BR112021022784A2 - Composições e métodos para tratamento do câncer - Google Patents

Composições e métodos para tratamento do câncer

Info

Publication number
BR112021022784A2
BR112021022784A2 BR112021022784A BR112021022784A BR112021022784A2 BR 112021022784 A2 BR112021022784 A2 BR 112021022784A2 BR 112021022784 A BR112021022784 A BR 112021022784A BR 112021022784 A BR112021022784 A BR 112021022784A BR 112021022784 A2 BR112021022784 A2 BR 112021022784A2
Authority
BR
Brazil
Prior art keywords
methods
compositions
cancer treatment
treating cancer
referenced
Prior art date
Application number
BR112021022784A
Other languages
English (en)
Inventor
Steven Hoffman
Original Assignee
Tyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tyme Inc filed Critical Tyme Inc
Publication of BR112021022784A2 publication Critical patent/BR112021022784A2/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37Coumarins, e.g. psoralen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

composições e métodos para tratamento do câncer referência remissiva a pedidos relacionados. a presente invenção fornece métodos para o tratamento do câncer
BR112021022784A 2019-05-14 2020-05-14 Composições e métodos para tratamento do câncer BR112021022784A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962847570P 2019-05-14 2019-05-14
PCT/US2020/032847 WO2020232227A1 (en) 2019-05-14 2020-05-14 Compositions and methods for treating cancer

Publications (1)

Publication Number Publication Date
BR112021022784A2 true BR112021022784A2 (pt) 2022-03-22

Family

ID=73245256

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021022784A BR112021022784A2 (pt) 2019-05-14 2020-05-14 Composições e métodos para tratamento do câncer

Country Status (12)

Country Link
US (1) US11534420B2 (pt)
EP (1) EP3968785A4 (pt)
JP (1) JP2022532210A (pt)
KR (1) KR20220098682A (pt)
CN (1) CN114173578A (pt)
AU (1) AU2020276605A1 (pt)
BR (1) BR112021022784A2 (pt)
CA (1) CA3140042A1 (pt)
EA (1) EA202193111A1 (pt)
IL (1) IL287982A (pt)
MX (1) MX2021013901A (pt)
WO (1) WO2020232227A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3968785A4 (en) 2019-05-14 2023-01-11 Tyme, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
CN114599352A (zh) * 2019-10-15 2022-06-07 迪美公司 用于治疗癌症的α-甲基-DL-酪氨酸烷基酯
JP2023511319A (ja) * 2020-01-17 2023-03-17 タイム,インコーポレーテッド がんを調節するための組成物および方法
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
JP2023553011A (ja) * 2020-12-02 2023-12-20 ホフマン・テクノロジーズ・エルエルシー 非ヒト哺乳動物においてがんを調節するための組成物および方法

