BR112023002939A2 - Processo e intermediários para preparar um inibidor de jak1 - Google Patents
Processo e intermediários para preparar um inibidor de jak1Info
- Publication number
- BR112023002939A2 BR112023002939A2 BR112023002939A BR112023002939A BR112023002939A2 BR 112023002939 A2 BR112023002939 A2 BR 112023002939A2 BR 112023002939 A BR112023002939 A BR 112023002939A BR 112023002939 A BR112023002939 A BR 112023002939A BR 112023002939 A2 BR112023002939 A2 BR 112023002939A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparing
- intermediates
- jak1 inhibitor
- jak1
- inhibitor
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 3
- 229940116839 Janus kinase 1 inhibitor Drugs 0.000 title abstract 2
- KTBSXLIQKWEBRB-UHFFFAOYSA-N 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile Chemical compound C1=CN=C(C(F)(F)F)C(F)=C1C(=O)N1CCC(N2CC(CC#N)(C2)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CC1 KTBSXLIQKWEBRB-UHFFFAOYSA-N 0.000 abstract 1
- 229950001890 itacitinib Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCESSO E INTERMEDIÁRIOS PARA PREPARAR UM INIBIDOR DE JAK1. A presente invenção refere-se a processos para preparar itacitinib, ou um sal do mesmo, e intermediários sintéticos relacionados ao mesmo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063067062P | 2020-08-18 | 2020-08-18 | |
PCT/US2021/046286 WO2022040172A1 (en) | 2020-08-18 | 2021-08-17 | Process and intermediates for preparing a jak1 inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023002939A2 true BR112023002939A2 (pt) | 2023-04-25 |
Family
ID=77693614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023002939A BR112023002939A2 (pt) | 2020-08-18 | 2021-08-17 | Processo e intermediários para preparar um inibidor de jak1 |
Country Status (18)
Country | Link |
---|---|
US (1) | US11897889B2 (pt) |
EP (1) | EP4200278A1 (pt) |
JP (1) | JP2023538614A (pt) |
KR (1) | KR20230095923A (pt) |
CN (1) | CN117043152A (pt) |
AR (1) | AR123268A1 (pt) |
AU (1) | AU2021329301A1 (pt) |
BR (1) | BR112023002939A2 (pt) |
CA (1) | CA3192055A1 (pt) |
CL (1) | CL2023000482A1 (pt) |
CO (1) | CO2023003286A2 (pt) |
CR (1) | CR20230130A (pt) |
EC (1) | ECSP23019419A (pt) |
IL (1) | IL300557A (pt) |
MX (1) | MX2023002035A (pt) |
PE (1) | PE20231308A1 (pt) |
TW (1) | TW202212341A (pt) |
WO (1) | WO2022040172A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
US11897889B2 (en) | 2020-08-18 | 2024-02-13 | Incyte Corporation | Process and intermediates for preparing a JAK1 inhibitor |
KR20230096973A (ko) | 2020-08-18 | 2023-06-30 | 인사이트 코포레이션 | Jak 저해제를 제조하기 위한 방법 및 중간체 |
CA3226714A1 (en) * | 2021-07-12 | 2023-01-19 | Incyte Corporation | Process and intermediates for preparing baricitinib |
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KR20230096973A (ko) | 2020-08-18 | 2023-06-30 | 인사이트 코포레이션 | Jak 저해제를 제조하기 위한 방법 및 중간체 |
US11897889B2 (en) | 2020-08-18 | 2024-02-13 | Incyte Corporation | Process and intermediates for preparing a JAK1 inhibitor |
CA3226714A1 (en) | 2021-07-12 | 2023-01-19 | Incyte Corporation | Process and intermediates for preparing baricitinib |
CN113480546A (zh) | 2021-07-30 | 2021-10-08 | 江苏君若药业有限公司 | 巴瑞克替尼及其衍生物的制备 |
-
2021
- 2021-08-17 US US17/404,461 patent/US11897889B2/en active Active
- 2021-08-17 KR KR1020237009250A patent/KR20230095923A/ko unknown
- 2021-08-17 BR BR112023002939A patent/BR112023002939A2/pt unknown
- 2021-08-17 CN CN202180068687.0A patent/CN117043152A/zh active Pending
- 2021-08-17 IL IL300557A patent/IL300557A/en unknown
- 2021-08-17 CA CA3192055A patent/CA3192055A1/en active Pending
- 2021-08-17 MX MX2023002035A patent/MX2023002035A/es unknown
- 2021-08-17 PE PE2023000303A patent/PE20231308A1/es unknown
- 2021-08-17 AU AU2021329301A patent/AU2021329301A1/en active Pending
- 2021-08-17 JP JP2023512178A patent/JP2023538614A/ja active Pending
- 2021-08-17 WO PCT/US2021/046286 patent/WO2022040172A1/en active Application Filing
- 2021-08-17 EP EP21766776.5A patent/EP4200278A1/en active Pending
- 2021-08-17 TW TW110130370A patent/TW202212341A/zh unknown
- 2021-08-17 AR ARP210102307A patent/AR123268A1/es unknown
- 2021-08-17 CR CR20230130A patent/CR20230130A/es unknown
-
2023
- 2023-02-16 CL CL2023000482A patent/CL2023000482A1/es unknown
- 2023-03-16 EC ECSENADI202319419A patent/ECSP23019419A/es unknown
- 2023-03-16 CO CONC2023/0003286A patent/CO2023003286A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP23019419A (es) | 2023-04-28 |
US11897889B2 (en) | 2024-02-13 |
PE20231308A1 (es) | 2023-08-24 |
IL300557A (en) | 2023-04-01 |
WO2022040172A1 (en) | 2022-02-24 |
CL2023000482A1 (es) | 2023-09-29 |
KR20230095923A (ko) | 2023-06-29 |
CR20230130A (es) | 2023-07-13 |
CN117043152A (zh) | 2023-11-10 |
AU2021329301A1 (en) | 2023-04-13 |
JP2023538614A (ja) | 2023-09-08 |
US20220056034A1 (en) | 2022-02-24 |
EP4200278A1 (en) | 2023-06-28 |
AR123268A1 (es) | 2022-11-16 |
CO2023003286A2 (es) | 2023-06-09 |
TW202212341A (zh) | 2022-04-01 |
CA3192055A1 (en) | 2022-02-24 |
MX2023002035A (es) | 2023-06-12 |
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