DE69835279D1 - Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika - Google Patents

Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika

Info

Publication number
DE69835279D1
DE69835279D1 DE69835279T DE69835279T DE69835279D1 DE 69835279 D1 DE69835279 D1 DE 69835279D1 DE 69835279 T DE69835279 T DE 69835279T DE 69835279 T DE69835279 T DE 69835279T DE 69835279 D1 DE69835279 D1 DE 69835279D1
Authority
DE
Germany
Prior art keywords
infections
compositions
methods
antibiotics
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69835279T
Other languages
English (en)
Other versions
DE69835279T2 (de
Inventor
R Fraser
H West
J Mcnicol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biowest Therapeutics Inc
Original Assignee
Migenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/915,314 external-priority patent/US6180604B1/en
Application filed by Migenix Inc filed Critical Migenix Inc
Publication of DE69835279D1 publication Critical patent/DE69835279D1/de
Application granted granted Critical
Publication of DE69835279T2 publication Critical patent/DE69835279T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69835279T 1997-03-10 1998-03-10 Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika Expired - Fee Related DE69835279T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US30619 1987-03-27
US4064997P 1997-03-10 1997-03-10
US40649P 1997-03-10
US08/915,314 US6180604B1 (en) 1996-08-21 1997-08-20 Compositions and methods for treating infections using analogues of indolicidin
US915314 1997-08-20
US6009997P 1997-09-26 1997-09-26
US60099P 1997-09-26
US09/030,619 US6503881B2 (en) 1996-08-21 1998-02-25 Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
PCT/CA1998/000190 WO1998040401A2 (en) 1997-03-10 1998-03-10 Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics

Publications (2)

Publication Number Publication Date
DE69835279D1 true DE69835279D1 (de) 2006-08-31
DE69835279T2 DE69835279T2 (de) 2007-07-12

Family

ID=27487830

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69835279T Expired - Fee Related DE69835279T2 (de) 1997-03-10 1998-03-10 Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika

Country Status (10)

