SI2739298T1 - Dolgo delujoči rastni hormon in metode za njegovo proizvodnjo - Google Patents
Dolgo delujoči rastni hormon in metode za njegovo proizvodnjoInfo
- Publication number
- SI2739298T1 SI2739298T1 SI201231498T SI201231498T SI2739298T1 SI 2739298 T1 SI2739298 T1 SI 2739298T1 SI 201231498 T SI201231498 T SI 201231498T SI 201231498 T SI201231498 T SI 201231498T SI 2739298 T1 SI2739298 T1 SI 2739298T1
- Authority
- SI
- Slovenia
- Prior art keywords
- methods
- long
- growth hormone
- producing same
- acting growth
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/195,931 US8450269B2 (en) | 2006-02-03 | 2011-08-02 | Long-acting growth hormone and methods of producing same |
| EP12819794.4A EP2739298B1 (en) | 2011-08-02 | 2012-08-02 | Long-acting growth hormone and methods of producing same |
| PCT/IL2012/050288 WO2013018098A2 (en) | 2011-08-02 | 2012-08-02 | Long-acting growth hormone and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2739298T1 true SI2739298T1 (sl) | 2019-03-29 |
Family
ID=47629749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231498T SI2739298T1 (sl) | 2011-08-02 | 2012-08-02 | Dolgo delujoči rastni hormon in metode za njegovo proizvodnjo |
| SI201232065T SI3482765T1 (sl) | 2011-08-02 | 2012-08-02 | Dolgodelujoči rastni hormoni in metode za njegovo proizvodnjo |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201232065T SI3482765T1 (sl) | 2011-08-02 | 2012-08-02 | Dolgodelujoči rastni hormoni in metode za njegovo proizvodnjo |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8450269B2 (enExample) |
| EP (2) | EP3482765B1 (enExample) |
| JP (1) | JP6153930B2 (enExample) |
| KR (3) | KR102028524B1 (enExample) |
| CN (2) | CN104010650A (enExample) |
| AU (1) | AU2012291617B2 (enExample) |
| BR (1) | BR112014002491A2 (enExample) |
| CA (1) | CA2843672A1 (enExample) |
| CL (2) | CL2014000254A1 (enExample) |
| CO (1) | CO7020850A2 (enExample) |
| DK (2) | DK3482765T5 (enExample) |
| EA (2) | EA035352B1 (enExample) |
| ES (2) | ES2983610T3 (enExample) |
| FI (1) | FI3482765T3 (enExample) |
| HK (1) | HK1200349A1 (enExample) |
| HR (1) | HRP20240635T1 (enExample) |
| HU (2) | HUE066552T2 (enExample) |
| MX (2) | MX360802B (enExample) |
| PL (2) | PL3482765T3 (enExample) |
| PT (2) | PT2739298T (enExample) |
| SI (2) | SI2739298T1 (enExample) |
| TR (1) | TR201821186T4 (enExample) |
| WO (1) | WO2013018098A2 (enExample) |
Families Citing this family (72)
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|---|---|---|---|---|
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| CA3004716C (en) | 2008-04-29 | 2022-04-12 | Ascendis Pharma Endocrinology Division A/S | Pegylated recombinant human growth hormone compounds |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| EP2512450B1 (en) | 2009-12-15 | 2018-02-07 | Ascendis Pharma Endocrinology Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| WO2013157002A1 (en) | 2012-04-19 | 2013-10-24 | Prolor Biotech Inc. | Long-acting oxyntomodulin variants and methods of producing same |
| SG11201503879QA (en) * | 2012-11-20 | 2015-06-29 | Opko Biolog Ltd | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN103524626B (zh) * | 2013-09-27 | 2016-09-07 | 武汉龙科生物技术有限公司 | 重组双靶点蛋白药物及其应用 |
| HUE050002T2 (hu) * | 2013-10-21 | 2020-11-30 | Opko Biologics Ltd | Hosszan ható polipeptidek és eljárás azok elõállítására és beadására |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| KR102608645B1 (ko) | 2014-11-18 | 2023-12-01 | 아센디스 파마 엔도크리놀로지 디비전 에이/에스 | 신규한 중합체성 hGH 프로드러그 |
| EP4732848A3 (en) | 2014-11-21 | 2026-07-29 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms |
| KR102527180B1 (ko) | 2014-12-10 | 2023-04-27 | 옵코 바이오로직스 리미티드 | 장기간 작용성 ctp-변형된 성장 호르몬 폴리펩타이드의 제조 방법 |
| MY184625A (en) * | 2014-12-10 | 2021-04-09 | Opko Biologics Ltd | Methods of producing long acting ctp-modified growth hormone polypeptides |
| KR102662956B1 (ko) | 2015-06-19 | 2024-05-03 | 옵코 바이오로직스 리미티드 | 장기-작용성 응고 인자 및 그의 제조 방법 |
| AU2017205693B2 (en) | 2016-01-08 | 2022-03-31 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
| CA3008015A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Controlled-release c-type natriuretic peptide agonists with increased neutral endopeptidase stability |
| JP6968802B2 (ja) | 2016-01-08 | 2021-11-17 | アセンディス ファーマ グロース ディスオーダーズ エー／エス | 環部分にキャリア結合を有するｃｎｐプロドラッグ |
