ATE187740T1 - Modifizierte proteine und peptide enthaltende pharmazeutische mittel - Google Patents

Modifizierte proteine und peptide enthaltende pharmazeutische mittel

Info

Publication number
ATE187740T1
ATE187740T1 AT94914152T AT94914152T ATE187740T1 AT E187740 T1 ATE187740 T1 AT E187740T1 AT 94914152 T AT94914152 T AT 94914152T AT 94914152 T AT94914152 T AT 94914152T AT E187740 T1 ATE187740 T1 AT E187740T1
Authority
AT
Austria
Prior art keywords
peptides
amino acid
ctp units
pharmaceutical agents
containing modified
Prior art date
Application number
AT94914152T
Other languages
English (en)
Inventor
Irving Boime
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE187740T1 publication Critical patent/ATE187740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94914152T 1993-04-20 1994-04-13 Modifizierte proteine und peptide enthaltende pharmazeutische mittel ATE187740T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4986993A 1993-04-20 1993-04-20
PCT/US1994/004069 WO1994024148A1 (en) 1993-04-20 1994-04-13 Modified protein and peptide pharmaceuticals

Publications (1)

Publication Number Publication Date
ATE187740T1 true ATE187740T1 (de) 2000-01-15

Family

ID=21962168

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94914152T ATE187740T1 (de) 1993-04-20 1994-04-13 Modifizierte proteine und peptide enthaltende pharmazeutische mittel

Country Status (14)

Country Link
EP (1) EP0695307B1 (de)
JP (2) JP4156024B2 (de)
AT (1) ATE187740T1 (de)
AU (1) AU687053B2 (de)
CA (1) CA2160800C (de)
DE (1) DE69422169D1 (de)
ES (1) ES2141229T3 (de)
FI (1) FI954978A7 (de)
GR (1) GR3032775T3 (de)
NO (1) NO954188L (de)
NZ (1) NZ265529A (de)
PT (1) PT695307E (de)
WO (1) WO1994024148A1 (de)
ZA (1) ZA942729B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968513A (en) * 1996-06-24 1999-10-19 University Of Maryland Biotechnology Institute Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
US5997871A (en) * 1996-06-24 1999-12-07 University Of Maryland Biotechnology Insitute Treatment and prevention of cancer by administration of derivatives of human chorionic gonadotropin
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
US6583109B1 (en) 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
US7994278B1 (en) 1999-08-06 2011-08-09 Nobel Biosciences Llc Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
ATE320449T1 (de) * 2000-12-11 2006-04-15 Cheil Jedang Corp Fusionsprotein mit verbesserter in vivo erythropoietinwirkung
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
KR100467751B1 (ko) * 2001-12-03 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US7553941B2 (en) 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8304386B2 (en) 2006-02-03 2012-11-06 Prolor Biotech, Inc. Long-acting growth hormone and methods of producing same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
JP2015520128A (ja) 2012-04-19 2015-07-16 オプコ バイオロジクス リミテッド 長時間作用性オキシントモジュリン変異体とその作製方法
ES2882890T3 (es) 2012-11-20 2021-12-03 Opko Biologics Ltd Método para aumentar el volumen hidrodinámico de polipéptidos mediante la unión a péptidos carboxi terminales de la gonadotrofina
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
WO2016092550A2 (en) * 2014-12-10 2016-06-16 Opko Biologics Ltd. Methods of producing long acting ctp-modified polypeptides
EP3988113A1 (de) 2015-06-19 2022-04-27 OPKO Biologics Ltd. Gerinnungsfaktoren mit langzeitwirkung und verfahren zur herstellung davon
BR112019000610A2 (pt) 2016-07-11 2019-07-02 Opko Biologics Ltd fator vii de coagulação de longa ação e métodos de produção do mesmo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654324A (en) * 1981-08-27 1987-03-31 Eli Lilly And Company Human proinsulin pharmaceutical formulations
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
AU648020B2 (en) * 1989-02-21 1994-04-14 Washington University Modified forms of reproductive hormones
JPH04156024A (ja) * 1990-10-19 1992-05-28 Fujitsu Ltd サブレート交換方式

Also Published As

Publication number Publication date
GR3032775T3 (en) 2000-06-30
FI954978L (fi) 1995-11-15
AU6633194A (en) 1994-11-08
EP0695307A4 (de) 1996-08-21
CA2160800A1 (en) 1994-10-27
NZ265529A (en) 1998-01-26
JPH08509218A (ja) 1996-10-01
ZA942729B (en) 1995-01-09
WO1994024148A1 (en) 1994-10-27
DE69422169D1 (de) 2000-01-20
CA2160800C (en) 2010-06-01
AU687053B2 (en) 1998-02-19
EP0695307A1 (de) 1996-02-07
JP4156024B2 (ja) 2008-09-24
NO954188L (no) 1995-12-19
PT695307E (pt) 2000-05-31
FI954978A0 (fi) 1995-10-18
JP2008133295A (ja) 2008-06-12
FI954978A7 (fi) 1995-11-15
ES2141229T3 (es) 2000-03-16
EP0695307B1 (de) 1999-12-15
NO954188D0 (no) 1995-10-19

Similar Documents

Publication Publication Date Title
DE69422169D1 (de) Modifizierte proteine und peptide enthaltende pharmazeutische mittel
NO941186D0 (no) Hormonanaloger med multiple CTP-forlengelser
DE69428040D1 (de) Orale darreichungsform
NO952744D0 (no) Cytokinbegrensende midler
ATE136221T1 (de) Osteo-induktive pharmazeutische formulierungen
DK2016950T3 (da) Farmaceutisk sammensætning omfattende et exendin-4-peptid
DE3875108D1 (de) Physiologisch aktives polypeptid und pharmazeutische komposition.
DE69534165D1 (de) Adenovirus mit glutathion peroxydate gene
DE69520475D1 (de) Pharmaceutische Zusammensetzung von biologisch aktiven Peptiden oder Proteinen
ATE218616T1 (de) Humanes zirkulierendes cytokin cc-1
ES2087337T3 (es) Composiciones de implantes que contienen una proteina, peptido o polipeptido biologicamente activos.
BG103905A (en) New bpc peptide salts with organoprotective activity, method for their preparation and application in medicine
DE69325512D1 (de) Verwendung von remacemid zur behandlung des morbus parkinson
ATE265234T1 (de) Pharmazeutische zusammensetzung von hydrophob modifizierten hedgehog-proteinen und deren verwendung
NL1000332C1 (nl) Graduele chemische modificatie van biologisch actieve peptiden en eiwitten.
MX9604539A (es) Aminoacidos modificados para la distribucion de farmaco.
ATE75485T1 (de) Biologisch aktive peptide, deren verfahren zur herstellung und pharmazeutische zusammensetzungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification