EA024792B1 - Производные полимиксина - Google Patents

Производные полимиксина Download PDF

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Publication number
EA024792B1
EA024792B1 EA201490634A EA201490634A EA024792B1 EA 024792 B1 EA024792 B1 EA 024792B1 EA 201490634 A EA201490634 A EA 201490634A EA 201490634 A EA201490634 A EA 201490634A EA 024792 B1 EA024792 B1 EA 024792B1
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EA
Eurasian Patent Office
Prior art keywords
nanopeptide
alkyl
group
compound
formula
Prior art date
Application number
EA201490634A
Other languages
English (en)
Russian (ru)
Other versions
EA201490634A1 (ru
Inventor
Мона Саади
Эстер Дюперчи
Памела Браун
Майкл Джон Доусон
Сьёрд Николаас Вадман
Original Assignee
Новакта Биосистемс Лимитед
Кентаб Анти-Инфективис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новакта Биосистемс Лимитед, Кентаб Анти-Инфективис Лимитед filed Critical Новакта Биосистемс Лимитед
Publication of EA201490634A1 publication Critical patent/EA201490634A1/ru
Publication of EA024792B1 publication Critical patent/EA024792B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EA201490634A 2011-11-18 2012-11-16 Производные полимиксина EA024792B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561361P 2011-11-18 2011-11-18
PCT/GB2012/052844 WO2013072695A1 (en) 2011-11-18 2012-11-16 Polymyxin derivatives

Publications (2)

Publication Number Publication Date
EA201490634A1 EA201490634A1 (ru) 2014-12-30
EA024792B1 true EA024792B1 (ru) 2016-10-31

Family

ID=47297320

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490634A EA024792B1 (ru) 2011-11-18 2012-11-16 Производные полимиксина

Country Status (15)

Country Link
US (1) US9234006B2 (https=)
EP (1) EP2780357A1 (https=)
JP (1) JP6185920B2 (https=)
KR (1) KR20140091724A (https=)
CN (1) CN103946233A (https=)
AU (1) AU2012338571B2 (https=)
BR (1) BR112014012016A2 (https=)
CA (1) CA2855916A1 (https=)
CO (1) CO7061068A2 (https=)
EA (1) EA024792B1 (https=)
IL (1) IL232278A0 (https=)
MX (1) MX355217B (https=)
SG (1) SG11201402390PA (https=)
TW (1) TWI608019B (https=)
WO (1) WO2013072695A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2730012C2 (ru) * 2013-05-22 2020-08-14 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
RU2740190C2 (ru) * 2014-03-11 2021-01-12 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками

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CA2855916A1 (en) 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
JP2017512818A (ja) * 2014-04-01 2017-05-25 モナシュ、ユニバーシティＭｏｎａｓｈ Ｕｎｉｖｅｒｓｉｔｙ 抗菌性化合物としてのポリミキシン誘導体
US12146004B2 (en) 2014-11-26 2024-11-19 Spero Therapeutics, Inc. Polymyxin compounds and uses thereof
WO2016100578A2 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
FI126143B (en) 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
US10322187B2 (en) 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
EP3356387B1 (en) * 2015-09-29 2024-06-26 Monash University Antimicrobial polymyxin derivative compounds
WO2018051085A1 (en) * 2016-09-13 2018-03-22 Centauri Therapeutics Limited Novel compounds and therapeutic uses thereof
CN108226315B (zh) * 2016-12-15 2022-04-12 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
CN111527100A (zh) * 2017-11-02 2020-08-11 昆士兰大学 肽类抗生素
RS65128B1 (sr) 2018-06-25 2024-02-29 Spero Therapeutics Inc Jedinjenja
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
JP7045520B2 (ja) * 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
WO2022098950A1 (en) 2020-11-06 2022-05-12 Spero Therapeutics, Inc. Compounds
CN112755174B (zh) * 2021-02-26 2022-11-18 沈阳药科大学 多粘菌素衍生物及其制备方法和应用
WO2022262823A1 (zh) * 2021-06-18 2022-12-22 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用
NL2030897B1 (en) * 2022-02-11 2023-08-18 Univ Leiden Antibiotic compounds, formulations and methods of use

