DK2902039T3 - IL-17 antagonistic antibodies - Google Patents

IL-17 antagonistic antibodies Download PDF

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Publication number
DK2902039T3
DK2902039T3 DK15156029.9T DK15156029T DK2902039T3 DK 2902039 T3 DK2902039 T3 DK 2902039T3 DK 15156029 T DK15156029 T DK 15156029T DK 2902039 T3 DK2902039 T3 DK 2902039T3
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Denmark
Prior art keywords
amino acid
acid sequence
seq
cdr3
cdr2
Prior art date
Application number
DK15156029.9T
Other languages
Danish (da)
English (en)
Inventor
Padova Franco E Di
Hermann Gram
Margit Jeschke
Jean-Michel Rondeau
Den Berg Wim Van
Hans Hofstetter
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32982602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2902039(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
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Publication of DK2902039T3 publication Critical patent/DK2902039T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK15156029.9T 2004-08-05 2005-08-04 IL-17 antagonistic antibodies DK2902039T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417487.6A GB0417487D0 (en) 2004-08-05 2004-08-05 Organic compound
EP10174725.1A EP2366405B1 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies

Publications (1)

Publication Number Publication Date
DK2902039T3 true DK2902039T3 (en) 2018-07-16

Family

ID=32982602

Family Applications (4)

Application Number Title Priority Date Filing Date
DK05770286.2T DK1776142T6 (en) 2004-08-05 2005-08-04 Antagonistic antibodies against IL-17th
DK15156029.9T DK2902039T3 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies
DK10174725.1T DK2366405T3 (en) 2004-08-05 2005-08-04 Antagonistic IL-17 antibodies
DK10175150.1T DK2364729T6 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05770286.2T DK1776142T6 (en) 2004-08-05 2005-08-04 Antagonistic antibodies against IL-17th

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10174725.1T DK2366405T3 (en) 2004-08-05 2005-08-04 Antagonistic IL-17 antibodies
DK10175150.1T DK2364729T6 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies

Country Status (40)

Country Link
US (9) US7807155B2 (OSRAM)
EP (5) EP3409288A1 (OSRAM)
JP (1) JP4682200B2 (OSRAM)
KR (2) KR20080029018A (OSRAM)
CN (1) CN101001645B (OSRAM)
AR (1) AR050200A1 (OSRAM)
AT (1) ATE517924T1 (OSRAM)
AU (2) AU2005268857C1 (OSRAM)
BE (1) BE2015C041I2 (OSRAM)
BR (3) BR122017009404B1 (OSRAM)
CA (1) CA2573586C (OSRAM)
CY (6) CY1111963T1 (OSRAM)
DK (4) DK1776142T6 (OSRAM)
EC (1) ECSP077198A (OSRAM)
ES (4) ES2367440T7 (OSRAM)
FR (1) FR15C0048I2 (OSRAM)
GB (1) GB0417487D0 (OSRAM)
HK (1) HK1256639A1 (OSRAM)
HR (3) HRP20110758T4 (OSRAM)
HU (4) HUE038187T2 (OSRAM)
IL (1) IL180717A (OSRAM)
LT (3) LT2902039T (OSRAM)
LU (2) LU92768I2 (OSRAM)
MA (1) MA28982B1 (OSRAM)
MX (1) MX2007001338A (OSRAM)
MY (1) MY144925A (OSRAM)
NL (1) NL300749I2 (OSRAM)
NO (9) NO336279B1 (OSRAM)
NZ (1) NZ552658A (OSRAM)
PE (1) PE20060418A1 (OSRAM)
PL (4) PL2364729T6 (OSRAM)
PT (4) PT2902039T (OSRAM)
RU (2) RU2426741C3 (OSRAM)
SG (1) SG155186A1 (OSRAM)
SI (4) SI2364729T1 (OSRAM)
TN (1) TNSN07034A1 (OSRAM)
TR (1) TR201808057T4 (OSRAM)
TW (1) TWI359153B (OSRAM)
WO (1) WO2006013107A1 (OSRAM)
ZA (1) ZA200700242B (OSRAM)

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BE2015C041I2 (OSRAM) 2024-10-08
EP1776142B3 (en) 2015-06-24
NO341384B1 (no) 2017-10-30
HRP20110758T4 (hr) 2015-07-31
ES2367440T7 (es) 2015-07-14
NO348010B1 (no) 2024-06-17
ES2487533T3 (es) 2014-08-21
EP3409288A1 (en) 2018-12-05
ECSP077198A (es) 2007-02-28
BR122018075556B1 (pt) 2022-10-18
CN101001645B (zh) 2012-09-05
MX2007001338A (es) 2008-03-11
ES2367440T9 (es) 2021-04-28
HUE038187T2 (hu) 2018-10-29
LT2902039T (lt) 2018-06-25
ZA200700242B (en) 2008-08-27
CY1120723T1 (el) 2019-12-11
NO2016017I1 (no) 2016-08-23
US8119131B2 (en) 2012-02-21
DK2364729T6 (en) 2015-07-06
US20250122277A1 (en) 2025-04-17
TWI359153B (en) 2012-03-01
NO20151787L (no) 2006-02-06
AU2005268857A1 (en) 2006-02-09
KR100852523B1 (ko) 2008-08-14
EP1776142B9 (en) 2016-09-07
BRPI0513078A (pt) 2008-04-22
CY2018027I2 (el) 2020-05-29
EP1776142A1 (en) 2007-04-25
IL180717A (en) 2012-07-31
FR15C0048I1 (fr) 2015-08-28
SG155186A1 (en) 2009-09-30
KR100852523B9 (ko) 2025-03-28
CY2015030I2 (el) 2017-11-14
EP2364729A2 (en) 2011-09-14
HUE025815T2 (en) 2016-04-28
ES2536228T3 (es) 2015-05-21
CY1115444T1 (el) 2017-01-04
CY1111963T1 (el) 2015-11-04
LU92768I2 (fr) 2015-11-03
EP2902039A1 (en) 2015-08-05
EP2364729A3 (en) 2012-01-18
US20150152178A1 (en) 2015-06-04
IL180717A0 (en) 2007-06-03
PL2366405T3 (pl) 2015-08-31
LTPA2018515I1 (lt) 2018-10-25
CA2573586C (en) 2013-06-25
LTC1776142I2 (lt) 2022-07-11
JP4682200B2 (ja) 2011-05-11
PE20060418A1 (es) 2006-06-15
PT2364729E (pt) 2014-09-01
US20100215666A1 (en) 2010-08-26
DK1776142T6 (en) 2015-07-06
HK1101277A1 (en) 2007-10-12
AU2005268857C1 (en) 2012-01-19
HRP20181069T1 (hr) 2018-09-07
ES2677245T3 (es) 2018-07-31
NO20150065L (no) 2007-03-30
BRPI0513078B1 (pt) 2019-02-19

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