YU48318B - Postupak za dobijanje novih trijodobenzen jedinjenja i kontrasnog agensa koji ih sadrži - Google Patents

Postupak za dobijanje novih trijodobenzen jedinjenja i kontrasnog agensa koji ih sadrži

Info

Publication number
YU48318B
YU48318B YU104289A YU104289A YU48318B YU 48318 B YU48318 B YU 48318B YU 104289 A YU104289 A YU 104289A YU 104289 A YU104289 A YU 104289A YU 48318 B YU48318 B YU 48318B
Authority
YU
Yugoslavia
Prior art keywords
contrast
triodobenzen
procedure
units
obtaining new
Prior art date
Application number
YU104289A
Other languages
English (en)
Other versions
YU104289A (en
Inventor
M. Schaefer
M. Dugast-Zrihen
M. Guillemot
D. Doucet
D. Meyer
Original Assignee
Guerbet S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8807369A external-priority patent/FR2632304B1/fr
Priority claimed from FR8900762A external-priority patent/FR2643077B1/fr
Application filed by Guerbet S.A. filed Critical Guerbet S.A.
Priority to SI8911042A priority Critical patent/SI8911042A/sl
Publication of YU104289A publication Critical patent/YU104289A/xx
Priority to HRP-1042/89A priority patent/HRP920498B1/xx
Publication of YU48318B publication Critical patent/YU48318B/sh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21HOBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH TRIJODOBENZEN JEDINJENJA I KONTRASNOG AGENSA KOJI IH SADRZI - Postupak za dobijanje trijodobenzen jedinjenja opste formule u kojoj R, predstavlja - CO-NR2R3 ili -CO-NR7R8 grupu, R2 predstavlja atom vodonika, C1-4 hidroksialkil grupu ili C1-4 polihidroksialkil grupu, R3 predstavlja atom vodonika, C1-4 alkil grupu, R7 predstavlja C1-4 hidroksialkil grupu ili C1-4 polihidroksialkil grupu, R8 predstavlja atom vodonika, C1-4 alkil grupu, R4 predstavlja atom vodonika, C1-4 alkil grupu, C1-4 hidroksialkil grupu ili C1-4 polihidroksialkil grupu, naznacen time, sto obuhvata: A) kada R1 je -CO-NR2R3 a) acilovanje amina formule XV: sa hloridom formule IV: RCOCl (IV) gde R je grupa: u kojoj su hidroksi grupe zasticene; radi dobijanja jedinjenja formule XVI: b) reakciju jedinjenja formule XVI sa aminom formule VII: radi dobijanja jedinjenja formule XVII: i tada po izboru c) alkilovanje jedinjenja formule XVII sa alkilacionim agensom formule V: R'4Z (V) gde R'4 predstavlja C1-4 alkil grupu, C1-4 hidroksialkil grupu ili C1-4 polihidroksialkil grupu, a Z predstavlja atom hlora, broma ili joda, u prisustvu baze takve kao sto je natrijum metoksid, natrijum etoksid, natrijum hidrid ili natrijum hidroksid; i d) eliminisanje zastitnih grupa -CH(CH2OH)2 grupe ili eliminisanje ovih zastitnih grupa pre alkilovanja; B) kada R1 je -CO-NR7R8 i R7 i R2 nisu isti i/ili R8 i R3 nisu isti: a) acilovanje amina formule XVIII: sa hloridom formule IV kao sto je definisano napred, i po izboru b) alkilovanje sa alkilacinim agensom formule R'4Z, kao sto je definisano napred, i c) eliminisanje zastitnih grupa -CH(CH2OH)2 grupe, C) kada R1 je -CO-NR7R8 i R7 i R2 nisu isti i/ili R8 i R3 nisu isti: a) acilovanje amina formule XIX: gde R'7 grupa predstavlja R7 grupu u kojoj su hidroksi grupe zasticene, sa hloridom formule IV kao sto je definisano napred, radi dobijanja jedinjenja formule XX b) reagovanje jedinjenja formule XX sa aminom formule VII: radi dobijanja jedinjenja formule XXI: i zatim po izboru c) alkilovanje jedinjenja formule XXI sa alkilacinim agensom formule R'4Z, kao sto je definisano napred, i d) eliminisanje zastitnih grupa - CH(CH2OH)2 grupe ili eliminisanje ovih zastitnih grupa pre alkilovanja. Prijava sadrzi jos 1 nezavisan zahtev.
YU104289A 1988-06-02 1989-05-22 Postupak za dobijanje novih trijodobenzen jedinjenja i kontrasnog agensa koji ih sadrži YU48318B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8911042A SI8911042A (en) 1988-06-02 1989-05-22 Process for obtaining triiodine benzene compounds with non-ionic iodine and contrast products containing them
HRP-1042/89A HRP920498B1 (en) 1988-06-02 1992-09-25 Process for the preparation of new triiodobenzene compounds with nonionic iodine and contrast products containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8807369A FR2632304B1 (fr) 1988-06-02 1988-06-02 Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant
FR8900762A FR2643077B1 (fr) 1989-01-23 1989-01-23 Nouveaux composes non ioniques iodes et produits de contraste les contenant

Publications (2)

Publication Number Publication Date
YU104289A YU104289A (en) 1991-04-30
YU48318B true YU48318B (sh) 1998-05-15

Family

ID=26226693

Family Applications (1)

Application Number Title Priority Date Filing Date
YU104289A YU48318B (sh) 1988-06-02 1989-05-22 Postupak za dobijanje novih trijodobenzen jedinjenja i kontrasnog agensa koji ih sadrži

Country Status (25)

Country Link
EP (1) EP0357467B1 (sh)
JP (1) JPH07100684B2 (sh)
KR (1) KR0148358B1 (sh)
CN (1) CN1021440C (sh)
AT (1) ATE98220T1 (sh)
AU (1) AU617810B2 (sh)
CA (1) CA1339665C (sh)
CZ (1) CZ277984B6 (sh)
DE (1) DE68911237T2 (sh)
DK (1) DK175034B1 (sh)
DZ (1) DZ1341A1 (sh)
EG (1) EG19008A (sh)
ES (1) ES2060800T3 (sh)
FI (1) FI102745B (sh)
GE (1) GEP19960460B (sh)
HR (1) HRP920498B1 (sh)
HU (1) HU201732B (sh)
IL (1) IL90326A (sh)
LV (1) LV10234B (sh)
MA (1) MA21565A1 (sh)
NO (1) NO177461C (sh)
PT (1) PT90696B (sh)
RU (1) RU1833365C (sh)
SI (1) SI8911042A (sh)
YU (1) YU48318B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2656865B1 (fr) * 1990-01-05 1993-03-26 Guerbet Sa Compose non ionique iode, son procede de preparation et produit de contraste le contenant.
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
CN110903275A (zh) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 制备碘比醇的方法、其中间体及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
DE3429949A1 (de) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel
KR960016747B1 (ko) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법
FR2632304B1 (fr) * 1988-06-02 1991-05-17 Guerbert Sa Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant

Also Published As

Publication number Publication date
LV10234B (en) 1995-04-20
LV10234A (lv) 1994-10-20
PT90696A (pt) 1989-12-29
EG19008A (en) 1994-06-30
DZ1341A1 (fr) 2004-09-13
DK175034B1 (da) 2004-05-03
HRP920498A2 (hr) 1994-04-30
JPH07100684B2 (ja) 1995-11-01
HRP920498B1 (en) 1998-06-30
FI892681A0 (fi) 1989-06-01
GEP19960460B (en) 1996-07-10
CN1038094A (zh) 1989-12-20
JPH0225456A (ja) 1990-01-26
EP0357467B1 (fr) 1993-12-08
CN1021440C (zh) 1993-06-30
DE68911237T2 (de) 1994-05-11
NO177461B (no) 1995-06-12
HUT50107A (en) 1989-12-28
KR900000329A (ko) 1990-01-30
CZ277984B6 (en) 1993-07-14
CA1339665C (en) 1998-02-10
NO892189L (no) 1989-12-04
YU104289A (en) 1991-04-30
ATE98220T1 (de) 1993-12-15
SI8911042A (en) 1997-10-31
AU617810B2 (en) 1991-12-05
NO892189D0 (no) 1989-05-31
DE68911237D1 (de) 1994-01-20
PT90696B (pt) 1995-03-01
FI102745B1 (fi) 1999-02-15
EP0357467A1 (fr) 1990-03-07
MA21565A1 (fr) 1989-12-31
DK259589A (da) 1989-12-03
DK259589D0 (da) 1989-05-26
CZ329189A3 (en) 1993-04-14
ES2060800T3 (es) 1994-12-01
AU3523589A (en) 1989-12-07
IL90326A (en) 1993-05-13
FI102745B (fi) 1999-02-15
HU201732B (en) 1990-12-28
IL90326A0 (en) 1989-12-15
FI892681A (fi) 1989-12-03
RU1833365C (ru) 1993-08-07
KR0148358B1 (ko) 1998-08-17
NO177461C (no) 1995-09-20

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