HUE042755T2 - Hosszú hatású növekedési hormon és eljárások annak elõállítására - Google Patents
Hosszú hatású növekedési hormon és eljárások annak elõállításáraInfo
- Publication number
- HUE042755T2 HUE042755T2 HUE12819794A HUE12819794A HUE042755T2 HU E042755 T2 HUE042755 T2 HU E042755T2 HU E12819794 A HUE12819794 A HU E12819794A HU E12819794 A HUE12819794 A HU E12819794A HU E042755 T2 HUE042755 T2 HU E042755T2
- Authority
- HU
- Hungary
- Prior art keywords
- methods
- long
- growth hormone
- producing same
- acting growth
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/195,931 US8450269B2 (en) | 2006-02-03 | 2011-08-02 | Long-acting growth hormone and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE042755T2 true HUE042755T2 (hu) | 2019-07-29 |
Family
ID=47629749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12819794A HUE042755T2 (hu) | 2011-08-02 | 2012-08-02 | Hosszú hatású növekedési hormon és eljárások annak elõállítására |
| HUE18198355A HUE066552T2 (hu) | 2011-08-02 | 2012-08-02 | Hosszú hatástartalmú növekedési hormon és elõállítási eljárásai |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE18198355A HUE066552T2 (hu) | 2011-08-02 | 2012-08-02 | Hosszú hatástartalmú növekedési hormon és elõállítási eljárásai |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8450269B2 (enExample) |
| EP (2) | EP3482765B1 (enExample) |
| JP (1) | JP6153930B2 (enExample) |
| KR (3) | KR102028524B1 (enExample) |
| CN (2) | CN104010650A (enExample) |
| AU (1) | AU2012291617B2 (enExample) |
| BR (1) | BR112014002491A2 (enExample) |
| CA (1) | CA2843672A1 (enExample) |
| CL (2) | CL2014000254A1 (enExample) |
| CO (1) | CO7020850A2 (enExample) |
| DK (2) | DK2739298T3 (enExample) |
| EA (2) | EA202090577A3 (enExample) |
| ES (2) | ES2983610T3 (enExample) |
| FI (1) | FI3482765T3 (enExample) |
| HK (1) | HK1200349A1 (enExample) |
| HR (1) | HRP20240635T1 (enExample) |
| HU (2) | HUE042755T2 (enExample) |
| MX (2) | MX360802B (enExample) |
| PL (2) | PL3482765T3 (enExample) |
| PT (2) | PT2739298T (enExample) |
| SI (2) | SI3482765T1 (enExample) |
| TR (1) | TR201821186T4 (enExample) |
| WO (1) | WO2013018098A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| WO2007092252A2 (en) | 2006-02-03 | 2007-08-16 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| SI2279007T1 (sl) | 2008-04-29 | 2016-09-30 | Ascendis Pharma Growth Disorders Division A/S | Spojine pegiliranega rekombinantnega humanega rastnega hormona |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| WO2011073234A2 (en) | 2009-12-15 | 2011-06-23 | Ascendis Pharma As | Growth hormone composition |
| JP2015520128A (ja) | 2012-04-19 | 2015-07-16 | オプコ バイオロジクス リミテッド | 長時間作用性オキシントモジュリン変異体とその作製方法 |
| CA2891393A1 (en) | 2012-11-20 | 2014-05-30 | Opko Biologics Ltd. | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN103524626B (zh) * | 2013-09-27 | 2016-09-07 | 武汉龙科生物技术有限公司 | 重组双靶点蛋白药物及其应用 |
| RU2746943C2 (ru) * | 2013-10-21 | 2021-04-22 | Опко Байолоджикс Лтд. | Полипептиды длительного действия и способы их получения и введения |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| MX394222B (es) | 2014-11-18 | 2025-03-24 | Ascendis Pharma Endocrinology Div A/S | Nuevos profarmacos polimericos de la hormona del crecimiento humana (hgh). |
| SI3220892T1 (sl) | 2014-11-21 | 2022-01-31 | Ascendis Pharma Endocrinology Division A/S | Oblike odmerjanja dolgotrajno delujočega rastnega hormona |
| AU2015358890B2 (en) | 2014-12-10 | 2019-06-13 | Opko Biologics Ltd. | Methods of producing long acting CTP-modified growth hormone polypeptides |
| CA2914916A1 (en) * | 2014-12-10 | 2016-06-10 | Opko Biologics Ltd. | Methods of producing ctp-modified growth hormone polypeptides |
| PL3310347T3 (pl) * | 2015-06-19 | 2021-12-27 | Opko Biologics Ltd. | Długo działające czynniki krzepnięcia i sposoby wytwarzania |
| IL259658B2 (en) | 2016-01-08 | 2024-06-01 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with reduced side-effects |
| KR20180100624A (ko) | 2016-01-08 | 2018-09-11 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | 증가된 nep 안정성을 갖는 제어 방출성 cnp 작용제 |
| CA3007976C (en) | 2016-01-08 | 2023-09-26 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with large carrier moieties |
| EP3400019B1 (en) | 2016-01-08 | 2022-09-28 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with carrier attachment at the ring moiety |
| AU2017205694B2 (en) | 2016-01-08 | 2022-05-26 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low NPR-C binding |
| CA3007982C (en) | 2016-01-08 | 2023-12-19 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with low initial npr-b activity |
| JP7059195B2 (ja) | 2016-03-01 | 2022-04-25 | アセンディス ファーマ ボーン ディジージズ エー／エス | Ｐｔｈプロドラッグ |
| JP7319187B2 (ja) | 2016-07-11 | 2023-08-01 | オプコ バイオロジクス リミテッド | 長時間作用型凝固因子ｖｉｉおよびその製造方法 |
| WO2018011266A1 (en) | 2016-07-13 | 2018-01-18 | Ascendis Pharma A/S | Conjugation method for carrier-linked prodrugs |
| IL290054B2 (en) | 2016-09-29 | 2024-03-01 | Ascendis Pharma Growth Disorders As | Combination therapy with controlled-release cnp agonists |
| KR20240013849A (ko) | 2016-09-29 | 2024-01-30 | 아센디스 파마 본 디지즈 에이/에스 | 조절 방출 pth 화합물을 위한 투여 용법 |
| EP3518982B1 (en) | 2016-09-29 | 2024-11-27 | Ascendis Pharma Bone Diseases A/S | Controlled-release pth compounds |
| SI3518961T1 (sl) | 2016-09-29 | 2023-07-31 | Ascendis Pharma Bone Diseases A/S | Spojine PTH z nizkimi razmerji med najvišjo in najnižjo vrednostjo |
| WO2019185706A1 (en) | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugates |
| EP3773680A1 (en) | 2018-03-28 | 2021-02-17 | Ascendis Pharma Oncology Division A/S | Il-2 conjugates |
| BR112020022306A2 (pt) | 2018-05-18 | 2021-02-23 | Ascendis Pharma Bone Diseases A/S | dose de partida de conjugados de pth |
| CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
| WO2020084621A1 (en) * | 2018-10-26 | 2020-04-30 | Tami Bar | Compositions and methods for biodegrading alcohol |
| SG11202107446QA (en) | 2019-02-11 | 2021-08-30 | Ascendis Pharma Growth Disorders As | Dry pharmaceutical formulations of cnp conjugates |
| US12403182B2 (en) | 2019-02-11 | 2025-09-02 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of PTH conjugates |
| US12303553B2 (en) | 2019-03-04 | 2025-05-20 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms with superior efficacy to daily somatropin |
| US20220305129A1 (en) | 2019-06-21 | 2022-09-29 | Ascendis Pharma A/S | Conjugates of heteroaromatic nitrogen-comprising compounds |
| KR20220024690A (ko) | 2019-06-21 | 2022-03-03 | 아센디스 파마 에이에스 | π 전자쌍 공여 헤테로방향족 질소 포함 화합물의 컨쥬게이트 |
| CA3143435A1 (en) | 2019-06-21 | 2020-12-24 | Nicola BISEK | Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds |
| CA3161098A1 (en) | 2020-01-03 | 2021-07-08 | Ascendis Pharma A/S | Conjugates undergoing intramolecular rearrangements |
| WO2021144249A1 (en) | 2020-01-13 | 2021-07-22 | Ascendis Pharma Bone Diseases A/S | Hypoparathyroidism treatment |
| CA3178074A1 (en) | 2020-06-03 | 2021-12-09 | Nina Gunnarsson | Il-2 sequences and uses thereof |
| WO2022029178A1 (en) | 2020-08-05 | 2022-02-10 | Ascendis Pharma A/S | Conjugates comprising reversible linkers and uses thereof |
| KR20230057447A (ko) | 2020-08-28 | 2023-04-28 | 아센디스 파마 온콜로지 디비전 에이/에스 | 글리코실화된 il-2 단백질 및 이의 용도 |
| JP2023543265A (ja) | 2020-09-28 | 2023-10-13 | アセンディス ファーマ ボーン ディジージズ エー／エス | 副甲状腺機能低下症を有する患者の身体的及び精神的ウェルビーイングの改善 |
| CN112175964B (zh) * | 2020-10-23 | 2022-03-29 | 安徽中起生物科技有限公司 | 一种重组猪生长激素及其制备方法和应用 |
| AU2022246997A1 (en) | 2021-04-01 | 2023-09-28 | Ascendis Pharma A/S | Use of long-acting growth hormone for treating inflammation-induced diseases |
| CN114010765A (zh) * | 2021-08-30 | 2022-02-08 | 上海延立药业有限公司 | 一种长效人生长激素 |
| AU2022350937A1 (en) | 2021-09-22 | 2024-03-21 | Ascendis Pharma Bone Diseases A/S | Long-acting pth compound treatments |
| CA3236278A1 (en) | 2021-12-13 | 2023-06-22 | Kennett Sprogoe | Effective doses of cnp conjugates |
| AU2023276829A1 (en) | 2022-05-23 | 2024-10-31 | Ascendis Pharma Growth Disorders A/S | Liquid pharmaceutical formulations of cnp compounds |
| EP4611891A1 (en) | 2022-11-02 | 2025-09-10 | Ascendis Pharma Bone Diseases A/S | Pth treatment regimen comprising two pth compounds |
| WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
| KR20250162619A (ko) | 2023-03-20 | 2025-11-18 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | 연골무형성증을 가진 인간 대상에서의 흉요추 변형의 치료 방법 |
| WO2025051711A1 (en) | 2023-09-04 | 2025-03-13 | Ascendis Pharma Bone Diseases A/S | Pth treatment of chronic kidney disease |
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