JP6185920B2 - ポリミキシン誘導体 - Google Patents
ポリミキシン誘導体 Download PDFInfo
- Publication number
- JP6185920B2 JP6185920B2 JP2014541753A JP2014541753A JP6185920B2 JP 6185920 B2 JP6185920 B2 JP 6185920B2 JP 2014541753 A JP2014541753 A JP 2014541753A JP 2014541753 A JP2014541753 A JP 2014541753A JP 6185920 B2 JP6185920 B2 JP 6185920B2
- Authority
- JP
- Japan
- Prior art keywords
- nonapeptide
- polymyxin
- alkyl
- group
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 108010040201 Polymyxins Proteins 0.000 title description 14
- 150000001875 compounds Chemical class 0.000 claims description 165
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- 108700026839 polymyxin B nonapeptide Proteins 0.000 claims description 88
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- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 claims description 65
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| US201161561361P | 2011-11-18 | 2011-11-18 | |
| US61/561,361 | 2011-11-18 | ||
| PCT/GB2012/052844 WO2013072695A1 (en) | 2011-11-18 | 2012-11-16 | Polymyxin derivatives |
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| JP2014533678A JP2014533678A (ja) | 2014-12-15 |
| JP2014533678A5 JP2014533678A5 (https=) | 2016-01-14 |
| JP6185920B2 true JP6185920B2 (ja) | 2017-08-23 |
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| EP (1) | EP2780357A1 (https=) |
| JP (1) | JP6185920B2 (https=) |
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| CN (1) | CN103946233A (https=) |
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| CO (1) | CO7061068A2 (https=) |
| EA (1) | EA024792B1 (https=) |
| IL (1) | IL232278A0 (https=) |
| MX (1) | MX355217B (https=) |
| SG (1) | SG11201402390PA (https=) |
| TW (1) | TWI608019B (https=) |
| WO (1) | WO2013072695A1 (https=) |
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| JP2016527186A (ja) * | 2013-05-22 | 2016-09-08 | ニュー・ファーマ・ライセンス・ホールディングス・リミテッド | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
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| CA2855916A1 (en) | 2011-11-18 | 2013-05-23 | Novacta Biosystems Limited | Polymyxin derivatives |
| MX359104B (es) * | 2014-03-11 | 2018-09-14 | New Pharma Licence Holdings Ltd | Derivados de polimixina y su uso en terapia de combinacion junto con diferentes antibioticos. |
| JP2017512818A (ja) * | 2014-04-01 | 2017-05-25 | モナシュ、ユニバーシティＭｏｎａｓｈ Ｕｎｉｖｅｒｓｉｔｙ | 抗菌性化合物としてのポリミキシン誘導体 |
| US12146004B2 (en) | 2014-11-26 | 2024-11-19 | Spero Therapeutics, Inc. | Polymyxin compounds and uses thereof |
| WO2016100578A2 (en) | 2014-12-16 | 2016-06-23 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
| FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| US10322187B2 (en) | 2015-08-10 | 2019-06-18 | Lehigh University | Reduced toxicity molecular conjugates of anti-fungal agents |
| EP3356387B1 (en) * | 2015-09-29 | 2024-06-26 | Monash University | Antimicrobial polymyxin derivative compounds |
| WO2018051085A1 (en) * | 2016-09-13 | 2018-03-22 | Centauri Therapeutics Limited | Novel compounds and therapeutic uses thereof |
| CN108226315B (zh) * | 2016-12-15 | 2022-04-12 | 上海医药工业研究院 | 一种检测多黏菌素e残留量的分析方法 |
| CN111527100A (zh) * | 2017-11-02 | 2020-08-11 | 昆士兰大学 | 肽类抗生素 |
| RS65128B1 (sr) | 2018-06-25 | 2024-02-29 | Spero Therapeutics Inc | Jedinjenja |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| JP7045520B2 (ja) * | 2020-01-02 | 2022-03-31 | 上海上薬第一生化薬業有限公司 | ポリミキシンｂ成分又はその塩、その製造方法及び使用 |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| WO2022098950A1 (en) | 2020-11-06 | 2022-05-12 | Spero Therapeutics, Inc. | Compounds |
| CN112755174B (zh) * | 2021-02-26 | 2022-11-18 | 沈阳药科大学 | 多粘菌素衍生物及其制备方法和应用 |
| WO2022262823A1 (zh) * | 2021-06-18 | 2022-12-22 | 华南理工大学 | 活性氧自由基响应的多粘菌素前药化合物及其应用 |
| NL2030897B1 (en) * | 2022-02-11 | 2023-08-18 | Univ Leiden | Antibiotic compounds, formulations and methods of use |
