DK3562486T3 - Anvendelse af sublingual dexmedetomidin til behandling af agitation - Google Patents

Anvendelse af sublingual dexmedetomidin til behandling af agitation Download PDF

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Publication number
DK3562486T3
DK3562486T3 DK17885750.4T DK17885750T DK3562486T3 DK 3562486 T3 DK3562486 T3 DK 3562486T3 DK 17885750 T DK17885750 T DK 17885750T DK 3562486 T3 DK3562486 T3 DK 3562486T3
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DK
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Prior art keywords
agitation
treatment
sublingual dexmedetomidine
dexmedetomidine
sublingual
Prior art date
Application number
DK17885750.4T
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Danish (da)
English (en)
Inventor
Krishnan Nandabalan
Frank Yocca
Sameer Sharma
Original Assignee
Bioxcel Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Bioxcel Therapeutics Inc filed Critical Bioxcel Therapeutics Inc
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Publication of DK3562486T3 publication Critical patent/DK3562486T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK17885750.4T 2016-12-31 2017-12-29 Anvendelse af sublingual dexmedetomidin til behandling af agitation DK3562486T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662441164P 2016-12-31 2016-12-31
US201762471393P 2017-03-15 2017-03-15
US201762542323P 2017-08-08 2017-08-08
PCT/US2017/069030 WO2018126182A1 (en) 2016-12-31 2017-12-29 Use of sublingual dexmedetomidine for the treatment of agitation

Publications (1)

Publication Number Publication Date
DK3562486T3 true DK3562486T3 (da) 2024-06-10

Family

ID=62710955

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17885750.4T DK3562486T3 (da) 2016-12-31 2017-12-29 Anvendelse af sublingual dexmedetomidin til behandling af agitation

Country Status (19)

Country Link
US (7) US11839604B2 (https=)
EP (3) EP3562486B1 (https=)
JP (6) JP6868698B2 (https=)
KR (2) KR102793584B1 (https=)
CN (1) CN110337290A (https=)
AU (3) AU2017388759B2 (https=)
BR (1) BR112019013503A2 (https=)
DK (1) DK3562486T3 (https=)
ES (1) ES2980126T3 (https=)
FI (1) FI3562486T3 (https=)
HU (1) HUE067266T2 (https=)
IL (1) IL267689B2 (https=)
MX (3) MX2019007923A (https=)
PL (1) PL3562486T3 (https=)
PT (1) PT3562486T (https=)
SG (1) SG10202107367SA (https=)
TW (3) TWI833550B (https=)
WO (1) WO2018126182A1 (https=)
ZA (1) ZA202006636B (https=)

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WO2020006119A1 (en) * 2018-06-27 2020-01-02 Bioxcel Therapeutics, Inc. Methods for treating agitation using dexmedetomidine hydrochloride
PL3813802T3 (pl) 2018-06-27 2025-04-22 Bioxcel Therapeutics, Inc. Formulacje błony zawierające deksmedetomidynę i sposoby ich wytwarzania
RU2692247C1 (ru) * 2018-12-06 2019-06-24 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации Способ лечения послеоперационного делирия
EP3999058A4 (en) * 2019-07-19 2023-05-03 Bioxcel Therapeutics, Inc. NON-SEDATIVE DEXMEDETOMIDINE-BASED TREATMENT REGIMEN
EP4031000A4 (en) * 2019-09-18 2023-09-27 Bioxcel Therapeutics, Inc. Systems and methods for detection and prevention of emergence of agitation
WO2021158059A1 (ko) * 2020-02-07 2021-08-12 건국대학교 글로컬산학협력단 릴메니딘 화합물을 유효성분으로 포함하는 취약 x 증후군 또는 관련 발달 장애 치료용 조성물
IL295489A (en) * 2020-02-14 2022-10-01 Bioxcel Therapeutics Inc Systems and methods for detecting and preventing the onset of restlessness
EP4225305A4 (en) * 2020-10-08 2024-10-23 Bioxcel Therapeutics, Inc. TREATMENT OF BIPOLAR DISEASES AND PSYCHOSES WITH DEXMEDETOMIDINE HYDROCHLORIDE
WO2022147537A1 (en) * 2021-01-04 2022-07-07 Bioxcel Therapeutics, Inc. Dexmedetomidine treatment regimens
CN116801863A (zh) * 2021-01-04 2023-09-22 比奥克斯塞尔医疗股份有限公司 右美托咪定治疗方案
TW202302094A (zh) * 2021-02-26 2023-01-16 美商百歐克斯賽爾治療公司 用於治療激躁之方法及組合物
JP2024511394A (ja) 2021-03-19 2024-03-13 オリオン コーポレーション タシピミジン製剤およびその使用
CA3224257A1 (en) * 2021-07-02 2023-01-05 Michael De Vivo Methods for treating depressive states
GB2618810A (en) * 2022-05-17 2023-11-22 Novumgen Ltd Pharmaceutical composition for sublingual administration of clonidine
IL318007A (en) 2022-07-27 2025-02-01 Universit?T Z?Rich Dexmedetocidin for the treatment of sleep disorders
WO2024055042A1 (en) * 2022-09-11 2024-03-14 Bioxcel Therapeutics, Inc. Methods for treating agitation in community settings
JP2025542586A (ja) * 2022-12-27 2025-12-26 アルセプター セラピューティクス, インコーポレイテッド 興奮治療のための(s)-(3-(1-(1h-イミダゾール-4-イル)エチル)-2-メチルフェニル)メタノール
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
WO2024263973A1 (en) * 2023-06-23 2024-12-26 Bioxcel Therapeutics, Inc. Dexmedetomidine treatment regimens
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WO2026072029A1 (en) * 2024-09-24 2026-04-02 Teikoku Pharma Usa, Inc. Transdermal dexmedetomidine for treating agitation
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TW201829018A (zh) 2018-08-16
EP4368169A2 (en) 2024-05-15
BR112019013503A2 (pt) 2020-01-07
US11931340B2 (en) 2024-03-19
AU2024219731A1 (en) 2024-10-10
US20240252470A1 (en) 2024-08-01
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JP2024014900A (ja) 2024-02-01
CN110337290A (zh) 2019-10-15
TWI791479B (zh) 2023-02-11
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IL267689B1 (en) 2025-01-01
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AU2022200892A1 (en) 2022-03-03
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IL267689B2 (en) 2025-05-01
IL267689A (en) 2019-08-29
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US20230081503A1 (en) 2023-03-16
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EP3562486A4 (en) 2020-08-19
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JP2021102654A (ja) 2021-07-15
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PL3562486T3 (pl) 2024-09-16
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JP6929479B2 (ja) 2021-09-01
US20220031663A1 (en) 2022-02-03
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