PL3482765T3 - Długo działający hormon wzrostu i sposoby jego wytwarzania - Google Patents
Długo działający hormon wzrostu i sposoby jego wytwarzaniaInfo
- Publication number
- PL3482765T3 PL3482765T3 PL18198355.2T PL18198355T PL3482765T3 PL 3482765 T3 PL3482765 T3 PL 3482765T3 PL 18198355 T PL18198355 T PL 18198355T PL 3482765 T3 PL3482765 T3 PL 3482765T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- long
- growth hormone
- producing same
- acting growth
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/195,931 US8450269B2 (en) | 2006-02-03 | 2011-08-02 | Long-acting growth hormone and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3482765T3 true PL3482765T3 (pl) | 2024-08-26 |
Family
ID=47629749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18198355.2T PL3482765T3 (pl) | 2011-08-02 | 2012-08-02 | Długo działający hormon wzrostu i sposoby jego wytwarzania |
| PL12819794T PL2739298T4 (pl) | 2011-08-02 | 2012-08-02 | Długo działający hormon wzrostu i sposoby jego wytwarzania |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12819794T PL2739298T4 (pl) | 2011-08-02 | 2012-08-02 | Długo działający hormon wzrostu i sposoby jego wytwarzania |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8450269B2 (pl) |
| EP (2) | EP3482765B1 (pl) |
| JP (1) | JP6153930B2 (pl) |
| KR (3) | KR102028524B1 (pl) |
| CN (2) | CN104010650A (pl) |
| AU (1) | AU2012291617B2 (pl) |
| BR (1) | BR112014002491A2 (pl) |
| CA (1) | CA2843672A1 (pl) |
| CL (2) | CL2014000254A1 (pl) |
| CO (1) | CO7020850A2 (pl) |
| DK (2) | DK2739298T3 (pl) |
| EA (2) | EA202090577A3 (pl) |
| ES (2) | ES2983610T3 (pl) |
| FI (1) | FI3482765T3 (pl) |
| HK (1) | HK1200349A1 (pl) |
| HR (1) | HRP20240635T1 (pl) |
| HU (2) | HUE066552T2 (pl) |
| MX (2) | MX360802B (pl) |
| PL (2) | PL3482765T3 (pl) |
| PT (2) | PT2739298T (pl) |
| SI (2) | SI3482765T1 (pl) |
| TR (1) | TR201821186T4 (pl) |
| WO (1) | WO2013018098A2 (pl) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US7553940B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting EPO polypeptides and derivatives thereof and methods thereof |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| DK2279007T3 (en) | 2008-04-29 | 2016-08-22 | Ascendis Pharma Growth Disorders Div As | Pegylated recombinant relations of human growth hormone |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| JP2013513647A (ja) | 2009-12-15 | 2013-04-22 | アセンディス ファーマ エー／エス | ポリマー担体に一時的に連結された乾燥成長ホルモン組成物 |
| US9522945B2 (en) | 2012-04-19 | 2016-12-20 | Opko Biologics Ltd. | Long-acting oxyntomodulin variants and methods of producing same |
| SG10201610223PA (en) * | 2012-11-20 | 2017-02-27 | Opko Biolog Ltd | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN103524626B (zh) * | 2013-09-27 | 2016-09-07 | 武汉龙科生物技术有限公司 | 重组双靶点蛋白药物及其应用 |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| TWI720940B (zh) * | 2013-10-21 | 2021-03-11 | 以色列商歐科生物製品有限公司 | 長效型多肽及其生產和給藥的方法 |
| KR102608645B1 (ko) | 2014-11-18 | 2023-12-01 | 아센디스 파마 엔도크리놀로지 디비전 에이/에스 | 신규한 중합체성 hGH 프로드러그 |
| HRP20211734T8 (hr) | 2014-11-21 | 2022-03-04 | Ascendis Pharma Endocrinology Division A/S | Dozni oblici dugodjelujućeg hormona rasta |
| JP7000153B2 (ja) * | 2014-12-10 | 2022-01-19 | オプコ バイオロジクス リミテッド | 長時間作用性ｃｔｐ修飾成長ホルモンポリペプチドを生成する方法 |
| SI3230309T1 (sl) | 2014-12-10 | 2023-08-31 | Opko Biologics Ltd. | Postopki za proizvodnjo dolgo delujočih, s CTP-spremenjenih polipeptidov rastnega hormona |
| CA3228939A1 (en) | 2015-06-19 | 2016-12-22 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| MX2018008061A (es) | 2016-01-08 | 2018-08-23 | Ascendis Pharma Growth Disorders As | Profarmacos de peptido natriuretico tipo c (cnp) con porciones portadoras grandes. |
| PL3400019T3 (pl) | 2016-01-08 | 2023-01-23 | Ascendis Pharma Growth Disorders A/S | Proleki cnp z przyłączeniem nośnika w ugrupowaniu pierścieniowy |
| CA3008015A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Controlled-release c-type natriuretic peptide agonists with increased neutral endopeptidase stability |
| IL297375B2 (en) | 2016-01-08 | 2024-02-01 | Ascendis Pharma Growth Disorders As | Controlled-release CNP agonists with low NPR–C binding |
| IL259658B2 (en) | 2016-01-08 | 2024-06-01 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with reduced side-effects |
| AU2017205693B2 (en) | 2016-01-08 | 2022-03-31 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
| KR102331820B1 (ko) | 2016-03-01 | 2021-11-29 | 아센디스 파마 본 디지즈 에이/에스 | Pth 프로드럭 |
| SG10202100189WA (en) | 2016-07-11 | 2021-02-25 | Opko Biologics Ltd | Long-acting coagulation factor vii and methods of producing same |
| AU2017295938C1 (en) | 2016-07-13 | 2021-10-07 | Ascendis Pharma A/S | Conjugation method for carrier-linked prodrugs |
| RU2768747C2 (ru) | 2016-09-29 | 2022-03-24 | Асцендис Фарма Гроус Дизордерс А/С | Комбинаторная терапия с агонистами cnp контролируемого высвобождения |
| EP4275677A3 (en) | 2016-09-29 | 2024-01-10 | Ascendis Pharma Bone Diseases A/S | Dosage regimen for a controlled-release pth compound |
| MX2019003182A (es) | 2016-09-29 | 2019-08-05 | Ascendis Pharma Bone Diseases As | Compuestos de hormona paratiroidea con bajas relaciones pico - valle. |
| EP4491239A3 (en) | 2016-09-29 | 2025-03-26 | Ascendis Pharma Bone Diseases A/S | Incremental dose finding in controlled-release pth compounds |
| CA3093083A1 (en) | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugates |
| SG11202007524QA (en) | 2018-03-28 | 2020-09-29 | Ascendis Pharma Oncology Div A/S | Il-2 conjugates |
| AU2019270464B2 (en) | 2018-05-18 | 2024-09-26 | Ascendis Pharma Bone Diseases A/S | Starting dose of PTH conjugates |
| CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
| CN113286876A (zh) * | 2018-10-26 | 2021-08-20 | T·巴尔 | 用于生物降解酒精的组合物和方法 |
| MX2021009370A (es) | 2019-02-11 | 2021-09-10 | Ascendis Pharma Bone Diseases As | Formulaciones farmaceuticas liquidas de conjugados de hormona paratiroidea. |
| SG11202107446QA (en) | 2019-02-11 | 2021-08-30 | Ascendis Pharma Growth Disorders As | Dry pharmaceutical formulations of cnp conjugates |
| US12303553B2 (en) | 2019-03-04 | 2025-05-20 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms with superior efficacy to daily somatropin |
| KR20220024690A (ko) | 2019-06-21 | 2022-03-03 | 아센디스 파마 에이에스 | π 전자쌍 공여 헤테로방향족 질소 포함 화합물의 컨쥬게이트 |
