DK175034B1 - Joderede, ikke-ioniske trijodbenzenforbindelser og kontrastmiddel indeholdende dem - Google Patents

Joderede, ikke-ioniske trijodbenzenforbindelser og kontrastmiddel indeholdende dem Download PDF

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Publication number
DK175034B1
DK175034B1 DK198902595A DK259589A DK175034B1 DK 175034 B1 DK175034 B1 DK 175034B1 DK 198902595 A DK198902595 A DK 198902595A DK 259589 A DK259589 A DK 259589A DK 175034 B1 DK175034 B1 DK 175034B1
Authority
DK
Denmark
Prior art keywords
formula
compound
compounds
mol
hydroxyethyl
Prior art date
Application number
DK198902595A
Other languages
Danish (da)
English (en)
Other versions
DK259589A (da
DK259589D0 (da
Inventor
Michel Schaefer
Didier Doucet
Dominique Meyer
Maryse Dugast-Zrihen
Michel Guillemot
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8807369A external-priority patent/FR2632304B1/fr
Priority claimed from FR8900762A external-priority patent/FR2643077B1/fr
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of DK259589D0 publication Critical patent/DK259589D0/da
Publication of DK259589A publication Critical patent/DK259589A/da
Application granted granted Critical
Publication of DK175034B1 publication Critical patent/DK175034B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198902595A 1988-06-02 1989-05-26 Joderede, ikke-ioniske trijodbenzenforbindelser og kontrastmiddel indeholdende dem DK175034B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8807369A FR2632304B1 (fr) 1988-06-02 1988-06-02 Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant
FR8807369 1988-06-02
FR8900762A FR2643077B1 (fr) 1989-01-23 1989-01-23 Nouveaux composes non ioniques iodes et produits de contraste les contenant
FR8900762 1989-01-23

Publications (3)

Publication Number Publication Date
DK259589D0 DK259589D0 (da) 1989-05-26
DK259589A DK259589A (da) 1989-12-03
DK175034B1 true DK175034B1 (da) 2004-05-03

Family

ID=26226693

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198902595A DK175034B1 (da) 1988-06-02 1989-05-26 Joderede, ikke-ioniske trijodbenzenforbindelser og kontrastmiddel indeholdende dem

Country Status (25)

Country Link
EP (1) EP0357467B1 (hr)
JP (1) JPH07100684B2 (hr)
KR (1) KR0148358B1 (hr)
CN (1) CN1021440C (hr)
AT (1) ATE98220T1 (hr)
AU (1) AU617810B2 (hr)
CA (1) CA1339665C (hr)
CZ (1) CZ277984B6 (hr)
DE (1) DE68911237T2 (hr)
DK (1) DK175034B1 (hr)
DZ (1) DZ1341A1 (hr)
EG (1) EG19008A (hr)
ES (1) ES2060800T3 (hr)
FI (1) FI102745B1 (hr)
GE (1) GEP19960460B (hr)
HR (1) HRP920498B1 (hr)
HU (1) HU201732B (hr)
IL (1) IL90326A (hr)
LV (1) LV10234B (hr)
MA (1) MA21565A1 (hr)
NO (1) NO177461C (hr)
PT (1) PT90696B (hr)
RU (1) RU1833365C (hr)
SI (1) SI8911042A (hr)
YU (1) YU48318B (hr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2656865B1 (fr) * 1990-01-05 1993-03-26 Guerbet Sa Compose non ionique iode, son procede de preparation et produit de contraste le contenant.
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
CN110903275A (zh) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 制备碘比醇的方法、其中间体及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
DE3429949A1 (de) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel
ATE79368T1 (de) * 1987-05-22 1992-08-15 Bracco Spa Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.
FR2632304B1 (fr) * 1988-06-02 1991-05-17 Guerbert Sa Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant

Also Published As

Publication number Publication date
CA1339665C (en) 1998-02-10
NO892189D0 (no) 1989-05-31
NO177461B (no) 1995-06-12
EG19008A (en) 1994-06-30
GEP19960460B (en) 1996-07-10
HU201732B (en) 1990-12-28
IL90326A (en) 1993-05-13
LV10234B (en) 1995-04-20
JPH0225456A (ja) 1990-01-26
AU617810B2 (en) 1991-12-05
FI892681A (fi) 1989-12-03
HRP920498A2 (hr) 1994-04-30
KR0148358B1 (ko) 1998-08-17
DE68911237D1 (de) 1994-01-20
DK259589A (da) 1989-12-03
FI892681A0 (fi) 1989-06-01
DK259589D0 (da) 1989-05-26
CN1038094A (zh) 1989-12-20
HRP920498B1 (en) 1998-06-30
DZ1341A1 (fr) 2004-09-13
KR900000329A (ko) 1990-01-30
FI102745B (fi) 1999-02-15
DE68911237T2 (de) 1994-05-11
SI8911042A (en) 1997-10-31
EP0357467B1 (fr) 1993-12-08
PT90696A (pt) 1989-12-29
CZ329189A3 (en) 1993-04-14
CN1021440C (zh) 1993-06-30
ATE98220T1 (de) 1993-12-15
RU1833365C (ru) 1993-08-07
CZ277984B6 (en) 1993-07-14
YU104289A (en) 1991-04-30
LV10234A (lv) 1994-10-20
EP0357467A1 (fr) 1990-03-07
AU3523589A (en) 1989-12-07
MA21565A1 (fr) 1989-12-31
HUT50107A (en) 1989-12-28
FI102745B1 (fi) 1999-02-15
YU48318B (sh) 1998-05-15
NO177461C (no) 1995-09-20
NO892189L (no) 1989-12-04
JPH07100684B2 (ja) 1995-11-01
IL90326A0 (en) 1989-12-15
PT90696B (pt) 1995-03-01
ES2060800T3 (es) 1994-12-01

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