DK1935427T3 - Anvendelser af opløselige, mutante ctla4-molekyler - Google Patents
Anvendelser af opløselige, mutante ctla4-molekyler Download PDFInfo
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- DK1935427T3 DK1935427T3 DK08001340.2T DK08001340T DK1935427T3 DK 1935427 T3 DK1935427 T3 DK 1935427T3 DK 08001340 T DK08001340 T DK 08001340T DK 1935427 T3 DK1935427 T3 DK 1935427T3
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Claims (14)
- ANVENDELSER AF OPLØSELIGE, MUT ANTE CTLA4-MOLEKYLER PATENTKRAV1. Opløseligt, mutant CTLA4-molekyle og kortikosteroid til anvendelse i behandling af graft-versus-host-sygdom, immunforstyrrelser i forbindelse med transplantatafvisning, kronisk afvisning og vævs- eller celleallotransplantat eller -xenotransplantater, psoriasis, T-cellelymfom, T-celle-akut lymfoblastisk leukæmi, angiocentrisk testikulært T-cellelymfom, godartet lymfocytisk angiitis, lupus, Hashimotos thyroiditis, primær myxødem, Graves' sygdom, pemiciøs anæmi, autoimmun atrofisk gastritis, Addisons sygdom, diabetes, Goodpasture-syndrom, myasthenia gravis, pemphigus, Crohns sygdom, sympatisk oftalmi, autoimmun uveitis, multipel sklerose, autoimmun hæniolytisk anæmi, idiopatisk trombocytopeni, primær biliær cirrose, kronisk aktiv hepatitis, ulceratis colitis, Sjøgrens syndrom, rheumatoid arthritis, polymyositis, sklerodermi og blandet bindevævssygdom, hvor det opløselige, mutante CTLA4-molekyle er et Ig-fusionsprotein, der omfatter det extracellulære domæne af CTLA4, og det extracellulære domæne af CTLA4 omfatter en mutation ved position +104 af CTLA4 som vist i Figur 24, hvor leucin ved position +104 er substitueret med glutaminsyre.
- 2. Opløseligt, mutant CTLA4-molekyle og kortikosteroid til anvendelse i behandling eller forebyggelse af akut eller kronisk allotransplantat- eller xenotransplantatafvisning til anvendelse ved induktion af tolerance, hvor det opløselige, mutante CTLA4-molekyle er et Ig-fusionsprotein, der omfatter det extracellulære domæne af CTLA4, og det extracellulære domæne af CTLA4 omfatter en mutation ved position +104 af CTLA4 som vist i Figur 24, hvor leucin ved position +104 er substitueret med glutaminsyre.
- 3. Opløseligt, mutant CTLA4-molekyle og kortikosteroid ifølge krav 1 eller 2 til anvendelsen ifølge krav 1 eller 2, hvor det opløselige, mutante CTLA4-molekyle er L104EIg, der starter med methionin ved position +1 til og med lysin ved position +357 som vist i Figur 18, eller L104EIg, der starter med alanin ved position -1 til og med lysin ved position +357 som vist i Figur 18.
- 4. Opløseligt, mutant CTLA4-molekyle og kortikosteroid ifølge krav 1 eller 2 til anvendelsen ifølge krav 1 eller 2, hvor det extracellulære domæne af CTLA4 omfatter en anden mutation ved position +29 af CTLA4 som vist i Figur 24, hvor alanin ved position +29 er substitueret med tyrosin.
- 5. Opløseligt, mutant CTLA4-molekyle og kortikosteroid ifølge krav 4 til anvendelsen ifølge krav 4, hvor det opløselige, mutante CTLA4-molekyle er: L104EA29YIg, der starter med methionin ved position +1 og slutter med lysin ved position +357 som vist i Figur 19, eller L104EA29YIg, der starter med alanin ved position -1 og slutter med lysin ved position +357 som vist i Figur 19.
- 6. Opløseligt, mutant CTLA4-molekyle og kortikosteroid ifølge krav 1 eller 2 til anvendelsen ifølge krav 1 eller 2, hvor det extracellulære domæne af CTLA4 omfatter en mutation ved a. position +104 af CTLA4 som vist i Figur 24, hvor leucin ved position +104 som vist i Figur 24 er substitueret med glutaminsyre, b. position +29 af CTLA4 som vist i Figur 24, hvor alanin ved position +29 er substitueret med tyrosin, og c. position +25 af CTLA4 som vist i Figur 24, hvor serin ved position +25 er substitueret med en hvilken som helst anden aminosyre.
- 7. Opløseligt, mutant CTLA4-molekyle og kortikosteroid ifølge et hvilket som helst af kravene 1 til 6 til anvendelsen ifølge et hvilket som helst af kravene 1 til 6, hvor kortikosteroidet er prednison.