| US20220304993A1 (en) | 2019-06-21 | 2022-09-29 | Ascendis Pharma A/S | Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds |
| US20220305129A1 (en) | 2019-06-21 | 2022-09-29 | Ascendis Pharma A/S | Conjugates of heteroaromatic nitrogen-comprising compounds |
| EP4084872A1 (en) | 2020-01-03 | 2022-11-09 | Ascendis Pharma A/S | Conjugates undergoing intramolecular rearrangements |
| CN115003320A (zh) | 2020-01-13 | 2022-09-02 | 阿森迪斯药物骨疾病股份有限公司 | 甲状旁腺功能减退的治疗 |
| MX2022014082A (es) | 2020-06-03 | 2022-12-07 | Ascendis Pharma Oncology Div A/S | Secuencias de interleucina (il-2) y usos de las mismas. |
| EP4192508A1 (en) | 2020-08-05 | 2023-06-14 | Ascendis Pharma A/S | Conjugates comprising reversible linkers and uses thereof |
| KR20230057447A (ko) | 2020-08-28 | 2023-04-28 | 아센디스 파마 온콜로지 디비전 에이/에스 | 글리코실화된 il-2 단백질 및 이의 용도 |
| JP2023543265A (ja) | 2020-09-28 | 2023-10-13 | アセンディス ファーマ ボーン ディジージズ エー／エス | 副甲状腺機能低下症を有する患者の身体的及び精神的ウェルビーイングの改善 |
| CN112175964B (zh) * | 2020-10-23 | 2022-03-29 | 安徽中起生物科技有限公司 | 一种重组猪生长激素及其制备方法和应用 |
| CN117396497A (zh) | 2021-04-01 | 2024-01-12 | 阿森迪斯药物股份有限公司 | 长效生长激素用于治疗炎症诱导的疾病的用途 |
| CN114010765A (zh) * | 2021-08-30 | 2022-02-08 | 上海延立药业有限公司 | 一种长效人生长激素 |
| EP4404951A1 (en) | 2021-09-22 | 2024-07-31 | Ascendis Pharma Bone Diseases A/S | Long-acting pth compound treatments |
| WO2023110758A1 (en) | 2021-12-13 | 2023-06-22 | Ascendis Pharma Growth Disorders A/S | Effective doses of cnp conjugates |
| EP4529454A1 (en) | 2022-05-23 | 2025-04-02 | Ascendis Pharma Growth Disorders A/S | Liquid pharmaceutical formulations of cnp compounds |
| EP4611891A1 (en) | 2022-11-02 | 2025-09-10 | Ascendis Pharma Bone Diseases A/S | Pth treatment regimen comprising two pth compounds |
| WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
| KR20250162619A (ko) | 2023-03-20 | 2025-11-18 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | 연골무형성증을 가진 인간 대상에서의 흉요추 변형의 치료 방법 |
| WO2025051711A1 (en) | 2023-09-04 | 2025-03-13 | Ascendis Pharma Bone Diseases A/S | Pth treatment of chronic kidney disease |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| JPS5781447A (en) | 1980-11-11 | 1982-05-21 | Toyo Jozo Co Ltd | Human chorionic gonadotropic hormone c-terminal fragment |
| US4853332A (en) | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| DE3421468A1 (de) | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| DE3751873T2 (de) | 1986-04-09 | 1997-02-13 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| DE68917883T2 (de) | 1988-05-06 | 1995-02-23 | Toray Industries | Stabile interferon-beta-zusammensetzung. |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| JP3045539B2 (ja) | 1989-02-21 | 2000-05-29 | ワシントン ユニバーシティ | 改変型生殖ホルモン |
| US5338835A (en) | 1989-02-21 | 1994-08-16 | Washington University | CTP-extended form of FSH |
| US6225449B1 (en) | 1991-10-04 | 2001-05-01 | Washington University | Hormone analogs with multiple CTP extensions |
| US5792460A (en) | 1989-02-21 | 1998-08-11 | Washington University | Modified glycoprotein hormones having a CTP at the amino terminus |
| US5705478A (en) | 1989-02-21 | 1998-01-06 | Washington University | Covalently linked β subunits of the glycoprotein hormones as antagonists |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US7217689B1 (en) | 1989-10-13 | 2007-05-15 | Amgen Inc. | Glycosylation analogs of erythropoietin |
| US5126324A (en) | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
| US6028177A (en) | 1991-10-04 | 2000-02-22 | Washington University | Methods of detecting single-chain forms of the glycoprotein hormone quartet |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| EP0695307B1 (en) | 1993-04-20 | 1999-12-15 | Washington University | Modified protein and peptide pharmaceuticals |
| US6737515B2 (en) | 1993-11-19 | 2004-05-18 | Washington University | Follicle stimulating hormone-glycosylation analogs |
| US6238890B1 (en) | 1994-02-18 | 2001-05-29 | Washington University | Single chain forms of the glycoprotein hormone quartet |
| US5935924A (en) | 1994-04-15 | 1999-08-10 | Genentech, Inc. | Treatment of congestive heart failure |
| US5541110A (en) | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
| MX9601320A (es) | 1994-08-12 | 1997-05-31 | Univ Washington | Formas de cadena unica de cuarteto de hormona de glicoproteina. |
| US6083725A (en) | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
| IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| US6310183B1 (en) | 1997-09-10 | 2001-10-30 | Novo Nordisk A/S | Coagulation factor VIIa composition |
| US6103501A (en) | 1997-11-17 | 2000-08-15 | Washington University | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
| IL142350A0 (en) | 1998-10-16 | 2002-03-10 | Biogen Inc | Interferon-beta fusion proteins and pharmaceutical compositions containing the same |
| US6514729B1 (en) | 1999-05-12 | 2003-02-04 | Xencor, Inc. | Recombinant interferon-beta muteins |
| JO2291B1 (en) | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
| US20020127652A1 (en) | 2000-02-11 | 2002-09-12 | Schambye Hans Thalsgard | Follicle stimulating hormones |
| US7094566B2 (en) | 2000-03-16 | 2006-08-22 | Amgen Inc., | IL-17 receptor like molecules and uses thereof |
| ATE416784T1 (de) | 2000-12-01 | 2008-12-15 | Takeda Pharmaceutical | Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz |
| JP4409135B2 (ja) | 2000-12-01 | 2010-02-03 | 武田薬品工業株式会社 | 生理活性物質含有製剤の製造法 |
| NZ525577A (en) | 2000-12-07 | 2005-05-27 | Lilly Co Eli | Glucagon-Like Peptide 1 heterologous fusion proteins for the treatment of non-insulin dependent diabetes mellitus |
| KR101229995B1 (ko) | 2000-12-11 | 2013-02-06 | 씨제이 주식회사 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
| AU2002222740A1 (en) | 2000-12-11 | 2002-06-24 | Cheil Jedang Corporation | Fusion protein having the enhanced in vivo activity of erythropoietin |
| US8637077B2 (en) | 2000-12-28 | 2014-01-28 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
| JP5160005B2 (ja) | 2000-12-28 | 2013-03-13 | 武田薬品工業株式会社 | 徐放性製剤 |
| US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| US6824769B2 (en) | 2001-08-28 | 2004-11-30 | Vertex Pharmaceuticals Incorporated | Optimal compositions and methods thereof for treating HCV infections |
| GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| US7081446B2 (en) | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
| US7173113B2 (en) | 2002-01-31 | 2007-02-06 | The Trustees Of Columbia University In The City Of New York | Long-acting hormone and growth factor compositions and uses thereof |
| US7459435B2 (en) | 2002-08-29 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| US7459436B2 (en) | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| JP4683319B2 (ja) | 2003-02-19 | 2011-05-18 | 武田薬品工業株式会社 | 徐放性製剤用の分散剤 |
| EP1595549A4 (en) | 2003-02-19 | 2010-09-22 | Takeda Pharmaceutical | DISPERSE FOR PREPARATIONS WITH DELAYED RELEASE |
| CN1243022C (zh) * | 2003-10-17 | 2006-02-22 | 华东师范大学 | 生物修饰重组人生长激素复合物及其制备方法 |
| WO2005047319A2 (en) | 2003-11-12 | 2005-05-26 | The University Of Georgia Research Foundation, Inc. | Dna sequence and expressed recombinant glycoproteins related to feline thyrotropin |
| JP2007514673A (ja) | 2003-12-19 | 2007-06-07 | エフ．ホフマン−ラ ロシュ アーゲー | 慢性炎症性腸疾患の際の鉄分布障害の処置におけるエリスロポエチンの使用 |
| AU2005228945B2 (en) | 2004-03-19 | 2010-09-30 | Baxter Healthcare S.A. | Factor IXa for the treatment of bleeding disorders |
| DE602005021509D1 (de) | 2004-08-17 | 2010-07-08 | Csl Behring Gmbh | Modifizierte vitamin-k-abhängige polypeptide |
| US8420602B2 (en) * | 2004-09-14 | 2013-04-16 | Landon C. G. Miller | Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders |
| EP1728798A1 (en) | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
| US7553940B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting EPO polypeptides and derivatives thereof and methods thereof |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US8304386B2 (en) | 2006-02-03 | 2012-11-06 | Prolor Biotech, Inc. | Long-acting growth hormone and methods of producing same |
| US8476234B2 (en) | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
| KR100900784B1 (ko) * | 2007-01-03 | 2009-06-02 | 주식회사 하이닉스반도체 | 반도체메모리소자 |
| WO2009114959A1 (zh) * | 2008-03-20 | 2009-09-24 | 中国人民解放军军事医学科学院毒物药物研究所 | 可注射用缓释药物制剂及其制备方法 |
-
2011
- 2011-08-02 US US13/195,931 patent/US8450269B2/en active Active
-
2012
- 2012-08-02 BR BR112014002491A patent/BR112014002491A2/pt not_active Application Discontinuation
- 2012-08-02 EA EA202090577A patent/EA202090577A3/ru unknown
- 2012-08-02 DK DK12819794.4T patent/DK2739298T3/en active
- 2012-08-02 CN CN201280048492.0A patent/CN104010650A/zh active Pending
- 2012-08-02 MX MX2014001335A patent/MX360802B/es active IP Right Grant
- 2012-08-02 HR HRP20240635TT patent/HRP20240635T1/hr unknown
- 2012-08-02 DK DK18198355.2T patent/DK3482765T5/da active
- 2012-08-02 PL PL18198355.2T patent/PL3482765T3/pl unknown
- 2012-08-02 PL PL12819794T patent/PL2739298T4/pl unknown
- 2012-08-02 EP EP18198355.2A patent/EP3482765B1/en active Active
- 2012-08-02 PT PT12819794T patent/PT2739298T/pt unknown
- 2012-08-02 HU HUE18198355A patent/HUE066552T2/hu unknown
- 2012-08-02 SI SI201232065T patent/SI3482765T1/sl unknown
- 2012-08-02 PT PT181983552T patent/PT3482765T/pt unknown
- 2012-08-02 WO PCT/IL2012/050288 patent/WO2013018098A2/en not_active Ceased
- 2012-08-02 FI FIEP18198355.2T patent/FI3482765T3/fi active
- 2012-08-02 ES ES18198355T patent/ES2983610T3/es active Active
- 2012-08-02 KR KR1020147005420A patent/KR102028524B1/ko active Active