Country Link
US (3) US6503881B2 (de)
EP (1) EP0966481B1 (de)
JP (1) JP2002544759A (de)
AT (1) ATE333464T1 (de)
AU (1) AU6604798A (de)
CA (1) CA2282807A1 (de)
DE (1) DE69835279T2 (de)
ES (1) ES2264198T3 (de)
HK (1) HK1025103A1 (de)
WO (1) WO1998040401A2 (de)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6172185B1 (en) 1998-05-20 2001-01-09 University Of British Columbia Antimicrobial cationic peptide derivatives of bactenecin
US8283315B2 (en) 1998-08-28 2012-10-09 Lytix Biopharma As Inhibition of tumour growth
GB9818938D0 (en) 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
US6288212B1 (en) * 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
JP2002530274A (ja) * 1998-10-30 2002-09-17 インターリンク・バイオテクノロジーズ・リミテッド・ライアビリティ・カンパニー プロテアーゼ分解に対する安定性の高いペプチド
US6946261B1 (en) * 1998-11-20 2005-09-20 Migenix Inc. Efficient methods for producing anti-microbial cationic peptides in host cells
HUP0300363A2 (hu) * 1999-02-03 2004-06-28 BIOGAL Gyógyszergyár Rt. Eljárás pszeudomonsav A előállítására mikrobiológiai eljárás segítségével
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US20030008369A1 (en) * 1999-03-03 2003-01-09 Board Of Regents, The University Of Texas System Genetic and epigenetic manipulation of ABC transporters and ecto-phosphatases
CA2365099C (en) * 1999-03-17 2012-05-29 University Of Victoria Innovation And Development Corporation Transgenic plants that are resistant to a broad spectrum of pathogens
US6835868B1 (en) 1999-03-17 2004-12-28 University Of Victoria Innovation And Development Corporation Transgenic plants expressing dermaseptin peptides providing broad spectrum resistance to pathogens
US6872225B1 (en) * 1999-05-27 2005-03-29 Biocompatibles Uk Limited Local drug delivery
US7015309B1 (en) 1999-06-23 2006-03-21 The Wistar Institute Of Anatomy And Biology Pyrrhocoricin-derived peptides, and methods of use thereof
PE20010635A1 (es) 1999-10-08 2001-08-15 Smithkline Beecham Corp Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas
MXPA02006143A (es) * 1999-12-20 2004-08-23 Majeste La Reine Du Chef Du Ca Metodo y composicion para el tratamiento y/o prevencion de infecciones por microorganismos resistentes a antibioticos.
CA2398808A1 (en) * 2000-01-21 2001-07-26 The Wistar Institute Of Anatomy & Biology Biocidal molecules, macromolecular targets and methods of production and use
US8003595B2 (en) 2000-03-01 2011-08-23 Cellectis Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
US6632616B2 (en) * 2000-03-16 2003-10-14 Duke University Compounds that selectively bind to expanded polyglutamine repeat domains and methods of use thereof
US6777592B2 (en) * 2000-04-14 2004-08-17 E.I. Du Pont Denemours And Company Arthropod defensins of Scolopendra canidens, Vaejovis carolinianus, and Argiope spp.
DE10030781A1 (de) * 2000-06-29 2002-01-17 Hassan Jomaa Kombinationspräparate von 3-N-Formylhydroxylaminopropylphosphonsäurederivaten oder 3-N-Acetylhydroxylaminopropylphosphonsäurederivaten mit spezielen pharmazeutischen Wirkstoffen
DE10042853A1 (de) * 2000-08-30 2002-04-25 Florian Lang Nachweis und Beeinflußung der Expression oder Funktion von CD95/CD95L bei Infektionen
AU2002246943A1 (en) * 2001-01-05 2002-10-15 Kemin Industries, Inc. Antibiotics from bacteria isolated from amphibian skin
EP1357954A1 (de) * 2001-02-09 2003-11-05 Johnson & Johnson Vision Care, Inc. Biomedizinisches gerät mit antimikrobiellen kationischen peptidbeschichtungen
CA2444597A1 (en) * 2001-04-06 2002-10-06 Affinium Pharmaceuticals, Inc. Fab i inhibitors
US7439045B2 (en) * 2001-06-21 2008-10-21 TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság pH controlled fermentation process for pseudomonic acid production
CN1516598A (zh) * 2001-06-22 2004-07-28 ��ͯ����ҽԺ 抗菌肽
US6835536B2 (en) * 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
US8933029B2 (en) 2001-08-24 2015-01-13 Carrus Capital Corporation Antimicrobial and anti-inflammatory peptides