| US10835578B2 (en) | 2016-01-08 | 2020-11-17 | Ascendis Pharma Growth Disorders A/S | CNP prodrugs with large carrier moieties |
| KR102518217B1 (ko) | 2016-01-08 | 2023-04-04 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | 낮은 npr-c 결합을 갖는 제어 방출성 cnp 작용제 |
| EP4710947A3 (en) | 2016-01-08 | 2026-06-17 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with reduced side-effects |
| SI3423103T1 (sl) | 2016-03-01 | 2024-12-31 | Ascendis Pharma Bone Diseases A/S | Predzdravila PTH |
| EP4303228B1 (en) | 2016-07-11 | 2026-05-27 | OPKO Biologics Ltd. | Long-acting coagulation factor vii and methods of producing same |
| AU2017295938C1 (en) | 2016-07-13 | 2021-10-07 | Ascendis Pharma A/S | Conjugation method for carrier-linked prodrugs |
| KR102611820B1 (ko) | 2016-09-29 | 2023-12-07 | 아센디스 파마 본 디지즈 에이/에스 | 낮은 피크 대 트로프 비를 가진 pth 화합물 |
| HUE063235T2 (hu) | 2016-09-29 | 2024-01-28 | Ascendis Pharma Bone Diseases As | Adagolási rendszer szabályozott leadású PTH vegyülethez |
| JP7039574B2 (ja) | 2016-09-29 | 2022-03-22 | アセンディス ファーマ ボーン ディジージズ エー／エス | 放出制御ｐｔｈ化合物の漸増用量設定 |
| RU2768747C2 (ru) | 2016-09-29 | 2022-03-24 | Асцендис Фарма Гроус Дизордерс А/С | Комбинаторная терапия с агонистами cnp контролируемого высвобождения |
| CA3093083A1 (en) | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugates |
| US12565525B2 (en) | 2018-03-28 | 2026-03-03 | Ascendis Pharma Oncology Division A/S | IL-2 conjugates |
| CA3099620A1 (en) | 2018-05-18 | 2019-11-21 | Ascendis Pharma Bone Diseases A/S | Starting dose of pth conjugates |
| CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
| EP3848388B1 (en) | 2018-09-05 | 2025-08-20 | LG Chem, Ltd. | Fusion polypeptide comprising polypeptide region that can be o-glycosylated |
| EP3870694A4 (en) * | 2018-10-26 | 2022-08-17 | Tami Bar | COMPOSITIONS AND METHODS FOR BIODEGRADING ALCOHOL |
| AU2020221491B2 (en) | 2019-02-11 | 2025-02-27 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of PTH conjugates |
| EP3923906A1 (en) | 2019-02-11 | 2021-12-22 | Ascendis Pharma Growth Disorders A/S | Dry pharmaceutical formulations of cnp conjugates |
| JP7524206B2 (ja) * | 2019-03-04 | 2024-07-29 | アセンディス ファーマ エンドクライノロジー ディヴィジョン エー／エス | １日ごとのソマトロピンよりも優れた効力を有する長時間作用性成長ホルモン剤形 |
| WO2020254602A1 (en) | 2019-06-21 | 2020-12-24 | Ascendis Pharma A/S | Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds |
| AU2020296297B2 (en) | 2019-06-21 | 2025-06-12 | Ascendis Pharma A/S | Conjugates of heteroaromatic nitrogen-comprising compounds |
| EP3986477A1 (en) | 2019-06-21 | 2022-04-27 | Ascendis Pharma A/S | CONJUGATES OF pi-ELECTRON-PAIR-DONATING HETEROAROMATIC NITROGEN-COMPRISING COMPOUNDS |
| CA3161098A1 (en) | 2020-01-03 | 2021-07-08 | Ascendis Pharma A/S | Conjugates undergoing intramolecular rearrangements |
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| CA3184998A1 (en) | 2020-08-05 | 2022-02-10 | Samuel WEISBROD | Conjugates comprising reversible linkers and uses thereof |
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| AU2022413318A1 (en) | 2021-12-13 | 2024-05-16 | Ascendis Pharma Growth Disorders A/S | Effective doses of cnp conjugates |
| WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
| AU2023276829A1 (en) | 2022-05-23 | 2024-10-31 | Ascendis Pharma Growth Disorders A/S | Liquid pharmaceutical formulations of cnp compounds |
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| CN115991792A (zh) * | 2022-12-19 | 2023-04-21 | 北京伟杰信生物科技有限公司 | 长效重组lh融合蛋白及其制备方法与应用 |
| KR20250162619A (ko) | 2023-03-20 | 2025-11-18 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | 연골무형성증을 가진 인간 대상에서의 흉요추 변형의 치료 방법 |
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| WO2026120176A1 (en) | 2024-12-06 | 2026-06-11 | Ascendis Pharma A/S | Conjugates comprising an aromatic carbamate-derived reversible linker |
| WO2026120177A1 (en) | 2024-12-06 | 2026-06-11 | Ascendis Pharma A/S | Novel long-acting degrader conjugates |
| WO2026139471A1 (en) | 2024-12-23 | 2026-07-02 | Ascendis Pharma Growth Disorders A/S | Use of cnp or cnp conjugates such as navepegritide to treat leg curvature in patients with skeletal dysplasia |
| WO2026150105A1 (en) | 2025-01-13 | 2026-07-16 | Ascendis Pharma A/S | Fgf23 degrader conjugates |
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