ATE333464T1 - Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika - Google Patents

Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika

Info

Publication number
ATE333464T1
ATE333464T1 AT98907779T AT98907779T ATE333464T1 AT E333464 T1 ATE333464 T1 AT E333464T1 AT 98907779 T AT98907779 T AT 98907779T AT 98907779 T AT98907779 T AT 98907779T AT E333464 T1 ATE333464 T1 AT E333464T1
Authority
AT
Austria
Prior art keywords
compositions
methods
antibiotics
combination
treating infections
Prior art date
Application number
AT98907779T
Other languages
English (en)
Inventor
Janet R Fraser
Michael H P West
Patricia J Mcnicol
Original Assignee
Migenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/915,314 external-priority patent/US6180604B1/en
Application filed by Migenix Inc filed Critical Migenix Inc
Application granted granted Critical
Publication of ATE333464T1 publication Critical patent/ATE333464T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AT98907779T 1997-03-10 1998-03-10 Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika ATE333464T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4064997P 1997-03-10 1997-03-10
US08/915,314 US6180604B1 (en) 1996-08-21 1997-08-20 Compositions and methods for treating infections using analogues of indolicidin
US6009997P 1997-09-26 1997-09-26
US09/030,619 US6503881B2 (en) 1996-08-21 1998-02-25 Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics

Publications (1)

Publication Number Publication Date
ATE333464T1 true ATE333464T1 (de) 2006-08-15

Family

ID=27487830

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98907779T ATE333464T1 (de) 1997-03-10 1998-03-10 Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika

Country Status (10)

Country Link
US (3) US6503881B2 (de)
EP (1) EP0966481B1 (de)
JP (1) JP2002544759A (de)
AT (1) ATE333464T1 (de)
AU (1) AU6604798A (de)
CA (1) CA2282807A1 (de)
DE (1) DE69835279T2 (de)
ES (1) ES2264198T3 (de)
HK (1) HK1025103A1 (de)
WO (1) WO1998040401A2 (de)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6172185B1 (en) 1998-05-20 2001-01-09 University Of British Columbia Antimicrobial cationic peptide derivatives of bactenecin
US8283315B2 (en) 1998-08-28 2012-10-09 Lytix Biopharma As Inhibition of tumour growth
GB9818938D0 (en) 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
US6288212B1 (en) * 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
JP2002530274A (ja) * 1998-10-30 2002-09-17 インターリンク・バイオテクノロジーズ・リミテッド・ライアビリティ・カンパニー プロテアーゼ分解に対する安定性の高いペプチド
US6946261B1 (en) 1998-11-20 2005-09-20 Migenix Inc. Efficient methods for producing anti-microbial cationic peptides in host cells
US6509177B1 (en) * 1999-02-03 2003-01-21 Biogal Gyogyszergyar Rt. Process for the preparation of pseudomonic acid A antibiotic by microbiological method
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US20030008369A1 (en) * 1999-03-03 2003-01-09 Board Of Regents, The University Of Texas System Genetic and epigenetic manipulation of ABC transporters and ecto-phosphatases
US6835868B1 (en) 1999-03-17 2004-12-28 University Of Victoria Innovation And Development Corporation Transgenic plants expressing dermaseptin peptides providing broad spectrum resistance to pathogens
JP2002538828A (ja) * 1999-03-17 2002-11-19 ユニバーシティ オブ ビクトリア イノベーション アンド ディベロップメント コーポレーション 広域性病原体に耐性を有するトランスジェニック植物
DE60026513T2 (de) * 1999-05-27 2006-10-05 Biocompatibles Uk Ltd., Farnham Lokale arzneistoffabgabe
US7015309B1 (en) 1999-06-23 2006-03-21 The Wistar Institute Of Anatomy And Biology Pyrrhocoricin-derived peptides, and methods of use thereof
JP4803935B2 (ja) * 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
WO2001045732A2 (en) * 1999-12-20 2001-06-28 Sa Majesté La Reine Du Chef Du Canada Agriculture Et Agroalimentaire Canada Method and composition for treatment and/or prevention of antibiotic-resistant microorganism infections
AU2795801A (en) * 2000-01-21 2001-07-31 Creighton University Biocidal molecules, macromolecular targets and methods of production and use
US8003595B2 (en) 2000-03-01 2011-08-23 Cellectis Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
US6632616B2 (en) * 2000-03-16 2003-10-14 Duke University Compounds that selectively bind to expanded polyglutamine repeat domains and methods of use thereof
US6777592B2 (en) * 2000-04-14 2004-08-17 E.I. Du Pont Denemours And Company Arthropod defensins of Scolopendra canidens, Vaejovis carolinianus, and Argiope spp.
DE10030781A1 (de) * 2000-06-29 2002-01-17 Hassan Jomaa Kombinationspräparate von 3-N-Formylhydroxylaminopropylphosphonsäurederivaten oder 3-N-Acetylhydroxylaminopropylphosphonsäurederivaten mit spezielen pharmazeutischen Wirkstoffen
DE10042853A1 (de) * 2000-08-30 2002-04-25 Florian Lang Nachweis und Beeinflußung der Expression oder Funktion von CD95/CD95L bei Infektionen
JP2004521935A (ja) * 2001-01-05 2004-07-22 ケミン、インダストリーズ、インコーポレーテッド 両生類の皮膚から単離した細菌由来の抗生物質
EP1357954A1 (de) * 2001-02-09 2003-11-05 Johnson & Johnson Vision Care, Inc. Biomedizinisches gerät mit antimikrobiellen kationischen peptidbeschichtungen
EP1560584B1 (de) * 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab-i-inhibitoren
TR200403211T3 (tr) * 2001-06-21 2005-02-21 Biogal Gyogyszergyar Rt Psödomonik asit üretimi için metabolik olarak kontrol edilen fermantasyon işlemi.
JP2004534084A (ja) * 2001-06-22 2004-11-11 ザ ホスピタル フォー シック チルドレン 抗菌ペプチド
US6835536B2 (en) * 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
CA2457885A1 (en) * 2001-08-24 2003-03-06 Micrologix Biotech Inc. Antimicrobial and anti-inflammatory peptides
KR100438416B1 (ko) * 2001-09-19 2004-07-02 학교법인조선대학교 Ｃａ－ｍａ 펩타이드의 아미노산 중 하나 또는 그 이상을치환하여 ＋ 전극과 소수성 영역이 증가된 신규한펩타이드 및 그를 포함하는 약학적 조성물
ES2387781T3 (es) * 2001-10-05 2012-10-01 Steris Inc. Procedimiento de evaluación in vitro para tratamientos priocidaces (anti-priones)
US7507787B2 (en) * 2001-12-03 2009-03-24 The University Of British Columbia Effectors of innate immunity
EP1455769A4 (de) 2001-12-28 2004-09-22 Biogal Gyogyszergyar Verfahren zur herstellung von kristallinem und amorphem mupirocin-calcium
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US20030219854A1 (en) * 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
CN1642540A (zh) * 2002-03-26 2005-07-20 东弗吉尼亚医学院 作为局部杀微生物药和避孕药的苏拉明及其衍生物
US7607436B2 (en) * 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
FR2839311A1 (fr) * 2002-05-06 2003-11-07 Entomed Peptides antibacteriens, genes codant les peptides, vecteurs, organismes transformes, leurs preparations et les compositions les contenant
EP1360961A1 (de) * 2002-05-07 2003-11-12 AM-Pharma B.V. Verwendung von antimikrobiell wirkenden Peptiden zur Aktivitätssteigerung von antimikrobiellen Wirkstoffen
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
EP2823820B1 (de) * 2002-10-29 2018-06-06 Insmed Incorporated Aminoglycosid enthaltende Liposome zur Behandlung von pulmonaren Infektionen
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
DK1575951T3 (da) * 2002-12-06 2014-09-15 Debiopharm Int Sa Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
CA2508796A1 (en) * 2002-12-10 2004-06-24 Biosynexus Incorporated Topical anti-infective formulations
DE10260537A1 (de) * 2002-12-21 2004-07-15 Kerek, Franz, Dr. Peptide mit hohem Cysteingehalt
JP4880448B2 (ja) * 2003-03-17 2012-02-22 アフィナム ファーマシューティカルズ，インコーポレーテッド 複数の抗生物質を含む組成物、及びそれを用いる方法
US6900184B2 (en) 2003-04-14 2005-05-31 Wyeth Holdings Corporation Compositions containing pipercillin and tazobactam useful for injection
ATE381947T1 (de) * 2003-04-14 2008-01-15 Wyeth Corp Zusammensetzungen enthaltend piperacillin und tazobactam zur injektion
AU2003230899A1 (en) * 2003-04-14 2004-11-26 Wyeth Holdings Corporation Compositions containing piperacillin and tazobactam useful for injection
US6989370B2 (en) * 2003-05-01 2006-01-24 The United States Of America As Represented By The Secretary Of Agriculture Bacteriocins and novel bacterial strains
SE0301431D0 (sv) 2003-05-19 2003-05-19 Dermagen Novel antimicrobial peptides
US7220422B2 (en) * 2003-05-20 2007-05-22 Allergan, Inc. Methods and compositions for treating eye disorders
KR101215821B1 (ko) 2003-06-30 2012-12-28 텔 아비브 유니버시티 퓨쳐 테크놀로지 디벨롭먼트 엘.피. 아밀로이드 관련 질환을 진단 및 처치하기 위한 펩타이드, 그것에 대한 항체, 및 그 사용방법
US20060121083A1 (en) * 2003-07-18 2006-06-08 Technion Research & Development Foundation Ltd. Anti-microbial medical implants and uses thereof
AU2003904225A0 (en) * 2003-08-08 2003-08-21 Ripetech Pty Limited Method for reducing precure during the curing of thermosetting resins
FR2858772A1 (fr) * 2003-08-14 2005-02-18 Diatos Composition anti bacterienne, plus particulierement contre les bacteries gram negatif, comprenant un peptide et un agent anti-bacterien avantageusement hydrophobe
WO2005016960A2 (en) * 2003-08-14 2005-02-24 Diatos Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
US20050108047A1 (en) * 2003-11-19 2005-05-19 Vvii Newco 2003, Inc. Business methods for commercializing antibiotics
US7455840B2 (en) * 2003-11-19 2008-11-25 The Scripps Research Institute Compositions and methods to reduce mutagenesis
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
WO2005089738A2 (en) * 2004-03-17 2005-09-29 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
US20050282755A1 (en) * 2004-03-18 2005-12-22 Ansata Therapeutics, Inc. Compositions having antimicrobial activity and uses thereof
DK1641438T3 (da) * 2004-06-01 2010-06-07 Teva Gyogyszergyar Zartkoeruen Fremgangsmåde til fremstilling af den amorfe form af et lægemiddel
WO2007053131A2 (en) 2004-06-04 2007-05-10 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as antibiotic agents
