CN103946233A - 多黏菌素衍生物 - Google Patents

多黏菌素衍生物 Download PDF

Info

Publication number
CN103946233A
CN103946233A CN201280055987.6A CN201280055987A CN103946233A CN 103946233 A CN103946233 A CN 103946233A CN 201280055987 A CN201280055987 A CN 201280055987A CN 103946233 A CN103946233 A CN 103946233A
Authority
CN
China
Prior art keywords
nonapeptide
polymyxin
compounds
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280055987.6A
Other languages
English (en)
Chinese (zh)
Inventor
莫娜·萨阿迪
伊斯特·杜珀尔奇
帕梅拉·布朗
迈克尔·约翰·道森
斯乔尔德·尼古拉阿斯·沃德曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CANTAB ANTI INFECTIVES Ltd
Original Assignee
Cantab Anti Infectives Ltd
Novacta Biosystems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cantab Anti Infectives Ltd, Novacta Biosystems Ltd filed Critical Cantab Anti Infectives Ltd
Publication of CN103946233A publication Critical patent/CN103946233A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201280055987.6A 2011-11-18 2012-11-16 多黏菌素衍生物 Pending CN103946233A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161561361P 2011-11-18 2011-11-18
US61/561,361 2011-11-18
PCT/GB2012/052844 WO2013072695A1 (en) 2011-11-18 2012-11-16 Polymyxin derivatives

Publications (1)

Publication Number Publication Date
CN103946233A true CN103946233A (zh) 2014-07-23

Family

ID=47297320

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280055987.6A Pending CN103946233A (zh) 2011-11-18 2012-11-16 多黏菌素衍生物

Country Status (15)

Country Link
US (1) US9234006B2 (https=)
EP (1) EP2780357A1 (https=)
JP (1) JP6185920B2 (https=)
KR (1) KR20140091724A (https=)
CN (1) CN103946233A (https=)
AU (1) AU2012338571B2 (https=)
BR (1) BR112014012016A2 (https=)
CA (1) CA2855916A1 (https=)
CO (1) CO7061068A2 (https=)
EA (1) EA024792B1 (https=)
IL (1) IL232278A0 (https=)
MX (1) MX355217B (https=)
SG (1) SG11201402390PA (https=)
TW (1) TWI608019B (https=)
WO (1) WO2013072695A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105308065A (zh) * 2013-05-22 2016-02-03 新药物许可控股有限公司 多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途
CN107108699A (zh) * 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
CN108226315A (zh) * 2016-12-15 2018-06-29 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
CN108350034A (zh) * 2015-09-29 2018-07-31 莫纳什大学 抗微生物的多黏菌素衍生的化合物
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
CN112789287A (zh) * 2018-06-25 2021-05-11 斯佩罗治疗公司 化合物
CN115490757A (zh) * 2021-06-18 2022-12-20 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2855916A1 (en) 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
MX359104B (es) * 2014-03-11 2018-09-14 New Pharma Licence Holdings Ltd Derivados de polimixina y su uso en terapia de combinacion junto con diferentes antibioticos.
JP2017512818A (ja) * 2014-04-01 2017-05-25 モナシュ、ユニバーシティＭｏｎａｓｈ Ｕｎｉｖｅｒｓｉｔｙ 抗菌性化合物としてのポリミキシン誘導体
WO2016100578A2 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
FI126143B (en) 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
US10322187B2 (en) 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
WO2018051085A1 (en) * 2016-09-13 2018-03-22 Centauri Therapeutics Limited Novel compounds and therapeutic uses thereof
CN111527100A (zh) * 2017-11-02 2020-08-11 昆士兰大学 肽类抗生素
JP7045520B2 (ja) * 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
WO2022098950A1 (en) 2020-11-06 2022-05-12 Spero Therapeutics, Inc. Compounds
CN112755174B (zh) * 2021-02-26 2022-11-18 沈阳药科大学 多粘菌素衍生物及其制备方法和应用
NL2030897B1 (en) * 2022-02-11 2023-08-18 Univ Leiden Antibiotic compounds, formulations and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008017734A1 (en) * 2006-08-11 2008-02-14 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
AU7753787A (en) 1986-08-06 1988-02-24 Jean-Luc Fauchere Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b
US20010021697A1 (en) 1987-09-14 2001-09-13 Henning Lowenstein Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components
TW274552B (https=) 1992-05-26 1996-04-21 Hoechst Ag
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
CA2540742A1 (en) 2003-09-30 2005-04-14 Terry Hicks Compositions and methods for treating burns
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
US8193148B2 (en) 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
ES2334547B1 (es) 2008-09-10 2010-12-03 Universidad De Barcelona Compuestos peptidicos antibacterianos.
CA2747995A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN101851270A (zh) 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
WO2010130007A1 (en) 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
CA2855916A1 (en) 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
KR102354902B1 (ko) 2013-05-22 2022-01-24 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
MX359104B (es) * 2014-03-11 2018-09-14 New Pharma Licence Holdings Ltd Derivados de polimixina y su uso en terapia de combinacion junto con diferentes antibioticos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008017734A1 (en) * 2006-08-11 2008-02-14 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KATSUMA NAOKO ET AL: "Development of Des-fatty acyl-polymyxin B decapeptide anslogs with Pseudomonas aeruginosa-specific antimicrobial activity", 《CHEMICAL AND PHARMACEUTICAL BULLETIN》, vol. 57, no. 4, 1 April 2009 (2009-04-01), pages 332 - 336, XP002683206 *
OKIMURA, KEIKO ET AL: "Antimicrobial activity of various aminocyclohexylcarbonyl-polymyxin B (2-10) derivatives", 《PEPTIDE SCIENCE》, 31 December 2008 (2008-12-31), pages 243 - 244 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105308065A (zh) * 2013-05-22 2016-02-03 新药物许可控股有限公司 多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途
CN105308065B (zh) * 2013-05-22 2021-10-15 斯佩罗治疗公司 多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途
CN107108699A (zh) * 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
TWI757229B (zh) * 2014-11-26 2022-03-11 美商斯佩羅治療學股份有限公司 用於治療微生物感染的化合物以及該化合物的用途
CN108350034A (zh) * 2015-09-29 2018-07-31 莫纳什大学 抗微生物的多黏菌素衍生的化合物
CN108350034B (zh) * 2015-09-29 2022-03-11 莫纳什大学 抗微生物的多黏菌素衍生的化合物
CN108226315A (zh) * 2016-12-15 2018-06-29 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
CN108226315B (zh) * 2016-12-15 2022-04-12 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
CN112789287A (zh) * 2018-06-25 2021-05-11 斯佩罗治疗公司 化合物
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
CN115490757A (zh) * 2021-06-18 2022-12-20 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用
WO2022262823A1 (zh) * 2021-06-18 2022-12-22 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用

Also Published As

Publication number Publication date
JP6185920B2 (ja) 2017-08-23
EA201490634A1 (ru) 2014-12-30
AU2012338571B2 (en) 2016-06-16
CA2855916A1 (en) 2013-05-23
US20150031602A1 (en) 2015-01-29
CO7061068A2 (es) 2014-09-19
EP2780357A1 (en) 2014-09-24
EA024792B1 (ru) 2016-10-31
MX355217B (es) 2018-04-10
SG11201402390PA (en) 2014-06-27
AU2012338571A1 (en) 2014-05-22
KR20140091724A (ko) 2014-07-22
JP2014533678A (ja) 2014-12-15
IL232278A0 (en) 2014-06-30
TW201326215A (zh) 2013-07-01
BR112014012016A2 (pt) 2017-05-16
MX2014005542A (es) 2014-10-24
WO2013072695A1 (en) 2013-05-23
TWI608019B (zh) 2017-12-11
US9234006B2 (en) 2016-01-12

Similar Documents

Publication Publication Date Title
JP6185920B2 (ja) ポリミキシン誘導体
RU2730012C2 (ru) Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
US8937040B2 (en) Antibiotic compositions for the treatment of gram negative infections
RU2740190C2 (ru) Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
US8415307B1 (en) Antibiotic compositions for the treatment of gram negative infections
TWI757229B (zh) 用於治療微生物感染的化合物以及該化合物的用途
JP7488774B2 (ja) 化合物
US20170218024A1 (en) Low substituted polymyxins and compositions thereof
JP2025505237A (ja) 抗生物質化合物、製剤および使用方法
EA047835B1 (ru) Соединения
BR112016020998B1 (pt) Compostos derivados de polimixina, composições farmacêuticas compreendedo os ditos compostos e usos terapêuticos dos mesmos
HK1221474B (en) Polymyxin derivatives and their use in combination therapy together with different antibiotics

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20170328

Address after: Valletta

Applicant after: CANTAB ANTI INFECTIVES LTD

Address before: Hertfordshire

Applicant before: Novacta Biosystems Ltd.

Applicant before: CANTAB ANTI INFECTIVES LTD

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140723