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029547A (en) 1974-07-01 1977-06-14 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Biologically active substance, bestatin, and production thereof
US4165382A (en) 1977-10-17 1979-08-21 Jose Pozuelo Method of pharmacologically treating schizophrenia with alpha-methyl-para-tyrosine
US4117161A (en) 1977-05-16 1978-09-26 Jose Pozuelo Method of pharmacologically treating drug addiction with alpha-methyl-para-tyrosine
US4389415A (en) 1978-01-24 1983-06-21 Merck & Co., Inc. Method of treating hypertension
US5206018A (en) 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
GB8706313D0 (en) 1987-03-17 1987-04-23 Health Lab Service Board Treatment & prevention of viral infections
DE8907335U1 (de) 1989-06-15 1990-10-18 Espe Stiftung & Co Produktions- und Vertriebs KG, 8031 Seefeld Mischvorrichtung für Pasten
JPH04500528A (ja) 1989-06-30 1992-01-30 ケミカル ワークス オブ ゲデオン リヒター リミティド スレオ―3―〔(2―アミノフェニル)チオ〕―2―ヒドロキシ―3―(4―メトキシフェニル)プロピオン酸の分割方法
US5029760A (en) 1989-10-26 1991-07-09 Gamblin Rodger L Centrifugal grinding and mixing apparatus
JPH03161442A (ja) 1989-11-21 1991-07-11 Chiyouseidou Seiyaku Kk コール酸又はそのナトリウム塩からなる脳代謝改善剤
US5225435A (en) 1990-05-18 1993-07-06 Yale University Soluble melanin
US5310539A (en) 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
AU4327193A (en) 1992-07-08 1994-01-31 Dianorm-Gerate G. Maierhofer Liposomes, method of preparing them and their use in the preparation of drugs
DE4342174C1 (de) 1993-12-10 1995-05-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung
JP2000507938A (ja) 1996-03-22 2000-06-27 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ 結腸直腸の化学的保護のためのウルソデオキシコール酸化合物及びnsaidの組合せ
US5733926A (en) 1996-12-13 1998-03-31 Gorbach; Sherwood L. Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions
IT1291633B1 (it) 1997-04-22 1999-01-11 Pharmaconsult S A S Uso dell'alfa-metil-p-tirosina per inibire la produzione di melanina nei melanociti dell'iride
US5929055A (en) 1997-06-23 1999-07-27 The Research Foundation Of State University Of New York Therapeutic method for management of diabetes mellitus
US5952374A (en) 1997-09-29 1999-09-14 Protein Technologies International, Inc. Method for inhibiting the development of Alzheimer's disease and related dementias- and for preserving cognitive function
WO2000010507A2 (en) 1998-08-21 2000-03-02 The Children's Medical Center Corporation Use of melanin for inhibition of angiogenesis and macular degeneration
DE19906977C1 (de) 1999-02-19 2000-06-15 Lohmann Therapie Syst Lts Desoxypeganin-TTS und seine Verwendung
JP2002196006A (ja) 2000-12-27 2002-07-10 Olympus Optical Co Ltd 自動分析装置
LT3143995T (lt) 2001-02-19 2019-01-25 Novartis Ag Rapamicino darinys, skirtas plaučių vėžio gydymui
WO2002098403A1 (en) 2001-06-01 2002-12-12 Georgetown University Steroid hormone and non-steroidal anti-inflammatory drug combinations for inducing tumor cell apoptosis
JP4609875B2 (ja) 2001-07-31 2011-01-12 有限会社大長企画 健康食品
US7338971B2 (en) 2001-08-30 2008-03-04 El-Naggar Mawaheb M Treatment of inflammatory, cancer, and thrombosis disorders
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
JP4091557B2 (ja) 2003-03-18 2008-05-28 株式会社マンダム 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品
EP1713443A2 (en) 2004-01-29 2006-10-25 Baxter International Inc. Nanosuspensions of anti-retroviral agents for increased central nervous system delivery
EP1718145A4 (en) 2004-02-02 2012-03-07 Biosight Ltd CONJUGATES FOR CANCER THERAPY AND DIAGNOSIS
EP1674081A1 (de) 2004-12-23 2006-06-28 KTB Tumorforschungsgesellschaft mbH Herstellung von lipidbasierten Nanopartikeln unter Einsatz einer dualen asymmetrischen Zentrifuge
WO2006099685A1 (en) 2005-03-24 2006-09-28 Medical Therapies Limited Method for the prophylaxis or treatment of carcinomas
JP2008534505A (ja) 2005-03-25 2008-08-28 メルク エンド カムパニー インコーポレーテッド テストステロンサプリメントおよび5アルファ−レダクターゼインヒビターによる男性の治療方法
US20060223877A1 (en) 2005-03-31 2006-10-05 Zemlan Frank P Methods of treatment utilizing certain melatonin derivatives
CN102225046A (zh) 2005-08-05 2011-10-26 努沃研究公司 透皮释药剂型
EP2441454B1 (en) 2005-11-15 2015-09-16 JC (Wuxi) COMPANY, Inc. The use of isothiocyanate compounds in treating prostatitis