US20090156471A1 (en) * 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
SG10201606278UA (en) * 2004-08-18 2016-09-29 Novabiotics Ltd Peptide
US7700308B2 (en) * 2004-09-16 2010-04-20 University Of Washington Methods for determining susceptibility to dental caries
WO2006049580A1 (en) * 2004-11-04 2006-05-11 National University Of Singapore Anticoagulant peptides
EP1657249A1 (de) * 2004-11-10 2006-05-17 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Antibiotisch wirksame Drosocinderivate
SE0402807D0 (sv) * 2004-11-17 2004-11-17 Dermagen Ab Novel antimicrobial peptides
CN101111256B (zh) 2004-12-15 2012-04-25 科罗拉多大学 抗菌肽及其使用方法
PL1858488T5 (pl) * 2005-03-14 2024-01-03 Wyeth Llc Kompozycje tygecykliny i sposoby wytwarzania
US20060286574A1 (en) * 2005-04-05 2006-12-21 The Scripps Research Institute & Achaogen, Inc. Compositions and methods for enhancing drug sensitivity and treating drug resistant infections and diseases
US7517852B2 (en) 2005-07-28 2009-04-14 Biosynexus Incorporated Compositions and methods for treating bacteria
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
AU2006322076C1 (en) 2005-12-08 2013-11-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
CA2637221A1 (en) * 2006-02-10 2007-08-16 Dermagen Ab Novel antimicrobial peptides and use thereof
JP2009526045A (ja) * 2006-02-10 2009-07-16 デルマゲン アクティエボラーグ 新規抗菌ペプチド及びその使用
EP2012750B1 (de) * 2006-04-06 2018-02-21 Insmed Incorporated Verfahren für koazervationsinduzierte liposomale verkapselung und formulierungen daraus
CA2651990C (en) * 2006-05-16 2014-12-23 Dermagen Ab Improved antimicrobial peptides
IL176303A0 (en) * 2006-06-14 2006-10-05 Shmuel Shraga Pharmaceutical composition for the treatment of otomycosis
CA2658506C (en) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
WO2008033119A1 (en) * 2006-09-12 2008-03-20 Chaperone Technologies, Inc. Novel combinations of dnak inhibitors with known antibacterial agents
WO2008070116A2 (en) * 2006-12-04 2008-06-12 Concert, Llc Topical compositions for treatment of skin conditions
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) * 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
WO2008150845A1 (en) * 2007-05-31 2008-12-11 Vanderbilt University Screening for wnt pathway modulators and pyrvinium for the treatment of cance
JP5702601B2 (ja) * 2007-07-06 2015-04-15 ラクレード，インコーポレーテッド 気道中の生物膜を溶解するための加水分解酵素および酸化酵素の使用
DE102007036128A1 (de) * 2007-07-23 2009-02-12 Universität Leipzig Antibiotische Peptide
RU2010114018A (ru) * 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) Применение пептид тимозина бета 4 индивидуально или в сочетании с цекропином а в качестве терапевтического средства
WO2009033661A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
DE102008031283A1 (de) * 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit von durch Trichomonadida hervorgerufenen Krankheiten
DE102008031284A1 (de) * 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit der Giardiose
US20100008897A1 (en) * 2008-07-09 2010-01-14 Susan Daly Composition for providing a benefit to a keratin-containing substrate
GB0815484D0 (en) * 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
CA2739842A1 (en) * 2008-10-06 2010-04-15 The Regents Of The University Of Colorado, A Body Corporate Antimicrobial peptides and methods of use
EP2437770A4 (de) * 2009-06-05 2013-11-06 Univ Colorado Regents Antimikrobielle peptide
EA037202B1 (ru) 2009-06-26 2021-02-18 Катхолике Университейт Лёвен, К.У. Лёвен Р Энд Д Слитые белки для лечения инфекций, вызванных грамотрицательными бактериями
WO2010149795A1 (en) 2009-06-26 2010-12-29 Lysando Holding Establishment Antimicrobial agents
TW201125577A (en) * 2009-12-02 2011-08-01 Novozymes As Use of defensins for treatment of infective endocarditis
WO2012066549A1 (en) 2010-11-15 2012-05-24 Ramot At Tel-Aviv University Ltd. Dipeptide analogs for treating conditions associated with amyloid fibril formation
US20130345249A1 (en) * 2011-01-15 2013-12-26 The Regents Of The University Of California Formulations for the prevention and treatment of Wolbachia-related disease
KR102092361B1 (ko) 2012-05-21 2020-03-23 인스메드 인코포레이티드 폐 감염을 치료하기 위한 시스템
KR101720885B1 (ko) 2012-06-19 2017-03-28 데비오팜 인터네셔날 에스 에이 (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
MX2015006681A (es) 2012-11-29 2016-04-06 Insmed Inc Formulaciones de vancomicina estabilizadas.
US9096679B2 (en) 2012-12-03 2015-08-04 The Board Of Regents Of The University Of Oklahoma Peptide compounds and methods of production and use thereof
AU2013355391B2 (en) * 2012-12-03 2017-08-03 The Board Of Regents Of The University Of Oklahoma Peptide compounds and methods of production and use thereof
DK2986309T3 (en) 2013-04-16 2018-05-07 Univ Oklahoma PEPTIME RELATIONS AND PROCEDURES FOR PREPARING AND USING THEREOF
US20200157159A1 (en) 2013-04-16 2020-05-21 The Board Of Regents Of The University Of Oklahoma Peptide compounds and compositions thereof
EP2994154B1 (de) 2013-05-10 2020-02-26 Academisch Ziekenhuis Leiden h.o.d.n. LUMC Antimikrobielles peptid
KR101550965B1 (ko) * 2013-07-31 2015-09-07 씨제이제일제당 (주) 초고압을 이용한 야채류 식품의 제조방법
US10751440B2 (en) * 2013-10-14 2020-08-25 University Of Houston System Esculentin 1a derivatives and uses thereof
US10059752B2 (en) * 2013-10-14 2018-08-28 University Of Houston System Esculentin 1a derivatives and uses thereof
ES2757563T3 (es) * 2013-10-31 2020-04-29 Hutchison Biofilm Medical Solutions Ltd Uso de péptidos en resistencia a antibióticos
WO2015063613A2 (en) 2013-11-01 2015-05-07 Spherium Biomed S.L. Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
ES2981634T3 (es) 2014-05-15 2024-10-09 Insmed Incorporated Métodos para tratar infecciones micobacterianas pulmonares no tuberculosas
WO2015188140A1 (en) * 2014-06-06 2015-12-10 The Curators Of The University Of Missouri Enhancement of antibiotic efficacy
EP4134076A1 (de) * 2014-10-24 2023-02-15 Redhill Biopharma Ltd. Therapie zur hemmung der replikation eines einzelsträngigen rna-virus
CA2975971C (en) * 2015-02-22 2024-06-11 Omnix Medical Ltd. Antimicrobial peptides
KR101773390B1 (ko) * 2015-05-08 2017-08-31 동아인코팜 주식회사 여드름 개선용 화장료 조성물
CN109562137A (zh) 2015-09-01 2019-04-02 第波生物公司 用于治疗与异常炎性反应有关的病况的方法和组合物
LT3419628T (lt) 2016-02-26 2021-01-25 Debiopharm International Sa Medikamentas diabetinėms pėdų infekcijoms gydyti
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
ITUA20163612A1 (it) 2016-05-19 2017-11-19 Icf Srl Nuovi composti attivi contro microorganismi patogeni
WO2017223098A1 (en) 2016-06-21 2017-12-28 The Curators Of The University Of Missouri Bis-amino acid based compound and use thereof
CN106589135B (zh) * 2016-11-25 2018-08-28 东北农业大学 一种靶向抗菌肽及其制备方法和应用
AU2018213284B2 (en) 2017-01-24 2024-03-28 Flagship Pioneering Innovations V, Inc. Compositions and related methods for agriculture
BR112019014931A2 (pt) * 2017-01-24 2020-03-31 Flagship Pioneering Innovations V, Inc. Composições e métodos relacionados para agricul-tura
BR112019014929B1 (pt) 2017-01-24 2023-03-07 Flagship Pioneering Innovations V, Inc Método para aumentar o perfil nutricional de um inseto e usos de bactérias
CN110869038A (zh) 2017-01-24 2020-03-06 旗舰创业创新五公司 用于控制媒介传播的疾病的组合物和相关方法
US20190365853A1 (en) * 2017-01-24 2019-12-05 Flagship Pioneering Innovations V, Inc. Compositions and related methods for controlling vector-borne diseases
CA3048497A1 (en) 2017-02-24 2018-08-30 Flagship Pioneering Innovations V, Inc. Compositions and related methods for modulating endosymbionts
EP3773505A4 (de) 2018-03-30 2021-12-22 Insmed Incorporated Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten
CN108434438B (zh) * 2018-06-22 2020-08-25 安徽科技学院 抗菌肽在制备治疗幽门螺杆菌病的药物中的用途以及药物组合物
US11471433B1 (en) 2019-08-01 2022-10-18 Flagship Pioneering Innovations V, Inc. Postbiotic compositions and related methods for agriculture
US10980756B1 (en) 2020-03-16 2021-04-20 First Wave Bio, Inc. Methods of treatment

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
US5547939A (en) 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
NZ275205A (en) 1993-09-22 1998-03-25 Xoma Corp Use of bactericidal/permeability-increasing protein in treating gram-negative bacterial infection
ES2179095T3 (es) 1994-01-14 2003-01-16 Xoma Technology Ltd Metodos y materiales anti bacterias gram positivas.
US5574017A (en) * 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US5877274A (en) 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides
JP3860838B2 (ja) * 1995-08-23 2006-12-20 ユニバーシティー オブ ブリティッシュ コロンビア 抗微生物性陽イオン性ペプチドおよびそのスクリーニング方法
US5994308A (en) 1996-02-28 1999-11-30 Board Of Trustees Of Southern Illinois University Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6180604B1 (en) 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6551994B1 (en) 1997-04-10 2003-04-22 Mcgill University Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
AU2605099A (en) 1998-02-25 1999-09-15 Micrologix Biotech, Inc. Indolicidin and cationic peptides conjugated with polymers

Also Published As

Publication number Publication date
EP0966481B1 (de) 2006-07-19
CA2282807A1 (en) 1998-09-17
US7309759B2 (en) 2007-12-18
WO1998040401A3 (en) 1998-12-17
HK1025103A1 (en) 2000-11-03
DE69835279D1 (de) 2006-08-31
JP2002544759A (ja) 2002-12-24
WO1998040401A2 (en) 1998-09-17
US6503881B2 (en) 2003-01-07
US20110150780A1 (en) 2011-06-23
ES2264198T3 (es) 2006-12-16
AU6604798A (en) 1998-09-29
US20020035061A1 (en) 2002-03-21
DE69835279T2 (de) 2007-07-12
EP0966481A2 (de) 1999-12-29
US20030232750A1 (en) 2003-12-18

Similar Documents

Publication Publication Date Title
ATE333464T1 (de) Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika
ATE218579T1 (de) Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin- analogen
DE69731373D1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
DE69732871D1 (de) Basisches Protein Zusammensetzung, basisches Peptid Zusammensetzung und deren Verwendung
MX9705954A (es) Formulaciones y metodos para reducir irritacion de la piel.
DE69435096D1 (de) Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
DE69531741D1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
DK0661989T3 (da) Proteinsammensætninger med vedvarende frigivelse
WO1993023434A3 (en) Bpi-immunoglobulin fusion proteins
GR3019901T3 (en) Osteoinductive pharmaceutical formulations
ATE338771T1 (de) Antagonisten des intestinotrophen glp-2 peptides
AU6020099A (en) Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
WO1996028470A3 (en) Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
GR3024379T3 (en) Peptides with organo-protective activity, the process for preparing them and their use in therapy
CA2131565A1 (en) Organopolysiloxanes Containing Hydrophilic Groups
ATE408685T1 (de) Antimikrobielle peptide, abstammend von ubiquicidin
TR199901190T2 (xx) Interferon-(alfa) N�kleik asitlerinin verilmesi ve sentezlenmesi i�in y�ntemler ve bile�imler.
EP1174439A3 (de) Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen
AU8811298A (en) Novel peptides and polypeptides useful for regenerating the nervous system
BG103905A (en) New bpc peptide salts with organoprotective activity, method for their preparation and application in medicine
HK1047228A1 (en) Endoparasiticidal agents
DE69534738D1 (de) Leukocyten-aktivierender Faktor
DE69434914D1 (de) Verfahren und zusammensetzungen zur herstellung von rekombinantem osteogenischem protein
ITMI912837A0 (it) Procedimento per preparare prodotti peptidici e/o proteinici arricchiti con amminoacidi legati in modo covalente
GB9723824D0 (en) Cytostatic agents

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties