CN111247162A - 多黏菌素类似物及其制备方法 - Google Patents

多黏菌素类似物及其制备方法 Download PDF

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Publication number
CN111247162A
CN111247162A CN201880070045.2A CN201880070045A CN111247162A CN 111247162 A CN111247162 A CN 111247162A CN 201880070045 A CN201880070045 A CN 201880070045A CN 111247162 A CN111247162 A CN 111247162A
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CN201880070045.2A
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CN111247162B (zh
Inventor
冯军
张喜全
路建光
东圆珍
张友
唐汉卿
徐宏江
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Shanghai Institute of Pharmaceutical Industry
Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Shanghai Institute of Pharmaceutical Industry
Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本发明属于医药领域，涉及具有高抗菌活性的多黏菌素类似物及其制备方法与应用，本发明的多黏菌素类似物对耐药细菌、真菌具有广谱、高效的杀菌效果。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201880070045.2A 2017-10-31 2018-10-31 多黏菌素类似物及其制备方法 Active CN111247162B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201711043181 2017-10-31
CN2017110431816 2017-10-31
PCT/CN2018/112889 WO2019085926A1 (zh) 2017-10-31 2018-10-31 多黏菌素类似物及其制备方法

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CN111247162A true CN111247162A (zh) 2020-06-05
CN111247162B CN111247162B (zh) 2022-02-18

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CN (1) CN111247162B (zh)
WO (1) WO2019085926A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110669107A (zh) * 2018-07-02 2020-01-10 上海医药工业研究院 抗菌肽及其制备方法
CN113248572A (zh) * 2021-04-30 2021-08-13 重庆理工大学 一种抗多重耐药菌环肽及其应用

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055543A2 (en) * 2001-01-16 2002-07-18 Univ Ramot Hybrid peptides for treatment of bacteremia and septicemia
US20090081733A1 (en) * 2007-07-20 2009-03-26 Joy Doran-Peterson Methods for producing and using polymyxins
WO2009139635A1 (en) * 2008-05-15 2009-11-19 Prosensa Technologies B.V. Polymyxin derivatives and uses thereof
CN101851270A (zh) * 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
CN101970461A (zh) * 2008-02-08 2011-02-09 北方抗生素有限公司 短链脂肪酸尾多粘菌素衍生物及其用途
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
EP2679301A1 (de) * 2012-06-28 2014-01-01 Zentrum für biomedizinische Technologie der Donau- Universität Krems Extrakorporale Perfusionsvorrichtung
US20140162937A1 (en) * 2008-02-08 2014-06-12 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
CN105308065A (zh) * 2013-05-22 2016-02-03 新药物许可控股有限公司 多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途
EP3173421A1 (en) * 2015-11-30 2017-05-31 Universitat de Barcelona Peptidic compounds useful as antibacterial agents

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055543A2 (en) * 2001-01-16 2002-07-18 Univ Ramot Hybrid peptides for treatment of bacteremia and septicemia
US20090081733A1 (en) * 2007-07-20 2009-03-26 Joy Doran-Peterson Methods for producing and using polymyxins
CN101970461A (zh) * 2008-02-08 2011-02-09 北方抗生素有限公司 短链脂肪酸尾多粘菌素衍生物及其用途
US20140162937A1 (en) * 2008-02-08 2014-06-12 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
WO2009139635A1 (en) * 2008-05-15 2009-11-19 Prosensa Technologies B.V. Polymyxin derivatives and uses thereof
CN101851270A (zh) * 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
EP2679301A1 (de) * 2012-06-28 2014-01-01 Zentrum für biomedizinische Technologie der Donau- Universität Krems Extrakorporale Perfusionsvorrichtung
CN105308065A (zh) * 2013-05-22 2016-02-03 新药物许可控股有限公司 多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途
EP3173421A1 (en) * 2015-11-30 2017-05-31 Universitat de Barcelona Peptidic compounds useful as antibacterial agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KARIM NAGHMOUCHI ET AL: "Antibacterial activity of class I and IIa bacteriocins combined with polymyxin E against resistant variants of Listeria monocytogenes and Escherichia coli", 《RES MICROBIOL》 *
TRIMBLE MJ ET AL: "Polymyxin: Alternative Mechanisms of Action and Resistance.", 《COLD SPRING HARBOR PERSPECTIVES IN MEDICINE》 *
周忠新等: "治疗多药耐药革兰阴性细菌感染的一线药物—多黏菌素的复兴", 《国外医药(抗生素分册)》 *
邝俊健等: "多黏菌素的研究进展与用药安全性", 《中国执业药师》 *
马骏等: "多重耐药的严峻形势下多黏菌素E临床应用进展", 《中华临床医师杂志》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110669107A (zh) * 2018-07-02 2020-01-10 上海医药工业研究院 抗菌肽及其制备方法
CN110669107B (zh) * 2018-07-02 2024-04-02 上海医药工业研究院 抗菌肽及其制备方法
CN113248572A (zh) * 2021-04-30 2021-08-13 重庆理工大学 一种抗多重耐药菌环肽及其应用

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Publication number Publication date
CN111247162B (zh) 2022-02-18
WO2019085926A1 (zh) 2019-05-09

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