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| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| AU7753787A (en) | 1986-08-06 | 1988-02-24 | Jean-Luc Fauchere | Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b |
| US20010021697A1 (en) | 1987-09-14 | 2001-09-13 | Henning Lowenstein | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components |
| TW274552B (https=) | 1992-05-26 | 1996-04-21 | Hoechst Ag | |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| CA2540742A1 (en) | 2003-09-30 | 2005-04-14 | Terry Hicks | Compositions and methods for treating burns |
| US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| BRPI0715095B8 (pt) * | 2006-08-11 | 2021-05-25 | Northern Antibiotics Oy | derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i). |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| US8193148B2 (en) | 2008-02-08 | 2012-06-05 | Northern Antibiotics Ltd. | Short fatty acid tail polymyxin derivatives and uses thereof |
| US8329645B2 (en) | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| ES2334547B1 (es) | 2008-09-10 | 2010-12-03 | Universidad De Barcelona | Compuestos peptidicos antibacterianos. |
| CA2747995A1 (en) | 2008-12-23 | 2010-07-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| CN101851270A (zh) | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| WO2012168820A1 (en) * | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| CA2855916A1 (en) | 2011-11-18 | 2013-05-23 | Novacta Biosystems Limited | Polymyxin derivatives |
| KR102354902B1 (ko) | 2013-05-22 | 2022-01-24 | 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 | 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 |
| MX359104B (es) * | 2014-03-11 | 2018-09-14 | New Pharma Licence Holdings Ltd | Derivados de polimixina y su uso en terapia de combinacion junto con diferentes antibioticos. |
-
2012
- 2012-11-16 CA CA2855916A patent/CA2855916A1/en not_active Abandoned
- 2012-11-16 MX MX2014005542A patent/MX355217B/es active IP Right Grant
- 2012-11-16 EP EP12797961.5A patent/EP2780357A1/en not_active Withdrawn
- 2012-11-16 AU AU2012338571A patent/AU2012338571B2/en not_active Ceased
- 2012-11-16 BR BR112014012016A patent/BR112014012016A2/pt not_active Application Discontinuation
- 2012-11-16 US US14/356,868 patent/US9234006B2/en active Active
- 2012-11-16 KR KR1020147014427A patent/KR20140091724A/ko not_active Withdrawn
- 2012-11-16 CN CN201280055987.6A patent/CN103946233A/zh active Pending
- 2012-11-16 JP JP2014541753A patent/JP6185920B2/ja not_active Expired - Fee Related
- 2012-11-16 TW TW101142961A patent/TWI608019B/zh not_active IP Right Cessation
- 2012-11-16 WO PCT/GB2012/052844 patent/WO2013072695A1/en not_active Ceased
- 2012-11-16 SG SG11201402390PA patent/SG11201402390PA/en unknown
- 2012-11-16 EA EA201490634A patent/EA024792B1/ru not_active IP Right Cessation
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2014
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016527186A (ja) * | 2013-05-22 | 2016-09-08 | ニュー・ファーマ・ライセンス・ホールディングス・リミテッド | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201490634A1 (ru) | 2014-12-30 |
| AU2012338571B2 (en) | 2016-06-16 |
| CA2855916A1 (en) | 2013-05-23 |
| US20150031602A1 (en) | 2015-01-29 |
| CO7061068A2 (es) | 2014-09-19 |
| EP2780357A1 (en) | 2014-09-24 |
| EA024792B1 (ru) | 2016-10-31 |
| MX355217B (es) | 2018-04-10 |
| SG11201402390PA (en) | 2014-06-27 |
| AU2012338571A1 (en) | 2014-05-22 |
| KR20140091724A (ko) | 2014-07-22 |
| JP2014533678A (ja) | 2014-12-15 |
| CN103946233A (zh) | 2014-07-23 |
| IL232278A0 (en) | 2014-06-30 |
| TW201326215A (zh) | 2013-07-01 |
| BR112014012016A2 (pt) | 2017-05-16 |
| MX2014005542A (es) | 2014-10-24 |
| WO2013072695A1 (en) | 2013-05-23 |
| TWI608019B (zh) | 2017-12-11 |
| US9234006B2 (en) | 2016-01-12 |
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