DK2755980T3 - Fremgangsmåder og systemer til dannelse boronsyre og mellemprodukter deraf - Google Patents

Fremgangsmåder og systemer til dannelse boronsyre og mellemprodukter deraf Download PDF

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Publication number
DK2755980T3
DK2755980T3 DK12832249.2T DK12832249T DK2755980T3 DK 2755980 T3 DK2755980 T3 DK 2755980T3 DK 12832249 T DK12832249 T DK 12832249T DK 2755980 T3 DK2755980 T3 DK 2755980T3
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DK
Denmark
Prior art keywords
intermediates
procedures
creating
systems
boronic acid
Prior art date
Application number
DK12832249.2T
Other languages
English (en)
Inventor
Catherine A Menning
D Wayne Blaylock
Mark V M Emonds
Original Assignee
Dow Agrosciences Llc
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Publication of DK2755980T3 publication Critical patent/DK2755980T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/02—Lithium compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00004—Scale aspects
    • B01J2219/00011—Laboratory-scale plants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/0004—Processes in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00094—Jackets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792—One or more tube-shaped elements
    • B01J2219/00795—Spiral-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00813—Fluidic connections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00822—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets
DK12832249.2T 2011-09-14 2012-09-14 Fremgangsmåder og systemer til dannelse boronsyre og mellemprodukter deraf DK2755980T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161534768P 2011-09-14 2011-09-14
PCT/US2012/055605 WO2013040479A1 (en) 2011-09-14 2012-09-14 Methods and systems for forming boronic acids and intermediates thereof

Publications (1)

Publication Number Publication Date
DK2755980T3 true DK2755980T3 (da) 2020-01-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK12832249.2T DK2755980T3 (da) 2011-09-14 2012-09-14 Fremgangsmåder og systemer til dannelse boronsyre og mellemprodukter deraf

Country Status (14)

Country Link
US (1) US9145428B2 (da)
EP (1) EP2755980B1 (da)
JP (3) JP6425543B2 (da)
KR (2) KR102062323B1 (da)
CN (1) CN103827124B (da)
CA (1) CA2847858A1 (da)
CO (1) CO6930354A2 (da)
DK (1) DK2755980T3 (da)
HK (1) HK1199262A1 (da)
IL (1) IL231391A (da)
MX (1) MX2014003064A (da)
PL (1) PL2755980T3 (da)
RU (1) RU2607941C2 (da)
WO (1) WO2013040479A1 (da)

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Publication number Priority date Publication date Assignee Title
FR3012145B1 (fr) * 2013-10-18 2015-12-18 Yriel Procede continu de preparation d'acides boroniques et de leurs derives
US9771380B2 (en) * 2014-06-09 2017-09-26 University Of Oregon Gold nanoparticles and methods of making and using gold nanoparticles
CN105056842B (zh) * 2015-07-23 2017-12-15 厦门大学 一种反应装置及其在合成硼酸酯中的应用
CN106422985A (zh) * 2016-11-30 2017-02-22 南京睿宇物联网科技有限公司 用于安全添加叔丁基锂至反应器的反应系统
JOP20190188A1 (ar) 2017-02-01 2019-08-01 Rempex Pharmaceuticals Inc جهاز وعملية تدفق مستمرة لإنتاج مشتق حمض بورونيك
EP4121416A1 (en) 2020-03-18 2023-01-25 Corteva Agriscience LLC Improved synthesis of 6-aryl-4-aminopicolinates
US20230357155A1 (en) 2020-03-18 2023-11-09 Corteva Agriscience Llc Improved synthesis of 4-amino-6-(heterocyclic)picolinates
EP4281440A1 (en) 2021-01-21 2023-11-29 Corteva Agriscience LLC Processes related to formation of n-(3-chloro-1-(pyridin-3-yl)-1h-pyrazol-4-yl)-2-(methylsulfonyl)propanamide
CN112979688B (zh) * 2021-05-20 2022-02-01 凯莱英医药集团（天津）股份有限公司 2-氟-4-三氟甲基苯硼酸的制备方法

