NO954188L - Modifisert-protein- og -peptid - farmasöytika - Google Patents

Modifisert-protein- og -peptid - farmasöytika

Info

Publication number
NO954188L
NO954188L NO954188A NO954188A NO954188L NO 954188 L NO954188 L NO 954188L NO 954188 A NO954188 A NO 954188A NO 954188 A NO954188 A NO 954188A NO 954188 L NO954188 L NO 954188L
Authority
NO
Norway
Prior art keywords
amino acid
ctp units
modified
partial
complete
Prior art date
Application number
NO954188A
Other languages
English (en)
Other versions
NO954188D0 (no
Inventor
Irving Boime
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of NO954188D0 publication Critical patent/NO954188D0/no
Publication of NO954188L publication Critical patent/NO954188L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"Partielle" og "komplette" CTP-enheter benyttes for å modifisere biologisk aktive proteiner og peptider for å endre deres clearance-mønster. "Komplette" CTP-enheter har ' aminosyresekvensen som finnes i posisjonene 112-118 til posisjon 145 i S-subenheten av humant choriongonadotropin. "Partielle" CTP-enheter mangler minst en aminosyre i regionen fra og med posisjon 118 til og med 145. Varianter av disse CTP-enheter inneholder l til 5 konservative aminosyre- substitusjoner som ikke ødelegger aktiviteten. Passende peptider eller proteiner som kan modifiseres på denne måte er bl.a. forskjellige hormoner og cytokiner.
NO954188A 1993-04-20 1995-10-19 Modifisert-protein- og -peptid - farmasöytika NO954188L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4986993A 1993-04-20 1993-04-20
PCT/US1994/004069 WO1994024148A1 (en) 1993-04-20 1994-04-13 Modified protein and peptide pharmaceuticals

Publications (2)

Publication Number Publication Date
NO954188D0 NO954188D0 (no) 1995-10-19
NO954188L true NO954188L (no) 1995-12-19

Family

ID=21962168

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954188A NO954188L (no) 1993-04-20 1995-10-19 Modifisert-protein- og -peptid - farmasöytika

Country Status (14)

Country Link
EP (1) EP0695307B1 (no)
JP (2) JP4156024B2 (no)
AT (1) ATE187740T1 (no)
AU (1) AU687053B2 (no)
CA (1) CA2160800C (no)
DE (1) DE69422169D1 (no)
ES (1) ES2141229T3 (no)
FI (1) FI954978A (no)
GR (1) GR3032775T3 (no)
NO (1) NO954188L (no)
NZ (1) NZ265529A (no)
PT (1) PT695307E (no)
WO (1) WO1994024148A1 (no)
ZA (1) ZA942729B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968513A (en) * 1996-06-24 1999-10-19 University Of Maryland Biotechnology Institute Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
US5997871A (en) * 1996-06-24 1999-12-07 University Of Maryland Biotechnology Insitute Treatment and prevention of cancer by administration of derivatives of human chorionic gonadotropin
US6319504B1 (en) * 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
US6583109B1 (en) 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
US7994278B1 (en) 1999-08-06 2011-08-09 Nobel Biosciences Llc Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
JP3946638B2 (ja) * 2000-12-11 2007-07-18 シージェイ コーポレーション 生体内エリスロポエチン活性が増強された融合蛋白質
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
KR100467751B1 (ko) * 2001-12-03 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US8304386B2 (en) 2006-02-03 2012-11-06 Prolor Biotech, Inc. Long-acting growth hormone and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US7553941B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
EP2838552A4 (en) 2012-04-19 2016-05-18 Opko Biolog Ltd OXYNTOMODULIN VARIANTS WITH EXTENDED ACTION AND PROCESSES FOR PRODUCING SAME
SG10202010383YA (en) 2012-11-20 2020-11-27 Opko Biologics Ltd Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
EP3240564A4 (en) * 2014-12-10 2018-05-30 OPKO Biologics Ltd. Methods of producing long acting ctp-modified polypeptides
KR102662956B1 (ko) 2015-06-19 2024-05-03 옵코 바이오로직스 리미티드 장기-작용성 응고 인자 및 그의 제조 방법
EA201990255A1 (ru) 2016-07-11 2019-07-31 Опко Байолоджикс Лтд Фактор свертывания крови vii пролонгированного действия и способы его получения

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654324A (en) * 1981-08-27 1987-03-31 Eli Lilly And Company Human proinsulin pharmaceutical formulations
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
ATE148171T1 (de) * 1989-02-21 1997-02-15 Univ Washington Modifizierte formen von fortpflanzungshormonen
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
JPH04156024A (ja) * 1990-10-19 1992-05-28 Fujitsu Ltd サブレート交換方式

Also Published As

Publication number Publication date
AU687053B2 (en) 1998-02-19
WO1994024148A1 (en) 1994-10-27
CA2160800C (en) 2010-06-01
PT695307E (pt) 2000-05-31
ES2141229T3 (es) 2000-03-16
ZA942729B (en) 1995-01-09
JP2008133295A (ja) 2008-06-12
EP0695307A1 (en) 1996-02-07
GR3032775T3 (en) 2000-06-30
JP4156024B2 (ja) 2008-09-24
DE69422169D1 (de) 2000-01-20
JPH08509218A (ja) 1996-10-01
FI954978A (fi) 1995-11-15
EP0695307A4 (en) 1996-08-21
NZ265529A (en) 1998-01-26
AU6633194A (en) 1994-11-08
EP0695307B1 (en) 1999-12-15
NO954188D0 (no) 1995-10-19
ATE187740T1 (de) 2000-01-15
FI954978A0 (fi) 1995-10-18
CA2160800A1 (en) 1994-10-27

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