WO2007120153A1 (en) 2006-04-19 2007-10-25 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
EP1884243A1 (en) 2006-05-02 2008-02-06 Charité - Universitätsmedizin Berlin Use of an antipsychotic drug for the treatment of ALS-associated cachexia
CN101138634A (zh) 2006-09-07 2008-03-12 于保法 用于治疗肿瘤的组合物
US20100239661A1 (en) 2006-10-26 2010-09-23 Sunilendu Bhushan Roy Pharmaceutical compositions of ursodiol
US9198965B2 (en) 2008-06-13 2015-12-01 Wisconsin Alumni Research Foundation Peptide adjuvant for influenza vaccination
EP2208497A1 (en) 2009-01-15 2010-07-21 Charité-Universitätsmedizin Berlin (Charité) Use of Ursodeoxycholic acid (UDCA) for enhancing the general health condition of a tumor patient
US20170029892A1 (en) 2009-05-29 2017-02-02 Jay L. Lombard Methods and compositions for the treatment of post-traumatic stress disorder
JP2013500265A (ja) 2009-07-23 2013-01-07 ザ トラスティーズ オブ プリンストン ユニバーシティ 抗ウイルス剤として用いられるmTORキナーゼ阻害剤
AU2010310515B2 (en) 2009-10-22 2016-01-07 University Of Southern California Methods and nutritional formulations to increase the efficacy and reduce the side effects of cancer treatment
WO2011053835A1 (en) 2009-10-30 2011-05-05 Aton Pharma, Inc. Stereoselective synthesis of metyrosine
KR101131675B1 (ko) 2010-01-28 2012-03-28 조선대학교산학협력단 우루소데옥시콜린산을 유효성분으로 함유하는 위암의 예방 또는 치료용 조성물
SG184901A1 (en) 2010-04-16 2012-11-29 Davos Life Science Pte Ltd Synergistic interaction of at least one vitamin e component and tyrosinase inhibitors for dermatological applications
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US9949923B2 (en) 2011-03-15 2018-04-24 Optinose As Nasal delivery
PL220308B1 (pl) 2011-06-03 2015-10-30 Kobel Buys Krystyna Zastosowanie klenbuterolu do leczenia objawów autyzmu dziecięcego oraz klenbuterol do zastosowania w leczeniu objawów autyzmu dziecięcego
CN102397550B (zh) 2011-08-30 2013-05-08 广东医学院 一组由阿司匹林与雌激素组成的防治骨质疏松症的药物组合物
WO2013061161A2 (en) 2011-10-28 2013-05-02 Green Bcn Consulting Services Sl New combination therapies for treating neurological disorders
WO2013096870A1 (en) 2011-12-22 2013-06-27 Knopp Neurosciences Inc Compositions and methods for treating amyotrophic lateral sclerosis
WO2013103250A1 (ko) 2012-01-06 2013-07-11 주식회사 대웅제약 타우로우루소데옥시콜릭산을 포함하는 조성물
US10272068B2 (en) 2012-01-17 2019-04-30 Tyme, Inc. Pharmaceutical compositions and methods
US8481498B1 (en) 2012-01-17 2013-07-09 Steven Hoffman Pharmaceutical compositions and methods
US10646552B2 (en) 2012-01-17 2020-05-12 Tyme, Inc. Pharmaceutical compositions and methods
US20210386832A1 (en) 2012-01-17 2021-12-16 Tyme, Inc. Pharmaceutical Compositions And Methods
BR112014017613A2 (pt) 2012-01-17 2017-07-04 Tyme Inc composição farmacêutica, kit, método para tratar câncer em um indivíduo e método para reduzir a proliferação celular em um indivíduo
US20130183263A1 (en) 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
WO2013142490A2 (en) 2012-03-20 2013-09-26 Metselex, Inc. Tauroursodeoxycholic acid attenuates or abolishes formation and deposition of amyloid-b peptide
US9962362B2 (en) 2012-03-29 2018-05-08 Children's Hospital Medical Center Use of small molecule inhibitors targeting EYA tyrosine phosphatase
GB201216800D0 (en) 2012-09-20 2012-11-07 Immodulon Therapeutics Ltd Novel use
WO2014078724A1 (en) 2012-11-16 2014-05-22 Finzi Eric Treatment of post-traumatic stress disorder using botulinum toxin a
US9872865B2 (en) 2013-03-24 2018-01-23 Amylyx Pharmaceuticals Inc. Compositions for improving cell viability and methods of use thereof
WO2015005419A1 (ja) 2013-07-11 2015-01-15 株式会社ポーラファルマ 使用時泡状を呈する外用組成物
US9326962B2 (en) 2013-10-22 2016-05-03 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US9585841B2 (en) 2013-10-22 2017-03-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
US20150111878A1 (en) 2013-10-22 2015-04-23 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US9724657B2 (en) 2013-10-22 2017-08-08 Tyme, Inc. High-speed centrifugal mixing devices and methods of use
US20170080093A1 (en) 2013-10-22 2017-03-23 Tyme, Inc. Tyrosine Derivatives And Compositions Comprising Them
CN103919787A (zh) 2014-04-17 2014-07-16 厦门大学 牛磺熊脱氧胆酸及其可接受的盐的制药用途
WO2016007741A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of California Tumor selective macropinocytosis-dependent rapidly internalizing antibodies
WO2016045642A1 (en) 2014-09-28 2016-03-31 National Institute Of Biological Sciences, Beijing Polymeric bile acid derivatives inhibit hepatitis b and d virus and ntcp transport
GB201419257D0 (en) 2014-10-29 2014-12-10 Jagotec Ag Pharmaceutical compositions
US9687528B2 (en) 2014-12-23 2017-06-27 Steven Hoffman Transdermal formulations
JP6836991B2 (ja) 2014-12-23 2021-03-03 スティーブン・ホフマン 経皮製剤
CN106031731A (zh) 2015-03-18 2016-10-19 中国医学科学院基础医学研究所 牛磺熊去氧胆酸的新用途
EA038339B1 (ru) 2015-04-14 2021-08-11 Стивен Хоффман Способы лечения аутизма
US20170181993A1 (en) 2015-12-28 2017-06-29 Steven Hoffman Methods of Treating Amyotrophic Lateral Sclerosis and Symptoms
US20190091252A1 (en) 2016-03-15 2019-03-28 Tyme, Inc. Pharmaceutical compositions for the treatment of cancer
JP2019516709A (ja) 2016-05-18 2019-06-20 タイム,インコーポレーテッド 癌の処置におけるジヒドロテストステロンならびにジヒドロテストステロン誘導体および促進剤
AU2017322332A1 (en) 2016-09-12 2019-04-04 Steven Hoffman Compositions for treating dementia
CA3040922A1 (en) 2016-11-15 2018-05-24 Tyme, Inc. Pharmaceutical compositions and methods for the treatment of cancer
BR112019011033A2 (pt) 2016-11-30 2019-10-15 Tyme Inc composição, método para reduzir a proliferação celular em um indivíduo, método para tratar câncer em um indivíduo e kit
EA201992515A1 (ru) 2017-04-21 2020-04-09 Стивен Хоффман Композиции и способы для лечения ретинопатии
WO2018204669A1 (en) 2017-05-03 2018-11-08 Nanobio Corporation Intravenous immunoglobulin compositions specific for respiratory syncytial virus and methods of making and using the same
KR20200038481A (ko) 2017-07-19 2020-04-13 호프만 테크놀로지스, 인크. 스트레스-관련 장애를 치료하기 위한 조성물
MX2020002894A (es) 2017-09-15 2020-10-07 Tyme Inc Formulaciones transdermicas.
KR102377742B1 (ko) 2017-12-28 2022-03-22 제이 파마 가부시끼가이샤 암치료약
MX2021000314A (es) 2018-07-09 2021-03-25 Tyme Inc Formulaciones reductoras de tumores y metodos de uso de las mismas.
CN112584841A (zh) 2018-07-09 2021-03-30 迪美公司 肿瘤减小制剂及其使用方法
CN112822997A (zh) 2018-07-19 2021-05-18 亚莫制药有限公司 用于治疗孤独症的组合物和方法
WO2020112766A1 (en) 2018-11-26 2020-06-04 Steven Hoffman Compositions and methods for treating nerve agent exposure
CN110563602A (zh) 2018-12-26 2019-12-13 南宁多灵生物科技有限公司 迷迭香酸衍生物及其制备方法和应用
EA202192084A1 (ru) 2019-02-01 2021-10-20 ХОФФМАН ТЕКНОЛОДЖИЗ ЭлЭлСи. Композиции и способы для лечения связанных с тревожностью нарушений
US20200282014A1 (en) 2019-03-05 2020-09-10 Hoffman Technologies Llc Percutaneous anti-microbiota formulations
MX2021011484A (es) 2019-03-22 2021-11-12 Tyme Inc Composiciones de d-metirosina y metodos para preparar las mismas.
AU2020257406A1 (en) 2019-04-19 2021-12-16 Hoffman Technologies Llc Sustained release formulations
EP3968785A4 (en) 2019-05-14 2023-01-11 Tyme, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
US20220323551A1 (en) 2019-07-22 2022-10-13 Korea University Research And Business Foundation Composition for preventing, treating, or ameliorating viral infection disease, containing active oxygen production inhibitor and active oxygen scavenger complex as active ingredients
CN114599352A (zh) 2019-10-15 2022-06-07 迪美公司 用于治疗癌症的α-甲基-DL-酪氨酸烷基酯
US20210169903A1 (en) 2019-12-09 2021-06-10 Tyme, Inc. Pharmaceutical compositions and methods
JP2023511319A (ja) 2020-01-17 2023-03-17 タイム,インコーポレーテッド がんを調節するための組成物および方法
CA3179419A1 (en) 2020-04-08 2021-10-14 Hoffman Technologies Llc Methods of treating conditions characterized by insulin deficiency in animals
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
WO2021231931A1 (en) 2020-05-14 2021-11-18 Tyme, Inc. Methods of treating sars-cov-2 infections
WO2022006366A1 (en) 2020-07-01 2022-01-06 Tyme, Inc. Crystalline forms of metyrosine

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EP3968785A1 (en) 2022-03-23
MX2021013901A (es) 2022-04-12
CN114173578A (zh) 2022-03-11
IL287982A (en) 2022-01-01
KR20220098682A (ko) 2022-07-12
EP3968785A4 (en) 2023-01-11
US20200360328A1 (en) 2020-11-19
WO2020232227A1 (en) 2020-11-19
US11534420B2 (en) 2022-12-27

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