KR100438416B1 (ko) * 2001-09-19 2004-07-02 학교법인조선대학교 Ｃａ－ｍａ 펩타이드의 아미노산 중 하나 또는 그 이상을치환하여 ＋ 전극과 소수성 영역이 증가된 신규한펩타이드 및 그를 포함하는 약학적 조성물
CA2812761C (en) * 2001-10-05 2018-03-20 Steris Inc. In vitro model for priocidal activity
US7507787B2 (en) * 2001-12-03 2009-03-24 The University Of British Columbia Effectors of innate immunity
HUP0600679A2 (en) * 2001-12-28 2008-06-30 Biogal Gyogyszergyar Processes for preparing crystalline and amorphous mupirocin calcium and pharmaceutical compositions containing the same
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US20030219854A1 (en) * 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
AU2003224767A1 (en) * 2002-03-26 2003-10-13 Eastern Virginia Medical School Suramin and derivatives thereof as topical microbicide and contraceptive
US7607436B2 (en) * 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
FR2839311A1 (fr) * 2002-05-06 2003-11-07 Entomed Peptides antibacteriens, genes codant les peptides, vecteurs, organismes transformes, leurs preparations et les compositions les contenant
EP1360961A1 (de) * 2002-05-07 2003-11-12 AM-Pharma B.V. Verwendung von antimikrobiell wirkenden Peptiden zur Aktivitätssteigerung von antimikrobiellen Wirkstoffen
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
SI2363114T1 (sl) * 2002-10-29 2015-07-31 Insmed Incorporated Zadržano sproščanje antiinfektivov
US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
AP2005003346A0 (en) * 2002-12-10 2005-06-30 Biosynexus Inc Topical anti-infective formulations
DE10260537A1 (de) * 2002-12-21 2004-07-15 Kerek, Franz, Dr. Peptide mit hohem Cysteingehalt
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
AU2003230899A1 (en) * 2003-04-14 2004-11-26 Wyeth Holdings Corporation Compositions containing piperacillin and tazobactam useful for injection
US6900184B2 (en) 2003-04-14 2005-05-31 Wyeth Holdings Corporation Compositions containing pipercillin and tazobactam useful for injection
PT1468697E (pt) * 2003-04-14 2008-03-05 Wyeth Corp Composições contendo piperacilina e tazobactam úteis para injecção
US6989370B2 (en) 2003-05-01 2006-01-24 The United States Of America As Represented By The Secretary Of Agriculture Bacteriocins and novel bacterial strains
SE0301431D0 (sv) 2003-05-19 2003-05-19 Dermagen Novel antimicrobial peptides
US7220422B2 (en) * 2003-05-20 2007-05-22 Allergan, Inc. Methods and compositions for treating eye disorders
EP2719394B1 (de) 2003-06-30 2015-07-29 Tel Aviv University Future Technology Development L.P. Peptide zur Behandlung von amyloidbedingten Erkrankungen
WO2005006938A2 (en) * 2003-07-18 2005-01-27 Technion Research & Development Foundation Ltd. Anti-microbial medical implants and uses thereof
AU2003904225A0 (en) * 2003-08-08 2003-08-21 Ripetech Pty Limited Method for reducing precure during the curing of thermosetting resins
JP4633055B2 (ja) * 2003-08-14 2011-02-16 ディアトス （ソシエテ アノニム） ペプチド及び有利に疎水性の抗菌剤からなる特にグラム陰性菌を制御するための抗菌組成物
FR2858772A1 (fr) * 2003-08-14 2005-02-18 Diatos Composition anti bacterienne, plus particulierement contre les bacteries gram negatif, comprenant un peptide et un agent anti-bacterien avantageusement hydrophobe
US20050108047A1 (en) * 2003-11-19 2005-05-19 Vvii Newco 2003, Inc. Business methods for commercializing antibiotics
US7455840B2 (en) * 2003-11-19 2008-11-25 The Scripps Research Institute Compositions and methods to reduce mutagenesis
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
WO2005089738A2 (en) * 2004-03-17 2005-09-29 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
WO2005090385A2 (en) * 2004-03-18 2005-09-29 Ansata Therapeutics, Inc. Compositions having antimicrobial activity and uses thereof
WO2005117837A1 (en) * 2004-06-01 2005-12-15 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of amorphous form of a drug
EP2848614A3 (de) * 2004-06-04 2015-07-29 Debiopharm International SA Acrylamidderivate und ihre Verwendung als Antibiotika