- 8. Opløseligt, mutant CTLA4-molekyle og kortikosteroid ifølge et hvilket som helst af kravene 1 til 7 til anvendelsen ifølge et hvilket som helst af kravene 1 til 7, hvor det opløselige, mutante CTLA4-molekyle og kortikosteroidet er beregnet til administration samtidigt eller sekventielt.
- 9. Farmaceutisk sammensætning, der omfatter en farmaceutisk acceptabel bærer og en effektiv mængde af opløseligt, mutant CTLA4-molekyle og et kortikosteroid, hvor det opløselige, mutante CTLA4-molekyle er et Ig-fusionsprotein, der omfatter det extracellulære domæne af CTLA4 og det extracellulære domæne af CTLA4 omfatter en mutation ved position +104 af CTLA4, hvor leucin ved position +104 som vist i Figur 24 er substitueret med glutaminsyre og en mutation ved position +29 af CTLA4, hvor alanin ved position +29 som vist i Figur 24 er substitueret med tyrosin.
- 10. Farmaceutisk sammensætning ifølge krav 9, hvor det opløselige, mutante CTLA4-molekyle er L104EA29YIg.
- 11. Farmaceutisk sammensætning ifølge krav 10, hvor L104EA29YIg starter med methionin ved position +1 og slutter med lysin ved position +357 som vist i Figur 19.
- 12. Farmaceutisk sammensætning ifølge krav 10, hvor L104EA29YIg starter med alanin ved position -1 og slutter med lysin ved position +357 som vist i Figur 19.
- 13. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 9 til 12, hvor kortikosteroidet er prednison.
- 14. Farmaceutisk sammensætning ifølge krav 9, hvor den farmaceutisk acceptable bærer er udvalgt fra ionbyttere, alumiumoxid, aluminiumstearat, lecithin, serumproteiner, såsom humant serumalbumin, bufferstoffer, glycin, sorbinsyre, kaliumsorbat, partielle glyceridblandinger af mættede vegetabilske fedtsyrer, phosphatbufferet saltopløsning, vand, emulsioner, salte eller elektrolytter, kolloidal kiselsyre, magnesiumtrisilicat, polyvinylpyrrolidon, cellulosebaserede stoffer, polyethylenglycol, sterile opløsninger, tabletter, excipienser, saccharose, glucose, maltose, smags- og farvetilsætningsstoffer, lipidsammensætninger og polymersammensætninger.
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Application Number | Priority Date | Filing Date | Title |
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US21591300P | 2000-07-03 | 2000-07-03 | |
EP01952420A EP1372696B1 (en) | 2000-07-03 | 2001-07-02 | Methods for treating rheumatic diseases using a soluble ctla4 molecule |
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DK1935427T3 true DK1935427T3 (da) | 2018-06-06 |
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DK08001340.2T DK1935427T3 (da) | 2000-07-03 | 2001-07-02 | Anvendelser af opløselige, mutante ctla4-molekyler |
DK01952420T DK1372696T3 (da) | 2000-07-03 | 2001-07-02 | Fremgangsmåder til behandling af rheumatiske sygdomme under anvendelse af et oplöseligt CTLA4-molekyle |
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DK01952420T DK1372696T3 (da) | 2000-07-03 | 2001-07-02 | Fremgangsmåder til behandling af rheumatiske sygdomme under anvendelse af et oplöseligt CTLA4-molekyle |
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US (1) | US7455835B2 (da) |
EP (4) | EP1372696B1 (da) |
JP (1) | JP2004517806A (da) |
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SI (3) | SI1935427T1 (da) |
SK (1) | SK287940B6 (da) |
TR (1) | TR201807700T4 (da) |
TW (2) | TWI322153B (da) |
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Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
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US6887471B1 (en) | 1991-06-27 | 2005-05-03 | Bristol-Myers Squibb Company | Method to inhibit T cell interactions with soluble B7 |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
EP0892643B2 (en) * | 1996-03-20 | 2009-09-02 | Bristol-Myers Squibb Company | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
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2008
- 2008-05-09 AR ARP080101975A patent/AR066511A2/es unknown
- 2008-10-21 CY CY20081101167T patent/CY1109786T1/el unknown
- 2008-11-05 CY CY2008017C patent/CY2008017I2/el unknown
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2010
- 2010-03-05 BG BG110611A patent/BG66454B1/bg unknown
- 2010-04-22 NO NO20100579A patent/NO20100579L/no unknown
- 2010-04-22 NO NO20100580A patent/NO20100580L/no not_active Application Discontinuation
- 2010-04-27 HU HUS1000008C patent/HUS1000008I1/hu unknown
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2018
- 2018-05-23 CY CY20181100546T patent/CY1120577T1/el unknown
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