- 2012-08-02 HU HUE12819794A patent/HUE042755T2/hu unknown
- 2012-08-02 CN CN201710103795.2A patent/CN107080835A/zh active Pending
- 2012-08-02 JP JP2014523441A patent/JP6153930B2/ja active Active
- 2012-08-02 AU AU2012291617A patent/AU2012291617B2/en active Active
- 2012-08-02 CA CA2843672A patent/CA2843672A1/en active Pending
- 2012-08-02 SI SI201231498T patent/SI2739298T1/sl unknown
- 2012-08-02 EA EA201490393A patent/EA035352B1/ru unknown
- 2012-08-02 KR KR1020217002411A patent/KR20210013300A/ko not_active Ceased
- 2012-08-02 KR KR1020197028467A patent/KR20190116526A/ko not_active Ceased
- 2012-08-02 ES ES12819794T patent/ES2706734T3/es active Active
- 2012-08-02 TR TR2018/21186T patent/TR201821186T4/tr unknown
- 2012-08-02 EP EP12819794.4A patent/EP2739298B1/en active Active
- 2012-08-02 HK HK15100967.2A patent/HK1200349A1/xx unknown
-
2014
- 2014-01-31 MX MX2018014072A patent/MX2018014072A/es unknown
- 2014-01-31 CL CL2014000254A patent/CL2014000254A1/es unknown
- 2014-02-12 CO CO14029693A patent/CO7020850A2/es unknown
-
2020
- 2020-07-31 CL CL2020002010A patent/CL2020002010A1/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI2739298T1 (sl) | Dolgo delujoči rastni hormon in metode za njegovo proizvodnjo | |
| IL282121B (en) | Long-term coagulation factors and methods for their preparation | |
| IL235184A0 (en) | Variants of oxyntomodulin with prolonged activity and methods for their preparation | |
| GB201117522D0 (en) | Visor and method of manufacture | |
| EP2761113A4 (en) | INSULATED CONCRETE MOLDING AND USE METHOD THEREFOR | |
| ZA201306490B (en) | Methods of forming polycrystalline tables and polycrystalline elements and related structures | |
| ZA201306489B (en) | Methods of forming polycrystalline tables and polycrystalline elements and related structures | |
| IL248217B (en) | A method for the production of inganol-3-englate | |
| GB2503842B (en) | Composition and method of manufacture | |
| IL213865A0 (en) | Antiballistic article and method of producing same | |
| IL228072A0 (en) | Alkyl-substituted quinazoline compounds and methods of use | |
| PL2785701T3 (pl) | Krystaliczna postać kabazytakselu i sposób jej otrzymywania | |
| EP2747975A4 (en) | MANUFACTURED ARTICLE AND PROCESS FOR PREPARING THE SAME | |
| EP2788014B8 (en) | Use of growth hormone fragments | |
| EP2773713A4 (en) | PRINTED CHROMIUM BELT AND METHOD FOR THE PRODUCTION THEREOF | |
| ZA201401905B (en) | Methods of forming polycrystalline compacts and resulting compacts | |
| EP2698159A4 (en) | PITAVASTATE-CONTAINING PREPARATION AND METHOD OF MANUFACTURING THEREOF | |
| GB201115521D0 (en) | Colorant-polyesters and methods of producing colorant-polyesters | |
| GB201115069D0 (en) | Elongate tape and method of producing same | |
| IL230757A0 (en) | Long-term growth hormone and methods of preparation | |
| ZA201404698B (en) | Use of growth hormone fragments | |
| GB201121448D0 (en) | Artificial vines and method of producing artificial vines | |
| IL234082A0 (en) | Long-term coagulation factors and methods for their preparation | |
| AU2011905132A0 (en) | Use of growth hormone fragments | |
| AU2011905133A0 (en) | Use of growth hormone fragments |