DK3162402T3 - Næsespraydyse til anvendelse i medicinsk sprøjte - Google Patents

Næsespraydyse til anvendelse i medicinsk sprøjte Download PDF

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Publication number
DK3162402T3
DK3162402T3 DK15811100.5T DK15811100T DK3162402T3 DK 3162402 T3 DK3162402 T3 DK 3162402T3 DK 15811100 T DK15811100 T DK 15811100T DK 3162402 T3 DK3162402 T3 DK 3162402T3
Authority
DK
Denmark
Prior art keywords
medical syringe
nose sprayer
sprayer
nose
syringe
Prior art date
Application number
DK15811100.5T
Other languages
English (en)
Inventor
Taizou Kamishita
Takashi Miyazaki
Shinya Hoshino
Original Assignee
Toko Yakuhin Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toko Yakuhin Kogyo Kk filed Critical Toko Yakuhin Kogyo Kk
Application granted granted Critical
Publication of DK3162402T3 publication Critical patent/DK3162402T3/da

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/34Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007Syringe-type or piston-type sprayers or atomisers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0618Nose
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Virology (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
DK15811100.5T 2014-06-25 2015-06-24 Næsespraydyse til anvendelse i medicinsk sprøjte DK3162402T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014130150A JP6322844B2 (ja) 2014-06-25 2014-06-25 医療用シリンジに用いられる点鼻用噴霧ノズル
PCT/JP2015/068199 WO2015199130A1 (ja) 2014-06-25 2015-06-24 医療用シリンジに用いられる点鼻用噴霧ノズル

Publications (1)

Publication Number Publication Date
DK3162402T3 true DK3162402T3 (da) 2021-05-17

Family

ID=54938208

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15811100.5T DK3162402T3 (da) 2014-06-25 2015-06-24 Næsespraydyse til anvendelse i medicinsk sprøjte

Country Status (23)

Country Link
US (1) US11020346B2 (da)
EP (1) EP3162402B1 (da)
JP (1) JP6322844B2 (da)
KR (1) KR102159423B1 (da)
CN (1) CN106535969A (da)
AU (1) AU2015281149B2 (da)
BR (1) BR112016030457B1 (da)
CA (1) CA2953083C (da)
CY (1) CY1124225T1 (da)
DK (1) DK3162402T3 (da)
ES (1) ES2865257T3 (da)
HR (1) HRP20210633T1 (da)
HU (1) HUE053891T2 (da)
LT (1) LT3162402T (da)
PH (1) PH12016502531A1 (da)
PL (1) PL3162402T3 (da)
PT (1) PT3162402T (da)
RS (1) RS61768B1 (da)
RU (1) RU2710346C2 (da)
SG (1) SG11201610607UA (da)
SI (1) SI3162402T1 (da)
TW (1) TWI677353B (da)
WO (1) WO2015199130A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3436117B1 (en) * 2016-03-31 2021-09-22 Philip Morris Products S.A. Vaporizing assembly comprising sheet heating element
US10244795B2 (en) * 2016-03-31 2019-04-02 Altria Client Services Llc Vaporizing assembly comprising sheet heating element and liquid delivery device for an aerosol generating system
FR3061967B1 (fr) * 2017-01-16 2021-04-09 Aptar France Sas Procede d'analyse d'un spray genere par un dispositif de distribution de produit fluide
JP6702237B2 (ja) * 2017-03-14 2020-05-27 ニプロ株式会社 シリンジ型噴出装置
JP6558392B2 (ja) 2017-04-04 2019-08-14 ニプロ株式会社 シリンジ型噴出装置
KR101964422B1 (ko) 2017-05-16 2019-04-01 (주)제이엠씨코리아 (Jmc Korea Co.,Ltd.) 약물 방출용 분무 카데터
CN107497036A (zh) * 2017-08-28 2017-12-22 宁波正力药品包装有限公司 一种鼻腔给药装置
WO2019050169A1 (ko) * 2017-09-08 2019-03-14 주식회사 삼양바이오팜 실란트 실린지 어셈블리
TWI811248B (zh) 2017-10-05 2023-08-11 日商東興藥品工業股份有限公司 經鼻b型肝炎疫苗組成物及其製造方法
JP2021503988A (ja) 2017-11-21 2021-02-15 インペル ニューロファーマ インコーポレイテッド インレットインターフェースを用いた鼻腔内装置
JP7282735B2 (ja) 2018-02-26 2023-05-29 株式会社新日本科学 粉末製剤、カートリッジ、及びデバイス
US20210213213A1 (en) * 2018-05-29 2021-07-15 Shl Medical Ag Nozzle and cartridge assembly
CU24686B1 (es) * 2018-06-05 2023-11-07 Ct Ingenieria Genetica Biotecnologia Composición de vacuna contra la hepatitis b, proceso de obtención de dicha composición y sistema de rinovacunación para prevenir y tratar la hepatitis b
EP4039296A4 (en) * 2019-10-01 2023-10-25 Toko Yakuhin Kogyo Co., Ltd. NOSE SPRAY INJECTION NOZZLE AND ASSISTANT FOR ADMINISTRATION OF NOSE DROPS
KR102282078B1 (ko) 2019-10-10 2021-07-27 김만석 약물분사장치
JP2023541279A (ja) * 2020-09-16 2023-09-29 サノタイズ リサーチ アンド ディベロップメント コープ. デュアルチャンバ噴霧デバイス
GB202202890D0 (en) * 2022-03-02 2022-04-13 Consort Medical Ltd Improvements relating to nasal pieces
USD1021066S1 (en) 2022-03-03 2024-04-02 Consort Medical Limited Inhaler
USD1021067S1 (en) 2022-04-08 2024-04-02 Consort Medical Limited Inhaler

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3669359A (en) * 1970-09-18 1972-06-13 Precision Valve Corp Aerosol mechanical break-up nozzle insert
JPH0291553A (ja) 1988-09-29 1990-03-30 Toshiba Corp 産業用ct装置
JPH0529703Y2 (da) * 1988-12-28 1993-07-29
JPH0678245B2 (ja) 1989-07-04 1994-10-05 東興薬品工業株式会社 鼻腔内噴霧投与用インフルエンザワクチンゲル製剤
US5215739A (en) 1989-04-05 1993-06-01 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
JP2922935B2 (ja) * 1989-08-11 1999-07-26 東興薬品工業株式会社 粘稠液用鼻孔内噴霧容器の使捨てアダプタ
JP2509203Y2 (ja) * 1990-03-05 1996-08-28 伸晃化学株式会社 薬液噴霧ノズル
JPH03114248A (ja) 1990-08-30 1991-05-15 Ibiden Co Ltd 半導体搭載用プリント配線基板の製造方法
IT1249600B (it) 1991-02-21 1995-03-09 Elettro Plastica Spa Erogatore nasale di sostanze farmaceutiche nebulizzate
US5601077A (en) 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
GB9125699D0 (en) * 1991-12-03 1992-01-29 Glaxo Group Ltd Device
US6016800A (en) * 1997-10-24 2000-01-25 Century; Theodore J. Intrapulmonary aerosolizer
FR2771296B1 (fr) * 1997-11-25 2000-03-10 Sofab Embout nasal avec fermeture d'extremite
FR2773784B1 (fr) * 1998-01-16 2000-03-24 Valois Sa Tete de pulverisation pour un distributeur de produit fluide
ATE257399T1 (de) 1999-10-14 2004-01-15 Becton Dickinson Co Nasales verabreichungsgerät mit zerstäuberdüse
CN100528257C (zh) 2002-05-09 2009-08-19 葛兰素集团有限公司 流体分配设备
LT2014305T (lt) 2006-04-21 2017-10-25 Toko Yakuhin Kogyo Kabushiki Kaisha Purškiamas gelinis limpantis prie odos/gleivinės preparatas ir skyrimo sistema, naudojant šį preparatą
GB0719299D0 (en) * 2007-10-03 2007-11-14 Optinose As Nasal delivery devices
TW201513903A (zh) 2007-11-29 2015-04-16 Glaxo Group Ltd 施配裝置
CN101980738A (zh) * 2008-02-07 2011-02-23 华盛顿大学 圆周气雾设备
JP5762307B2 (ja) * 2009-03-31 2015-08-12 国立感染症研究所長 経鼻投与用ワクチンを用いるインフルエンザの予防方法
FR2951442B1 (fr) * 2009-10-20 2012-01-20 Valois Sas Tete de distribution pour dispositif de distribution de produit fluide.
CN103316407A (zh) * 2012-03-20 2013-09-25 山东威高集团医用高分子制品股份有限公司 鼻腔喷雾式预灌封注射器
KR101706837B1 (ko) * 2012-03-30 2017-02-14 가부시키가이샤 요시노 고교쇼 주사기형 정량 디스펜서
JP5917367B2 (ja) 2012-10-31 2016-05-11 株式会社吉野工業所 蓄圧式シリンジ型空気混合液噴出器
PL2939692T3 (pl) 2012-12-28 2019-10-31 Japan As Represented By Director General Of Nat Institute Of Infectious Diseases Kompozycja szczepionki do nosa przeciw grypie

Also Published As

Publication number Publication date
US11020346B2 (en) 2021-06-01
HRP20210633T1 (hr) 2021-05-28
TWI677353B (zh) 2019-11-21
CY1124225T1 (el) 2022-05-27
KR20170023092A (ko) 2017-03-02
RU2710346C2 (ru) 2019-12-25
AU2015281149A1 (en) 2017-01-12
LT3162402T (lt) 2021-05-10
CA2953083A1 (en) 2015-12-30
US20170128364A1 (en) 2017-05-11
EP3162402A1 (en) 2017-05-03
WO2015199130A1 (ja) 2015-12-30
BR112016030457B1 (pt) 2022-06-21
PH12016502531B1 (en) 2017-04-10
RU2017101995A (ru) 2018-07-25
PH12016502531A1 (en) 2017-04-10
KR102159423B1 (ko) 2020-09-23
SI3162402T1 (sl) 2021-09-30
PT3162402T (pt) 2021-04-20
CA2953083C (en) 2020-06-30
BR112016030457A2 (da) 2017-08-22
PL3162402T3 (pl) 2021-10-25
RU2017101995A3 (da) 2018-12-11
CN106535969A (zh) 2017-03-22
JP6322844B2 (ja) 2018-05-16
EP3162402A4 (en) 2018-03-07
ES2865257T3 (es) 2021-10-15
AU2015281149A2 (en) 2017-06-15
AU2015281149B2 (en) 2020-03-12
SG11201610607UA (en) 2017-01-27
TW201603836A (zh) 2016-02-01
JP2016007409A (ja) 2016-01-18
HUE053891T2 (hu) 2021-07-28
EP3162402B1 (en) 2021-03-17
RS61768B1 (sr) 2021-05-31

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