DK2162467T3 - Polypeptider, variable antistofdomæner & antagonister - Google Patents
Polypeptider, variable antistofdomæner & antagonister Download PDFInfo
- Publication number
- DK2162467T3 DK2162467T3 DK08750800.8T DK08750800T DK2162467T3 DK 2162467 T3 DK2162467 T3 DK 2162467T3 DK 08750800 T DK08750800 T DK 08750800T DK 2162467 T3 DK2162467 T3 DK 2162467T3
- Authority
- DK
- Denmark
- Prior art keywords
- protease
- tnfr1
- polypeptide
- dab
- antagonist
- Prior art date
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- 0 C[C@]1C(*IIIC)*(CC(C2)C3(C)*2OC3)[C@](C)C1 Chemical compound C[C@]1C(*IIIC)*(CC(C2)C3(C)*2OC3)[C@](C)C1 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
Claims (16)
1. Variabelt enkeltdomæne af anti-TNFa-receptor-type-l-immunglobulin omfattende den følgende aminosyresekvens: EVQLLESGGGLVQPGGSLRLSCAASGFTFAHETMVWVRQAPGKGLEWV SHIPPDGQDPFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYHCAL LPKRGPWFDYWGQGTLVTVSS
2. Variabelt enkeltdomæne af anti-TNFa-receptor-type-l-immunglobulin ifølge krav 1, kodet ved en sekvens, som er identisk med nukleotidsekvensen af DOMIh-131-206 vist på figur 19.
3. TNFa-receptor-type-l-antagonist omfattende en variabelt enkeltdomæne af anti-TNFRl-immunglobulin ifølge et hvilket som helst foregående krav.
4. Antagonist ifølge krav 3, omfattende første og andet variable enkeltdomæner af immunglobulin, hvor hvert variabelt domæne er ifølge et hvilket som helst af krav 1- 2.
5. Antagonist ifølge krav 3 eller 4, hvor antagonisten omfatter en monomer af det variable enkeltdomæne eller en homodimer af det variable enkeltdomæne, hvor det variable domæne er identisk med aminosyresekvensen af DOMlh-131-206.
6. TNFRl-antagonist ifølge kravene 3-5 til anvendelse i medicin, hvor det indgives oralt, via fordøjelseskanalen eller via pulmonal fremføring.
7. TNFRl-antagonist ifølge kravene 3-5 til anvendelse i behandling af og/eller forebyggelse af en inflammatorisk tilstand.
8. TNFRl-antagonist ifølge krav 7, hvor den inflammatoriske tilstand er valgt blandt: pulmonal sygdom, psoriasis, arthrit, inflammatorisk tarmsygdom.
9. TNFRl-antagonist ifølge kravene 3-5 til anvendelse i behandling af og/eller forebyggelse af en respiratorisk sygdom hos et humant subjekt.
10. TNFRl-antagonist ifølge krav 9, hvor den respiratoriske sygdom er valgt blandt: lungeinflammation, kronisk obstruktiv lungesygdom (ENG: COPD), Astma, Pneumoni, cystiskfibrose, interstitiel lungesygdom, allergi, pulmonal inflammation.
11. Dobbelt-specifik ligand omfattende et variabelt domæne ifølge et hvilket som helst af krav 1-2.
12. Isoleret eller rekombinant nukleinsyre, der koder for et polypeptid omfattende et variabelt enkeltdomæne af immunglobulin ifølge et hvilket som helst af krav 1-2.
13. Vektor omfattende nukleinsyren ifølge krav 12.
14. Værtscelle omfattende nukleinsyren ifølge krav 12 eller vektoren ifølge krav 13.
15. Farmaceutisk sammensætning omfattende et variabelt enkeltdomæne af immunglobulin ifølge et hvilket som helst af krav 1 til 2 eller en antagonist ifølge et hvilket som helst af krav 3 til 5 og et farmaceutisk acceptabelt bærestof, excipiens eller fortyndingsmiddel.