US20090156471A1 (en) * 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
CA2974538A1 (en) * 2004-08-18 2006-02-23 Novabiotics Limited Antimicrobial peptides comprising an arginine-and/or lysine-containing motif
US7700308B2 (en) * 2004-09-16 2010-04-20 University Of Washington Methods for determining susceptibility to dental caries
WO2006049580A1 (en) * 2004-11-04 2006-05-11 National University Of Singapore Anticoagulant peptides
EP1657249A1 (de) * 2004-11-10 2006-05-17 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Antibiotisch wirksame Drosocinderivate
SE0402807D0 (sv) * 2004-11-17 2004-11-17 Dermagen Ab Novel antimicrobial peptides
US8252737B2 (en) 2004-12-15 2012-08-28 The Regents Of The University Of Colorado Antimicrobial peptides and methods of use
JP4972081B2 (ja) * 2005-03-14 2012-07-11 ワイス・エルエルシー チゲサイクリン組成物および調製方法
EP1871910A4 (de) * 2005-04-05 2009-07-29 Scripps Research Inst Zusammensetzungen und verfahren zur verbesserung der wirkstoffempfindlichkeit und behandlung wirkstoffresistenter infektionen und krankheiten
JP5619352B2 (ja) 2005-07-28 2014-11-05 バイオシネクサス インコーポレーティッド 細菌を処置するための組成物および方法
JP2009518399A (ja) * 2005-12-05 2009-05-07 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
PL1962805T3 (pl) 2005-12-08 2017-01-31 Insmed Incorporated Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych
WO2007091958A1 (en) * 2006-02-10 2007-08-16 Dermagen Ab Novel antimicrobial peptides and use thereof
WO2007091959A1 (en) * 2006-02-10 2007-08-16 Dermagen Ab Novel antimicrobial peptides and use thereof
ES2668554T3 (es) * 2006-04-06 2018-05-18 Insmed Incorporated Métodos para la encapsulación liposomal inducida por coacervación y sus formulaciones
AU2007250558B2 (en) * 2006-05-16 2012-10-25 Pergamum Ab Improved antimicrobial peptides
IL176303A0 (en) * 2006-06-14 2006-10-05 Shmuel Shraga Pharmaceutical composition for the treatment of otomycosis
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2008033119A1 (en) * 2006-09-12 2008-03-20 Chaperone Technologies, Inc. Novel combinations of dnak inhibitors with known antibacterial agents
US20080139518A1 (en) * 2006-12-04 2008-06-12 Concert, Llc Topical compositions for treatment of skin conditions
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9114081B2 (en) * 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
WO2008150845A1 (en) * 2007-05-31 2008-12-11 Vanderbilt University Screening for wnt pathway modulators and pyrvinium for the treatment of cance
BRPI0814412A2 (pt) * 2007-07-06 2017-05-23 Laclede Inc uso de enzimas hidrolíticas e oxidativas para dissolver biofilme nas passagens das vias aéreas
DE102007036128A1 (de) * 2007-07-23 2009-02-12 Universität Leipzig Antibiotische Peptide
RU2010114012A (ru) * 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) ПРИМЕНЕНИЕ Tyr-W-Mif-1 И УРОКОРТИНА 2 В КАЧЕСТВЕ ТЕРАПЕВТИЧЕСКИХ СРЕДСТВ
CA2698783A1 (en) * 2007-09-11 2009-03-19 Dorian Bevec Use of a peptide as a therapeutic agent
DE102008031283A1 (de) * 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit von durch Trichomonadida hervorgerufenen Krankheiten
DE102008031284A1 (de) * 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit der Giardiose
US20100008897A1 (en) * 2008-07-09 2010-01-14 Susan Daly Composition for providing a benefit to a keratin-containing substrate
GB0815484D0 (en) * 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
WO2010042534A1 (en) * 2008-10-06 2010-04-15 The Regents Of The University Of Colorado, A Body Corporate Peptides and methods of use
EP2437770A4 (de) * 2009-06-05 2013-11-06 Univ Colorado Regents Antimikrobielle peptide
JP6034188B2 (ja) 2009-06-26 2016-11-30 ライサンド アクツィエンゲゼルシャフト 抗微生物剤
JP6034187B2 (ja) 2009-06-26 2016-11-30 カトリック ユニバーシテイト ルーベン ケイ．ユー． ルーベン アール アンド ディー 抗微生物剤
TW201125577A (en) * 2009-12-02 2011-08-01 Novozymes As Use of defensins for treatment of infective endocarditis
