EA020777B1 - 4-пиразолил-n-арилпиримидин-2-амины, 4-пиразолил-n-пиразолилпиримидин-2-амины и 4-пиразолил-n-пиридилпиримидин-2-амины в качестве ингибиторов киназ janus - Google Patents

4-пиразолил-n-арилпиримидин-2-амины, 4-пиразолил-n-пиразолилпиримидин-2-амины и 4-пиразолил-n-пиридилпиримидин-2-амины в качестве ингибиторов киназ janus Download PDF

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EA020777B1
EA020777B1 EA201070618A EA201070618A EA020777B1 EA 020777 B1 EA020777 B1 EA 020777B1 EA 201070618 A EA201070618 A EA 201070618A EA 201070618 A EA201070618 A EA 201070618A EA 020777 B1 EA020777 B1 EA 020777B1
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Prior art keywords
pyrazol
pyrimidin
phenylamino
cyano
propannitrile
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EA201070618A
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English (en)
Russian (ru)
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EA201070618A1 (ru
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Юнь-Лун Ли
Вэньцин Яо
Джеймс Д. Роджерс
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Инсайт Корпорейшн
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Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA201070618A1 publication Critical patent/EA201070618A1/ru
Publication of EA020777B1 publication Critical patent/EA020777B1/ru

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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EA201070618A 2007-11-16 2008-11-13 4-пиразолил-n-арилпиримидин-2-амины, 4-пиразолил-n-пиразолилпиримидин-2-амины и 4-пиразолил-n-пиридилпиримидин-2-амины в качестве ингибиторов киназ janus EA020777B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98860607P 2007-11-16 2007-11-16
PCT/US2008/083319 WO2009064835A1 (en) 2007-11-16 2008-11-13 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201070618A1 EA201070618A1 (ru) 2010-12-30
EA020777B1 true EA020777B1 (ru) 2015-01-30

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EA201070618A EA020777B1 (ru) 2007-11-16 2008-11-13 4-пиразолил-n-арилпиримидин-2-амины, 4-пиразолил-n-пиразолилпиримидин-2-амины и 4-пиразолил-n-пиридилпиримидин-2-амины в качестве ингибиторов киназ janus

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US (1) US8309718B2 (OSRAM)
EP (1) EP2220068B1 (OSRAM)
JP (1) JP5480813B2 (OSRAM)
KR (1) KR101580482B1 (OSRAM)
CN (1) CN101910152B (OSRAM)
AU (1) AU2008321046B2 (OSRAM)
BR (1) BRPI0820544A2 (OSRAM)
CA (1) CA2704599C (OSRAM)
CO (1) CO6280420A2 (OSRAM)
CR (1) CR11430A (OSRAM)
EA (1) EA020777B1 (OSRAM)
EC (1) ECSP10010263A (OSRAM)
ES (1) ES2569528T3 (OSRAM)
IL (1) IL205571A (OSRAM)
MX (1) MX2010005300A (OSRAM)
MY (1) MY152948A (OSRAM)
NZ (1) NZ585139A (OSRAM)
UA (1) UA104849C2 (OSRAM)
WO (1) WO2009064835A1 (OSRAM)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2649001C1 (ru) * 2014-02-25 2018-03-29 Шанхай Хайянь Фармасьютикал Текнолоджи Ко., Лтд. Производные 2,4-дизамещенного фенилен-1,5-диамина и их применения, фармацевтические композиции и фармацевтически приемлемые композиции, полученные из них

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060106020A1 (en) * 2004-04-28 2006-05-18 Rodgers James D Tetracyclic inhibitors of Janus kinases
PT1966202E (pt) 2005-12-13 2012-01-03 Incyte Corp Pirrolo[2,3-b] pirimidinas e pirrolo[2,3-b]piridinas substituídas com heteroarilo como inibidores de janus quinase
EP2121692B1 (en) * 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
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CN101910152B (zh) 2014-08-06
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