CA2704599C - 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors - Google Patents

4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors Download PDF

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CA2704599C
CA2704599C CA2704599A CA2704599A CA2704599C CA 2704599 C CA2704599 C CA 2704599C CA 2704599 A CA2704599 A CA 2704599A CA 2704599 A CA2704599 A CA 2704599A CA 2704599 C CA2704599 C CA 2704599C
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pyrazol
pyrimidin
phenylamino
ylamino
cyano
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French (fr)
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CA2704599A1 (en
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Yun-Long Li
Wenqing Yao
James D. Rodgers
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Incyte Holdings Corp
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Incyte Corp
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CA2704599A 2007-11-16 2008-11-13 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors Active CA2704599C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98860607P 2007-11-16 2007-11-16
US60/988,606 2007-11-16
PCT/US2008/083319 WO2009064835A1 (en) 2007-11-16 2008-11-13 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors

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CA2704599A1 CA2704599A1 (en) 2009-05-22
CA2704599C true CA2704599C (en) 2015-05-12

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CA2704599A Active CA2704599C (en) 2007-11-16 2008-11-13 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors

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US (1) US8309718B2 (OSRAM)
EP (1) EP2220068B1 (OSRAM)
JP (1) JP5480813B2 (OSRAM)
KR (1) KR101580482B1 (OSRAM)
CN (1) CN101910152B (OSRAM)
AU (1) AU2008321046B2 (OSRAM)
BR (1) BRPI0820544A2 (OSRAM)
CA (1) CA2704599C (OSRAM)
CO (1) CO6280420A2 (OSRAM)
CR (1) CR11430A (OSRAM)
EA (1) EA020777B1 (OSRAM)
EC (1) ECSP10010263A (OSRAM)
ES (1) ES2569528T3 (OSRAM)
IL (1) IL205571A (OSRAM)
MX (1) MX2010005300A (OSRAM)
MY (1) MY152948A (OSRAM)
NZ (1) NZ585139A (OSRAM)
UA (1) UA104849C2 (OSRAM)
WO (1) WO2009064835A1 (OSRAM)
ZA (1) ZA201004055B (OSRAM)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105814A1 (en) * 2004-04-28 2005-11-10 Incyte Corporation Tetracyclic inhibitors of janus kinases
UA116187C2 (uk) * 2005-12-13 2018-02-26 Інсайт Холдінгс Корпорейшн ГЕТЕРОАРИЛЗАМІЩЕНІ ПІРОЛО[2,3-b]ПІРИДИНИ Й ПІРОЛО[2,3-b]ПІРИМІДИНИ ЯК ІНГІБІТОРИ ЯНУС-КІНАЗИ
EP2121692B1 (en) 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
WO2008157208A2 (en) 2007-06-13 2008-12-24 Incyte Corporation Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
FR2938537B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
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