DK2379084T3 - MODULATION OF FACTOR 11 EXPRESSION - Google Patents

MODULATION OF FACTOR 11 EXPRESSION Download PDF

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Publication number
DK2379084T3
DK2379084T3 DK09821293.9T DK09821293T DK2379084T3 DK 2379084 T3 DK2379084 T3 DK 2379084T3 DK 09821293 T DK09821293 T DK 09821293T DK 2379084 T3 DK2379084 T3 DK 2379084T3
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Prior art keywords
factor
isis
antisense
seq
mice
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DK09821293.9T
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Danish (da)
English (en)
Inventor
Susan M Freier
Brett P Monia
Hong Zhang
Chenguang Zhao
Jeffrey R Crosby
Andrew M Siwkowski
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21027—Coagulation factor XIa (3.4.21.27)
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DK09821293.9T 2008-10-15 2009-10-15 MODULATION OF FACTOR 11 EXPRESSION DK2379084T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10577208P 2008-10-15 2008-10-15
US17446109P 2009-04-30 2009-04-30
PCT/US2009/060922 WO2010045509A2 (en) 2008-10-15 2009-10-15 Modulation of factor 11 expression

Publications (1)

Publication Number Publication Date
DK2379084T3 true DK2379084T3 (en) 2018-01-22

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DK09821293.9T DK2379084T3 (en) 2008-10-15 2009-10-15 MODULATION OF FACTOR 11 EXPRESSION

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US (7) US8334372B2 (OSRAM)
EP (2) EP3335715A3 (OSRAM)
JP (4) JP5809058B2 (OSRAM)
KR (2) KR101773551B1 (OSRAM)
CN (4) CN103820450B (OSRAM)
AU (2) AU2009305636A1 (OSRAM)
BR (1) BRPI0920263B1 (OSRAM)
CA (2) CA2740785C (OSRAM)
CY (1) CY1119909T1 (OSRAM)
DK (1) DK2379084T3 (OSRAM)
ES (1) ES2657679T3 (OSRAM)
HR (1) HRP20171969T1 (OSRAM)
HU (1) HUE035888T2 (OSRAM)
IL (2) IL212267A (OSRAM)
LT (1) LT2379084T (OSRAM)
MX (1) MX2011004097A (OSRAM)
NO (1) NO2379084T3 (OSRAM)
NZ (2) NZ592203A (OSRAM)
PL (1) PL2379084T3 (OSRAM)
PT (1) PT2379084T (OSRAM)
RU (2) RU2535964C2 (OSRAM)
SI (1) SI2379084T1 (OSRAM)
WO (1) WO2010045509A2 (OSRAM)

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US9150864B2 (en) * 2010-11-08 2015-10-06 Isis Pharmaceuticals, Inc. Methods for modulating factor 12 expression
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WO2013070771A1 (en) * 2011-11-07 2013-05-16 Isis Pharmaceuticals, Inc. Administration of factor xi antisense oligonucleotides
EP2856172A4 (en) 2012-05-25 2016-03-02 Univ Vermont COMPOSITIONS AND METHODS FOR TESTING THROMBOCYTE REACTIVITY AND TREATMENT SELECTION
BR112015027322A8 (pt) 2013-05-01 2018-01-02 Isis Pharmaceuticals Inc Compostos antissenso conjugados e sua utilização
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TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
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EP3719128B1 (en) 2017-12-01 2025-01-15 Suzhou Ribo Life Science Co., Ltd. Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method therefor and use thereof
JP7360716B2 (ja) 2017-12-01 2023-10-13 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用
CN118291456A (zh) 2017-12-01 2024-07-05 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
JP7436030B2 (ja) 2017-12-29 2024-02-21 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 複合体及びその調製方法と使用
AU2019255622B2 (en) * 2018-04-20 2025-02-27 The University Of Vermont And State Agriculture College Compositions and methods for treating cardiovascular disease in selected patients
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WO2020038377A1 (zh) 2018-08-21 2020-02-27 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
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CN118256498A (zh) 2019-05-22 2024-06-28 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
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