659B (Direct)
GT (1) GT201500069A (Direct)
HR (1) HRP20161558T1 (Direct)
HU (1) HUE031248T2 (Direct)
IL (1) IL237163A (Direct)
IN (1) IN2015DN01119A (Direct)
LT (1) LT2897956T (Direct)
MA (1) MA37886B1 (Direct)
MD (1) MD4583B1 (Direct)
ME (1) ME02571B (Direct)
MX (1) MX360599B (Direct)
MY (1) MY181891A (Direct)
NI (1) NI201500038A (Direct)
NZ (1) NZ704863A (Direct)
PE (1) PE20150686A1 (Direct)
PH (1) PH12015500376A1 (Direct)
PL (1) PL2897956T3 (Direct)
PT (1) PT2897956T (Direct)
RS (1) RS55426B1 (Direct)
SG (1) SG11201501074WA (Direct)
SI (1) SI2897956T1 (Direct)
TN (1) TN2015000084A1 (Direct)
TW (1) TWI500616B (Direct)
UA (1) UA110688C2 (Direct)
UY (1) UY35039A (Direct)
WO (1) WO2014045156A1 (Direct)
ZA (1) ZA201501195B (Direct)

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UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
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US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
KR101886945B1 (ko) * 2014-04-01 2018-08-08 화이자 인코포레이티드 감마-세크레타제 조절제로서의 크로멘 및 1,1a,2,7b-테트라히드로시클로프로파[c]크로멘 피리도피라진디온
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DK4069691T3 (da) 2019-12-06 2024-10-28 Vertex Pharma Substituerede tetrahydrofuraner som modulatorer af natriumkanaler
CN113402490B (zh) * 2021-03-29 2023-01-03 白银京宇新药业有限公司 一种1，2，6，7-四氢-8H-茚并[5，4-b]呋喃-8-酮的制备方法
MA64853B1 (fr) 2021-06-04 2025-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques
CN114034792B (zh) * 2021-11-09 2024-06-25 山东新华制药股份有限公司 检测氯酮含量的液相色谱分析方法

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