DK2739298T3 - LONG-TERM EFFECTIVE GROWTH HORMON AND PROCEDURES FOR PRODUCING THEREOF - Google Patents
LONG-TERM EFFECTIVE GROWTH HORMON AND PROCEDURES FOR PRODUCING THEREOF Download PDFInfo
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- DK2739298T3 DK2739298T3 DK12819794.4T DK12819794T DK2739298T3 DK 2739298 T3 DK2739298 T3 DK 2739298T3 DK 12819794 T DK12819794 T DK 12819794T DK 2739298 T3 DK2739298 T3 DK 2739298T3
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- leu
- hgh
- growth hormone
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
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- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/IL2012/050288 WO2013018098A2 (en) | 2011-08-02 | 2012-08-02 | Long-acting growth hormone and methods of producing same |
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| DK2739298T3 true DK2739298T3 (en) | 2019-01-28 |
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| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
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| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| PT3050576T (pt) | 2008-04-29 | 2021-06-01 | Ascendis Pharma Growth Disorders Div A/S | Compostos recombinantes e peguilados da hormona de crescimento humana |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
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| MX2014012625A (es) | 2012-04-19 | 2015-05-15 | Opko Biolog Ltd | Variantes de oxintomodulina de accion prolongada y metodos para su produccion. |
| BR112015011583B1 (pt) * | 2012-11-20 | 2023-03-14 | Opko Biologics Ltd | Métodos para aumentar o tamanho ou volume hidrodinâmico de hormônio de crescimento humano, método para aumentar o peso molecular aparente de um polipeptídeo e método para aumentar a meia-vida de um polipeptídeo |
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| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| CA2968282A1 (en) | 2014-11-18 | 2016-05-26 | Thomas Kurpiers | Polymeric hgh prodrugs |
| PT3220892T (pt) | 2014-11-21 | 2021-11-05 | Ascendis Pharma Endocrinology Div A/S | Formas de dosagem de hormona do crescimento de longa ação |
| MY184625A (en) * | 2014-12-10 | 2021-04-09 | Opko Biologics Ltd | Methods of producing long acting ctp-modified growth hormone polypeptides |
| SG11201704706RA (en) | 2014-12-10 | 2017-07-28 | Opko Biologics Ltd | Methods of producing long acting ctp-modified growth hormone polypeptides |
| PL3310347T3 (pl) | 2015-06-19 | 2021-12-27 | Opko Biologics Ltd. | Długo działające czynniki krzepnięcia i sposoby wytwarzania |
| MX2018008061A (es) | 2016-01-08 | 2018-08-23 | Ascendis Pharma Growth Disorders As | Profarmacos de peptido natriuretico tipo c (cnp) con porciones portadoras grandes. |
| IL297375B2 (en) | 2016-01-08 | 2024-02-01 | Ascendis Pharma Growth Disorders As | Controlled-release CNP agonists with low NPR–C binding |
| PL3400019T3 (pl) | 2016-01-08 | 2023-01-23 | Ascendis Pharma Growth Disorders A/S | Proleki cnp z przyłączeniem nośnika w ugrupowaniu pierścieniowy |
| US11389510B2 (en) | 2016-01-08 | 2022-07-19 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
| IL259658B2 (en) | 2016-01-08 | 2024-06-01 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with reduced side-effects |
| EP3400018A1 (en) | 2016-01-08 | 2018-11-14 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with increased nep stability |
| FI3423103T3 (fi) | 2016-03-01 | 2024-11-20 | Ascendis Pharma Bone Diseases As | PTH-aihiolääkkeitä |
| WO2018011799A1 (en) | 2016-07-11 | 2018-01-18 | Opko Biologics Ltd. | Long-acting coagulation factor vii and methods of producing same |
| US11896671B2 (en) | 2016-07-13 | 2024-02-13 | Ascendis Pharma A/S | Conjugation method for carrier-linked prodrugs |
| HRP20250102T1 (hr) | 2016-09-29 | 2025-03-28 | Ascendis Pharma Bone Diseases A/S | Pth spojevi s kontroliranim oslobađanjem |
| MY199903A (en) | 2016-09-29 | 2023-11-28 | Ascendis Pharma Growth Disorders As | Combination therapy with controlled-release cnp agonists |
| DK3518960T5 (da) | 2016-09-29 | 2024-09-02 | Ascendis Pharma Bone Diseases As | Doseringsskema for en PTH-forbindelse med kontrolleret frigivelse |
| CN109789188B (zh) | 2016-09-29 | 2023-07-14 | 阿森迪斯药物骨疾病股份有限公司 | 具有低峰-谷比的pth化合物 |
| MA52662A (fr) | 2018-03-28 | 2021-02-17 | Ascendis Pharma Oncology Div A/S | Conjugués d'il-2 |
| WO2019185706A1 (en) | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugates |
| BR112020022306A2 (pt) | 2018-05-18 | 2021-02-23 | Ascendis Pharma Bone Diseases A/S | dose de partida de conjugados de pth |
| CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
| WO2020084621A1 (en) * | 2018-10-26 | 2020-04-30 | Tami Bar | Compositions and methods for biodegrading alcohol |
| KR102893903B1 (ko) | 2019-02-11 | 2025-12-01 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | Cnp 접합체의 건조 약학 제제 |
| KR20250171437A (ko) | 2019-02-11 | 2025-12-08 | 아센디스 파마 본 디지즈 에이/에스 | Pth 접합체의 액체 약학 제제 |
| US12303553B2 (en) | 2019-03-04 | 2025-05-20 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms with superior efficacy to daily somatropin |
| US20230065814A1 (en) | 2019-06-21 | 2023-03-02 | Ascendis Pharma A/S | Conjugates of-electron-pair-donating heteroaromatic nitrogen-comprising compounds |
| US20220304993A1 (en) | 2019-06-21 | 2022-09-29 | Ascendis Pharma A/S | Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds |
| US20220305129A1 (en) | 2019-06-21 | 2022-09-29 | Ascendis Pharma A/S | Conjugates of heteroaromatic nitrogen-comprising compounds |
| CN115175738A (zh) | 2020-01-03 | 2022-10-11 | 阿森迪斯药物股份有限公司 | 经历分子内重排的结合物 |
| BR112022010419A2 (pt) | 2020-01-13 | 2022-08-23 | Ascendis Pharma Bone Diseases As | Tratamento de hipoparatireoidismo |
| TW202210502A (zh) | 2020-06-03 | 2022-03-16 | 丹麥商阿森迪斯腫瘤製藥有限公司 | 新穎il-2序列及其用途 |
| WO2022029178A1 (en) | 2020-08-05 | 2022-02-10 | Ascendis Pharma A/S | Conjugates comprising reversible linkers and uses thereof |
| AU2021335032A1 (en) | 2020-08-28 | 2023-03-09 | Ascendis Pharma Oncology Division A/S | Glycosylated IL-2 proteins and uses thereof |
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| KR20230164709A (ko) | 2021-04-01 | 2023-12-04 | 아센디스 파마 에이에스 | 염증 유발 질환을 치료하기 위한 지속형 성장 호르몬의 용도 |
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| KR20240082355A (ko) | 2021-09-22 | 2024-06-10 | 아센디스 파마 본 디지즈 에이/에스 | 장시간 작용형 pth 화합물 치료 |
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| CA3249311A1 (en) | 2022-05-23 | 2023-11-30 | Ascendis Pharma Growth Disorders A/S | LIQUID PHARMACEUTICAL FORMULATIONS OF CNP COMPOUNDS |
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| WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
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