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WO2008017734A1 (en) * 2006-08-11 2008-02-14 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
WO2009098357A1 (en) * 2008-02-08 2009-08-13 Northern Antibiotics Oy Short fatty acid tail polymyxin derivatives and uses thereof
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents

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GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
AU7753787A (en) 1986-08-06 1988-02-24 Jean-Luc Fauchere Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b
US20010021697A1 (en) 1987-09-14 2001-09-13 Henning Lowenstein Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components
TW274552B (https=) 1992-05-26 1996-04-21 Hoechst Ag
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
CA2540742A1 (en) 2003-09-30 2005-04-14 Terry Hicks Compositions and methods for treating burns
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
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US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
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CA2855916A1 (en) 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
KR102354902B1 (ko) 2013-05-22 2022-01-24 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
MX359104B (es) * 2014-03-11 2018-09-14 New Pharma Licence Holdings Ltd Derivados de polimixina y su uso en terapia de combinacion junto con diferentes antibioticos.

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008017734A1 (en) * 2006-08-11 2008-02-14 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
WO2009098357A1 (en) * 2008-02-08 2009-08-13 Northern Antibiotics Oy Short fatty acid tail polymyxin derivatives and uses thereof
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents

Non-Patent Citations (6)

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KATSUMA NAOKO , SATO YUKI , OHKI KAZUHIRO , OKIMURA KEIKO, UCHIDA YOSHIKI , SHINDO MITSUNO , SAKURA NAOKI: "Antimicrobial activity of Des-fatty acyl-polymyxin B decapeptide N-terminal analogs", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO,, JP, vol. 2004, 1 January 2005 (2005-01-01), JP, pages 549 - 550, XP002690946, ISSN: 1344-7661 *
KATSUMA NAOKO, ET AL: "Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 57, no. 4, 1 April 2009 (2009-04-01), JP, pages 332 - 336, XP002683206, ISSN: 0009-2363 *
OKIMURA KEIKO, SATO YUKI, OHKI KAZUHIRO, OHNISHI KUNIHARU, SAKURA NAOKI: "Antimicrobial activity of various aminocyclohexylcarbonyl-polymyxin B (2-10) derivatives", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO,, JP, no. NUMB 45, 1 January 2009 (2009-01-01), JP, pages 243 - 244, XP002690948, ISSN: 1344-7661 *
SATO Y., KATSUMA N., OHKI K., OKIMURA K., UCHIDA Y., OHNISHI K., SAKURA N.: "Des-fatty acyl-polymyxin B decapeptide analogs with antimicrobial activity specifically against Pseudomonas aeruginosa", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO,, JP, no. NUMB 44, 1 January 2007 (2007-01-01), JP, pages 307 - 308, XP002690947, ISSN: 1344-7661 *
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YUKIO KIMURA, HISAMI MATSUNAGA, MARTTI VAARA: "Polymyxin B octapeptide and polymyxin B heptapeptide are potent outer membrane permeability-increasing agents.", THE JOURNAL OF ANTIBIOTICS, vol. 45, no. 5, 1 January 1992 (1992-01-01), pages 742 - 749, XP055050711, ISSN: 00218820, DOI: 10.7164/antibiotics.45.742 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2730012C2 (ru) * 2013-05-22 2020-08-14 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
RU2740190C2 (ru) * 2014-03-11 2021-01-12 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками

Also Published As

Publication number Publication date
JP6185920B2 (ja) 2017-08-23
EA201490634A1 (ru) 2014-12-30
AU2012338571B2 (en) 2016-06-16
CA2855916A1 (en) 2013-05-23
US20150031602A1 (en) 2015-01-29
CO7061068A2 (es) 2014-09-19
EP2780357A1 (en) 2014-09-24
MX355217B (es) 2018-04-10
SG11201402390PA (en) 2014-06-27
AU2012338571A1 (en) 2014-05-22
KR20140091724A (ko) 2014-07-22
JP2014533678A (ja) 2014-12-15
CN103946233A (zh) 2014-07-23
IL232278A0 (en) 2014-06-30
TW201326215A (zh) 2013-07-01
BR112014012016A2 (pt) 2017-05-16
MX2014005542A (es) 2014-10-24
WO2013072695A1 (en) 2013-05-23
TWI608019B (zh) 2017-12-11
US9234006B2 (en) 2016-01-12

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU