PT2739298T - Hormona do crescimento de ação prolongada e métodos de produção da mesma - Google Patents
Hormona do crescimento de ação prolongada e métodos de produção da mesmaInfo
- Publication number
- PT2739298T PT2739298T PT12819794T PT12819794T PT2739298T PT 2739298 T PT2739298 T PT 2739298T PT 12819794 T PT12819794 T PT 12819794T PT 12819794 T PT12819794 T PT 12819794T PT 2739298 T PT2739298 T PT 2739298T
- Authority
- PT
- Portugal
- Prior art keywords
- methods
- long
- growth hormone
- producing same
- acting growth
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/195,931 US8450269B2 (en) | 2006-02-03 | 2011-08-02 | Long-acting growth hormone and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2739298T true PT2739298T (pt) | 2019-01-11 |
Family
ID=47629749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT12819794T PT2739298T (pt) | 2011-08-02 | 2012-08-02 | Hormona do crescimento de ação prolongada e métodos de produção da mesma |
| PT181983552T PT3482765T (pt) | 2011-08-02 | 2012-08-02 | Hormona de crescimento de ação prolongada e métodos de produção da mesma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT181983552T PT3482765T (pt) | 2011-08-02 | 2012-08-02 | Hormona de crescimento de ação prolongada e métodos de produção da mesma |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8450269B2 (enExample) |
| EP (2) | EP2739298B1 (enExample) |
| JP (1) | JP6153930B2 (enExample) |
| KR (3) | KR20210013300A (enExample) |
| CN (2) | CN104010650A (enExample) |
| AU (1) | AU2012291617B2 (enExample) |
| BR (1) | BR112014002491A2 (enExample) |
| CA (1) | CA2843672A1 (enExample) |
| CL (2) | CL2014000254A1 (enExample) |
| CO (1) | CO7020850A2 (enExample) |
| DK (2) | DK2739298T3 (enExample) |
| EA (2) | EA202090577A3 (enExample) |
| ES (2) | ES2983610T3 (enExample) |
| FI (1) | FI3482765T3 (enExample) |
| HK (1) | HK1200349A1 (enExample) |
| HR (1) | HRP20240635T1 (enExample) |
| HU (2) | HUE066552T2 (enExample) |
| MX (2) | MX360802B (enExample) |
| PL (2) | PL3482765T3 (enExample) |
| PT (2) | PT2739298T (enExample) |
| SI (2) | SI3482765T1 (enExample) |
| TR (1) | TR201821186T4 (enExample) |
| WO (1) | WO2013018098A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| CA2721947C (en) | 2008-04-29 | 2016-03-08 | Ascendis Pharma As | Pegylated recombinant human growth hormone compounds |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| RU2012129674A (ru) | 2009-12-15 | 2014-01-27 | Аспендис Фарма Ас | Композиция гормона роста |
| MX2014012625A (es) | 2012-04-19 | 2015-05-15 | Opko Biolog Ltd | Variantes de oxintomodulina de accion prolongada y metodos para su produccion. |
| EP3848386A1 (en) | 2012-11-20 | 2021-07-14 | OPKO Biologics Ltd. | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN103524626B (zh) * | 2013-09-27 | 2016-09-07 | 武汉龙科生物技术有限公司 | 重组双靶点蛋白药物及其应用 |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| KR20160068969A (ko) * | 2013-10-21 | 2016-06-15 | 옵코 바이오로직스 리미티드 | 장시간-작용하는 폴리펩티드, 그의 생산 방법, 및 그의 투여 방법 |
| RU2718664C2 (ru) | 2014-11-18 | 2020-04-13 | Асцендис Фарма Эндокринолоджи Дивижн А/С | НОВЫЕ ПОЛИМЕРНЫЕ hGH ПРОЛЕКАРСТВА |
| PL3220892T3 (pl) | 2014-11-21 | 2022-01-31 | Ascendis Pharma Endocrinology Division A/S | Postacie dawkowane długo działającego hormonu wzrostu |
| CA2914916A1 (en) * | 2014-12-10 | 2016-06-10 | Opko Biologics Ltd. | Methods of producing ctp-modified growth hormone polypeptides |
| PE20171380A1 (es) | 2014-12-10 | 2017-09-15 | Opko Biologics Ltd | Metodos de produccion de polipeptidos de hormona de crecimiento modificada por ctp de accion prolongada |
| KR102662956B1 (ko) | 2015-06-19 | 2024-05-03 | 옵코 바이오로직스 리미티드 | 장기-작용성 응고 인자 및 그의 제조 방법 |
| SI3400019T1 (sl) | 2016-01-08 | 2023-01-31 | Ascendis Pharma Growth Disorders Division A/S | Predzdravila CNP s povezavo nosilca na obročni ostanek |
| IL297375B2 (en) | 2016-01-08 | 2024-02-01 | Ascendis Pharma Growth Disorders As | Controlled-release CNP agonists with low NPR–C binding |
| US11389510B2 (en) | 2016-01-08 | 2022-07-19 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
| WO2017118693A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with large carrier moieties |
