DK3482765T3 - Langtidsvirkende væksthormon og fremgangsmåder til produktion deraf - Google Patents
Langtidsvirkende væksthormon og fremgangsmåder til produktion deraf Download PDFInfo
- Publication number
- DK3482765T3 DK3482765T3 DK18198355.2T DK18198355T DK3482765T3 DK 3482765 T3 DK3482765 T3 DK 3482765T3 DK 18198355 T DK18198355 T DK 18198355T DK 3482765 T3 DK3482765 T3 DK 3482765T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- methods
- long
- growth hormone
- acting growth
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/195,931 US8450269B2 (en) | 2006-02-03 | 2011-08-02 | Long-acting growth hormone and methods of producing same |
| EP12819794.4A EP2739298B1 (en) | 2011-08-02 | 2012-08-02 | Long-acting growth hormone and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3482765T3 true DK3482765T3 (da) | 2024-05-21 |
Family
ID=47629749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18198355.2T DK3482765T3 (da) | 2011-08-02 | 2012-08-02 | Langtidsvirkende væksthormon og fremgangsmåder til produktion deraf |
| DK12819794.4T DK2739298T3 (da) | 2011-08-02 | 2012-08-02 | Langtidsvirkende væksthormon og fremgangsmåder til produktion deraf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12819794.4T DK2739298T3 (da) | 2011-08-02 | 2012-08-02 | Langtidsvirkende væksthormon og fremgangsmåder til produktion deraf |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8450269B2 (da) |
| EP (2) | EP3482765B1 (da) |
| JP (1) | JP6153930B2 (da) |
| KR (3) | KR102028524B1 (da) |
| CN (2) | CN107080835A (da) |
| AU (1) | AU2012291617B2 (da) |
| BR (1) | BR112014002491A2 (da) |
| CA (1) | CA2843672A1 (da) |
| CL (2) | CL2014000254A1 (da) |
| CO (1) | CO7020850A2 (da) |
| DK (2) | DK3482765T3 (da) |
| EA (2) | EA035352B1 (da) |
| ES (1) | ES2706734T3 (da) |
| FI (1) | FI3482765T3 (da) |
| HK (1) | HK1200349A1 (da) |
| HU (1) | HUE042755T2 (da) |
| MX (2) | MX360802B (da) |
| PL (1) | PL2739298T4 (da) |
| PT (2) | PT3482765T (da) |
| SI (1) | SI2739298T1 (da) |
| TR (1) | TR201821186T4 (da) |
| WO (1) | WO2013018098A2 (da) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| WO2007092252A2 (en) | 2006-02-03 | 2007-08-16 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| PE20142405A1 (es) | 2012-04-19 | 2015-01-25 | Opko Biolog Ltd | Variantes de oxintomodulina de accion prolongada y metodos de produccion de las mismas |
| CN112661863A (zh) | 2012-11-20 | 2021-04-16 | 奥普科生物制品有限公司 | 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法 |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN103524626B (zh) * | 2013-09-27 | 2016-09-07 | 武汉龙科生物技术有限公司 | 重组双靶点蛋白药物及其应用 |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| IL297219B2 (en) * | 2013-10-21 | 2024-02-01 | Opko Biologics Ltd | Long-acting polypeptides and methods for their preparation and administration |
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| MY184625A (en) * | 2014-12-10 | 2021-04-09 | Opko Biologics Ltd | Methods of producing long acting ctp-modified growth hormone polypeptides |
| TWI746427B (zh) * | 2014-12-10 | 2021-11-21 | 以色列商歐科生物製品有限公司 | 製造長效ｃｔｐ修飾的多肽之方法 |
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| CA3008017C (en) | 2016-01-08 | 2024-01-02 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with reduced side-effects |
| NZ743489A (en) | 2016-01-08 | 2022-09-30 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with low npr-c binding |
| EP3400020A1 (en) | 2016-01-08 | 2018-11-14 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with large carrier moieties |
| SG11201805028RA (en) | 2016-01-08 | 2018-07-30 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with increased nep stability |
| HUE060521T2 (hu) | 2016-01-08 | 2023-03-28 | Ascendis Pharma Growth Disorders As | A gyûrûn hordozó gyököt tartalmazó CNP elõvegyületek |
| NZ743488A (en) | 2016-01-08 | 2023-02-24 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with low initial npr-b activity |
| SG11201806092TA (en) | 2016-03-01 | 2018-08-30 | Ascendis Pharma Bone Diseases As | Pth prodrugs |
| MX2019000554A (es) | 2016-07-11 | 2019-09-19 | Opko Biologics Ltd | Factor vii de coagulación de acción prolongada y métodos para producir el mismo. |
| WO2018011266A1 (en) | 2016-07-13 | 2018-01-18 | Ascendis Pharma A/S | Conjugation method for carrier-linked prodrugs |
| AU2017336253B2 (en) | 2016-09-29 | 2023-02-23 | Ascendis Pharma Growth Disorders A/S | Combination therapy with controlled-release CNP agonists |
| WO2018060310A1 (en) | 2016-09-29 | 2018-04-05 | Ascendis Pharma Bone Diseases A/S | Dosage regimen for a controlled-release pth compound |
| MA46428A (fr) | 2016-09-29 | 2019-08-07 | Ascendis Pharma Bone Diseases As | Schéma posologique incrémentiel dans des composés de pth à libération contrôlée |
| CA3037447A1 (en) | 2016-09-29 | 2018-04-05 | Ascendis Pharma Bone Diseases A/S | Pth compounds with low peak-to-trough ratios |
| JP7490563B2 (ja) | 2018-03-28 | 2024-05-27 | アセンディス ファーマ オンコロジー ディヴィジョン エー／エス | Ｉｌ－２コンジュゲート |
| EP3773681A1 (en) | 2018-03-28 | 2021-02-17 | Ascendis Pharma A/S | Conjugates |
| MX2020012179A (es) | 2018-05-18 | 2021-01-29 | Ascendis Pharma Bone Diseases As | Dosis inicial de conjugados de hormona paratiroidea (pth). |
| CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
| WO2020084621A1 (en) * | 2018-10-26 | 2020-04-30 | Tami Bar | Compositions and methods for biodegrading alcohol |
| SG11202107446QA (en) | 2019-02-11 | 2021-08-30 | Ascendis Pharma Growth Disorders As | Dry pharmaceutical formulations of cnp conjugates |
| CA3129357A1 (en) | 2019-02-11 | 2020-08-20 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of pth conjugates |
| MX2021010286A (es) * | 2019-03-04 | 2021-09-23 | Ascendis Pharma Endocrinology Div A/S | Formas de dosificacion de la hormona del crecimiento de accion prolongada con eficacia superior a la somatropina diaria. |
| CN114026080A (zh) | 2019-06-21 | 2022-02-08 | 阿森迪斯药物股份有限公司 | 含有提供π-电子对的杂芳族氮的化合物的缀合物 |
| WO2020254602A1 (en) | 2019-06-21 | 2020-12-24 | Ascendis Pharma A/S | Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds |
| US20220305129A1 (en) | 2019-06-21 | 2022-09-29 | Ascendis Pharma A/S | Conjugates of heteroaromatic nitrogen-comprising compounds |
| KR20220123421A (ko) | 2020-01-03 | 2022-09-06 | 아센디스 파마 에이에스 | 분자내 재배열 처리된 컨쥬게이트 |
| EP4090357A1 (en) | 2020-01-13 | 2022-11-23 | Ascendis Pharma Bone Diseases A/S | Hypoparathyroidism treatment |
| EP4161956A1 (en) | 2020-06-03 | 2023-04-12 | Ascendis Pharma Oncology Division A/S | Il-2 sequences and uses thereof |
| CA3184998A1 (en) | 2020-08-05 | 2022-02-10 | Samuel WEISBROD | Conjugates comprising reversible linkers and uses thereof |
| US20230340055A1 (en) | 2020-08-28 | 2023-10-26 | Ascendis Pharma Oncology Division A/S | Glycosylated il-2 proteins and uses thereof |
| US20230364199A1 (en) | 2020-09-28 | 2023-11-16 | Ascendis Pharma Bone Diseases A/S | Improvement of physical and mental well-being of patients with hypoparathyroidism |
| CN112175964B (zh) * | 2020-10-23 | 2022-03-29 | 安徽中起生物科技有限公司 | 一种重组猪生长激素及其制备方法和应用 |
| AU2022246997A1 (en) | 2021-04-01 | 2023-09-28 | Ascendis Pharma A/S | Use of long-acting growth hormone for treating inflammation-induced diseases |
| CN114010765A (zh) * | 2021-08-30 | 2022-02-08 | 上海延立药业有限公司 | 一种长效人生长激素 |
| IL311539A (en) | 2021-09-22 | 2024-05-01 | Ascendis Pharma Bone Diseases As | Long-term PTH compound treatments |
| WO2023110758A1 (en) | 2021-12-13 | 2023-06-22 | Ascendis Pharma Growth Disorders A/S | Effective doses of cnp conjugates |
| WO2023227505A1 (en) | 2022-05-23 | 2023-11-30 | Ascendis Pharma Growth Disorders A/S | Liquid pharmaceutical formulations of cnp compounds |
| WO2024094673A1 (en) | 2022-11-02 | 2024-05-10 | Ascendis Pharma Bone Diseases A/S | Pth treatment regimen comprising two pth compounds |
| WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
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