BR112022005895A2 - Inibidores de aldose redutase para tratamento de deficiência de fosfomanomutase 2 - Google Patents

Inibidores de aldose redutase para tratamento de deficiência de fosfomanomutase 2

Info

Publication number
BR112022005895A2
BR112022005895A2 BR112022005895A BR112022005895A BR112022005895A2 BR 112022005895 A2 BR112022005895 A2 BR 112022005895A2 BR 112022005895 A BR112022005895 A BR 112022005895A BR 112022005895 A BR112022005895 A BR 112022005895A BR 112022005895 A2 BR112022005895 A2 BR 112022005895A2
Authority
BR
Brazil
Prior art keywords
aldose
inhibitors
phosphomanomutase
redutase
deficiency
Prior art date
Application number
BR112022005895A
Other languages
English (en)
Inventor
Perfetti Riccardo
Shendelman Shoshana
Original Assignee
Applied Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Therapeutics Inc filed Critical Applied Therapeutics Inc
Publication of BR112022005895A2 publication Critical patent/BR112022005895A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A presente invenção refere-se a métodos para tratar PMM2-CDG com o uso de inibidores de aldose redutase.
BR112022005895A 2019-10-08 2020-10-07 Inibidores de aldose redutase para tratamento de deficiência de fosfomanomutase 2 BR112022005895A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962912441P 2019-10-08 2019-10-08
PCT/US2020/054607 WO2021071965A1 (en) 2019-10-08 2020-10-07 Aldose reductase inhibitors for treatment of phosphomannomutase 2 deficiency

Publications (1)

Publication Number Publication Date
BR112022005895A2 true BR112022005895A2 (pt) 2022-06-28

Family

ID=75437528

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005895A BR112022005895A2 (pt) 2019-10-08 2020-10-07 Inibidores de aldose redutase para tratamento de deficiência de fosfomanomutase 2

Country Status (10)

Country Link
US (1) US20220226323A1 (pt)
EP (1) EP4041219A4 (pt)
JP (1) JP2022552831A (pt)
CN (1) CN114667139A (pt)
AU (1) AU2020363699A1 (pt)
BR (1) BR112022005895A2 (pt)
CA (1) CA3153108A1 (pt)
IL (1) IL291946A (pt)
MX (1) MX2022004270A (pt)
WO (1) WO2021071965A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018307964B2 (en) 2017-07-28 2023-11-16 Applied Therapeutics Inc. Compositions and methods for treating galactosemia
WO2024064147A1 (en) * 2022-09-20 2024-03-28 Mayo Foundation For Medical Education And Research Treating congenital disorders of glycosylation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10161929B2 (en) * 2012-02-15 2018-12-25 Sanford Burnham Prebys Medical Discovery Theranostics platform and methods of use
EP3352754B1 (en) * 2016-06-21 2020-09-02 The Trustees of Columbia University in the City of New York Aldose reductase inhibitors and methods of use thereof
AU2018307964B2 (en) * 2017-07-28 2023-11-16 Applied Therapeutics Inc. Compositions and methods for treating galactosemia
WO2020040831A1 (en) * 2018-08-20 2020-02-27 Perlara Pbc Methods for treating congenital disorders of glycosylation
WO2020205846A1 (en) * 2019-04-01 2020-10-08 Applied Therapeutics Inc. Inhibitors of aldose reductase

Also Published As

Publication number Publication date
JP2022552831A (ja) 2022-12-20
AU2020363699A1 (en) 2022-05-26
CN114667139A (zh) 2022-06-24
CA3153108A1 (en) 2021-04-15
US20220226323A1 (en) 2022-07-21
WO2021071965A1 (en) 2021-04-15
EP4041219A4 (en) 2023-11-01
MX2022004270A (es) 2022-05-03
IL291946A (en) 2022-06-01
EP4041219A1 (en) 2022-08-17

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