MX2013005413A (es) 2010-11-15 2014-02-27 Univ Ramot Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides.
WO2012097258A2 (en) * 2011-01-15 2012-07-19 The Regents Of The University Of California Formulations for the prevention and treatment of wolbachia-related disease
CN108743537B (zh) 2012-05-21 2021-06-11 英斯麦德公司 治疗肺部感染的系统
AU2013279021C1 (en) 2012-06-19 2017-03-16 Debiopharm International Sa Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
US9096679B2 (en) 2012-12-03 2015-08-04 The Board Of Regents Of The University Of Oklahoma Peptide compounds and methods of production and use thereof
US9603896B2 (en) 2012-12-03 2017-03-28 The Board Of Regents Of The University Of Oklahoma Peptide compounds and methods of production and use thereof
US20200157159A1 (en) 2013-04-16 2020-05-21 The Board Of Regents Of The University Of Oklahoma Peptide compounds and compositions thereof
JP6405365B2 (ja) 2013-04-16 2018-10-17 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ オクラホマ ペプチド化合物及びその製造方法及びその使用
KR102137941B1 (ko) 2013-05-10 2020-07-29 아카데미슈 지켄후이스 라이덴 항균 펩티드
KR101550965B1 (ko) * 2013-07-31 2015-09-07 씨제이제일제당 (주) 초고압을 이용한 야채류 식품의 제조방법
US10751440B2 (en) * 2013-10-14 2020-08-25 University Of Houston System Esculentin 1a derivatives and uses thereof
US10059752B2 (en) * 2013-10-14 2018-08-28 University Of Houston System Esculentin 1a derivatives and uses thereof
EP3065753B1 (de) * 2013-10-31 2019-09-11 Hutchison Biofilm Medical Solutions Limited Verwendung von peptiden bei antibiotikaresistenz
MX2016005614A (es) 2013-11-01 2016-12-09 Spherium Biomed S L Cuerpos de inclusion para el suministro transdermico de agentes terapeuticos y cosmeticos.
ES2755941T3 (es) 2014-05-15 2020-04-24 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas
WO2015188140A1 (en) * 2014-06-06 2015-12-10 The Curators Of The University Of Missouri Enhancement of antibiotic efficacy
KR20170070234A (ko) 2014-10-24 2017-06-21 레드힐 바이오파마 엘티디 단일 가닥 ｒｎａ 바이러스 복제의 억제를 위한 요법
ES2740273T3 (es) * 2015-02-22 2020-02-05 Omnix Medical Ltd Péptidos antimicrobianos
KR101773390B1 (ko) * 2015-05-08 2017-08-31 동아인코팜 주식회사 여드름 개선용 화장료 조성물
SG10201914118SA (en) 2015-09-01 2020-02-27 First Wave Bio Inc Methods and compositions for treating conditions associated with an abnormal inflammatory responses
KR20180114177A (ko) 2016-02-26 2018-10-17 데비오팜 인터네셔날 에스 에이 당뇨병성 족부 감염의 치료제
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
ITUA20163612A1 (it) * 2016-05-19 2017-11-19 Icf Srl Nuovi composti attivi contro microorganismi patogeni
WO2017223098A1 (en) 2016-06-21 2017-12-28 The Curators Of The University Of Missouri Bis-amino acid based compound and use thereof
CN106589135B (zh) * 2016-11-25 2018-08-28 东北农业大学 一种靶向抗菌肽及其制备方法和应用
AU2018213301B2 (en) 2017-01-24 2023-08-17 Flagship Pioneering Innovations V, Inc. Methods and related compositions for manufacturing food and feed
AU2018213306A1 (en) 2017-01-24 2019-07-04 Flagship Pioneering Innovations V, Inc. Compositions and related methods for controlling vector-borne diseases
UA127733C2 (uk) * 2017-01-24 2023-12-20 Флегшіп Пайонірінг Інновейшнз V, Інк. Композиції і відповідні способи для сільського господарства
WO2018140507A1 (en) * 2017-01-24 2018-08-02 Flagship Pioneering, Inc. Compositions and related methods for controlling vector-borne diseases
EP3573447A4 (de) 2017-01-24 2020-07-08 Flagship Pioneering Innovations V, Inc. Zusammensetzungen und zugehörige verfahren für die landwirtschaft
EP3585171A4 (de) 2017-02-24 2020-08-26 Flagship Pioneering Innovations V, Inc. Zusammensetzungen und verwandte verfahren zur modulation von endosymbionten
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
CN108434438B (zh) * 2018-06-22 2020-08-25 安徽科技学院 抗菌肽在制备治疗幽门螺杆菌病的药物中的用途以及药物组合物
US11471433B1 (en) 2019-08-01 2022-10-18 Flagship Pioneering Innovations V, Inc. Postbiotic compositions and related methods for agriculture
US10980756B1 (en) 2020-03-16 2021-04-20 First Wave Bio, Inc. Methods of treatment

