ATE136221T1 - Osteo-induktive pharmazeutische formulierungen - Google Patents

Osteo-induktive pharmazeutische formulierungen

Info

Publication number
ATE136221T1
ATE136221T1 AT91911720T AT91911720T ATE136221T1 AT E136221 T1 ATE136221 T1 AT E136221T1 AT 91911720 T AT91911720 T AT 91911720T AT 91911720 T AT91911720 T AT 91911720T AT E136221 T1 ATE136221 T1 AT E136221T1
Authority
AT
Austria
Prior art keywords
pharmaceutical formulations
inductive
osteo
cartilage
formulations
Prior art date
Application number
AT91911720T
Other languages
English (en)
Inventor
Tobin N Gerhart
Elizabeth A Wang
Mary Jo Kriz
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Application granted granted Critical
Publication of ATE136221T1 publication Critical patent/ATE136221T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT91911720T 1990-06-18 1991-06-18 Osteo-induktive pharmazeutische formulierungen ATE136221T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/539,756 US5364839A (en) 1990-06-18 1990-06-18 Osteoinductive pharmaceutical formulations

Publications (1)

Publication Number Publication Date
ATE136221T1 true ATE136221T1 (de) 1996-04-15

Family

ID=24152509

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91911720T ATE136221T1 (de) 1990-06-18 1991-06-18 Osteo-induktive pharmazeutische formulierungen

Country Status (10)

Country Link
US (1) US5364839A (de)
EP (1) EP0535091B1 (de)
JP (1) JP3191937B2 (de)
AT (1) ATE136221T1 (de)
CA (1) CA2085750C (de)
DE (1) DE69118535T2 (de)
DK (1) DK0535091T3 (de)
ES (1) ES2088006T3 (de)
GR (1) GR3019901T3 (de)
WO (1) WO1991019510A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
GB2245559A (en) * 1990-06-25 1992-01-08 Farmos Oy Bioceramic system for delivery of a bioactive compound.
US7196054B1 (en) * 1990-11-27 2007-03-27 The American National Red Cross Methods for treating wound tissue and forming a supplemented fibrin matrix
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
DE69233022T2 (de) 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US5780436A (en) * 1995-05-01 1998-07-14 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US5661127A (en) * 1995-05-01 1997-08-26 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US6638912B2 (en) 1995-05-01 2003-10-28 The Regents Of The University Of California Peptide compositions mimicking TGF-β activity
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
WO1998017190A2 (en) 1996-10-23 1998-04-30 Oratec Interventions, Inc. Method and apparatus for treating intervertebral discs
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US6126682A (en) 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
EP1459691A1 (de) 1996-10-23 2004-09-22 Oratec Interventions, Inc. Verfahren und vorrichtung zur behandlung von zwischenwirbelscheiben
US6593290B1 (en) * 1996-11-01 2003-07-15 Genentech, Inc. Treatment of inner ear hair cells
US7255712B1 (en) 1997-04-15 2007-08-14 Active Implants Corporation Bone growth promoting implant
CN1068793C (zh) * 1997-04-17 2001-07-25 中国人民解放军第四军医大学全军创伤骨科研究所 骨生长刺激素注射剂及其制备方法
IL136230A0 (en) 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP0953576B1 (de) * 1998-04-30 2005-11-02 Curis, Inc. Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
DE19841698A1 (de) * 1998-09-11 2000-03-16 Curative Technologies Gmbh Wachstumsfaktor-enthaltende Zusammensetzung zur Heilung von Gewebeschäden
IL143866A0 (en) 1999-01-06 2002-04-21 Genentech Inc Insulin-like growth factor (igf) i mutant variants
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
PT1223990E (pt) 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
DE60120372T2 (de) 2000-03-24 2007-07-05 Genentech Inc., San Francisco Verwendung von insulin zur behandlung von knorpelkrankheiten
DE10020125A1 (de) * 2000-04-18 2001-10-25 Friedrich Schiller Uni Jena Bu Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren
AU2001263215A1 (en) 2000-05-16 2001-11-26 Genentech Inc. Method for treating cartilage disorders
WO2002033085A2 (en) 2000-10-16 2002-04-25 Genentech, Inc. Wisp polypeptides and therapeutical applications thereof
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
WO2003039587A1 (en) * 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and protein s inhibitors
US20030124118A1 (en) * 2001-11-27 2003-07-03 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and protein S inhibitors
US20080057059A1 (en) * 2001-11-09 2008-03-06 Novo Nordisk Healthcare A/G Pharmaceutical Composition Comprising Factor VII Polypeptides and Protein S Inhibitors
AU2002353484A1 (en) 2001-12-04 2003-06-17 Discure Ltd. Cushion bearing implants for load bearing applications
CN100586398C (zh) 2002-05-23 2010-02-03 活性移植公司 植入体
KR20060133961A (ko) 2003-09-12 2006-12-27 와이어쓰 골형성 단백질 전달용의 주사 가능한 인산칼슘 고형 로드및 페이스트
WO2006105161A2 (en) * 2005-03-30 2006-10-05 Cartilix, Inc. Coated medical device
BRPI0609504A2 (pt) * 2005-03-30 2010-04-13 Wyeth Corp métodos para estimular o crescimento capilar administrando proteìnas morfogenéticas ósseas (bmps)
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
ES2962777T3 (es) * 2007-11-15 2024-03-21 Amgen Inc Formulación acuosa de anticuerpos estabilizada por antioxidantes para la administración parenteral
CN104628855A (zh) 2008-05-05 2015-05-20 诺维莫尼公司 抗il-17a/il-17f交叉反应性抗体及其使用方法
AU2010244142B2 (en) 2009-05-05 2016-07-21 Novimmune Sa Anti-IL-17F antibodies and methods of use thereof
JP2013542837A (ja) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス,インコーポレイティド 骨空隙充填剤
US11596712B2 (en) 2017-10-19 2023-03-07 Genera Istrazivanja D.O.O. Autologous bone graft substitute composition
JP2020537590A (ja) * 2017-10-19 2020-12-24 パーフォーム バイオロジクス インコーポレイテッドPerform Biologics, Inc. 自家骨移植代替物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
SU733665A1 (ru) * 1978-03-30 1980-05-15 Семипалатинский Государственный Медицинский Институт Способ остеосинтеза трубчатых костей
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
EP0166263A1 (de) * 1984-05-31 1986-01-02 Green Cross Corporation Füllmaterial für Knochendefekte oder Knochenhohlräume, Kit oder Set zur Herstellung dieses Füllmaterials
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4902296A (en) * 1986-10-29 1990-02-20 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
WO1989004646A1 (en) * 1987-11-13 1989-06-01 Jefferies Steven R Bone repair material and delayed drug delivery
IL84911A (en) * 1987-12-22 1993-04-04 Yissum Res Dev Co Processes for the preparation of collagen products, and pharmaceutical compositions containing the same
AU3433989A (en) * 1988-04-06 1989-11-03 Celtrix Laboratories, Inc. Bone-inducing protein
KR900700617A (ko) * 1988-04-08 1990-08-16 브루스 엠. 에이센 뼈 및 연골 유도 조성물
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide

Also Published As

Publication number Publication date
DE69118535D1 (de) 1996-05-09
EP0535091A1 (de) 1993-04-07
GR3019901T3 (en) 1996-08-31
JPH05507930A (ja) 1993-11-11
CA2085750A1 (en) 1991-12-19
JP3191937B2 (ja) 2001-07-23
EP0535091B1 (de) 1996-04-03
DE69118535T2 (de) 1996-09-26
ES2088006T3 (es) 1996-08-01
DK0535091T3 (da) 1996-05-06
WO1991019510A1 (en) 1991-12-26
US5364839A (en) 1994-11-15
CA2085750C (en) 2003-02-18

Similar Documents

Publication Publication Date Title
ATE136221T1 (de) Osteo-induktive pharmazeutische formulierungen
ES2191102T3 (es) Heterociclos de peptidilo utiles en el tratamiento de las afecciones relacionadas con la trombina.
NO971889D0 (no) Forbindelser og sammensetninger for levering av aktive midler
DE3585556D1 (de) Pharmazeutische zusammensetzungen, welche ein dipeptid enthalten.
DE693928T1 (de) Aminozucker- und glykosaminoglykanzusammensetzung zur behandlung und reparatus von bindegewebe
DE69835279D1 (de) Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika
PT739355E (pt) Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos
DK0484401T3 (da) Fremstilling af vaskulær endothelcellevækstfaktor
FI961037A (fi) Valmisteet osteogenisten proteiinien antamiseksi
DE69232323T2 (de) Verwendung von Adenosinantagonisten zur Vorbeugung und Behandlung von Pankreatitis und Ulcera
ATE187740T1 (de) Modifizierte proteine und peptide enthaltende pharmazeutische mittel
TR199802534T2 (xx) Leptin (OB Protein) fragmanlar�
ATE147981T1 (de) Verabreichung von lamotrigin zur behandlung von neuro-aids
ID18079A (id) Komposisi farmasi yang mengandung bahan pemercepat osteogenesis
ATE273031T1 (de) Aminobiguanide und ihre verwendung zur desinfektion von kontaktlinsen und konservierung von pharmazeutischen zubereitungen
ITMI931649A1 (it) Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
DE69420229T2 (de) Pharmazeutische Zusammensetzung zur Behandlung von AIDS
IL83775A (en) Amino acid esters and amides of fumaric acid and pharmaceutical compositions containing them for use in the treatment of psoriasis
EP1080724A4 (de) Zusammenstellung die die mpt-aktivität mindert
EE200000163A (et) Protsess kirurgiliste instrumentide puhastamiseks
NZ235497A (en) Peptides (possibly related to hirudin) and pharmaceutical compositions for reducing blood coagulation
FI942938A (fi) Soijaproteiini tai -hydrolysaatit farmaseuttisissa koostumuksissa bioaktiivisten peptidien suojana entsymaattista inaktivoitumista vastaan
ATE193450T1 (de) Pharmazeutische zusammensetzung zur vorbeugung oder behandlung von knochenbrüchen
SI1173194T1 (en) Recombinant sp-a for the treatment or prevention of pulmonary infection and inflammation
KR950701812A (ko) 렌티바이러스-유도된 질환의 치료에 유용한 생물학적으로 활성인 우레이도 유도체(Biologically active ureido dervatives useful in the treatment of lentivirus-induced sisease)

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee