JPH08509218A - 修飾されたタンパク質及びペプチド医薬品 - Google Patents
修飾されたタンパク質及びペプチド医薬品Info
- Publication number
- JPH08509218A JPH08509218A JP6523422A JP52342294A JPH08509218A JP H08509218 A JPH08509218 A JP H08509218A JP 6523422 A JP6523422 A JP 6523422A JP 52342294 A JP52342294 A JP 52342294A JP H08509218 A JPH08509218 A JP H08509218A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- ctp
- peptide
- modified
- sites
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.修飾されたタンパク質又はペプチド医薬品であって、前記修飾は「完全な」 又は「部分」CTP単位又はその変異体を前記タンパク質又はペプチドの重要で ない領域に挿入することを含み、但し前記重要でない領域がC−末端である場合 、前記挿入は部分CTP単位で行うことを特徴とする修飾されたタンパク質又は ペプチド医薬品。 2.請求項1記載の修飾されたペプチド又はタンパク質であって、 前記CTP単位は天然型CTP単位に見いだされる4つの全てのグリコシレー ション部位(部位1、2、3及び4)を含むか; 前記CTP単位中のグリコシレーション部位が、部位1、2及び3;又は部位 1、3及び4;又は部位1、2及び4;又は部位2、3及び4から成るか; 前記CTP単位中のグリコシレーション部位が、部位1及び2;又は部位1及 び3;又は部位1及び4;又は部位2及び3;部位2及び4;又は部位3及び4 から成るか;又は 前記CTP単位中のグリコシレーション部位が、部位1、又は部位2、又は部 位3、又は部位4から成るか、 であることを特徴とする修飾されたペプチド又はタ ンパタ質。 3.請求項1記載の修飾されたペプチド又はタンパク質であって、前記部分CT P単位がアミノ酸位置が、112〜132;115〜132;116〜132; 又は118〜132;又は112〜127;115〜127;116〜127; 又は118〜127から成ることを特徴とする修飾されたペプチド又はタンパク 質。 4.請求項1記載の修飾されたペプチド又はタンパク質であって、前記重要でな い領域がC−末端の近傍にあるか;又は 前記重要でない領域がN−末端の近傍にあることを特徴とする修飾されたペプ チド又はタンパク質。 5.少なくとも2つのCTP単位を含む請求項1記載の修飾されたペプチド又は タンパク質。 6.請求項5記載の修飾されたペプチド又はタンパク質であって、前記少なくと も2つのCTP単位が異なったものであるか;又は 前記少なくとも2つのCTP単位が同一のものである ことを特徴とする修飾されたペプチド又はタンパク質。 7.請求項1記載の修飾されたペプチド又はタンパク質であって、前記ペプチド 又はタンパク質がヒトの生殖酵素のαサブユニットであり、前記重要でない領域 がN−末端の近傍にあることを特徴とする修飾されたペプチド又はタンパク質。 8.前記ペプチド又はタンパク質がサイトカインである請求項1記載の修飾され たペプチド又はタンパク質。 9.前記ペプチド又はタンパク質がIL−3である請求項8記載の修飾されたペ プチド又はタンパク質。 10.請求項1記載の修飾されたペプチド又はタンパク質であって、前記ペプチ ド又はタンパク質がプロインスリンであるか; 前記ペプチド又はタンパク質がヒトのFSHβであるか; 前記ペプチド又はタンパク質がヒトのTSHβであるか;又は 前記ペプチド又はタンパク質がヒトのLHβであることを特徴とする修飾され たペプチド又はタンパク質。 11.製薬的に受け入れることのできる賦形剤との混合物として請求項1記載の 修飾されたタンパク質又はペプチドを含む医薬品組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4986993A | 1993-04-20 | 1993-04-20 | |
US08/049,869 | 1993-04-20 | ||
PCT/US1994/004069 WO1994024148A1 (en) | 1993-04-20 | 1994-04-13 | Modified protein and peptide pharmaceuticals |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2008021365A Division JP2008133295A (ja) | 1993-04-20 | 2008-01-31 | 修飾されたペプチド医薬品 |
Publications (2)
Publication Number | Publication Date |
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JPH08509218A true JPH08509218A (ja) | 1996-10-01 |
JP4156024B2 JP4156024B2 (ja) | 2008-09-24 |
Family
ID=21962168
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP52342294A Expired - Lifetime JP4156024B2 (ja) | 1993-04-20 | 1994-04-13 | 修飾されたタンパク質及びペプチド医薬品 |
JP2008021365A Pending JP2008133295A (ja) | 1993-04-20 | 2008-01-31 | 修飾されたペプチド医薬品 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2008021365A Pending JP2008133295A (ja) | 1993-04-20 | 2008-01-31 | 修飾されたペプチド医薬品 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0695307B1 (ja) |
JP (2) | JP4156024B2 (ja) |
AT (1) | ATE187740T1 (ja) |
AU (1) | AU687053B2 (ja) |
CA (1) | CA2160800C (ja) |
DE (1) | DE69422169D1 (ja) |
ES (1) | ES2141229T3 (ja) |
FI (1) | FI954978A (ja) |
GR (1) | GR3032775T3 (ja) |
NO (1) | NO954188L (ja) |
NZ (1) | NZ265529A (ja) |
PT (1) | PT695307E (ja) |
WO (1) | WO1994024148A1 (ja) |
ZA (1) | ZA942729B (ja) |
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US5997871A (en) * | 1996-06-24 | 1999-12-07 | University Of Maryland Biotechnology Insitute | Treatment and prevention of cancer by administration of derivatives of human chorionic gonadotropin |
US5968513A (en) * | 1996-06-24 | 1999-10-19 | University Of Maryland Biotechnology Institute | Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin |
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US6583109B1 (en) | 1997-06-24 | 2003-06-24 | Robert C. Gallo | Therapeutic polypeptides from β-hCG and derivatives |
US7994278B1 (en) | 1999-08-06 | 2011-08-09 | Nobel Biosciences Llc | Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) |
JP2001333772A (ja) | 2000-04-25 | 2001-12-04 | Washington Univ | 可変性の活性を有する単鎖稔性ホルモン |
AU2002222740A1 (en) * | 2000-12-11 | 2002-06-24 | Cheil Jedang Corporation | Fusion protein having the enhanced in vivo activity of erythropoietin |
US6987172B2 (en) | 2001-03-05 | 2006-01-17 | Washington University In St. Louis | Multifunctional single chain glycoprotein hormones comprising three or more β subunits |
KR100467751B1 (ko) * | 2001-12-03 | 2005-01-24 | 씨제이 주식회사 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
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AU648020B2 (en) * | 1989-02-21 | 1994-04-14 | Washington University | Modified forms of reproductive hormones |
JPH04156024A (ja) * | 1990-10-19 | 1992-05-28 | Fujitsu Ltd | サブレート交換方式 |
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1994
- 1994-04-13 AU AU66331/94A patent/AU687053B2/en not_active Expired
- 1994-04-13 ES ES94914152T patent/ES2141229T3/es not_active Expired - Lifetime
- 1994-04-13 AT AT94914152T patent/ATE187740T1/de active
- 1994-04-13 EP EP94914152A patent/EP0695307B1/en not_active Expired - Lifetime
- 1994-04-13 PT PT94914152T patent/PT695307E/pt unknown
- 1994-04-13 JP JP52342294A patent/JP4156024B2/ja not_active Expired - Lifetime
- 1994-04-13 NZ NZ265529A patent/NZ265529A/en unknown
- 1994-04-13 CA CA2160800A patent/CA2160800C/en not_active Expired - Lifetime
- 1994-04-13 DE DE69422169T patent/DE69422169D1/de not_active Expired - Lifetime
- 1994-04-13 WO PCT/US1994/004069 patent/WO1994024148A1/en active IP Right Grant
- 1994-04-20 ZA ZA942729A patent/ZA942729B/xx unknown
-
1995
- 1995-10-18 FI FI954978A patent/FI954978A/fi unknown
- 1995-10-19 NO NO954188A patent/NO954188L/no not_active Application Discontinuation
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2000
- 2000-02-28 GR GR20000400477T patent/GR3032775T3/el unknown
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Also Published As
Publication number | Publication date |
---|---|
WO1994024148A1 (en) | 1994-10-27 |
FI954978A (fi) | 1995-11-15 |
JP4156024B2 (ja) | 2008-09-24 |
CA2160800C (en) | 2010-06-01 |
AU6633194A (en) | 1994-11-08 |
EP0695307A1 (en) | 1996-02-07 |
GR3032775T3 (en) | 2000-06-30 |
AU687053B2 (en) | 1998-02-19 |
CA2160800A1 (en) | 1994-10-27 |
ATE187740T1 (de) | 2000-01-15 |
NO954188D0 (no) | 1995-10-19 |
ES2141229T3 (es) | 2000-03-16 |
EP0695307A4 (en) | 1996-08-21 |
ZA942729B (en) | 1995-01-09 |
NO954188L (no) | 1995-12-19 |
EP0695307B1 (en) | 1999-12-15 |
JP2008133295A (ja) | 2008-06-12 |
FI954978A0 (fi) | 1995-10-18 |
PT695307E (pt) | 2000-05-31 |
NZ265529A (en) | 1998-01-26 |
DE69422169D1 (de) | 2000-01-20 |
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