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
US5547939A (en) 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5523288A (en) 1993-09-22 1996-06-04 Xoma Corporation Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
DK0754050T3 (da) 1994-01-14 2002-10-21 Xoma Technology Ltd Anti-gram-positive bakterielle fremgangsmåder og materialer
US5574017A (en) * 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US5877274A (en) 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides
CA2230160A1 (en) 1995-08-23 1997-03-06 The University Of British Columbia Antimicrobial cationic peptides and methods of screening for the same
US5994308A (en) 1996-02-28 1999-11-30 Board Of Trustees Of Southern Illinois University Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6180604B1 (en) 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6551994B1 (en) 1997-04-10 2003-04-22 Mcgill University Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
WO1999043357A1 (en) 1998-02-25 1999-09-02 Micrologix Biotech Inc. Indolicidin and cationic peptides conjugated with polymers

Also Published As

Publication number Publication date
EP0966481A2 (de) 1999-12-29
ATE333464T1 (de) 2006-08-15
WO1998040401A3 (en) 1998-12-17
US20020035061A1 (en) 2002-03-21
US20110150780A1 (en) 2011-06-23
ES2264198T3 (es) 2006-12-16
JP2002544759A (ja) 2002-12-24
HK1025103A1 (en) 2000-11-03
CA2282807A1 (en) 1998-09-17
AU6604798A (en) 1998-09-29
US20030232750A1 (en) 2003-12-18
DE69835279T2 (de) 2007-07-12
WO1998040401A2 (en) 1998-09-17
US7309759B2 (en) 2007-12-18
US6503881B2 (en) 2003-01-07
EP0966481B1 (de) 2006-07-19

Similar Documents

Publication Publication Date Title
DE69835279D1 (de) Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika
ATE218579T1 (de) Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin- analogen
DE69731373D1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
MX9703643A (es) Metodos para tratamiento de esclerosis multiple usando analogos de peptidos de proteina basica de mielina humana.
ATE393831T1 (de) Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
GR3019901T3 (en) Osteoinductive pharmaceutical formulations
DE69531741D1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
DE69922819D1 (de) Methode zur prävention und behandlung von dehnungsstreifen (striae distensae) und deren verwendung in dermatologie
DK0429570T3 (da) Osteoinducerende præparater
DE69703689T2 (de) Therapeutische anwendungen von bpi-protein-produkten zur behandlung von humaner meningococcämia
AU6020099A (en) Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
ES2170239T3 (es) Peptidos antifungicos de d-aminoacidos basados en histatina.
WO1996028470A3 (en) Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
ATE494301T1 (de) Alpha-fetoprotein-peptide und ihre verwendung
DE69837265D1 (de) Polypeptide zur regenerierung des nervensystems
EP1174439A3 (de) Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen
ATE251462T1 (de) Verfahren zur behandlung von narbengewebe
BG103905A (en) New bpc peptide salts with organoprotective activity, method for their preparation and application in medicine
DE60234843D1 (de) Modifizierte peptide und deren verwendung zur behandlung von autoimmunkrankheiten
DE69534738D1 (de) Leukocyten-aktivierender Faktor
GB9723824D0 (en) Cytostatic agents
MX9604539A (es) Aminoacidos modificados para la distribucion de farmaco.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee