CN105308065A - 多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途 - Google Patents
多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途 Download PDFInfo
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Classifications
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- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
实例 | 第二试剂 | IC50HK-2细胞μg/mL |
多粘菌素B | 利福平 | 7.2 |
10 | 利福平 | 24 |
17 | 利福平 | 26 |
27 | 利福平 | 28 |
Claims (77)
Applications Claiming Priority (5)
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GB201309248A GB201309248D0 (en) | 2013-05-22 | 2013-05-22 | Compounds and combinations |
GB1309248.1 | 2013-05-22 | ||
GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
GB1404301.2 | 2014-03-11 | ||
PCT/GB2014/051547 WO2014188178A1 (en) | 2013-05-22 | 2014-05-21 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
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CN105308065A true CN105308065A (zh) | 2016-02-03 |
CN105308065B CN105308065B (zh) | 2021-10-15 |
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Cited By (3)
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CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
CN111247162A (zh) * | 2017-10-31 | 2020-06-05 | 正大天晴药业集团股份有限公司 | 多黏菌素类似物及其制备方法 |
CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
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EP2780357A1 (en) * | 2011-11-18 | 2014-09-24 | Novacta Biosystems Limited | Polymyxin derivatives |
PL2999711T3 (pl) | 2013-05-22 | 2022-09-26 | Spero Therapeutics, Inc. | Pochodne polimyksyny i ich zastosowanie w terapii skojarzonej razem z różnymi antybiotykami |
WO2015031579A2 (en) | 2013-08-28 | 2015-03-05 | The Medicines Company | Methods for treating bacterial infections using oritavancin and polymyxins |
LT3116897T (lt) * | 2014-03-11 | 2022-05-10 | Spero Therapeutics, Inc. | Polimiksino dariniai ir jų panaudojimas kompleksinėje terapijoje kartu su skirtingais antibiotikais |
KR102585108B1 (ko) * | 2014-12-16 | 2023-10-05 | 상하이 미큐알엑스 파마슈티컬 컴퍼니 리미티드 | 세균 감염의 치료를 위한 항미생물성 폴리믹신 |
FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
KR101790296B1 (ko) * | 2015-03-26 | 2017-10-26 | 한국생명공학연구원 | 네트롭신을 유효성분으로 포함하는 그람음성 세균에 대한 폴리믹신의 항균 활성을 증가시키는 조성물 |
WO2016166103A1 (en) * | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
JP7367950B2 (ja) * | 2015-09-29 | 2023-10-24 | モナッシュ ユニバーシティ | 抗菌性ポリミキシン誘導体化合物 |
CA3032971A1 (en) * | 2016-08-16 | 2018-02-22 | University Of Rochester | Pharmaceutical composition containing polymyxin b/trimethoprim based therapeutics |
CN106631902A (zh) * | 2016-09-23 | 2017-05-10 | 上海步越化工科技有限公司 | 一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法 |
WO2019018286A1 (en) * | 2017-07-17 | 2019-01-24 | President And Fellows Of Harvard College | METHODS OF TREATING BACTERIAL INFECTIONS |
US11279733B2 (en) | 2017-11-02 | 2022-03-22 | The University Of Queensland | Peptide antibiotics |
US11713335B2 (en) | 2018-03-12 | 2023-08-01 | President And Fellows Of Harvard College | Aminocoumarin compounds and methods of their use |
BR112020026663A2 (pt) | 2018-06-25 | 2021-03-23 | Spero Therapeutics, Inc. | Compostos |
WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
US20230233590A1 (en) * | 2020-07-02 | 2023-07-27 | Purdue Research Foundation | Inhalation formulations of antimicrobial compounds |
WO2022098950A1 (en) | 2020-11-06 | 2022-05-12 | Spero Therapeutics, Inc. | Compounds |
EP4289272A1 (en) * | 2021-02-02 | 2023-12-13 | Korea Research Institute of Bioscience and Biotechnology | Antimicrobial adjuvant containing biphenyl derivative compound as active ingredient, and uses thereof |
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WO2024003042A1 (en) | 2022-06-28 | 2024-01-04 | Breakthrough Biotech Drift Aps | Novel combinations of sesquiterpene alcohols, polymyxins and nisin compounds as antimicobial and/or antifungal compounds |
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CN101501063A (zh) * | 2006-08-11 | 2009-08-05 | 北方抗生素有限公司 | 多粘菌素衍生物及其用途 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111247162A (zh) * | 2017-10-31 | 2020-06-05 | 正大天晴药业集团股份有限公司 | 多黏菌素类似物及其制备方法 |
CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
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WO2014188178A9 (en) | 2015-01-08 |
CN105308065B (zh) | 2021-10-15 |
DK2999711T3 (da) | 2022-07-18 |
JP6643758B2 (ja) | 2020-02-12 |
TWI665218B (zh) | 2019-07-11 |
KR102354902B1 (ko) | 2022-01-24 |
EP2999711B1 (en) | 2022-06-29 |
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