16. Variabelt enkeltdomæne af immunglobulin ifølge et hvilket som helst af krav 1 til 2 eller en antagonist ifølge et hvilket som helst af krav 3 til 5 omfattende et konstant anti- stofdomæne.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93363207P | 2007-06-06 | 2007-06-06 | |
GBGB0724331.4A GB0724331D0 (en) | 2007-12-13 | 2007-12-13 | Compositions for pulmonary delivery |
PCT/GB2008/050405 WO2008149148A2 (en) | 2007-06-06 | 2008-06-04 | Polypeptides, antibody variable domains and antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2162467T3 true DK2162467T3 (da) | 2015-08-24 |
Family
ID=39791116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08750800.8T DK2162467T3 (da) | 2007-06-06 | 2008-06-04 | Polypeptider, variable antistofdomæner & antagonister |
Country Status (32)
Country | Link |
---|---|
US (5) | US8398979B2 (da) |
EP (5) | EP2746290B1 (da) |
JP (3) | JP2010530364A (da) |
KR (4) | KR20100018040A (da) |
CN (4) | CN101802004A (da) |
AR (3) | AR066850A1 (da) |
AU (4) | AU2008259590A1 (da) |
BR (3) | BRPI0813899A2 (da) |
CA (6) | CA2688434A1 (da) |
CL (3) | CL2008001676A1 (da) |
CO (2) | CO6251322A2 (da) |
CR (2) | CR11194A (da) |
CY (1) | CY1116762T1 (da) |
DK (1) | DK2162467T3 (da) |
DO (1) | DOP2009000268A (da) |
EA (5) | EA200901494A1 (da) |
ES (1) | ES2546943T3 (da) |
HK (1) | HK1138022A1 (da) |
HR (1) | HRP20151024T1 (da) |
HU (1) | HUE025899T2 (da) |
IL (2) | IL201398A0 (da) |
MA (2) | MA31403B1 (da) |
MX (4) | MX2009013137A (da) |
NZ (1) | NZ581372A (da) |
PE (3) | PE20090763A1 (da) |
PL (1) | PL2162467T3 (da) |
PT (1) | PT2162467E (da) |
SG (2) | SG182141A1 (da) |
SI (1) | SI2162467T1 (da) |
TW (6) | TW200902551A (da) |
WO (3) | WO2008149149A2 (da) |
ZA (1) | ZA200908470B (da) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
MX363423B (es) | 2005-05-18 | 2019-03-22 | Ablynx Nv | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
CA2688434A1 (en) | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
EA200901301A1 (ru) * | 2007-06-06 | 2010-06-30 | Домантис Лимитед | Полипептиды, вариабельные домены антител и антагонисты |
GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
BRPI0819932A2 (pt) * | 2007-12-13 | 2019-07-30 | Glaxo Group Ltd | composição, uso de uma composição, dispositivo nebulizador, inalador ou intranasal, processos para produzir uma composição farmacêutica e uma composição polipeptídica, e, uso de um tampão fisiologicamente aceitável. |
CA2721202A1 (en) | 2008-04-17 | 2009-10-22 | Hilde Adi Pierrette Revets | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
AU2009264565C1 (en) | 2008-06-25 | 2022-01-27 | Novartis Ag | Stable and soluble antibodies inhibiting VEGF |
US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
BRPI0921319A2 (pt) * | 2008-11-26 | 2018-10-16 | Glaxo Group Ltd | composição, método para dispensação de uma composição, e para tratar, prevenir ou diagnosticar uma condição ocular, e, processo para produzir uma composição farmacêutica |
WO2010081787A1 (en) | 2009-01-14 | 2010-07-22 | Domantis Limited | IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS |
NZ595242A (en) * | 2009-02-19 | 2013-11-29 | Glaxo Group Ltd | Improved anti-serum albumin binding variants |
EA022925B1 (ru) * | 2009-02-19 | 2016-03-31 | Глаксо Груп Лимитед | Улучшенные полипептиды, вариабельные домены антител и антагонисты против tnfr1 |
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