HRP20200599T1 - Antimikrobijalni peptid - Google Patents
Antimikrobijalni peptid Download PDFInfo
- Publication number
- HRP20200599T1 HRP20200599T1 HRP20200599TT HRP20200599T HRP20200599T1 HR P20200599 T1 HRP20200599 T1 HR P20200599T1 HR P20200599T T HRP20200599T T HR P20200599TT HR P20200599 T HRP20200599 T HR P20200599T HR P20200599 T1 HRP20200599 T1 HR P20200599T1
- Authority
- HR
- Croatia
- Prior art keywords
- amino acid
- substitution
- group
- polypeptide
- amino acids
- Prior art date
Links
- 108700042778 Antimicrobial Peptides Proteins 0.000 title 1
- 102000044503 Antimicrobial Peptides Human genes 0.000 title 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 claims 92
- 235000001014 amino acid Nutrition 0.000 claims 80
- 229940024606 amino acid Drugs 0.000 claims 52
- 238000006467 substitution reaction Methods 0.000 claims 44
- 229920001184 polypeptide Polymers 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 21
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- -1 acetyl- Chemical group 0.000 claims 4
- 230000000844 anti-bacterial effect Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N N-methylaminoacetic acid Natural products C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 3
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- RDFMDVXONNIGBC-UHFFFAOYSA-N 2-aminoheptanoic acid Chemical compound CCCCCC(N)C(O)=O RDFMDVXONNIGBC-UHFFFAOYSA-N 0.000 claims 2
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- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
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- KTKVMAROVGNKSB-MWBUKTMBSA-N (2S)-2-amino-3-(4-bromophenyl)propanoic acid (2S)-2-(1-benzothiophen-3-ylamino)propanoic acid Chemical compound N[C@@H](Cc1ccc(Br)cc1)C(O)=O.C[C@H](Nc1csc2ccccc12)C(O)=O KTKVMAROVGNKSB-MWBUKTMBSA-N 0.000 claims 1
- WNNNWFKQCKFSDK-SCSAIBSYSA-N (2r)-2-azaniumylpent-4-enoate Chemical compound [O-]C(=O)[C@H]([NH3+])CC=C WNNNWFKQCKFSDK-SCSAIBSYSA-N 0.000 claims 1
- BAPRUDZDYCKSOQ-GDVGLLTNSA-N (2s)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound CC(=O)N1CC(O)C[C@H]1C(O)=O BAPRUDZDYCKSOQ-GDVGLLTNSA-N 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/04—Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Claims (15)
1. Izolirani ili rekombinantni polipeptid koji sadrži do 200 aminokiselina u dužini i sadrži aminokiselinsku sekvencu LAREYKKIVEKLKRWLRQVLRTLR ili varijantu navedene aminokiselinske sekvence, pri čemu, navedeni polipeptid ima antibakterijsku aktivnost, navedena varijanta ima najmanje 16 aminokiselina i:
- ima najviše do 5 od sljedećih aminokiselinskih supstitucija:
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine L, I, V ili A, drugom aminokiselinom odabranom iz navedene grupe;
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine R, K ili H, drugom aminokiselinom odabranom iz navedene grupe;
• supstituciju E sa Q
• supstituciju Y ili W sa F
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine Q, N, A, S ili T, drugom aminokiselinom odabranom iz navedene grupe
- ima jednu ili više supstitucija aminokiseline odgovarajućom D-aminokiselinom,
- ima najviše do 5 supstitucija aminokiseline odgovarajućom aminokiselinom koja se ne nalazi u prirodi, pri čemu je navedena odgovarajuća aminokiselina koja se ne nalazi u prirodi:
- odgovarajuća β-aminokiselina;
- t-butilalanin, 2-naftilalanin; L-3-(2-naftil)alanin ili 2-aminoizouljna kiselina, kada je prirodna aminokiselina alanin;
- homoarginin, ornitin, N5-karbamoilornitin ili 3-amino-propionska kiselina, kada je prirodna aminokiselina arginin;
- N-etilasparagin, kada je prirodna aminokiselina asparagin;
- 4-terc-butil vodik 2-azidosukcinat, kada je prirodna aminokiselina asparaginska kiselina.
- cisteinska kiselina ili homocistein, kada je prirodna aminokiselina cistein;
- γ-karboksi-DL-glutaminska kiselina ili 4-fluoro-DL-glutaminska kiselina, kada je prirodna aminokiselina glutaminska kiselina;
- D-citrulin ili tio-L-citrulin, kada je prirodna aminokiselina glutamin;
- N- metilglicin, t-butilglicin, N-metilglicin ili D-alilglicin, kada je prirodna aminokiselina glicin;
- 3-(3-metil-4-nitrobenzil)-L-histidin metil estar, kada je prirodna aminokiselina histidin;
- izodezmozin, N-metilizoleucin ili alo-izoleucin kada je prirodna aminokiselina izoleucin;
- norleucin, dezmozin ili 5,5,5-trifluoro-leucin, kada je prirodna aminokiselina leucin;
- 6-N-metilizin, 2-aminoheptanska kiselin, N-acetillizin, hidroksilizin ili alo-hidroksilizin, kada je prirodna aminokiselina lizin;
- metionin sulfoksid kada je prirodna aminokiselina metionin;
- p-amino-L-fenilalanin, 3-benzotienilalanin p-bromofenilalanin, p-acil-L-fenilalanin, 2-fluorofenilalanin, 3-fluorofenilalanin ili 4-fluorofenilalanin, kada je prirodna aminokiselina fenilalanin;
- 3-hidroksiprolin, 4-hidroksiprolin ili 1-acetil-4-hidroksi-L-prolin, kada je prirodna aminokiselina prolin;
- homoserin, izoserin ili 3-fenilserin, kada je prirodna aminokiselina serin;
- D-tiroksin ili alo-treonin, kada je prirodna aminokiselina treonin;
- 5-hidroksi-triptofan, 5-metoksi-triptofan ili 5-fluoro-triptofan, kada je prirodna aminokiselina triptofan.
- O-metil-L-tirozin, O-4-alil-L-tirozin ili 3-hloro-tirozin, kada je prirodna aminokiselina tirozin; ili
- norvalin, N-metilvalin ili 3-fluoro-valin kada je prirodna aminokiselina valin; i/ili
- ima retro-inverznu sekvencu od najmanje 16 konsekutivnih aminokiselina iz navedene aminokiselinske sekvence.
2. Izolirani ili rekombinantni polipeptid koji sadrži do 200 aminokiselina u dužini i sadrži aminokiselinsku sekvencu LAREYKKIVEKLKRWLRQVLRTLR, ili varijantu navedene aminokiselinske sekvence, pri čemu navedeni polipeptid ima antibakterijsku aktivnost, navedena varijanata ima najmanje 16 aminokiselina i najviše do 5 od sljedećih aminokiselinskih supstitucija:
- supstituciju L na aminokiselinskoj poziciji 1 sa I, V ili A
- supstituciju A na aminokiselinskoj poziciji 2 sa L, V, Q ili I
- supstituciju R na aminokiselinskoj poziciji 3 sa K ili H
- supstituciju E na aminokiselinskoj poziciji 4 sa Q
- supstituciju Y na aminokiselinskoj poziciji 5 sa F ili W
- supstituciju K na aminokiselinskoj poziciji 6 sa R ili H
- supstituciju K na aminokiselinskoj poziciji 7 sa R ili H
- supstituciju I na aminokiselinskoj poziciji 8 sa L, V ili A
- supstituciju V na aminokiselinskoj poziciji 9 sa L, I ili A
- supstituciju E na aminokiselinskoj poziciji 10 sa Q
- supstituciju K na aminokiselinskoj poziciji 11 sa R ili H
- supstituciju L na aminokiselinskoj poziciji 12 sa I, V ili A
- supstituciju K na aminokiselinskoj poziciji 13 sa R ili H
- supstituciju R na aminokiselinskoj poziciji 14 sa K ili H
- supstituciju W na aminokiselinskoj poziciji 15 sa F ili Y
- supstituciju R na aminokiselinskoj poziciji 17 sa H ili K
- supstituciju Q na aminokiselinskoj poziciji 18 sa N, A, S ili T
- supstituciju V na aminokiselinskoj poziciji 19 sa L, I ili A
- supstituciju L na aminokiselinskoj poziciji 20 sa I, V ili A
- supstituciju R na aminokiselinskoj poziciji 21 sa K ili H
- supstituciju T na aminokiselinskoj poziciji 22 sa Q, N ili A
- supstituciju R na aminokiselinskoj poziciji 24 sa H ili K.
3. Polipeptid prema patentnom zahtjevu 1, naznačen time što je navedeni polipeptid N-terminalno i/ili C-terminalno modificiran, poželjno sadrži N-terminalni acetil-, heksanoil-, dekanoil-, miristoil-, NH-(CH2-CH2-O)11-CO- ili propionil-ostatak i/ili sadrži C-terminalni amid-, NH-(CH2-CH2-O)11-CO-amid-, ili jednu ili dvije amino-heksanoil grupe.
4. Polipeptid prema patentnom zahtjevu 1 ili 3, naznačen time što navedena varijanta sadrži najmanje jednu aminokiselinsku sekvencu YKKIVEKLKRWLRQVL koja ima najviše do 5 od aminokiselinskih supstitucija definiranih u patentnom zahtjevu 1.
5. Molekulu nukleinske kiseline koji sadrži sekvencu nukleinske kiseline koja kodira polipeptid prema patentnom zahtjevu 2 ili polipeptid koji sadrži najviše do 200 aminokiselina u dužini i sadrži aminokiselinsku sekvencu LAREYKKIVEKLKRWLRQVLRTLR ili varijantu navedene aminokiselinske sekvence, pri čemu navedeni polipeptid ima antibakterijsku aktivnost,
navedena varijanta ima najmanje 16 aminokiselina i:
- ima najviše do 5 od sljedećih aminokiselinskih supstitucija:
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine L, I, V ili A, drugom aminokiselinom odabranom iz navedene grupe;
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine R, K ili H, drugom aminokiselinom odabranom iz navedene grupe;
• supstituciju E sa Q
• supstituciju Y ili W sa F
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine Q, N, A, S ili T, drugom aminokiselinom odabranom iz navedene grupe i/ili
- ima retro-inverznu sekvencu od najmanje 16 konsekutivnih aminokiselina iz navedene aminokiselinske sekvence.
6. Vektor koji sadrži molekulu nukleinske kiseline prema patentnom zahtjevu 5.
7. Rekombinantna stanica domaćin koja sadrži molekulu nukleinske kiseline prema patentnom zahtjevu 5 i/ili vektor prema patentnom zahtjevu 6.
8. Farmaceutska kompozicija koja sadrži polipeptid prema bilo kojem od patentnih zahtjeva 1-4 ili njegovu farmaceutski prihvatljivu sol, molekulu nukleinske kiseline prema patentnom zahtjevu 5 i/ili vektor prema patentnom zahtjevu 6 i najmanje jedan farmaceutski prihvatljiv nosač, razblaživač i/ili ekscipijens.
9. Farmaceutska kompozicija prema patentnom zahtjevu 8 koja je formulirana za topikalnu primjenu, kao što je krema, gel, mast, losion, pjena, suspenzija, sprej, aerosol, praškasti aerosol.
10. Farmaceutska kompozicija prema patentnom zahtjevu 8 ili 9, koja dalje sadrži dodatno antimikrobijalno sredstvo, poželjno odabrano iz grupe koja se sastoji od penicilina, cefalosporina, mupirocina, karbapenema.
11. Farmaceutska kompozicija prema bilo kom od patentnih zahtjeva 8-10 koja sadrži nosač za kontrolirano oslobađanje i/ili ciljanu dostavu, koji sadrži navedeni polipeptid, pri čemu je navedeni nosač poželjno odabran iz grupe koja se sastoji od nanočestica, mikročestica, nanokapsula, mikrokapsula, lipozoma, mikrosfera, hidrogelova, polimera, lipidnih kompleksa, serumskog albumina, antitela, ciklodekstrina i dekstrana.
12. Obloga za medicinsko sredstvo koja sadrži polipeptid prema bilo kojem od patentnih zahtjeva 1-4.
13. Polipeptid prema bilo kojem od patentnih zahtjeva 1-4 i/ili molekula nukleinske kiseline prema patentnom zahtjevu 5 za uporabu kao terapeutsko, profilaktičko ili dijagnostičko sredstvo.
14. Polipeptid i/ili molekula nukleinske kiseline za uporabu prema patentnom zahtjevu 13 u liječenju bakterijske infekcije i/ili u liječenju stanja nastalog uslijed bakterijske infekcije.
15. Postupak za pripremu polipeptida
prema patentnom zahtjevu 2 ili polipeptida koji sadrži najviše 200 aminokiselina u dužini i sadrži aminokiselinsku sekvencu LAREYKKIVEKLKRWLRQVLRTLR ili varijantu navedene aminokiselinske sekvence, pri čemu navedeni polipeptid ima antibakterijsku aktivnost,
navedena varijanta ima najmanje 16 aminokiselina i:
- ima najviše do 5 od sljedećih aminokiselinskih supstitucija:
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine L, I, V ili A, drugom aminokiselinom odabranom iz navedene grupe;
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine R, K ili H, drugom aminokiselinom odabranom iz navedene grupe;
• supstituciju E sa Q
• supstituciju Y ili W sa F
• supstituciju jedne ili više aminokiselina odabranih iz grupe koju čine Q, N, A, S ili T, drugom aminokiselinom odabranom iz navedene grupe i/ili
- ima retro-inverznu sekvencu od najmanje 16 konsekutivnih aminokiselina navedene aminokiselinske sekvence, gdje navedeni postupak sadrži:
- pružanje molekula nukleinske kiseline prema patentnom zahtjevu 5;
- transformaciju stanice domaćina navedenom molekulom nukleinske kiseline;
- uzgajanje navedene stanice domaćina pod uvjetima koji omogućavaju ekspresiju navedenog polipetida;
- prikupljanje navedenog polipetida iz navedenih stanica;
- izborno N-terminalno ili C-terminalno modificiranje navedenog polipeptida.
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| EP13167240 | 2013-05-10 | ||
| EP14726437.8A EP2994154B1 (en) | 2013-05-10 | 2014-05-09 | Antimicrobial peptide |
| PCT/NL2014/050295 WO2014182172A1 (en) | 2013-05-10 | 2014-05-09 | Antimicrobial peptide |
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| HRP20200599T1 true HRP20200599T1 (hr) | 2020-08-07 |
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| HRP20200599TT HRP20200599T1 (hr) | 2013-05-10 | 2020-04-15 | Antimikrobijalni peptid |
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| US (1) | US9562085B2 (hr) |
| EP (1) | EP2994154B1 (hr) |
| JP (1) | JP6683601B2 (hr) |
| KR (1) | KR102137941B1 (hr) |
| CN (1) | CN105555290B (hr) |
| AU (1) | AU2014263279B2 (hr) |
| CA (1) | CA2911919A1 (hr) |
| CY (1) | CY1123189T1 (hr) |
| DK (1) | DK2994154T3 (hr) |
| ES (1) | ES2784484T3 (hr) |
| HR (1) | HRP20200599T1 (hr) |
| HU (1) | HUE049103T2 (hr) |
| LT (1) | LT2994154T (hr) |
| MX (1) | MX364942B (hr) |
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| PT (1) | PT2994154T (hr) |
| RS (1) | RS60248B1 (hr) |
| RU (1) | RU2695455C2 (hr) |
| SI (1) | SI2994154T1 (hr) |
| WO (1) | WO2014182172A1 (hr) |
Families Citing this family (12)
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| DE112008001301T5 (de) | 2007-05-14 | 2010-04-29 | Reserach Foundation Of State University Of New York | Induktion einer physiologischen Dispersions-Antwort in Bakterien-Zellen in einem Biofilm |
| PT2994154T (pt) | 2013-05-10 | 2020-04-22 | Academisch Ziekenhuis Leiden | Péptido antimicrobiano |
| CA2933469C (en) * | 2013-12-12 | 2022-05-03 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Antimicrobial peptide and uses thereof |
| US11207378B2 (en) | 2016-04-04 | 2021-12-28 | University Of Virginia Patent Foundation | Compositions for inhibiting formation of and/or disrupting bacterial biofilms and methods of use therefor |
| CN105801672B (zh) * | 2016-04-06 | 2019-03-26 | 长兴蓝杉生物科技有限公司 | 抗菌聚多肽及其制备方法 |
| FR3061715B1 (fr) * | 2017-01-12 | 2021-07-30 | Institut National Univ Jean Francois Champollion | Peptide immunomodulateur |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| CN111973805B (zh) * | 2019-08-16 | 2022-03-01 | 苏州吉美瑞生医学科技有限公司 | 抗菌肽hCAP18/LL-37在抗感染生物工程肺中的应用 |
| CN111012736A (zh) * | 2020-02-11 | 2020-04-17 | 福建蓝昊肽生物科技发展有限公司 | 一种阻断新型冠状病毒2019-nCov的无菌喷剂敷料的应用 |
| IT202000006481A1 (it) * | 2020-03-27 | 2021-09-27 | Sanidrink S R L | Condotti tubolari antimicrobici |
| CN114848793B (zh) * | 2021-02-05 | 2023-11-03 | 四川大学 | 多肽在抗冠状病毒中的用途 |
| CN114028622A (zh) * | 2021-12-07 | 2022-02-11 | 天津市口腔医院(天津市整形外科医院、南开大学口腔医院) | 一种含有抗菌肽的骨修复材料的制备方法 |
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| US5912230A (en) | 1991-11-01 | 1999-06-15 | Periodontix, Inc. | Anti-fungal and anti-bacterial histatin-based peptides |
| US5733872A (en) | 1993-03-12 | 1998-03-31 | Xoma Corporation | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
| AU1086595A (en) | 1993-11-08 | 1995-05-29 | Demeter Biotechnologies, Ltd. | Methylated lysine-rich lytic peptides and method of making same by reductive alkylation |
| JP3459314B2 (ja) | 1994-08-31 | 2003-10-20 | 社団法人農林水産技術情報協会 | 新規ペプチド、抗菌剤、新規ペプチド遺伝子、新規な組み換え体ｄｎａ及び新規ペプチドの製造法 |
| US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US20030083244A1 (en) | 2000-04-26 | 2003-05-01 | Vernet Corine A.M. | Novel proteins and nucleic acids encoding same |
| US20060173162A1 (en) * | 2002-08-15 | 2006-08-03 | Rene Djurup | Bactericidak anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp) |
| US7718618B2 (en) | 2003-10-21 | 2010-05-18 | The Regents Of The University Of California | Human cathelicidin antimicrobial peptides |
| EP1621205A1 (en) * | 2004-07-28 | 2006-02-01 | OctoPlus Technologies B.V. | Antimicrobial peptides derived from CAP18 |
| CN100584860C (zh) | 2007-01-11 | 2010-01-27 | 中国人民解放军第三军医大学第一附属医院 | 一种改建的抗菌肽及其制备方法和应用 |
| PT2994154T (pt) | 2013-05-10 | 2020-04-22 | Academisch Ziekenhuis Leiden | Péptido antimicrobiano |
-
2014
- 2014-05-09 PT PT147264378T patent/PT2994154T/pt unknown
- 2014-05-09 SI SI201431548T patent/SI2994154T1/sl unknown
- 2014-05-09 AU AU2014263279A patent/AU2014263279B2/en active Active
- 2014-05-09 LT LTEP14726437.8T patent/LT2994154T/lt unknown
- 2014-05-09 JP JP2016512870A patent/JP6683601B2/ja not_active Expired - Fee Related
- 2014-05-09 CN CN201480039600.7A patent/CN105555290B/zh active Active
- 2014-05-09 RS RS20200415A patent/RS60248B1/sr unknown
- 2014-05-09 CA CA2911919A patent/CA2911919A1/en not_active Abandoned
- 2014-05-09 KR KR1020157035027A patent/KR102137941B1/ko active IP Right Grant
- 2014-05-09 MX MX2015015506A patent/MX364942B/es active IP Right Grant
- 2014-05-09 PL PL14726437T patent/PL2994154T3/pl unknown
- 2014-05-09 US US14/890,415 patent/US9562085B2/en active Active
- 2014-05-09 HU HUE14726437A patent/HUE049103T2/hu unknown
- 2014-05-09 ES ES14726437T patent/ES2784484T3/es active Active
- 2014-05-09 DK DK14726437.8T patent/DK2994154T3/da active
- 2014-05-09 EP EP14726437.8A patent/EP2994154B1/en active Active
- 2014-05-09 WO PCT/NL2014/050295 patent/WO2014182172A1/en active Application Filing
- 2014-05-09 RU RU2015148642A patent/RU2695455C2/ru active
-
2020
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Also Published As
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| KR20160018549A (ko) | 2016-02-17 |
| MX2015015506A (es) | 2016-07-06 |
| WO2014182172A1 (en) | 2014-11-13 |
| AU2014263279B2 (en) | 2018-02-15 |
| US20160075749A1 (en) | 2016-03-17 |
| CN105555290B (zh) | 2021-11-09 |
| DK2994154T3 (da) | 2020-04-20 |
| RU2015148642A3 (hr) | 2018-03-21 |
| EP2994154A1 (en) | 2016-03-16 |
| AU2014263279A1 (en) | 2015-11-26 |
| RU2695455C2 (ru) | 2019-07-23 |
| KR102137941B1 (ko) | 2020-07-29 |
| JP6683601B2 (ja) | 2020-04-22 |
| CA2911919A1 (en) | 2014-11-13 |
| PT2994154T (pt) | 2020-04-22 |
| LT2994154T (lt) | 2020-06-25 |
| EP2994154B1 (en) | 2020-02-26 |
| RS60248B1 (sr) | 2020-06-30 |
| SI2994154T1 (sl) | 2020-07-31 |
| MX364942B (es) | 2019-05-15 |
| CN105555290A (zh) | 2016-05-04 |
| HUE049103T2 (hu) | 2020-09-28 |
| PL2994154T3 (pl) | 2020-07-27 |
| US9562085B2 (en) | 2017-02-07 |
| JP2016526020A (ja) | 2016-09-01 |
| ES2784484T3 (es) | 2020-09-28 |
| CY1123189T1 (el) | 2021-10-29 |
| RU2015148642A (ru) | 2017-06-16 |
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