| CA3008017C (en) | 2016-01-08 | 2024-01-02 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with reduced side-effects |
| MX2018008050A (es) | 2016-01-08 | 2018-08-23 | Ascendis Pharma Growth Disorders As | Agonistas de peptido natriuretico tipo c (cnp) de liberacion controlada con estabilidad endopeptidasa neutral (nep) incrementada. |
| CN109069659B (zh) | 2016-03-01 | 2022-04-19 | 阿森迪斯药物骨疾病股份有限公司 | Pth前药 |
| US11976106B2 (en) | 2016-07-11 | 2024-05-07 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US11896671B2 (en) | 2016-07-13 | 2024-02-13 | Ascendis Pharma A/S | Conjugation method for carrier-linked prodrugs |
| NZ792622A (en) | 2016-09-29 | 2025-08-29 | Ascendis Pharma Bone Diseases As | Pth compounds with low peak-to-trough ratios |
| IL304086A (en) | 2016-09-29 | 2023-08-01 | Ascendis Pharma Bone Diseases As | Dosing regimen for a controlled-release PTH compound |
| DK3518982T3 (da) | 2016-09-29 | 2025-02-03 | Ascendis Pharma Bone Diseases As | Pth-forbindelser med kontrolleret frigivelse |
| HUE062117T2 (hu) | 2016-09-29 | 2023-09-28 | Ascendis Pharma Growth Disorders As | Kombinációs terápia szabályozott felszabadulású CNP agonistákkal |
| IL277572B2 (en) | 2018-03-28 | 2024-05-01 | Ascendis Pharma Oncology Div A/S | Il-2 conjugates |
| WO2019185706A1 (en) | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugates |
| AU2019270464B2 (en) | 2018-05-18 | 2024-09-26 | Ascendis Pharma Bone Diseases A/S | Starting dose of PTH conjugates |
| CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
| CN113286876A (zh) * | 2018-10-26 | 2021-08-20 | T·巴尔 | 用于生物降解酒精的组合物和方法 |
| EP3923906A1 (en) | 2019-02-11 | 2021-12-22 | Ascendis Pharma Growth Disorders A/S | Dry pharmaceutical formulations of cnp conjugates |
| MY209748A (en) | 2019-02-11 | 2025-07-31 | Ascendis Pharma Bone Diseases As | Liquid pharmaceutical formulations of pth conjugates |
| JP7524206B2 (ja) * | 2019-03-04 | 2024-07-29 | アセンディス ファーマ エンドクライノロジー ディヴィジョン エー／エス | １日ごとのソマトロピンよりも優れた効力を有する長時間作用性成長ホルモン剤形 |
| AU2020296297B2 (en) | 2019-06-21 | 2025-06-12 | Ascendis Pharma A/S | Conjugates of heteroaromatic nitrogen-comprising compounds |
| CA3143435A1 (en) | 2019-06-21 | 2020-12-24 | Nicola BISEK | Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds |
| JP2022537405A (ja) | 2019-06-21 | 2022-08-25 | アセンディス ファーマ エー／エス | π電子対供与複素環式芳香族窒素含有化合物のコンジュゲート |
| CA3161098A1 (en) | 2020-01-03 | 2021-07-08 | Ascendis Pharma A/S | Conjugates undergoing intramolecular rearrangements |
| CA3161101A1 (en) | 2020-01-13 | 2021-07-22 | Kennett Sprogoe | Hypoparathyroidism treatment |
| CN116133676A (zh) | 2020-06-03 | 2023-05-16 | 阿森迪斯药物肿瘤股份有限公司 | Il-2序列及其用途 |
| CA3184998A1 (en) | 2020-08-05 | 2022-02-10 | Samuel WEISBROD | Conjugates comprising reversible linkers and uses thereof |
| AU2021335032A1 (en) | 2020-08-28 | 2023-03-09 | Ascendis Pharma Oncology Division A/S | Glycosylated IL-2 proteins and uses thereof |
| MX2023003540A (es) | 2020-09-28 | 2023-04-21 | Ascendis Pharma Bone Diseases As | Mejora del bienestar fisico y mental de los pacientes con hipoparatiroidismo. |
| CN112175964B (zh) * | 2020-10-23 | 2022-03-29 | 安徽中起生物科技有限公司 | 一种重组猪生长激素及其制备方法和应用 |
| KR20230164709A (ko) | 2021-04-01 | 2023-12-04 | 아센디스 파마 에이에스 | 염증 유발 질환을 치료하기 위한 지속형 성장 호르몬의 용도 |
| CN114010765A (zh) * | 2021-08-30 | 2022-02-08 | 上海延立药业有限公司 | 一种长效人生长激素 |
| IL311539A (en) | 2021-09-22 | 2024-05-01 | Ascendis Pharma Bone Diseases As | Long-acting pth compound treatments |
| WO2023110758A1 (en) | 2021-12-13 | 2023-06-22 | Ascendis Pharma Growth Disorders A/S | Effective doses of cnp conjugates |
| IL316466A (en) | 2022-05-23 | 2024-12-01 | Ascendis Pharma Growth Disorders As | Liquid pharmaceutical formulations of cnp compounds |
| AU2023374533A1 (en) | 2022-11-02 | 2025-04-10 | Ascendis Pharma Bone Diseases A/S | Pth treatment regimen comprising two pth compounds |
| WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
| CN121219011A (zh) | 2023-03-20 | 2025-12-26 | 阿森迪斯药物生长障碍股份有限公司 | 治疗患有软骨发育不全患者胸腰椎畸形的方法 |
| WO2025051711A1 (en) | 2023-09-04 | 2025-03-13 | Ascendis Pharma Bone Diseases A/S | Pth treatment of chronic kidney disease |
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