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DE19858856A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Arylmetallverbindungen und deren Umsetzung mit Elektrophilen
CA2431904A1 (en) * 2000-12-20 2002-08-01 Merck & Co., Inc. (halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents
DE10110051C2 (de) * 2001-03-02 2003-07-03 Clariant Gmbh Verfahren zur Herstellung von Boron- und Borinsäuren
DE10139664A1 (de) * 2001-08-11 2003-02-20 Clariant Gmbh Verfahren zur Herstellung von Aryl- und Alkyl-Bor-Verbindungen in Mikroreaktoren
DE10150615A1 (de) * 2001-10-12 2003-04-30 Clariant Gmbh Verfahren zur metallorganischen Herstellung organischer Zwischenprodukte
PL373339A1 (en) * 2002-04-19 2005-08-22 Smithkline Beecham Corporation Novel compounds
JP4639042B2 (ja) * 2003-09-29 2011-02-23 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
FR2864083B1 (fr) 2003-12-18 2007-04-13 Galderma Res & Dev Nouveaux derives d'acides phenyl-boroniques et leurs procedes de preparation.
DE102005037547A1 (de) 2005-08-09 2007-02-15 Basf Ag Verfahren zur Herstellung von Arylboronsäureestern
BR122015016965B8 (pt) * 2006-01-13 2022-06-28 Dow Agrosciences Llc 6-(aril polissubstituído)-4-aminopicolinatos, composição herbicida, e método para controle de vegetação indesejável
AU2007204887B2 (en) 2006-01-13 2011-06-23 Corteva Agriscience Llc 2-(poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides
US7998418B1 (en) * 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
BRPI0816075A2 (pt) * 2007-08-30 2015-02-24 Dow Agrosciences Llc 2-(fenil substituído)-6-amino-5-alcóxi, tioalcóxi e aminoalquil-4-pirimidinacarboxilatos e seus usos como herbicidas
CA2711308C (en) * 2008-01-11 2017-01-24 Dow Agrosciences Llc Process for the selective deprotonation and functionalization of 1-fluoro-2-substituted-3-chlorobenzenes
JP5441923B2 (ja) * 2008-12-25 2014-03-12 日本曹達株式会社 有機リチウム化合物の製造方法および置換芳香族化合物の製造方法
MX337469B (es) * 2011-10-26 2016-03-02 Pfizer Ltd Derivados de (4-fenilimidazol-2-il)etilamina utiles como moduladores de canal de sodio.

Also Published As

Publication number Publication date
KR20140061505A (ko) 2014-05-21
KR102062323B1 (ko) 2020-01-03
US9145428B2 (en) 2015-09-29
MX2014003064A (es) 2014-05-07
JP2019038827A (ja) 2019-03-14
US20130066115A1 (en) 2013-03-14
EP2755980B1 (en) 2019-10-30
RU2014114533A (ru) 2015-10-20
EP2755980A4 (en) 2015-06-03
WO2013040479A1 (en) 2013-03-21
KR20190112820A (ko) 2019-10-07
IL231391A (en) 2016-12-29
RU2607941C2 (ru) 2017-01-11
PL2755980T3 (pl) 2020-05-18
CN103827124B (zh) 2017-06-06
CN103827124A (zh) 2014-05-28
EP2755980A1 (en) 2014-07-23
JP2014530193A (ja) 2014-11-17
NZ622139A (en) 2015-05-29
CA2847858A1 (en) 2013-03-21
HK1199262A1 (en) 2015-06-26
JP2017095472A (ja) 2017-06-01
JP6456907B2 (ja) 2019-01-23
IL231391A0 (en) 2014-04-30
JP6425543B2 (ja) 2018-11-21
CO6930354A2 (es) 2014-04-28

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